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1. Late presentation of chronic HBV and HCV patients seeking first time specialist care in Spain: a 2-year registry review

Author

Camila A. Picchio, Sabela Lens, Manuel Hernandez-Guerra, Juan Arenas, Raúl J. Andrade, Javier Crespo, Javier García-Samaniego, Manuel Romero-Gómez, Juan Turnes, José Luis Calleja, Miguel Ángel Simón, Trenton M. White, Mar Riveiro-Barciela, Anna Pocurull, Dalia Morales-Arraez, Alexandra Gómez, Maria Buti, and Jeffrey V. Lazarus

Subjects
Medicine, Science
Abstract

Abstract Chronic viral hepatitis infection affects an estimated 325 million people globally. People who initiate treatment after significant disease progression face increased risk of severe liver complications and death. Data are scarce on the characteristics and risk factors of people who present late to care in Spain and globally. Data were collected from January 2018 to December 2019 to report late presentation (LP) to specialist care at 11 large university hospitals in Spain to assess related risk factors using a multivariable logistic regression model. 2290 (CHB = 505, CHC = 1785) patients were analysed, with 581 (25.2%) presenting late. Hepatitis C patients more frequently reported LP compared to hepatitis B patients (28.1% vs 15.0%; p

Published
2021
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2. Sophisticated viral quasispecies with a genotype-related pattern of mutations in the hepatitis B X gene of HBeAg-ve chronically infected patients

Author

Maria Francesca Cortese, Carolina González, Josep Gregori, Rosario Casillas, Luca Carioti, Mercedes Guerrero-Murillo, Mar Riveiro-Barciela, Cristina Godoy, Sara Sopena, Marçal Yll, Josep Quer, Ariadna Rando, Rosa Lopez-Martinez, Beatriz Pacín Ruiz, Selene García-García, Rafael Esteban-Mur, David Tabernero, Maria Buti, and Francisco Rodríguez-Frías

Subjects
Medicine, Science
Abstract

Abstract Patients with HBeAg-negative chronic infection (CI) have not been extensively studied because of low viremia. The HBx protein, encoded by HBX, has a key role in viral replication. Here, we analyzed the viral quasispecies at the 5′ end of HBX in CI patients and compared it with that of patients in other clinical stages. Fifty-eight HBeAg-negative patients were included: 16 CI, 19 chronic hepatitis B, 16 hepatocellular carcinoma and 6 liver cirrhosis. Quasispecies complexity and conservation were determined in the region between nucleotides 1255 and 1611. Amino acid changes detected were tested in vitro. CI patients showed higher complexity in terms of mutation frequency and nucleotide diversity and higher quasispecies conservation (p

Published
2021
Full Text
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3. Sophisticated viral quasispecies with a genotype-related pattern of mutations in the hepatitis B X gene of HBeAg-ve chronically infected patients

Author

Marçal Yll, L. Carioti, Mercedes Guerrero-Murillo, Rosa Lopez-Martinez, Rafael Esteban-Mur, Mar Riveiro-Barciela, Cristina Godoy, Carolina González, Ariadna Rando, Josep Gregori, Selene Garcia-Garcia, Francisco Rodriguez-Frias, Maria Francesca Cortese, David Tabernero, Sara Sopena, Beatriz Pacín Ruiz, Rosario Casillas, Josep Quer, Maria Buti, Institut Català de la Salut, [Cortese MF, Casillas R, Sopena S, Yll M] Liver Unit, Liver Disease Laboratory Viral Hepatitis, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Unitat de Patologia Hepàtica, Servei de Bioquímica i Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [González C, Rando A, Lopez-Martinez R] Unitat de Patologia Hepàtica, Servei de Bioquímica i Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Gregori J] Liver Unit, Liver Disease Laboratory Viral Hepatitis, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Roche Diagnostics SL, Sant Cugat del Vallès, Spain. [Carioti L] Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy. [Guerrero-Murillo M] Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Riveiro-Barciela M, Esteban-Mur R, Buti M] Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto De Salud Carlos III, Madrid, Spain. Unitat del Fetge, Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Godoy C, Tabernero D, Rodríguez-Frías F] Unitat de Patologia Hepàtica, Servei de Bioquímica i Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto De Salud Carlos III, Madrid, Spain. [Quer J] Liver Unit, Liver Disease Laboratory Viral Hepatitis, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto De Salud Carlos III, Madrid, Spain. [Pacín Ruiz B, García-García S] Liver Unit, Liver Disease Laboratory Viral Hepatitis, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
0301 basic medicine, Liver Cirrhosis, Male, Genes, Viral, viruses, Virus Replication, 0302 clinical medicine, Genotype, fenómenos genéticos::variación genética::cuasiespecies [FENÓMENOS Y PROCESOS], Sequencing, Hepatitis B e Antigens, Genètica vírica, Virus Diseases::DNA Virus Infections::Hepadnaviridae Infections::Hepatitis B::Hepatitis B, Chronic [DISEASES], Multidisciplinary, Otros calificadores::Otros calificadores::/genética [Otros calificadores], Liver Neoplasms, Hepatitis B, Middle Aged, HBx, HBeAg, Hepatocellular carcinoma, Infectious diseases, Medicine, 030211 gastroenterology & hepatology, Female, Adult, Hepatitis B virus, Genetic Phenomena::Genetic Variation::Quasispecies [PHENOMENA AND PROCESSES], Carcinoma, Hepatocellular, Science, Viremia, Viral quasispecies, Biology, Article, 03 medical and health sciences, Hepatitis B, Chronic, medicine, Other subheadings::Other subheadings::/genetics [Other subheadings], Humans, Aged, Virus de l'hepatitis B, medicine.disease, Virology, virosis::infecciones por virus ADN::infecciones por Hepadnaviridae::hepatitis B::hepatitis B crónica [ENFERMEDADES], digestive system diseases, Quasispecies, 030104 developmental biology, Viral replication, Haplotypes, Mutation, DNA, Viral
Abstract

Haplotipos; Enfermedades infecciosas; Mutación Haplotips; Enfermetats infeccioses; Mutació Haplotypes; Infectious diseases; Mutation Patients with HBeAg-negative chronic infection (CI) have not been extensively studied because of low viremia. The HBx protein, encoded by HBX, has a key role in viral replication. Here, we analyzed the viral quasispecies at the 5′ end of HBX in CI patients and compared it with that of patients in other clinical stages. Fifty-eight HBeAg-negative patients were included: 16 CI, 19 chronic hepatitis B, 16 hepatocellular carcinoma and 6 liver cirrhosis. Quasispecies complexity and conservation were determined in the region between nucleotides 1255 and 1611. Amino acid changes detected were tested in vitro. CI patients showed higher complexity in terms of mutation frequency and nucleotide diversity and higher quasispecies conservation (p

Published
2021

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