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A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer
- Source :
- Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
- Publication Year :
- 2016
- Publisher :
- Nature Portfolio, 2016.
-
Abstract
- The formation of blood vessels in tumours, angiogenesis, is a promising target for therapy. Here, the authors show that microRNA192 has anti-angiogenic functions and negatively regulates EGR1 and HOXB9, and that delivery of this microRNA to tumours in vivocan reduce angiogenesis and tumour growth.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 7
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b7d16e04f0748669c65e11456597cc9
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/ncomms11169