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Start Over Descriptor "hormone insufficiency" Publisher mdpi ag
2 results on '"hormone insufficiency"'

1. Bacterial Heat-Stable Enterotoxins: Translation of Pathogenic Peptides into Novel Targeted Diagnostics and Therapeutics

Author

Chang Chang, Brian A. Stoecker, Adam E. Snook, Peng Li, Michael S. Magee, Glen Marszalowicz, Michael Valentino, Jieru E. Lin, and Scott A. Waldman

Subjects
heat-stable enterotoxins (STa), guanylyl cyclase C, guanylin, uroguanylin, colorectal cancer, hormone insufficiency, hormone replacement therapy, tumor vaccine, irritable bowel syndrome, biomarker, targeted delivery, Medicine
Abstract

Heat-stable toxins (STs) produced by enterotoxigenic bacteria cause endemic and traveler’s diarrhea by binding to and activating the intestinal receptor guanylyl cyclase C (GC-C). Advances in understanding the biology of GC-C have extended ST from a diarrheagenic peptide to a novel therapeutic agent. Here, we summarize the physiological and pathophysiological role of GC-C in fluid-electrolyte regulation and intestinal crypt-villus homeostasis, as well as describe translational opportunities offered by STs, reflecting the unique characteristics of GC-C, in treating irritable bowel syndrome and chronic constipation, and in preventing and treating colorectal cancer.

Published
2010
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2. Bacterial Heat-Stable Enterotoxins: Translation of Pathogenic Peptides into Novel Targeted Diagnostics and Therapeutics

Author

Peng Li, Brian Arthur Stoecker, Glen P Marszalowicz, Adam E. Snook, Michael S. Magee, Michael A. Valentino, Jieru E. Lin, Chang Chang, and Scott A. Waldman

Subjects
Receptors, Peptide, Health, Toxicology and Mutagenesis, Guanylin, Bacterial Toxins, Molecular Sequence Data, lcsh:Medicine, Receptors, Enterotoxin, colorectal cancer, Review, Enterotoxin, Biology, guanylin, Toxicology, Irritable Bowel Syndrome, Enterotoxins, chemistry.chemical_compound, medicine, Animals, Humans, Amino Acid Sequence, guanylyl cyclase C, Irritable bowel syndrome, heat-stable enterotoxins (STa), Neoplasm Staging, hormone insufficiency, Escherichia coli Proteins, lcsh:R, uroguanylin, targeted delivery, Guanylate cyclase 2C, medicine.disease, hormone replacement therapy, Biomarker, Diarrhea, Receptors, Guanylate Cyclase-Coupled, chemistry, Immunology, tumor vaccine, biomarker, medicine.symptom, Signal transduction, Colorectal Neoplasms, Peptides, Constipation, Signal Transduction, Uroguanylin
Abstract

Heat-stable toxins (STs) produced by enterotoxigenic bacteria cause endemic and traveler’s diarrhea by binding to and activating the intestinal receptor guanylyl cyclase C (GC-C). Advances in understanding the biology of GC-C have extended ST from a diarrheagenic peptide to a novel therapeutic agent. Here, we summarize the physiological and pathophysiological role of GC-C in fluid-electrolyte regulation and intestinal crypt-villus homeostasis, as well as describe translational opportunities offered by STs, reflecting the unique characteristics of GC-C, in treating irritable bowel syndrome and chronic constipation, and in preventing and treating colorectal cancer.

Published
2010

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