1. Effects of Maternal Fish Oil and/or 5-Methyl-Tetrahydrofolate Supplementation during Pregnancy on Offspring Brain Resting-State at 10 Years Old: A Follow-Up Study from the NUHEAL Randomized Controlled Trial
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Cristina Martínez-Zaldívar, Andrés Catena, Cristina Martín-Pérez, Berthold Koletzko, Daniel Campos, Miguel Pérez-García, José Antonio García-Santos, Cristina Campoy, Hatim Azaryah, Francisco J. Torres-Espínola, Juan Verdejo-Román, [Azaryah,H, García-Santos,JA, Martínez-Zaldívar,C, Torres-Espínola,FJ, Campos,D, Campoy,C] Department of Paediatrics, School of Medicine, University of Granada, Granada, Spain. [Azaryah,H, Campoy,C] EURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, Granada, Spain. [Verdejo-Román,J, Martin-Pérez,C, Pérez-García,M, Catena,A] Mind, Brain and Behaviour International Research Centre (CIMCYC), University of Granada, Granada, Spain. [García-Santos,JA, Campoy,C] Instituto de Investigación Biosanitaria de Granada (Ibs-GRANADA), Health Sciences Technological Park, Granada, Spain. [Koletzko,B] Ludwig-Maximiliams-Universität München, Dr. von Hauner Children’s Hospital, University of Munich Hospitals, Munich, Germany. [Campoy,C] Spanish Network of Biomedical Research in Epidemiology and Public Health (CIBERESP), Granada’s Node, Institute of Health Carlos III, Madrid, Spain., This work was supported by the Commission of the European Community’s 7th Framework Program (FP7/2008–2013), Grant agreement No. 212652 (NUTRIMENTHE Project), within the 6th Framework Program, Contract no. 007036 (EARNEST Project), and and supported in part by the Commission of the European Community within the 5th Framework Program, Contract No. QLK1-CT-1999-00888 (NUHEAL EU Project). This publication is the work of the authors and does not necessarily reflect the views of the Commission of the European Community. The work of B.K. is supported by the European Research Council Advanced Grant ERC-2012-AdG-No.322605 META-GROWTH. J.V.-R is supported by a grant from the Spanish Ministry of Science, Innovation and Universities (FJCI-2017-33396). The funders had no role in the design, analysis or writing of this article.
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Male ,0301 basic medicine ,Fish oils ,Folate ,Neurodevelopment ,Physiology ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Magnetic Resonance Imaging [Medical Subject Headings] ,Brain function ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Principal Component Analysis [Medical Subject Headings] ,fish oil ,law.invention ,Resting-state functional neuroimaging ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,Child Development ,0302 clinical medicine ,Randomized controlled trial ,law ,Pregnancy ,Aceites de pescado ,Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure::Maternal Exposure [Medical Subject Headings] ,Child ,Children ,Tetrahydrofolates ,Default mode network ,Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy [Medical Subject Headings] ,Principal Component Analysis ,Nutrition and Dietetics ,Maternal nutritional physiological phenomena ,Fenómenos fisiologicos nutricionales maternos ,neurodevelopment ,Neuropsychology ,Brain ,Magnetic Resonance Imaging ,3. Good health ,Maternal Exposure ,Niño ,Technology and Food and Beverages::Food and Beverages::Food::Dietary Supplements [Medical Subject Headings] ,Regression Analysis ,Female ,Ácido fólico ,pregnancy ,lcsh:Nutrition. Foods and food supply ,Adult ,Anthropology, Education, Sociology and Social Phenomena::Human Activities::Leisure Activities::Relaxation::Rest [Medical Subject Headings] ,Anatomy::Nervous System::Nerve Net [Medical Subject Headings] ,Offspring ,Embarazo ,Phenomena and Processes::Physiological Phenomena::Physiological Processes::Growth and Development::Human Development::Child Development [Medical Subject Headings] ,Rest ,Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Pteridines::Pterins::Folic Acid::Tetrahydrofolates [Medical Subject Headings] ,Check Tags::Male [Medical Subject Headings] ,lcsh:TX341-641 ,Fish oil ,Placebo ,folate ,Article ,Angular gyrus ,brain function ,03 medical and health sciences ,Fish Oils ,children ,Chemicals and Drugs::Lipids::Oils::Fish Oils [Medical Subject Headings] ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies [Medical Subject Headings] ,medicine ,Humans ,Persons::Persons::Age Groups::Child [Medical Subject Headings] ,Persons::Persons::Age Groups::Adult [Medical Subject Headings] ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Regression Analysis [Medical Subject Headings] ,030109 nutrition & dietetics ,Resting state fMRI ,Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Maternal Nutritional Physiological Phenomena [Medical Subject Headings] ,business.industry ,resting-state functional neuroimaging ,Maternal Nutritional Physiological Phenomena ,Anatomy::Nervous System::Central Nervous System::Brain [Medical Subject Headings] ,medicine.disease ,Check Tags::Female [Medical Subject Headings] ,Dietary Supplements ,Nerve Net ,business ,030217 neurology & neurosurgery ,Follow-Up Studies ,Food Science - Abstract
Recent studies have shown that maternal supplementation with folate and long-chain polyunsaturated fatty acids (LC-PUFAs) during pregnancy may affect children&rsquo, s brain development. We aimed at examining the potential long-term effect of maternal supplementation with fish oil (FO) and/or 5-methyl-tetrahydrofolate (5-MTHF) on the brain functionality of offspring at the age of 9.5&ndash, 10 years. The current study was conducted as a follow-up of the Spanish participants belonging to the Nutraceuticals for a Healthier Life (NUHEAL) project, 57 children were divided into groups according to mother&rsquo, s supplementation and assessed through functional magnetic resonance imaging (fMRI) scanning and neurodevelopment testing. Independent component analysis and double regression methods were implemented to investigate plausible associations. Children born to mothers supplemented with FO (FO and FO + 5-MTHF groups, n = 33) showed weaker functional connectivity in the default mode (DM) (angular gyrus), the sensorimotor (SM) (motor and somatosensory cortices) and the fronto-parietal (FP) (angular gyrus) networks compared to the No-FO group (placebo and 5-MTHF groups, n = 24) (PFWE <, 0.05). Furthermore, no differences were found regarding the neuropsychological tests, except for a trend of better results in an object recall (memory) test. Considering the No-FO group, the aforementioned networks were associated negatively with attention and speed-processing functions. Mother&rsquo, s FO supplementation during pregnancy seems to be able to shape resting-state network functioning in their children at school age and appears to produce long-term effects on children´, s cognitive processing.
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- 2020
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