151 results on '"I. Khan"'
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2. Variable viscosity and activation energy aspects in convection heat transfer over gravity driven solar collector plate for thermal energy storage.
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Ben Khedher N, Ullah Z, Boujelbene M, Makinde OD, Faqihi AA, Aljohani AF, Omer ASA, and Khan I
- Abstract
Variable viscosity, activation energy and microgravity effects on Darcy nanofluid for the thermal performance improvement in thermal energy storage systems through stretching flat plate solar collector is the focus of this research. Thermal energy storage (TES) can be improved though solar collectors, phase change materials and photovoltaic cells using nanofluid in the base liquid. To increase the reaction rate in nanoparticles, the activation energy and solar radiations are used for the efficiency of TES. The viscosity of nanofluid improves the heat and mass transmission. Due to solar radiations, nanofluid plays prominent role in TES applications such as heat exchangers, electronic cooling devices and solar power generation through solar plate collector. Solar energy based mathematical model is developed to execute the frequency of oscillating heat transfer in TES numerically. Primitive and Stokes coefficients are used for feasible programming. Finite difference analysis is performed to display oscillatory thermal energy using Gaussian-elimination matrix scheme. Steady velocity, surface temperature and concentrations are plotted and utilized in oscillatory formula to perform oscillatory skin friction, oscillatory heat transfer and oscillatory mass transfer along π⁄4 angle. Fluid velocity enhances but temperature and concentration variation decreases as viscosity decreases. High amplitude in velocity, temperature and concentration is sketched as activation energy and microgravity increases. Steady heat and mass transmission enhances as thermophoretic and Brownian motion enhances. Amplitude and frequency of oscillations in heat transport, skin friction and mass transport enhances as Prandtl and Schmidt component enhances. In validation of results, the 0.00064% percentage error for heat transport and 0.00102% percentage error for mass transmission are deduced., (© 2024. The Author(s).)
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- 2024
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3. Real world outcome analysis of treosulfan-based conditioning prior to allo-HCT in patients with MDS compared to clinical trial data.
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Stelljes M, Sockel K, Floeth M, Schetelig J, Bornhäuser M, Reicherts C, Lenz G, Schroeder T, Markiewicz M, Labussiere-Wallet H, Reményi P, Ciceri F, Khan I, Pichlmeier U, Li X, and Stölzel F
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- 2024
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4. Engineering of self-assembled silver-peptide colloidal nanohybrids with enhanced biocompatibility and antibacterial activity.
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Saeed N, Atiq A, Rafiq F, Khan I, Atiq M, Saleem M, Anjum DH, Usman Z, and Abbas M
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- Microbial Sensitivity Tests, Peptides chemistry, Peptides pharmacology, Metal Nanoparticles chemistry, Humans, Escherichia coli drug effects, Silver chemistry, Silver pharmacology, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents chemistry, Colloids chemistry, Biocompatible Materials chemistry, Biocompatible Materials pharmacology
- Abstract
Several bacterial strains have developed resistance against commercial antibiotics, and interestingly, supramolecular nanomaterials have shown considerable advantages for antibacterial applications. However, the main challenges in adopting nanotechnology for antibacterial studies are random aggregation, compromised toxicity, multi-step preparation approaches, and unclear structure-function properties. Herein, we designed the amphiphilic tripeptide that acts as a reducing and capping agent for silver metal to form silver-peptide colloidal nanohybrids with the mild assistance of UV light (254 nm) through the photochemical reduction method. The nanohybrids are characterized by different spectroscopic and microscopic techniques, and non-covalent molecular interactions between metal and peptide building blocks confirm their central role in the formation of nanohybrids. The tripeptide is biocompatible and can reduce the toxicity of silver ions (Ag
+ ) by reducing to Ag0 . These colloidal nanohybrids showed antibacterial activity against gram-negative and gram-positive bacterial strains, and the possible mechanism of killing bacterial cells could be membrane disruption. This synthetic strategy is facile and green, which helps avoid using toxic chemicals or reagents and complicated methods for colloidal nanohybrid preparation for biomedical applications., (© 2024. The Author(s).)- Published
- 2024
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5. Statistical analysis of seroprevalence and risk factors of hepatitis C in Nowshera District, Pakistan.
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Amin R, Albalawi O, Khan I, Ullah R, Boukhris I, and Ahmad B
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- Humans, Pakistan epidemiology, Female, Male, Risk Factors, Adult, Seroepidemiologic Studies, Middle Aged, Cross-Sectional Studies, Young Adult, Adolescent, Hepacivirus, Aged, Hepatitis C epidemiology, Hepatitis C transmission
- Abstract
Hepatitis C virus (HCV) transmission remains a significant public health concern. It is well documented globally, however, Nowshera district, Pakistan, is lacking such profile. This study aims to explore the relationship between HCV infection and several risk factors, including socio-demographic, clinical and personal life-style factors. This study using a cross-sectional design, examined 606 randomly selected individuals visiting the Pathology department at Qazi Hussain Medical Complex and District Headquarter (DHQ) Hospital Nowshera between May 1, 2022 and Jun 30, 2023. This research investigation employed a methodical approach involving formal interviews in conjunction with structured questionnaires to gather comprehensive information related to socio-demographic characteristics, clinical history, and personal hygiene practices. We collected 10 ml of blood samples and tested the separated serum to identify markers using the Immuno-Chromatographic Test (ICT) and the Enzyme-Linked Immunosorbent Assay (ELISA). IBM SPSS Statistics version 27 was used for data analysis. To measure the association between dependent variable and independent variables, a chi-square and risk analysis was carried out; multiple logistic regression was employed for modeling the risk factors associated with independent variable. A statistical significance level was established at a P-value of less than 0.05. In present study, which included 606 participants, 12% were found to be infected with HCV. Importantly it revealed that facial shave at barber (adjusted odds ratio, aOR = 40.65, p = 0.000) represents the most prevalent mode of HCV transmission. Additionally, a strong association was observed between HCV infection and history of past surgery (RR = 2.98, p = 0.001), HCV infected family member (aOR = 4.28, p = 0.001), workplace injuries (aOR = 6.68, p = 0.000), history of hospital admission (RR = 2.09), practicing ear and nose piercing (aOR = 5.01, p = 0.001), dental treatment (RR = 2.31) and the frequency of injections (aOR = 8.607, p = 0.000). These findings underscore the pressing need for targeted interventions. This study highlights the paramount importance of understanding the modes of HCV transmission and their associated risk factors. The results emphasize the need for educational initiatives, both within the healthcare sector and among the general public, to combat HCV transmission effectively. By implementing sterilization procedures and increasing awareness, we can make significant strides in reducing the burden of HCV infection. Moreover, proactive measures within families can help contain the spread of the virus, ultimately contributing to improved public health., (© 2024. The Author(s).)
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- 2024
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6. Bayesian control chart using variable sample size with engineering applications.
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Khan I, Alamri AM, Almarashi AM, Elhag AA, Aripov M, and Hussain S
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In this study, we suggested an innovative approach by introducing an Adaptive Exponential Weighted Moving Average (AEWMA) control chart utilizing Variable Sample Size (VSS) under Bayesian methodology. The proposed methodology utilized an integer linear function to dynamically adjust sample sizes according to the AEWMA statistic. Another appealing feature of our adaptive framework is the integration of the smoothing constant of an EWMA chart, which enhances monitoring responsiveness. We reveal the superiority of our recommended control chart by extensive simulations to existing Bayesian EWMA and Bayesian AEWMA control charts using Fixed sample size (FSS). The offered Bayesian VAEWMA control chart is more sensitive to detection improvement, a decrease in the false alarm rate, and overall more effective than the existing methods. These findings provide additional justification for the basic notion that process control statistical tools needed to be dynamic, as the manufacturing process itself was dynamic. The results suggest the importance of introducing adaptive SPC methods in dynamic manufacturing environments. A real data application is performed to evaluate the validity and optimal performance of our recommended chart."Please check article if captured correctly."="Dear Editor we have checked and found corrrect."As per standard instruction, city is required for affiliations; however, this information is missing in affiliations [1, 5]. Please check if the provided city is correct and amend if necessary."Dear Editor we have checked and found correct. thanks youPlease check and confirm that the authors and their respective affiliations have been correctly identified and amend if necessary."Dear Editor we have checked and found correct. thank you"., (© 2024. The Author(s).)
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- 2024
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7. Evaluating and optimizing NBR-modified bituminous mixes: a rheological and RSM-based study.
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Khan I, Khan ZA, Khan MI, Ali M, Khan N, Paulraj M, and Avudaiappan S
- Abstract
Bitumen shows visco-elastic behavior, exhibiting both elastic and viscous properties as predicted by dynamic response and phase angle. Modern asphalt bituminous pavements face issues such as early-stage fatigue cracks, rutting, and permanent deformations due to low-temperature cracking, high-temperature deformation, moisture susceptibility, and overloading. These pavement distresses result in the formation of potholes, alligator cracks, and various deformations, which accelerate the need for rehabilitation and maintenance. To address these concerns, this study focused on utilizing Nitrile Butadiene Rubber derived from surgical gloves as an additive in conventional asphalt pavements to assess its effect on stiffness. Nitrile Butadiene Rubber was added in intervals of 2%, 4%, 6%, and 8% to conventional bituminous pavement. The rheological properties, marshall properties, dynamic modulus, and phase angle were evaluated for varying percentages of Nitrile Butadiene Rubber at different temperature, and frequency. The dynamic response was determined using a simple performance tester at four different temperatures (4.4 °C, 21.1 °C, 37.8 °C, and 54.4 °C) and six different frequencies (0.1, 0.5, 1, 5, 10, and 25 Hz). Response surface methodology was employed to establish a relationship between input and output variables and to optimize the amount of Nitrile Butadiene Rubber in the mix based on dynamic modulus and phase angle. The study concluded that adding up to 6% of Nitrile Butadiene Rubber improved Marshall stability, while higher percentages led to reduced stability. A similar trend was observed in the dynamic modulus, which peaked with the addition of 6% Nitrile Butadiene Rubber, regardless of frequency and temperature. The response surface methodology model indicated that coupling the percentage of Nitrile Butadiene Rubber with frequency increased the dynamic modulus at a constant temperature, with the highest value occurring at 4.4 °C. However, the dynamic modulus decreased as the temperature rose for the same combinations of Nitrile Butadiene Rubber percentages and frequencies. Numerical optimization suggested that a maximum of 5.9% Nitrile Butadiene Rubber should be added to achieve the highest dynamic modulus and lowest phase angle., (© 2024. The Author(s).)
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- 2024
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8. A comparative study of finite difference approach and bvp4c techniques for water base hybrid nanofluid containing multiple walls carbon nanotubes and magnetic oxide.
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Manigandan J, Iranian D, Omer ASA, Aljohani AF, and Khan I
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This study investigates the thermal behaviour of unsteady hybrid nanofluid flow on an infinite vertical plate. The investigation takes into account parameters such as magnetohydrodynamics and radiation effects, as well as the stratified medium. The systems of equations were solved by employing the explicit finite difference approach of Dufort-Frankel method. The main motivation of the study is to compare the performance of water, magnetic oxide, and multi-wall carbon nanotubes as working fluids. Additionally, velocity, temperature, and concentration outlines are visualized through plots, elucidating the fluid behaviour. Tables are provided for the Skin friction, Nusselt number, and Sherwood number, offering comprehensive insights crucial for optimizing performance in engineering applications ranging from thermal management systems to renewable energy technologies. The main finding of this study indicates that the quantitative result reveals that the temperature outline escalates among increasing values of radiation. In contrast, the outlines of a velocity and concentration show a decrease as the values of magnetohydrodynamics increase. In addition, multi-walled carbon nanotubes consume a larger outcome on temperature. A statistical study displays that the thermal stream rate of magnetic oxide-multi-wall carbon nanotubes-water increases from 1.7615 percentages to 7.4415 percentages, respectively, when the volume fraction of nanoparticles rises from 0.01 to 0.05. Future research is important to understanding hybrid nanofluid flows and their applications in thermal engineering systems such as energy systems, nuclear reactors, biomedical applications, electronics cooling, solar thermal systems, chemical processing, and other heat transfer applications where improved thermal performance is crucial., (© 2024. The Author(s).)
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- 2024
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9. Time delayed fractional diabetes mellitus model and consistent numerical algorithm.
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Rafique M, Ur Rehamn MA, Rafiq M, Iqbal Z, Ahmed N, Alhazmi H, Niazai S, and Khan I
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- Humans, Time Factors, Computer Simulation, Models, Theoretical, Models, Biological, Algorithms, Diabetes Mellitus
- Abstract
The diabetes mellitus model (DMM) is explored in this study. Many health issues are caused by this disease. For this reason, the integer order DMM is converted into the time delayed fractional order model by fitting the fractional order Caputo differential operator and delay factor in the model. It is proved that the generalized model has the advantage of a unique solution for every time t. Moreover, every solution of the system is positive and bounded. Two equilibrium states of the fractional model are worked out i.e. disease free equilibrium state and the endemic equilibrium state. The risk factor indicator, R
0 is computed for the system. The stability analysis is carried out for the underlying system at both the equilibrium states. The key role of R0 is investigated for the disease dynamics and stability of the system. The hybridized finite difference numerical method is formulated for obtaining the numerical solutions of the delayed fractional DMM. The physical features of the numerical method are examined. Simulated graphs are presented to assess the biological behavior of the numerical method. Lastly, the outcomes of the study are furnished in the conclusion section., (© 2024. The Author(s).)- Published
- 2024
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10. Performance evaluation of indented macro synthetic polypropylene fibers in high strength self-compacting concrete (SCC).
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Yaqin C, Haq SU, Iqbal S, Khan I, Room S, and Khan SA
- Abstract
Concrete is used worldwide as a construction material in many projects. It exhibits a brittle nature, and fibers' addition to it improves its mechanical properties. Polypropylene (PP) fibers stand out as widely employed fibers in concrete. However, conventional micro-PP fibers pose challenges due to their smooth texture, affecting bonding within concrete and their propensity to clump during mixing due to their thin and soft nature. Addressing these concerns, a novel type of PP fiber is proposed by gluing thin fibers jointly and incorporating surface indentations to enhance mechanical anchorage. This study investigates the incorporation of macro-PP fibers into high-strength concrete, examining its fresh and mechanical properties. Three different concrete strengths 40 MPa, 45 MPa, and 50 MPa, were studied with fiber content of 0-1.5% v/f. ASTM specifications were utilized to test the fresh and mechanical properties, while the RILEM specifications were adopted to test the bond of bar reinforcements in concrete. Test results indicate a decrease in workability, increased air content, and no substantial shift in fresh concrete density. Hardened concrete tests, adding macro-PP fibers, show a significant increase in splitting tensile strength, bond strength, and flexural strength with a maximum increase of 34.5%, 35%, and 100%, respectively. Concrete exhibits strain-hardening behavior with 1% and 1.5% fiber content, and the flexural toughness increases remarkably from 2.2 to 47.1. Thus, macro PP fibers can effectively improve concrete's mechanical properties and resistance against crack initiation and spread., (© 2024. The Author(s).)
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- 2024
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11. A numerical study of heat and mass transfer characteristic of three-dimensional thermally radiated bi-directional slip flow over a permeable stretching surface.
- Author
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Ullah H, Abas SA, Fiza M, Khan I, Rahimzai AA, and Akgul A
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Within fluid mechanics, the flow of hybrid nanofluids over a stretching surface has been extensively researched due to their influence on the flow and heat transfer properties. Expanding on this concept by introducing porous media, the current study explore the flow and heat and mass transport characteristics of hybrid nanofluid. This investigation includes the effect of magnetohydrodynamic (MHD) with chemical reaction, thermal radiation, and slip effects. The nanoparticles, copper, and alumina are combined with water for the formation of a hybrid nanofluid. Using the self-similar method for the reduction of Partial differential equations (PDEs) to the system of Ordinary differential equations (ODEs). These nonlinear equation systems are solved numerically using the bvp4c (boundary value solver) technique. The effect of the different physical non-dimensional flow parameters on different flow profiles such as velocity, temperature, concentration, skin friction, Nusselt and mass transfer rate are depicted through graphs and tables. The velocity profiles diminish with the effect of magnetic and slip parameters. The temperature and concentration slip parameters reduce the temperature and concentration profile respectively. The higher values of magnetic factor lessened the skin friction coefficient for both slip and no-slip conditions. An elevation in the thermal slip parameter reduced the boundary layer thickness and the heat transfer from the surface to the fluid. The Nusselt number amplified with the climbing values of the radiation parameter. The mass transfer rate depressed with the solutal slip parameter. Comparison is made with the published work in the literature and there is excellent agreement between them., (© 2024. The Author(s).)
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- 2024
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12. Thermal slip and variable viscosity analysis on heat rate and magnetic flux through accelerating non-conducting wedge in the presence of induced magnetic field.
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Ullah Z, Alotaibi H, Usman A, Khan I, and Omer ASA
- Abstract
The focus of present study is to incorporate the variable viscosity and temperature slip impact on heating rate and induced magnetic gradient along the moving non-conducting wedge under magnetic field. In industrial and engineering procedures, the impact of induced magnetization improves the efficiency of thermal systems to main the heating rates. The similarity transformations and stream functions are applied to reduce the governing equations into ordinary form. During this transformation, the pertinent parameters such as wedge parameter, moving parameter, Prandtl factor, viscosity parameter and temperature-slip parameter is obtained. These parameters play a prominent role on the physical values of fluid velocity, induced magnetic field and temperature distributions. The skin friction, Nusselt coefficient and induced magnetic gradient are incorporated through these parameters. The numerical values are executed by using the Keller box analysis with Newton-Raphson technique. It is depicted that the maximum slip in fluid velocity and temperature distribution is obtained for each values of thermal-slip parameter. It is noticed that maximum magnitude in induced magnetic field is reported for each wedge factor. The maximum velocity slip and temperature slip is observed for each choice of moving parameter. It is reported that the maximum variation in heating rate and induced magnetic gradient is obtained for magnetic force and viscosity parameter. The enhancing behavior of skin friction is observed for maximum values of Prandtl number., (© 2024. The Author(s).)
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- 2024
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13. Author Correction: Heat generation/absorption effect on natural convective heat transfer in a wavy triangular cavity filled with nanofluid.
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Islam T, Alam MN, Niazai S, Khan I, Fayz-Al-Asad M, and Alqahtani S
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- 2024
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14. Publisher Correction: Evaluation of machine learning models for predicting TiO 2 photocatalytic degradation of air contaminants.
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Javed MF, Shahab MZ, Asif U, Najeh T, Aslam F, Ali M, and Khan I
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- 2024
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15. An evaluation of inflammatory and endothelial dysfunction markers as determinants of peripheral arterial disease in those with diabetes mellitus.
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Zaib S, Ahmad S, Khan I, Bin Jardan YA, and Fentahun Wondmie G
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- Humans, Male, Female, Middle Aged, Aged, Inflammation blood, Interleukin-6 blood, Intercellular Adhesion Molecule-1 blood, Interleukin-8 blood, Endothelium, Vascular physiopathology, Endothelium, Vascular metabolism, Case-Control Studies, Biomarkers blood, Peripheral Arterial Disease blood, Peripheral Arterial Disease diagnosis, Diabetes Mellitus, Type 2 complications, Diabetes Mellitus, Type 2 blood, Vascular Cell Adhesion Molecule-1 blood
- Abstract
The most serious long-term effects of diabetes is peripheral artery disease (PAD) which increases the chance of developing diabetic foot ulcers, gangrene and even lower limb amputation. The clinical manifestations of PAD which are typically not revealed until symptoms like intermittent claudication, rest pain and ischemic gangrene develop, are not present in majority of diabetes mellitus patients with PAD due to diabetic peripheral neuropathy. Therefore, current study is aimed to evaluate the inflammatory and endothelial dysfunction markers with their correlation to biomarkers that can help for in-time diagnosis and efficient prognosis of developing diabetes-associated PAD. Enzyme-linked immunosorbent assay was used to evaluate the interlukin-6, interlukin-8, intercellular adhesion molecule (ICAM) and vascular cell adhesion molecule (VCAM) in PAD with diabetes group, diabetic group and healthy individual group while biomarkers were measured by kit method. It was observed that serum IL-6, IL-8, ICAM and VCAM levels in type II diabetes mellitus (T2DM) with PAD patients were increased significantly (85.93, 597.08, 94.80 and 80.66) as compared to T2DM patients (59.52, 231.34, 56.88 and 50.19) and healthy individuals (4.81, 16.93, 5.55 and 5.16). The overall means for the parameters, IL-6, IL-8, ICAM, VCAM, urea, S/creatinine, CK-MB, AST, ALT, cholesterol, triglyceride, HDL, LDL, PT, aPTT, INR, HbA1C, and CRP within all groups were significantly (P < 0.05) different from each other. Therefore, it was concluded that the change in IL-6, IL-8, ICAM and VCAM can serve as an accurate diagnostic indicator and successful treatment., (© 2024. The Author(s).)
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- 2024
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16. Investigating pseudo parabolic dynamics through phase portraits, sensitivity, chaos and soliton behavior.
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Jhangeer A, Ibraheem F, Jamal T, Abdul Rahimzai A, and Khan I
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This research examines pseudoparabolic nonlinear Oskolkov-Benjamin-Bona-Mahony-Burgers (OBBMB) equation, widely applicable in fields like optical fiber, soil consolidation, thermodynamics, nonlinear networks, wave propagation, and fluid flow in rock discontinuities. Wave transformation and the generalized Kudryashov method is utilized to derive ordinary differential equations (ODE) and obtain analytical solutions, including bright, anti-kink, dark, and kink solitons. The system of ODE, has been then examined by means of bifurcation analysis at the equilibrium points taking parameter variation into account. Furthermore, in order to get insight into the influence of some external force perturbation theory has been employed. For this purpose, a variety of chaos detecting techniques, for instance poincaré diagram, time series profile, 3D phase portraits, multistability investigation, lyapounov exponents and bifurcation diagram are implemented to identify the quasi periodic and chaotic motions of the perturbed dynamical model. These techniques enabled to analyze how perturbed dynamical system behaves chaotically and departs from regular patterns. Moreover, it is observed that the underlying model is quite sensitivity, as it changing dramatically even with slight changes to the initial condition. The findings are intriguing, novel and theoretically useful in mathematical and physical models. These provide a valuable mechanism to scientists and researchers to investigate how these perturbations influence the system's behavior and the extent to which it deviates from the unperturbed case., (© 2024. The Author(s).)
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- 2024
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17. Genetic characterization and phylogenetic analysis of the Nigella sativa (black seed) plastome.
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Lubna, Asaf S, Khan I, Jan R, Asif S, Bilal S, Kim KM, and Al-Harrasi A
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- Genome, Plastid, Nigella sativa genetics, Nigella sativa chemistry, Phylogeny
- Abstract
In this study, the complete plastome sequence of Nigella sativa (black seed), was analyzed for the first time. The plastome spans approximately 154,120 bp, comprising four sections: the Large Single-Copy (LSC) (85,538 bp), the Small Single-Copy (SSC) (17,984 bp), and two Inverted Repeat (IR) regions (25,299 bp). A comparative study of N. sativa's plastome with ten other species from various genera in the Ranunculaceae family reveals substantial structural variations. The contraction of the inverted repeat region in N. sativa influences the boundaries of single-copy regions, resulting in a shorter plastome size than other species. When comparing the plastome of N. sativa with those of its related species, significant divergence is observed, particularly except for N. damascena. Among these, the plastome of A. glaucifolium displays the highest average pairwise sequence divergence (0.2851) with N. sativa, followed by A. raddeana (0.2290) and A. coerulea (0.1222). Furthermore, the study identified 12 distinct hotspot regions characterized by elevated Pi values (> 0.1). These regions include trnH-GUG-psbA, matK-trnQ-UUG, psbK-trnR-UCU, atpF-atpI, rpoB-psbD, ycf3-ndhJ, ndhC-cemA, petA-psaJ, trnN-GUU-ndhF, trnV-GAC-rps12, ycf2-trnI-CAU, and ndhA-ycf1. Approximately, 24 tandem and 48 palindromic and forward repeats were detected in N. sativa plastome. The analysis revealed 32 microsatellites with the majority being mononucleotide repeats. In the N. sativa plastome, phenylalanine had the highest number of codons (1982 codons), while alanine was the least common amino acid with 260 codons. A phylogenetic tree, constructed using protein-coding genes, revealed a distinct monophyletic clade comprising N. sativa and N. damascene, closely aligned with the Cimicifugeae tribe and exhibiting robust support. This plastome provides valuable genetic information for precise species identification, phylogenetic resolution, and evolutionary studies of N. sativa., (© 2024. The Author(s).)
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- 2024
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18. Evaluation of machine learning models for predicting TiO 2 photocatalytic degradation of air contaminants.
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Javed MF, Shahab MZ, Asif U, Najeh T, Aslam F, Ali M, and Khan I
- Abstract
The escalation of global urbanization and industrial expansion has resulted in an increase in the emission of harmful substances into the atmosphere. Evaluating the effectiveness of titanium dioxide (TiO
2 ) in photocatalytic degradation through traditional methods is resource-intensive and complex due to the detailed photocatalyst structures and the wide range of contaminants. Therefore in this study, recent advancements in machine learning (ML) are used to offer data-driven approach using thirteen machine learning techniques namely XG Boost (XGB), decision tree (DT), lasso Regression (LR2), support vector regression (SVR), adaBoost (AB), voting Regressor (VR), CatBoost (CB), K-Nearest Neighbors (KNN), gradient boost (GB), random Forest (RF), artificial neural network (ANN), ridge regression (RR), linear regression (LR1) to address the problem of estimation of TiO2 photocatalytic degradation rate of air contaminants. The models are developed using literature data and different methodical tools are used to evaluate the developed ML models. XGB, DT and LR2 models have high R2 values of 0.93, 0.926 and 0.926 in training and 0.936, 0.924 and 0.924 in test phase. While ANN, RR and LR models have lowest R2 values of 0.70, 0.56 and 0.40 in training and 0.62, 0.63 and 0.31 in test phase respectively. XGB, DT and LR2 have low MAE and RMSE values of 0.450 min-1 /cm2 , 0.494 min-1 /cm2 and 0.49 min-1 /cm2 for RMSE and 0.263 min-1 /cm2 , 0.285 min-1 /cm2 and 0.29 min-1 /cm2 for MAE in test stage. XGB, DT, and LR2 have 93% percent errors within 20% error range in training phase. XGB has 92% and DT, and LR2 have 94% errors with 20% range in test phase. XGB, DT, LR2 models remained the highest performing models and XGB is the most robust and effective in predictions. Feature importances reveal the role of input parameters in prediction made by developed ML models. Dosage, humidity, UV light intensity remain important experimental factors. This study will impact positively in providing efficient models to estimate photocatalytic degradation rate of air contaminants using TiO2 ., (© 2024. The Author(s).)- Published
- 2024
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19. Optimal control strategies for toxoplasmosis disease transmission dynamics via harmonic mean-type incident rate.
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Khan U, Ali F, Alqasem OA, Elwahab MEA, Khan I, and Rahimzai AA
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- Animals, Humans, Cats, Incidence, Models, Theoretical, Toxoplasma pathogenicity, Toxoplasma physiology, Computer Simulation, Toxoplasmosis transmission, Toxoplasmosis epidemiology, Toxoplasmosis prevention & control
- Abstract
Toxoplasma infection in humans is considered due to direct contact with infected cats. Toxoplasma infection (an endemic disease) has the potential to affect various organs and systems (brain, eyes, heart, lungs, liver, and lymph nodes). Bilinear incidence rate and constant population (birth rate is equal to death rate) are used in the literature to explain the dynamics of Toxoplasmosis disease transmission in humans and cats. The goal of this study is to consider the mathematical model of Toxoplasma disease with harmonic mean type incident rate and also consider that the population of humans and cats is not equal (birth rate and the death rate are not equal). In examining Toxoplasma transmission dynamics in humans and cats, harmonic mean incidence rates are better than bilinear incidence rates. The disease dynamics are first schematically illustrated, and then the law of mass action is applied to obtain nonlinear ordinary differential equations (ODEs). Analysis of the boundedness, positivity, and equilibrium points of the system has been analyzed. The reproduction number is calculated using the next-generation matrix technique. The stability of disease-free and endemic equilibrium are analyzed. Sensitivity analysis is also done for reproduction number. Numerical simulation shows that the infection is spread in the population when the contact rate β h and β c increases while the infection is reduced when the recovery rate δ h increases. This study investigates the impact of various optimal control strategies, such as vaccinations for the control of disease and the awareness of disease awareness, on the management of disease., (© 2024. The Author(s).)
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- 2024
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20. Novel techniques to analyze dynamical properties of quantum chaos with peculiar evidence of hybrid systems confinement.
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Bary G, Ahmed W, Ahmad R, Niazai S, and Khan I
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Recent results demonstrate the dynamical peculiarities of the quantum chaos within the hybrid systems by chaotic parameters and probe the pattern formation under the influence of condensation. The complex dynamic behavior of the considered systems was determined with numerical simulation and presented an efficient technique that studied fractional systems comprising chaos-coherence fractions. The findings divulge the peculiar association between the coherence structure and the correlations at finite relative momenta. Thus the present study helps to explore the partially chaos hybrid systems in order to stimulate the experimental applications of nonlinear phenomena. The coherent-chaotic parameters can be measured by examining the chaos peculiarities that possess explicit relations with the condensations to demonstrate the environs of the physical systems. We investigate the influence of the multiplicities, chaos, momentum and temperature of the nonlinear system on the coherent-chaotic normalized correlations. The chaotic parameters are suppressed considerably with the coherence fraction and it appears numerically zero at maximum condensation and one at ideal chaos emissions. We procure that the meaningful parameters decrease significantly with the multiplicity of the nonlinear systems and increase with the momentum in the specified regimes. The identical multiplicity leads to contemplating the coherence and thus the normalized chaotic parameters within its spectacular influences exhibit significance worth contemplating in earnest. The findings underscore the significance of cogitating correlations in deciphering the nonlinear system characteristics and bestowing extraordinary perceptiveness into the convoluted essence of complex systems. The contemplated methodology can be applied to evaluating and analyzing the nonlinear systems and such an innovative approach computes the problems of celestial mechanics, heartbeats and chemical reactions in engineering and medical fields., (© 2024. The Author(s).)
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- 2024
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21. Parameter free AEWMA control chart for dispersion in semiconductor manufacturing.
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Zaagan AA, Khan I, Alzahrani ARR, and Ahmad B
- Abstract
The study presents a new parameter free adaptive exponentially weighted moving average (AEWMA) control chart tailored for monitoring process dispersion, utilizing an adaptive approach for determining the smoothing constant. This chart is crafted to adeptly detect shifts within anticipated ranges in process dispersion by dynamically computing the smoothing constant. To assess its effectiveness, the chart's performance is measured through concise run-length profiles generated from Monte Carlo simulations. A notable aspect is the incorporation of an unbiased estimator in computing the smoothing constant through the suggested function, thereby improving the chart's capability to identify different levels of increasing and decreasing shifts in process dispersion. The comparison with an established adaptive EWMA-S
2 dispersion chart highlights the considerable efficiency of the proposed chart in addressing diverse magnitudes of process dispersion shifts. Additionally, the study includes an application to a real-life dataset, showcasing the practicality and user-friendly nature of the proposed chart in real-world situations., (© 2024. The Author(s).)- Published
- 2024
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22. Max-mixed EWMA control chart for joint monitoring of mean and variance: an application to yogurt packing process.
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Malik S, Hanif M, Noor-Ul-Amin M, Khan I, Ahmad B, Abaker AOI, and Ahmed Darwish J
- Abstract
The Max-Mixed EWMA Exponentially Weighted Moving Average (MM EWMA) control chart is a statistical process control technique used for joint monitoring of the mean and variance of a process. This control chart is designed to detect small and moderate shifts in the mean and variance of a process by comparing the maximum of two statistics, one based on the mean and the other on the variance. In this paper, we propose a new MM EWMA control chart. The proposed chart is compared with existing control charts using simulation studies, and the results show that the chart performs better in detecting small and moderate shifts in both the mean and variance. The proposed chart can be helpful in quality control applications, where joint monitoring of mean and variance is necessary to ensure a product's or process's quality. The real-life application of the proposed control chart on yogurt packing in a cup data set shows the outperformance of the MM EWMA control chart. Both simulations & real-life application results demonstrate the better performance of the proposed chart in detecting smaller shifts during the production process., (© 2024. The Author(s).)
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- 2024
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23. Centrality dependency of proton, deuteron, and triton's temperatures in Au+Au collisions at 200 GeV.
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Khan I, Qudus A, Salouci M, and Ismail AH
- Abstract
The transverse momentum (p
T ) spectra of protons (p), deuterons (d), and tritons (t) in 200 GeV gold-gold (Au + Au) collisions at RHIC are examined across a range of centrality bins using the Levy Tsallis (TS) statistical model. The model's predictions closely match the experimental results from PHENIX (p) and STAR (d and t) Collaborations. Kinetic freeze-out temperatures of hadrons are obtained from particle spectra. The results showed that the kinetic freeze-out temperature decreases as collisions move from center to the periphery. This work found mass-dependent kinetic freeze-out temperatures, heavier particles arrive to the freeze-out phase before lighter ones. Comparison with same data fitted by blast wave function with Tsallis statistics (BWTS) showed that T0 values are increasing from central to peripheral collisions, while in case of TS function (current analysis) it decreases. This behavior puts a question mark on the reliability of using such functions for temperature extraction., (© 2024. The Author(s).)- Published
- 2024
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24. Novel FOXM1 inhibitor STL001 sensitizes human cancers to a broad-spectrum of cancer therapies.
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Raghuwanshi S, Zhang X, Arbieva Z, Khan I, Mohammed H, Wang Z, Domling A, Camacho CJ, and Gartel AL
- Abstract
Forkhead box protein M1 (FOXM1) is often overexpressed in human cancers and strongly associated with therapy resistance and less good patient survival. The chemotherapy options for patients with the most aggressive types of solid cancers remain very limited because of the acquired drug resistance, making the therapy less effective. NPM1 mutation through the inactivation of FOXM1 via FOXM1 relocalization to the cytoplasm confers more favorable treatment outcomes for AML patients, confirming FOXM1 as a crucial target to overcome drug resistance. Pharmacological inhibition of FOXM1 could be a promising approach to sensitize therapy-resistant cancers. Here, we explore a novel FOXM1 inhibitor STL001, a first-generation modification drug of our previously reported FOXM1 inhibitor STL427944. STL001 preserves the mode of action of the STL427944; however, STL001 is up to 50 times more efficient in reducing FOXM1 activity in a variety of solid cancers. The most conventional cancer therapies studied here induce FOXM1 overexpression in solid cancers. The therapy-induced FOXM1 overexpression may explain the failure or reduced efficacy of these drugs in cancer patients. Interestingly, STL001 increased the sensitivity of cancer cells to conventional cancer therapies by suppressing both the high-endogenous and drug-induced FOXM1. Notably, STL001 does not provide further sensitization to FOXM1-KD cancer cells, suggesting that the sensitization effect is conveyed specifically through FOXM1 suppression. RNA-seq and gene set enrichment studies revealed prominent suppression of FOXM1-dependent pathways and gene ontologies. Also, gene regulation by STL001 showed extensive overlap with FOXM1-KD, suggesting a high selectivity of STL001 toward the FOXM1 regulatory network. A completely new activity of FOXM1, mediated through steroid/cholesterol biosynthetic process and protein secretion in cancer cells was also detected. Collectively, STL001 offers intriguing translational opportunities as combination therapies targeting FOXM1 activity in a variety of human cancers driven by FOXM1., (© 2024. The Author(s).)
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- 2024
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25. An adaptive Bayesian approach for improved sensitivity in joint monitoring of mean and variance using Max-EWMA control chart.
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Zaagan AA, Noor-Ul-Amin M, Khan I, Iqbal J, and Hussain S
- Abstract
This article introduces an adaptive approach within the Bayesian Max-EWMA control chart framework. Various Bayesian loss functions were used to jointly monitor process deviations from the mean and variance of normally distributed processes. Our study proposes the mechanism of using a function-based adaptive method that picks self-adjusting weights incorporated in Bayesian Max-EWMA for the estimation of mean and variance. This adaptive mechanism significantly enhances the effectiveness and sensitivity of the Max-EWMA chart in detecting process shifts in both the mean and dispersion. The Monte Carlo simulation technique was used to calculate the run-length profiles of different combinations. A comparative performance analysis with an existing chart demonstrates its effectiveness. A practical example from the hard-bake process in semiconductor manufacturing is presented for practical context and illustration of the chart settings and performance. The empirical results showcase the superior performance of the Adaptive Bayesian Max-EWMA control chart in identifying out-of-control signals. The chart's ability to jointly monitor the mean and variance of a process, its adaptive nature, and its Bayesian framework make it a useful and effective control chart., (© 2024. The Author(s).)
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- 2024
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26. Risk adjusted EWMA control chart based on support vector machine with application to cardiac surgery data.
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Noor-Ul-Amin M, Khan I, Alzahrani ARR, Ayari-Akkari A, and Ahmad B
- Subjects
- Humans, Risk Factors, Risk Adjustment methods, Support Vector Machine, Cardiac Surgical Procedures methods
- Abstract
In the current study, we demonstrate the use of a quality framework to review the process for improving the quality and safety of the patient in the health care department. The researchers paid attention to assessing the performance of the health care service, where the data is usually heterogeneous to patient's health conditions. In our study, the support vector machine (SVM) regression model is used to handle the challenge of adjusting the risk factors attached to the patients. Further, the design of exponentially weighted moving average (EWMA) control charts is proposed based on the residuals obtained through SVM regression model. Analyzing real cardiac surgery patient data, we employed the SVM method to gauge patient condition. The resulting SVM-EWMA chart, fashioned via SVM modeling, revealed superior shift detection capabilities and demonstrated enhanced efficacy compared to the risk-adjusted EWMA control chart., (© 2024. The Author(s).)
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- 2024
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27. Computation and convergence of fixed-point with an RLC-electric circuit model in an extended b-suprametric space.
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Panda SK, Velusamy V, Khan I, and Niazai S
- Abstract
This article establishes various fixed-point results and introduces the idea of an extended b-suprametric space. We also give several applications pertaining to the existence and uniqueness of the solution to the equations concerning RLC electric circuits. At the end of the article, a few open questions are posed concerning the distortion of Chua's circuit and the formulation of the Lagrangian for Chua's circuit., (© 2024. The Author(s).)
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- 2024
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28. Memory type Bayesian adaptive max-EWMA control chart for weibull processes.
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A Zaagan A, Khan I, Ayari-Akkari A, Raza A, and Ahmad B
- Abstract
The simultaneous monitoring of both the process mean and dispersion has gained considerable attention in statistical process control, especially when the process follows the normal distribution. This paper introduces a novel Bayesian adaptive maximum exponentially weighted moving average (Max-EWMA) control chart, designed to jointly monitor the mean and dispersion of a non-normal process. This is achieved through the utilization of the inverse response function, particularly suitable for processes conforming to a Weibull distribution. To assess the effectiveness of the proposed control chart, we employed the average run length (ARL) and the standard deviation of run length (SDRL). Subsequently, we compared the performance of our proposed control chart with that of an existing Max-EWMA control chart. Our findings suggest that the proposed control chart demonstrates a higher level of sensitivity in detecting out-of-control signals. Finally, to illustrate the effectiveness of our Bayesian Max-EWMA control chart under various Loss Functions (LFs) for a Weibull process, we present a practical case study focusing on the hard-bake process in the semiconductor manufacturing industry. This case study highlights the adaptability of the chart to different scenarios. Our results provide compelling evidence of the exceptional performance of the suggested control chart in rapidly detecting out-of-control signals during the hard-bake process, thereby significantly contributing to the improvement of process monitoring and quality control., (© 2024. The Author(s).)
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- 2024
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29. A novel flexible exponent power-X family of distributions with applications to COVID-19 mortality rate in Mexico and Canada.
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Shah Z, Khan DM, Khan I, Ahmad B, Jeridi M, and Al-Marzouki S
- Subjects
- Humans, Bayes Theorem, Mexico epidemiology, Computer Simulation, Canada, COVID-19 epidemiology
- Abstract
This paper aims to introduce a novel family of probability distributions by the well-known method of the T-X family of distributions. The proposed family is called a "Novel Generalized Exponent Power X Family" of distributions. A three-parameters special sub-model of the proposed method is derived and named a "Novel Generalized Exponent Power Weibull" distribution (NGEP-Wei for short). For the proposed family, some statistical properties are derived including the hazard rate function, moments, moment generating function, order statistics, residual life, and reverse residual life. The well-known method of estimation, the maximum likelihood estimation method is used for estimating the model parameters. Besides, a comprehensive Monte Carlo simulation study is conducted to assess the efficacy of this estimation method. Finally, the model selection criterion such as Akaike information criterion (AINC), the correct information criterion (CINC), the Bayesian information criterion (BINC), the Hannan-Quinn information criterion (HQINC), the Cramer-von-Misses (CRMI), and the ANDA (Anderson-Darling) are used for comparison purpose. The comparison of the NGEP-Wei with other rival distributions is made by Two COVID-19 data sets. In terms of performance, we show that the proposed method outperforms the other competing methods included in this study., (© 2024. The Author(s).)
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- 2024
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30. Fractional epidemic model of coronavirus disease with vaccination and crowding effects.
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Saleem S, Rafiq M, Ahmed N, Arif MS, Raza A, Iqbal Z, Niazai S, and Khan I
- Subjects
- Humans, Vaccination, Basic Reproduction Number, Upper Extremity, COVID-19 epidemiology, COVID-19 prevention & control, Epidemics prevention & control
- Abstract
Most of the countries in the world are affected by the coronavirus epidemic that put people in danger, with many infected cases and deaths. The crowding factor plays a significant role in the transmission of coronavirus disease. On the other hand, the vaccines of the covid-19 played a decisive role in the control of coronavirus infection. In this paper, a fractional order epidemic model (SIVR) of coronavirus disease is proposed by considering the effects of crowding and vaccination because the transmission of this infection is highly influenced by these two factors. The nonlinear incidence rate with the inclusion of these effects is a better approach to understand and analyse the dynamics of the model. The positivity and boundedness of the fractional order model is ensured by applying some standard results of Mittag Leffler function and Laplace transformation. The equilibrium points are described analytically. The existence and uniqueness of the non-integer order model is also confirmed by using results of the fixed-point theory. Stability analysis is carried out for the system at both the steady states by using Jacobian matrix theory, Routh-Hurwitz criterion and Volterra-type Lyapunov functions. Basic reproductive number is calculated by using next generation matrix. It is verified that disease-free equilibrium is locally asymptotically stable if R 0 < 1 and endemic equilibrium is locally asymptotically stable if R 0 > 1 . Moreover, the disease-free equilibrium is globally asymptotically stable if R 0 < 1 and endemic equilibrium is globally asymptotically stable if R 0 > 1 . The non-standard finite difference (NSFD) scheme is developed to approximate the solutions of the system. The simulated graphs are presented to show the key features of the NSFD approach. It is proved that non-standard finite difference approach preserves the positivity and boundedness properties of model. The simulated graphs show that the implementation of control strategies reduced the infected population and increase the recovered population. The impact of fractional order parameter α is described by the graphical templates. The future trends of the virus transmission are predicted under some control measures. The current work will be a value addition in the literature. The article is closed by some useful concluding remarks., (© 2024. The Author(s).)
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- 2024
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31. Existence of common fuzzy fixed points via fuzzy F-contractions in b-metric spaces.
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Kanwal S, Waheed S, Rahimzai AA, and Khan I
- Abstract
The main goal of this study is to establish common fuzzy fixed points in the context of complete b-metric spaces for a pair of fuzzy mappings that satisfy F-contractions. To strengthen the validity of the derived results, non-trivial examples are provided to substantiate the conclusions. Moreover, prior discoveries have been drawn as logical extensions from pertinent literature. Our findings are further reinforced and integrated by the numerous implications that this technique has in the literature. Using fixed point techniques to approximate the solutions of differential and integral equations is very useful. Specifically, in order to enhance the validity of our findings, the existence result of the system of non-linear Fredholm integral equations of second-kind is incorporated as an application., (© 2024. The Author(s).)
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- 2024
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32. Multigrid simulations of non-Newtonian fluid flow and heat transfer in a ventilated square cavity with mixed convection and baffles.
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Rehman N, Mahmood R, Majeed AH, Khan I, and Mohamed A
- Abstract
The impact of baffles on a convective heat transfer of a non-Newtonian fluid is experimentally studied within a square cavity. The non-Newtonian fluid is pumped into the cavity through the inlet and subsequently departs from the cavity via the outlet. Given the inherent non-linearity of the model, a numerical technique has been selected as the method for obtaining the outcomes. Primarily, the governing equations within the two-dimensional domain have been discretized using the finite element method. For approximating velocity and pressure, we have employed the reliable P 2 - P 1 finite element pair, while for temperature, we have opted for the quadratic basis. To enhance convergence speed and accuracy, we employ the powerful multigrid approach. This study investigates how key parameters like Richardson number (Ri), Reynolds number (Re), and baffle gap b g influence heat transfer within a cavity comprising a non-Newtonian fluid. The baffle gap ( b g ) has been systematically altered within the range of 0.2-0.6, and for this research, three distinct power law indices have been selected namely: 0.5, 1.0, and 1.5. The primary outcomes of the investigation are illustrated through velocity profiles, streamlines, and isotherm visualizations. Furthermore, the study includes the computation of the Nu avg (average Nusselt number) across a range of parameter values. As the Richardson number (Ri) increases, Nu avg also rises, indicating that an increase in Ri results in augmented average heat transfer. Making the space between the baffles wider makes heat flow more intense. This, in turn, heats up more fluid within the cavity., (© 2024. The Author(s).)
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- 2024
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33. A comparative analysis of three distinct fractional derivatives for a second grade fluid with heat generation and chemical reaction.
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Sehra, Sadia H, Haq SU, Alhazmi H, Khan I, and Niazai S
- Abstract
This article provides a comparison among the generalized Second Grade fluid flow described by three recently proposed fractional derivatives i.e. Atangana Baleanu fractional derivative in Caputo sense (ABC), Caputo Fabrizio (CF) and Constant Proportional-Caputo hybrid (CPC) fractional derivative. The heat mass transfer is observed during the flow past a vertical porous plate that is accelerated exponentially under the effects of the Magneto hydro dynamics. The effects of the heat generation and exponential heating in the temperature boundary layer and chemical reaction at the concentration boundary layer are also analyzed in this article. The flow model is described by three partial differential equations and the set of non-dimensional PDE's is transformed into ODE's by utilization of the integral transform technique (Laplace transform). For the better understanding of the rheological properties of the Second Grade fluid we used the CF, ABC and CPC operators to describe the memory effects. The analytical exact solution of the problem is obtained in the form of G-functions and Mittag Leffler functions. For the physical significance of flow parameters, different parameters are graphed. From this analysis it is concluded that the CPC is the most suitable operator to describe the memory effects., (© 2024. The Author(s).)
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- 2024
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34. Molecular docking of bioactive compounds extracted and purified from selected medicinal plant species against covid-19 proteins and in vitro evaluation.
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Khanum A, Bibi Y, Khan I, Mustafa G, Attia KA, Mohammed AA, Yang SH, and Qayyum A
- Subjects
- Plant Extracts chemistry, Molecular Docking Simulation, Antifungal Agents, Antioxidants chemistry, Harmaline, Staphylococcus aureus, Escherichia coli, Anti-Bacterial Agents pharmacology, Antiviral Agents pharmacology, Plants, Medicinal chemistry, COVID-19, Sulfonic Acids, Benzothiazoles
- Abstract
Bioactive compounds are secondary metabolites of plants. They offer diverse pharmacological properties. Peganum harmala is reported to have pharmaceutical effects like insecticidal, antitumor, curing malaria, anti-spasmodic, vasorelaxant, antihistaminic effect. Rosa brunonii has medicinal importance in its flower and fruits effective against different diseases and juice of leaf is reported to be applied externally to cure wounds and cuts. Dryopteris ramosa aqueous leaf extract is used to treat stomach ulcers and stomachaches. Each of these three medicinal plants have been indicated to have anticancer, antiviral, antioxidant, cytotoxic and antifungal effects but efficacy of their bioactive compounds remained unexplored. Study was aimed to explore In-vitro and In-silico anticancer, antiviral, antioxidant, cytotoxic and antifungal effects of bioactive compounds of above three medicinal plants. DPPH and ABTS assay were applied for assessment of antioxidant properties of compounds. Antibacterial properties of compounds were checked by agar well diffusion method. Brine shrimp lethality assay was performed to check cytotoxic effect of compounds. Molecular docking was conducted to investigate the binding efficacy between isolated compounds and targeted proteins. The compound isomangiferrin and tiliroside presented strong antioxidant potential 78.32% (± 0.213) and 77.77% (± 0.211) respectively in DPPH assay while harmaline showed 80.71% (± 0.072) at 200 µg/mL in ABTS assay. The compound harmine, harmaline and PH-HM 17 exhibited highest zone of inhibition 22 mm, 23 mm, 22 mm respectively against Xanthomonas while Irriflophenone-3-C-β- D-glucopyranoside showed maximum zone of inhibition 34 mm against E. coli. The compound isomangiferrin and vasicine contained strong antibacterial activity 32 mm and 22 mm respectively against S. aureus. The compound mangiferrin, astragalin, tiliroside, quercitin-3-O-rhamnoside showed maximum inhibitory zone 32 mm, 26 mm, 24 mm and 22 mm respectively against Klebsiella pneumoniae. Highest cytotoxic effect was observed by compound tiliroside i.e. 95% with LD
50 value 73.59 µg/mL. The compound tiliroside showed the best binding mode of interaction to all targeted proteins presenting maximum hydrophobic interactions and hydrogen bonds. The binding affinity of tiliroside was - 17.9, - 14.9, - 14.6, - 13.8, - 12.8 against different proteins 6VAR, 5C5S, IEA3, 2XV7 and 6LUS respectively. Bioactive compounds are significant natural antioxidants, which could help to prevent the progression of various diseases caused by free radicals. Based on molecular docking we have concluded that phytochemicals can have better anticancer and antiviral potential., (© 2024. The Author(s).)- Published
- 2024
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35. Memory type Max-EWMA control chart for the Weibull process under the Bayesian theory.
- Author
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Noor-Ul-Amin M, Khan I, Iqbal J, Rasheed Z, Ismail EAA, and Ahmad B
- Abstract
The simultaneous monitoring of both process mean and dispersion, particularly in normal processes, has garnered significant attention within the field. In this article, we present a new Bayesian Max-EWMA control chart that is intended to track a non-normal process mean and dispersion simultaneously. This is accomplished through the utilization of the inverse response function, especially in cases where the procedure follows a Weibull distribution. We used the average run length (ARL) and the standard deviation of run length (SDRL) to assess the efficacy of our suggested control chart. Next, we contrast our suggested control chart's performance with an already-existing Max-EWMA control chart. Our results show that compared to the control chart under consideration, the proposed control chart exhibits a higher degree of sensitivity. Finally, we present a useful case study centered around the hard-bake process in the semiconductor manufacturing sector to demonstrate the performance of our Bayesian Max-EWMA control chart under different Loss Functions (LFs) for a Weibull process. The case study highlights how flexible the chart is to various situations. Our results offer strong proof of the outstanding ability of the Bayesian Max-EWMA control chart to quickly identify out-of-control signals during the hard-bake procedure. This in turn significantly contributes to the enhancement of process monitoring and quality control., (© 2024. The Author(s).)
- Published
- 2024
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36. Enhancing automic and optimal control systems through graphical structures.
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Panda SK, Khan I, Velusamy V, and Niazai S
- Abstract
The concept of graphical structures of extended suprametric space is introduced in this study and applied to supra-graphical contractive mapping. A recursive algorithm in connection with graphical notions can be employed in adaptive systems to construct a desired output function iteratively after specific conditions are first defined to ensure the existence of the solution by use of supra-graphical contractive mapping. After analyzing the historical context and relevant outcomes, we discuss the usage of graphical structures and supra-graphical contractive mappings in the conceptual frameworks of adaptive control and optimal control systems., (© 2024. The Author(s).)
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- 2024
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37. Phytoassisted synthesis of CuO and Ag-CuO nanocomposite, characterization, chemical sensing of ammonia, degradation of methylene blue.
- Author
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Farooq M, Shujah S, Tahir K, Hussain ST, Khan AU, Almarhoon ZM, Alabbosh KF, Alanazi AA, Althagafi TM, and Zaki MEA
- Abstract
The elimination of hazardous industrial pollutants from aqueous solutions is an emerging area of scientific research and a worldwide problem. An efficient catalyst, Ag-CuO was synthesized for the degradation of methylene blue, the chemical sensing of ammonia. A simple novel synthetic method was reported in which new plant material Capparis decidua was used for the reduction and stabilization of the synthesized nanocatalyst. A Varying amount of Ag was doped into CuO to optimize the best catalyst that met the required objectives. Through this, the Ag-CuO nanocomposite was characterized by XRD, SEM, HR-TEM, EDX, and FTIR techniques. The mechanism of increased catalytic activity with Ag doping involves the formation of charge sink and suppression of drop back probability of charge from conduction to valance band. Herein, 2.7 mol % Ag-CuO exhibited better catalytic activities and it was used through subsequent catalytic experiments. The experimental conditions such as pH, catalyst dose, analyte initial concentration, and contact time were optimized. The as-synthesized nanocomposite demonstrates an excellent degradation efficacy of MB which is 97% at pH 9. More interestingly, the as-synthesized catalyst was successfully applied for the chemical sensing of ammonia even at very low concentrations. The lower limit of detection (LLOD) also called analytic sensitivity was calculated for ammonia sensing and found to be 1.37 ppm., (© 2024. The Author(s).)
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- 2024
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38. FEM simulations for double diffusive transport mechanism hybrid nano fluid flow in corrugated enclosure by installing uniformly heated and concentrated cylinder.
- Author
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Bilal S, Shah IA, Khan I, Al-Otaibi S, and Rahimzai AA
- Abstract
Generation of fluid flow due to simultaneous occurrence of heat and mass diffusions caused by buoyancy differences is termed as double diffusion. Pervasive applications of such diffusion arise in numerous natural and scientific systems. This article investigates double diffusion in naturally convective flow of water-based fluid saturated in corrugated enclosure and containing hybrid nano particles composed of Copper (Cu) and Alumina (Al
2 O3 ). Impact of uniformly applied magnetic field is also accounted. To produce thermosolutal convective potential circular cylinder of constant radius is also adjusted by providing uniform temperature and concentration distributions. Finite element approach is capitalized to provide solution of utilized governing equations by utilizing Multiphysics COMSOL software. Wide-range of physical parameters are incorporated to depict their influence on associated distributions (velocity, temperature and concentration). Interesting physical quantities like Nusselt number, Sherwood numbers are also calculated against involved sundry parameters. It is note worthily observed that maximum strength of stream lines [Formula: see text] is 3.3 at [Formula: see text] and drops to 1.2 when [Formula: see text] is increased to 0.04. Furthermore, in the hydrodynamic case (Ha = 0), it is observed that the velocity field exhibits an increasing trend compared to the hydromagnetic case [Formula: see text] which is proved from the attained values of stream-function i.e., [Formula: see text] (in the absence of a magnetic field) and [Formula: see text] (in the presence of a magnetic field). It is revealed from the statistics of Nusselt number that increase in volume fraction of nano particles from 0 to 0.4, heat flux coefficient upsurges up to 7% approximately. Since, present work includes novel physical aspects of thermosolutal diffusion generated due to induction of hybrid nanoparticles in water contained in corrugated enclosure, so this study will provide innovative thought to the researchers to conduct research in this direction., (© 2024. The Author(s).)- Published
- 2024
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39. Monitoring of semiconductor manufacturing process on Bayesian AEWMA control chart under paired ranked set sampling schemes.
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Wang Y, Khan I, Noor-Ul-Amin M, AlQahtani SA, and Ahmad B
- Abstract
Quality control often employs memory-type control charts, including the exponentially weighted moving average (EWMA) and Shewhart control charts, to identify shifts in the location parameter of a process. This article pioneers a new Bayesian Adaptive EWMA (AEWMA) control chart, built on diverse loss functions (LFs) such as the square error loss function (SELF) and the Linex loss function (LLF). The proposed chart aims to enhance the process of identifying small to moderate as well as significant shifts in the mean, signifying a notable advancement in the field of quality control. These are implemented utilizing an informative prior for both posterior and posterior predictive distributions, employing various paired ranked set sampling (PRSS) schemes. The effectiveness of the suggested chart is appraised using average run length (ARL) and the standard deviation of run length (SDRL). Monte Carlo simulations are employed to contrast the recommended approach against other control charts. The outcomes demonstrate the dignitary performance of the recommended chart in identifying out-of-control signals, especially applying PRSS designs, in comparison to simple random sampling (SRS). Finally, a practical application was conducted in the semiconductor manufacturing context to appraise the efficacy of the offered chart using various paired ranked set sampling strategies. The results reveal that the suggested control chart performed well in capturing the out-of-control signals far better than the already in use control charts. Overall, this study interposes a new technique with diverse LFs and PRSS designs, improving the precision and effectiveness in detecting process mean shifts, thereby contributing to advancements in quality control and process monitoring., (© 2023. The Author(s).)
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- 2023
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40. Machine learning intelligent based hydromagnetic thermal transport under Soret and Dufour effects in convergent/divergent channels: a hybrid evolutionary numerical algorithm.
- Author
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Aslam MN, Shaukat N, Riaz A, Khan I, and Niazai S
- Abstract
In this research, we analyze the complex dynamics of hydro-magnetic flow and heat transport under Sorent and Dofour effects within wedge-shaped converging and diverging channels emphasizing its critical role in conventional system design, high-performance thermal equipment. We utilized artificial neural networks (ANNs) to investigation the dynamics of the problem. Our study centers on unraveling the intricacies of energy transport and entropy production arising from the pressure-driven flow of a non-Newtonian fluid within both convergent and divergent channel. The weights of ANN based fitness function ranging from - 10 to 10. To optimize the weights and biases of artificial neural networks (ANNs), employ a hybridization of advanced evolutionary optimization algorithms, specifically the artificial bee colony (ABC) optimization integrated with neural network algorithms (NNA). This approach allows us to identify and fine-tune the optimal weights within the neural network, enabling accurate prediction. We compare our results against the established different analytical and numerical methods to assess the effectiveness of our approach. The methodology undergoes a rigorous evaluation, encompassing multiple independent runs to ensure the robustness and reliability of our findings. Additionally, we conduct a comprehensive analysis that includes metrics such as mean squared error, minimum values, maximum values, average values, and standard deviation over these multiple independent runs. The minimum fitness function value is 1.32 × 10
-8 computed across these multiple runs. The absolute error, between the HAM and machine learning approach addressed ranging from 3.55 × 10-7 to 1.90 × 10-8 . This multifaceted evaluation ensures a thorough understanding of the performance and variability of our proposed approach, ultimately contributing to our understanding of entropy management in non-uniform channel flows, with valuable implications for diverse engineering applications., (© 2023. The Author(s).)- Published
- 2023
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41. Heat generation/absorption effect on natural convective heat transfer in a wavy triangular cavity filled with nanofluid.
- Author
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Islam T, Alam MN, Niazai S, Khan I, Fayz-Al-Asad M, and Alqahtani S
- Abstract
This study is numerically executed to investigate the influence of heat generation or absorption on free convective flow and temperature transport within a wavy triangular enclosure filled by the nanofluid taking the Brownian effect of nanoparticles. The water (H
2 O) is employed as base fluid and copper (Cu) as nanoparticles for making effective Cu-H2 O nanofluids. The perpendicular sinusoidally wavy wall is cooled at low temperature while the horizontal bottom sidewall is heated non-uniformly (sinusoidal). The inclined wall of the enclosure is insulated. The governing dimensionless non-linear PDEs are executed numerically with the help of the Galerkin weighted residual type finite element technique. The numerically simulated results are displayed through average Nusselt number, isothermal contours, and streamlines for the various model parameters such as Hartmann number, Rayleigh number, heat generation or absorption parameter, nanoparticles volume fraction, and undulation parameter. The outcomes illustrate that the temperature transport rate augments significantly for the enhancement of Rayleigh number as well as nanoparticles volume fraction whereas reduces for the increment of Hartman number. The heat transfer is significantly influenced by the size, shape, and Brownian motion of the nanoparticles. The rate of heat transport increases by 20.43% considering the Brownian effect for 1% nanoparticle volume. The thermal performance increases by 8.66% for the blade shape instead of the spherical shape of nanoparticles. In addition, heat transfer is impacted by the small size of nanoparticles. The thermal transport rate increases by 35.87% when the size of the nanoparticles reduces from 100 to 10 nm. Moreover, the rate of heat transmission increases efficiently as the undulation parameter rises. It is also seen that a crucial factor in the flow of nanofluids and heat transmission is the heat generation/absorption parameter that influences temperature distribution, heat transfer rates, and overall thermal performance., (© 2023. The Author(s).)- Published
- 2023
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42. A novel Bayesian Max-EWMA control chart for jointly monitoring the process mean and variance: an application to hard bake process.
- Author
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Iqbal J, Noor-Ul-Amin M, Khan I, AlQahtani SA, Yasmeen U, and Ahmad B
- Abstract
In this article, we introduce a novel Bayesian Max-EWMA control chart under various loss functions to concurrently monitor the mean and variance of a normally distributed process. The Bayesian Max-EWMA control chart exhibit strong overall performance in detecting shifts in both mean and dispersion across various magnitudes. To evaluate the performance of the proposed control chart, we employ Monte Carlo simulation methods to compute their run length characteristics. We conduct an extensive comparative analysis, contrasting the run length performance of our proposed charts with that of existing ones. Our findings highlight the heightened sensitivity of Bayesian Max-EWMA control chart to shifts of diverse magnitudes. Finally, to illustrate the efficacy of our Bayesian Max-EWMA control chart using various loss functions, we present a practical case study involving the hard-bake process in semiconductor manufacturing. Our results underscore the superior performance of the Bayesian Max-EWMA control chart in detecting out-of-control signals., (© 2023. The Author(s).)
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- 2023
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43. Monitoring the process mean under the Bayesian approach with application to hard bake process.
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Khan I, Noor-Ul-Amin M, Khan DM, Ismail EAA, Yasmeen U, and Rahimi J
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This study introduces the Bayesian adaptive exponentially weighted moving average (AEWMA) control chart within the framework of measurement error, examining two separate loss functions: the squared error loss function and the linex loss function. We conduct an analysis of the posterior and posterior predictive distributions utilizing a conjugate prior. In the presence of measurement error (ME), we employ a linear covariate model to assess the control chart's effectiveness. Additionally, we explore the impacts of measurement error by investigating multiple measurements and a method involving linearly increasing variance. We conduct a Monte Carlo simulation study to assess the control chart's performance under ME, examining its run length profile. Subsequently, we offer a specific numerical instance related to the hard-bake process in semiconductor manufacturing, serving to verify the functionality and practical application of the suggested Bayesian AEWMA control chart when confronted with ME., (© 2023. The Author(s).)
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- 2023
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44. Bayesian AEWMA control chart under ranked set sampling with application to reliability engineering.
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Khan I, Noor-Ul-Amin M, Muhammad Khan D, Khalil U, Ismail EAA, Yasmeen U, and Ahmad B
- Abstract
The article introduces a novel Bayesian AEWMA Control Chart that integrates different loss functions (LFs) like the square error loss function and Linex loss function under an informative prior for posterior and posterior predictive distributions, implemented across diverse ranked set sampling (RSS) designs. The main objective is to detect small to moderate shifts in the process mean, with the average run length and standard deviation of run length serving as performance measures. The study employs a hard bake process in semiconductor production to demonstrate the effectiveness of the proposed chart, comparing it with existing control charts through Monte Carlo simulations. The results underscore the superiority of the proposed approach, particularly under RSS designs compared to simple random sampling (SRS), in identifying out-of-control signals. Overall, this study contributes a comprehensive method integrating various LFs and RSS schemes, offering a more precise and efficient approach for detecting shifts in the process mean. Real-world applications highlight the heightened sensitivity of the suggested chart in identifying out-of-control signals compared to existing Bayesian charts using SRS., (© 2023. The Author(s).)
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- 2023
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45. A Weibull process monitoring with AEWMA control chart: an application to breaking strength of the fibrous composite.
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Sarwar MA, Noor-Ul-Amin M, Khan I, Ismail EAA, Sumelka W, and Nabi M
- Abstract
In recent times, there has been a growing focus among researchers on memory-based control charts. The Exponentially Weighted Moving Average (EWMA) and Cumulative Sum (CUSUM) charts and the adaptive control charting approaches got the attention. Control charts are commonly employed to oversee processes, assuming the monitored variable follows a normal distribution. However, it's worth noting that this assumption does not hold true in many real-world situations. The use of the algebraic expression for normalization, which can be used for all kinds of skewed distributions with a closed-form distribution function, using the proposed continuous function to adapt a smoothing constant, motivates this study. In the present manuscript, we design an EWMA statistic-based adaptive control chart to monitor the irregular variations in the mean of two parametric Weibull distribution and use Hasting approximation for normalization. The adaptive control charts are used to update the smoothing constant according to the estimated shift. Here we use the proposed continuous function to adapt the smoothing constant. The average run length and standard deviation of run length are calculated under different parameter settings. The effectiveness of the proposed chart is argued in terms of ARLs over the considered EWMA chart through Monte-Carlo (MC) simulation method. The proposed chart is examined, followed by a real data set to demonstrate the design and application procedures., (© 2023. The Author(s).)
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- 2023
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46. Analysis of risk factors and prognostic factors of brain metastasis in gastric cancer: a surveillance, epidemiology and end-results database study.
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Rehman MEU, Kulsoom A, Faraz F, Mustafa B, Shahid A, Cheema HA, Maqbool S, Khan I, Hussain T, Iftikhar A, Awan RU, Swed S, Raza S, and Anwer F
- Subjects
- Male, Humans, Female, Prognosis, Retrospective Studies, SEER Program, Risk Factors, Stomach Neoplasms pathology, Brain Neoplasms epidemiology, Brain Neoplasms secondary
- Abstract
Brain metastasis in gastric cancer (GC) patients is a rare phenomenon that is associated with adverse clinical outcomes and poor survival rates. We conducted a retrospective cohort study to investigate the incidence, risk factors and prognostic factors of brain metastasis in GC patients. Data on sociodemographic and tumor characteristics of GC patients from 2010 to 2019 was extracted from the Surveillance, Epidemiology and End-Results (SEER) database. Descriptive statistics, multivariable logistic and Cox regression were applied on SPSS. Kaplan-Meier-Survival curves and ROC curves were constructed. A total of 59,231 GC patients, aged 66.65 ± 13.410 years were included. Brain metastasis was reported in 368 (0.62%) patients. On logistic regression, the risk of brain metastasis was significantly greater in males, patients aged < 60 years and patients having concurrent bone and lung metastasis. High grade and high N stage were significant risk factors for development of brain metastasis. Patients who had undergone surgery for the primary tumor were at reduced risk for brain metastasis (adjusted odds ratio 0.210, 95% CI 0.131-0.337). The median OS was 3 months in patients with brain metastasis and 17 months in patients without brain metastasis (p < 0.05). On Cox regression, Grade IV tumors and primary antral tumors were significant predictable parameters for poor prognosis. Overall Survival (OS) and Cancer-Specific Survival (CSS) were prolonged in patients who had undergone surgery. Brain metastasis in gastric cancer is associated with significantly worse survival. Employing large-scale screening for high-risk patients holds a promising impact to improve survival rates, but it must be accurately balanced with a comprehensive understanding of clinicopathological aspects for accurate diagnosis and treatment., (© 2023. The Author(s).)
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- 2023
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47. Monitoring of manufacturing process using bayesian EWMA control chart under ranked based sampling designs.
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Khan I, Noor-Ul-Amin M, Khan DM, Ismail EAA, and Sumelka W
- Abstract
Control charts, including exponentially moving average (EWMA) , are valuable for efficiently detecting small to moderate shifts. This study introduces a Bayesian EWMA control chart that employs ranked set sampling (RSS) with known prior information and two distinct loss functions (LFs), the Square Error Loss function (SELF) and the Linex Loss function (LLF), for posterior and posterior predictive distributions. The chart's performance is assessed using average run length (ARL) and standard deviation of run length (SDRL) profiles, and it is compared to the Bayesian EWMA control chart based on simple random sampling (SRS). The results indicate that the proposed control chart detects small to moderate shifts more effectively. The application in semiconductor manufacturing provides concrete evidence that the Bayesian EWMA control chart, when implemented with RSS schemes, demonstrates a higher degree of sensitivity in detecting deviations from normal process behavior. Comparison to the Bayesian EWMA control chart using SRS, it exhibits a superior ability to identify and flag instances where the manufacturing process is going out of control. This heightened sensitivity is critical for promptly addressing and rectifying issues, which ultimately contributes to improved quality control in semiconductor production., (© 2023. Springer Nature Limited.)
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- 2023
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48. Heat transfer analysis of generalized second-grade fluid with exponential heating and thermal heat flux.
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Jan SU, Haq SU, Ullah N, Ullah W, Sehra, and Khan I
- Abstract
The aim of present work is to apply the Caputo-Fabrizio fractional derivative in the constitutive equations of heat transfer. Natural convection flow of an unsteady second grade fluid over a vertical plate with exponential heating is discussed. The generalized Fourier law is substituted in temperature profile. A portion of the dimensionless factors are utilized to make the governing equations into dimensionless structures. The solutions for temperature and velocity profiles of Caputo-Fabrizio model are acquired through the Laplace transform method. These solutions are greatly affected through the variation of different dimensionless variables like Prandtl number, Grashof number, and second-grade fluid parameter. Finally, the influence of embedded parameters is shown by plotting graphs through Mathcad. From the graphical results it is concluded that, the temperature of the fluid decreases with the increasing values of the Prandtl number and Second grade fluid parameter and increases with the passage of time. The velocity of the fluid increases with increasing values of the Grashof number, second grade parameter and time while decreases with increasing values of fractional parameter and Prandtl number., (© 2023. Springer Nature Limited.)
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- 2023
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49. Time fractional Yang-Abdel-Cattani derivative in generalized MHD Casson fluid flow with heat source and chemical reaction.
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Sehra, Sadia H, Haq SU, and Khan I
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This present research article investigates the exact analytical solution for the mathematical model of the generalized Casson fluid flow by using the new fractional operator with Rabotnov exponential kernel i.e. Yang-Abdel-Cattani operator. The impacts of heat source, magnetic hydrodynamics and chemical reactions on the flow of fractional Casson fluid through a vertical flat plate are studied in this article. For the sake of a better interpretation of the rheological behavior of Casson fluid we have used the new operator of fractional order with exponential kernel of Rabotnov known as Yang-Abdel-Cattani operator of fractional derivative. By making use of the technique of Laplace transform we have find the exact analytical solution of the problem in the Mittag-Leffler's form, for all the three governing equations i.e. Velocity, energy and concentration equation. It has been noticed from the literature that it is challenging to obtain analytical results from fractional fluid model derived by the various fractional operators. This article helps to address this issue by providing analytical solutions for fractionalized fluid models. To analyze the physical importance of different fluid parameters such as Schmidt number, Prandtl number, MHD and alpha on the heat, mass and momentum class are presented through graphs. The concentration of the fluid decreases with Schmidth number and temperature of the fluid decreases with the increasing Prandtl number. The velocity of the fluid decreases with increasing MHD effects and increases with increasing Alpha. The Yang-Abdel-Cattani operator of fractional order can describe the memory effects more suitably than the other fractional operators., (© 2023. Springer Nature Limited.)
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- 2023
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50. A reliable numerical investigation of an SEIR model of measles disease dynamics with fuzzy criteria.
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Dayan F, Ahmed N, Rafiq M, Raza A, Khan I, and Eldin EMT
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- Humans, Reproducibility of Results, Computer Simulation, Uncertainty, Measles
- Abstract
The terms susceptibility, exposure, infectiousness, and recovered all have some inherent ambiguity because different population members have different susceptibility levels, exposure levels, infectiousness levels, and recovery patterns. This uncertainty becomes more pronounced when examining population subgroups characterized by distinct behaviors, cultural norms, and varying degrees of resilience across different age brackets, thereby introducing the possibility of fluctuations. There is a need for more accurate models that take into account the various levels of susceptibility, exposure, infectiousness, and recovery of the individuals. A fuzzy SEIR model of the dynamics of the measles disease is discussed in this article. The rates of disease transmission and recovery are treated as fuzzy sets. Three distinct numerical approaches, the forward Euler, fourth-order Runge-Kutta, and nonstandard finite difference (NSFD) are employed for the resolution of this fuzzy SEIR model. Next, the outcomes of the three methods are examined. The results of the simulation demonstrate that the NSFD method adeptly portrays convergent solutions across various time step sizes. Conversely, the conventional Euler and RK-4 methods only exhibit positivity and convergence solutions when handling smaller step sizes. Even when considering larger step sizes, the NSFD method maintains its consistency, showcasing its efficacy. This demonstrates the NSFD technique's superior reliability when compared to the other two methods, while maintaining all essential aspects of a continuous dynamical system. Additionally, the results from numerical and simulation studies offer solid proof that the suggested NSFD technique is a reliable and effective tool for controlling these kinds of dynamical systems.The convergence and consistency analysis of the NSFD method are also studied., (© 2023. Springer Nature Limited.)
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- 2023
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