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Your search keyword '"Kshipra M. Gharpure"' showing total 6 results
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6 results on '"Kshipra M. Gharpure"'

1. FABP4 as a key determinant of metastatic potential of ovarian cancer

Author

Kshipra M. Gharpure, Sunila Pradeep, Marta Sans, Rajesha Rupaimoole, Cristina Ivan, Sherry Y. Wu, Emine Bayraktar, Archana S. Nagaraja, Lingegowda S. Mangala, Xinna Zhang, Monika Haemmerle, Wei Hu, Cristian Rodriguez-Aguayo, Michael McGuire, Celia Sze Ling Mak, Xiuhui Chen, Michelle A. Tran, Alejandro Villar-Prados, Guillermo Armaiz Pena, Ragini Kondetimmanahalli, Ryan Nini, Pranavi Koppula, Prahlad Ram, Jinsong Liu, Gabriel Lopez-Berestein, Keith Baggerly, Livia S. Eberlin, and Anil K. Sood

Subjects
Science
Abstract

In ovarian cancer, metastatic phenotype may impact surgical outcomes. Here, the authors show miR-409-3p regulates FABP4 which can increase metastatic potential of ovarian cancer, and treatment with DOPC nanoliposomes containing either miR-409--3p mimic or FABP4 siRNA inhibits tumor progression in mice.

Published
2018
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2. Platelets reduce anoikis and promote metastasis by activating YAP1 signaling

Author

Monika Haemmerle, Morgan L. Taylor, Tony Gutschner, Sunila Pradeep, Min Soon Cho, Jianting Sheng, Yasmin M. Lyons, Archana S. Nagaraja, Robert L. Dood, Yunfei Wen, Lingegowda S. Mangala, Jean M. Hansen, Rajesha Rupaimoole, Kshipra M. Gharpure, Cristian Rodriguez-Aguayo, Sun Young Yim, Ju-Seog Lee, Cristina Ivan, Wei Hu, Gabriel Lopez-Berestein, Stephen T. Wong, Beth Y. Karlan, Douglas A. Levine, Jinsong Liu, Vahid Afshar-Kharghan, and Anil K. Sood

Subjects
Science
Abstract

Platelets have been associated with increased tumor growth and metastasis but the mechanistic details of this interaction are still unclear. Here the authors show that platelets improve anoikis resistance of cancer cells and increase metastasis by activating Yap through a RhoA/MYPT-PP1 pathway.

Published
2017
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3. Author Correction: Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression

Author

Rajesha Rupaimoole, Sherry Y. Wu, Sunila Pradeep, Cristina Ivan, Chad V. Pecot, Kshipra M. Gharpure, Archana S. Nagaraja, Guillermo N. Armaiz-Pena, Michael McGuire, Behrouz Zand, Heather J. Dalton, Justyna Filant, Justin Bottsford Miller, Chunhua Lu, Nouara C. Sadaoui, Lingegowda S. Mangala, Morgan Taylor, Twan van den Beucken, Elizabeth Koch, Cristian Rodriguez-Aguayo, Li Huang, Menashe Bar-Eli, Bradly G. Wouters, Milan Radovich, Mircea Ivan, George A. Calin, Wei Zhang, Gabriel Lopez-Berestein, and Anil K. Sood

Subjects
Science
Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2020
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4. A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer

Author

Sherry Y. Wu, Rajesha Rupaimoole, Fangrong Shen, Sunila Pradeep, Chad V. Pecot, Cristina Ivan, Archana S. Nagaraja, Kshipra M. Gharpure, Elizabeth Pham, Hiroto Hatakeyama, Michael H. McGuire, Monika Haemmerle, Viviana Vidal-Anaya, Courtney Olsen, Cristian Rodriguez-Aguayo, Justyna Filant, Ehsan A. Ehsanipour, Shelley M. Herbrich, Sourindra N. Maiti, Li Huang, Ji Hoon Kim, Xinna Zhang, Hee-Dong Han, Guillermo N. Armaiz-Pena, Elena G. Seviour, Sue Tucker, Min Zhang, Da Yang, Laurence J. N. Cooper, Rouba Ali-Fehmi, Menashe Bar-Eli, Ju-Seog Lee, Prahlad T. Ram, Keith A. Baggerly, Gabriel Lopez-Berestein, Mien-Chie Hung, and Anil K. Sood

Subjects
Science
Abstract

The formation of blood vessels in tumours, angiogenesis, is a promising target for therapy. Here, the authors show that microRNA192 has anti-angiogenic functions and negatively regulates EGR1 and HOXB9, and that delivery of this microRNA to tumours in vivocan reduce angiogenesis and tumour growth.

Published
2016
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5. FABP4 as a key determinant of metastatic potential of ovarian cancer

Author

Jinsong Liu, Guillermo N. Armaiz Pena, Kshipra M. Gharpure, Prahlad T. Ram, Anil K. Sood, Lingegowda S. Mangala, Monika Haemmerle, Rajesha Rupaimoole, Alejandro Villar-Prados, Sunila Pradeep, Archana S. Nagaraja, Xinna Zhang, Sherry Y. Wu, Pranavi Koppula, Wei Hu, Celia Sze Ling Mak, Michael McGuire, Xiuhui Chen, Cristina Ivan, Ryan Nini, Livia S. Eberlin, Keith A. Baggerly, Emine Bayraktar, Ragini Kondetimmanahalli, Michelle A. Tran, Cristian Rodriguez-Aguayo, Marta Sans, and Gabriel Lopez-Berestein

Subjects
0301 basic medicine, medicine.medical_treatment, Science, Mice, Nude, General Physics and Astronomy, Disease, Fatty Acid-Binding Proteins, Article, General Biochemistry, Genetics and Molecular Biology, Metastasis, Mice, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, medicine, Animals, Humans, Neoplasm Invasiveness, lcsh:Science, Ovarian Neoplasms, Chemotherapy, Multidisciplinary, business.industry, General Chemistry, Hypoxia (medical), medicine.disease, Debulking, 3. Good health, Gene Expression Regulation, Neoplastic, MicroRNAs, 030104 developmental biology, Tumor progression, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, lcsh:Q, Female, medicine.symptom, Ovarian cancer, business
Abstract

The standard treatment for high-grade serous ovarian cancer is primary debulking surgery followed by chemotherapy. The extent of metastasis and invasive potential of lesions can influence the outcome of these primary surgeries. Here, we explored the underlying mechanisms that could increase metastatic potential in ovarian cancer. We discovered that FABP4 (fatty acid binding protein) can substantially increase the metastatic potential of cancer cells. We also found that miR-409-3p regulates FABP4 in ovarian cancer cells and that hypoxia decreases miR-409-3p levels. Treatment with DOPC nanoliposomes containing either miR-409-3p mimic or FABP4 siRNA inhibited tumor progression in mouse models. With RPPA and metabolite arrays, we found that FABP4 regulates pathways associated with metastasis and affects metabolic pathways in ovarian cancer cells. Collectively, these findings demonstrate that FABP4 is functionally responsible for aggressive patterns of disease that likely contribute to poor prognosis in ovarian cancer., In ovarian cancer, metastatic phenotype may impact surgical outcomes. Here, the authors show miR-409-3p regulates FABP4 which can increase metastatic potential of ovarian cancer, and treatment with DOPC nanoliposomes containing either miR-409--3p mimic or FABP4 siRNA inhibits tumor progression in mice.

Published
2018

6. Author Correction: Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression

Author

Mircea Ivan, Li Huang, Kshipra M. Gharpure, Nouara C. Sadaoui, Anil K. Sood, Cristina Ivan, Lingegowda S. Mangala, Behrouz Zand, Guillermo N. Armaiz-Pena, Elizabeth Koch, George A. Calin, Sherry Y. Wu, Morgan Taylor, Milan Radovich, Menashe Bar-Eli, Wei Zhang, Gabriel Lopez-Berestein, Justyna Filant, Rajesha Rupaimoole, Twan van den Beucken, Bradly G. Wouters, Sunila Pradeep, Michael McGuire, Cristian Rodriguez-Aguayo, Chad V. Pecot, Justin Bottsford Miller, Heather J. Dalton, Archana S. Nagaraja, and Chunhua Lu

Subjects
Multidisciplinary, business.industry, Science, General Physics and Astronomy, General Chemistry, Hypoxia (medical), Biology, General Biochemistry, Genetics and Molecular Biology, Text mining, Downregulation and upregulation, medicine, Cancer research, lcsh:Q, medicine.symptom, lcsh:Science, MiRNA biogenesis, business
Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2020

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