1. Evaluation of the LIAISON XL Zika Capture IgM II for the Diagnosis of Zika Virus Infections
- Author
-
María Paz Sánchez-Seco, Fernando de Ory, Ana Vázquez, Jesús de la Fuente, Pilar Balfagón, Teodora Minguito, Mayte Pérez-Olmeda, María Ángeles Murillo, and Instituto de Salud Carlos III
- Subjects
0301 basic medicine ,viruses ,030106 microbiology ,lcsh:QR1-502 ,Enzyme-Linked Immunosorbent Assay ,Dengue virus ,medicine.disease_cause ,Antibodies, Viral ,Rubella ,Measles ,Sensitivity and Specificity ,Virus ,lcsh:Microbiology ,Article ,Enzyme immunoassay ,Dengue fever ,Zika virus ,Measles virus ,03 medical and health sciences ,Virology ,medicine ,Humans ,False Positive Reactions ,Serologic Tests ,Chemiluminescent immunoassay ,Chikungunya ,chemiluminescent immunoassay ,dengue viruses ,chikungunya virus ,biology ,business.industry ,Zika Virus Infection ,virus diseases ,Zika Virus ,medicine.disease ,biology.organism_classification ,enzyme immunoassay ,030104 developmental biology ,Infectious Diseases ,Immunoglobulin M ,Virus Diseases ,Dengue viruses ,business ,Chikungunya virus - Abstract
The aim of this study is to evaluate the performance characteristics of the LIAISON XL Zika Capture IgM II. For this purpose we tested 128 samples obtained from recent infections caused by the Zika (ZIKV, 74 samples), dengue (DENV, 10 samples), chikungunya (CHIK V, 11 samples), rubella (RUBV, 10 samples) and measles (MeV, 10 samples) viruses, as well as human parvovirus B19 (HPVB19, 13 samples). The results of the assay under evaluation are compared with those obtained from an indirect immunofluorescence (IIF) assay, and the discrepancies are resolved by considering other laboratory results (PCR and a plaque-reduction neutralization test). The LIAISON showed excellent sensitivity (100%). The specificity (91.25%) was hampered by some false-positive results in recent dengue virus, chikungunya virus, measles virus and human parvovirus B19 infections. The method evaluated is adequate, but the low specificity makes it necessary to consider the clinical and epidemiological contexts of patients, as well as other laboratory results.
- Published
- 2020