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A metamaterial-based non-uniform dipole array antenna is presented for high gain 5G millimeter-wave applications with a wideband characteristic. Initially, a non-uniform dipole array is designed on a 0.202 mm thick Rogers RO4003C substrate, offering a wide operating bandwidth ranging from 23.1 GHz to 44.8 GHz. The dipole array antenna emits unidirectional end-fire radiation with a maximum gain of 8.1 dBi and an average gain of 6.7 dBi. Subsequently, to achieve high gain performance, a 5 × 7 metamaterial structure is designed in the direction of the antenna radiation. The implemented metamaterial structure is optimized for the operating frequency, enhancing the directivity of the antenna radiation and resulting in a gain increment of more than 3 dBi compared to the dipole array alone. The developed metamaterial-integrated dipole array antenna offers an operating bandwidth (S11 < −10 dB) of more than 21 GHz (63.92%), ranging from 23.1 GHz to 44.8 GHz, covering the most commonly used 5G millimeter-wave frequency bands (n257, n258, n259, n260, and n261). Furthermore, the presented antenna yields a stable high gain with a peak gain of 11.21 dBi and a good radiation efficiency of more than 64%. The proposed antenna is an excellent option for millimeter-wave 5G systems due to its overall properties, particularly its high gain and end-fire radiation characteristics, combined with a wide operating bandwidth.

Modern subway systems have increased in size and complexity, and this growth presents significant challenges for planners of emergency evacuations. In this study, the effectiveness of the simplified and advanced evacuation analysis methods recommended by the International Maritime Organization (IMO) are evaluated for Guryong Station in Seoul, South Korea. The simplified evacuation analysis method facilitates rapid assessments by using general parameters, while the advanced evacuation analysis entails performing detailed simulations of human behavior and physical interactions. Our findings indicate that the results of the simplified evacuation analysis method are reasonably close to those of the more time-consuming advanced evacuation analysis method, thereby demonstrating the practical applicability of the former method for conducting initial evacuation safety assessments. Specifically, both the simplified and advanced methods showed a 20% reduction in Total Evacuation Time when tunnel evacuation routes were utilized. This finding demonstrates that the simplified method can produce results comparable to the advanced method, making it a reliable tool for initial assessments and for evaluating alternative strategies to reduce evacuation time. By demonstrating that the simplified evacuation analysis method can yield reliable results, we provide valuable insights for developing smart, resilient cities with efficient emergency-response capabilities.

In this article, an ultra-wideband (UWB) antenna featuring two reconfigurable quasi-perfect stop bands at WLAN (5.25–5.75 GHz) and lower 5G (3.4–3.8 GHz) utilizing electromagnetic bandgaps (EBGs) and positive-intrinsic-negative (P-I-N) diodes is proposed. A pair of EBG structures are applied to generate sharp notch bands in the targeted frequency spectrum. Each EBG creates a traditional notch, while two regular notches are combined to make a quasi-perfect, sharp, notch band. Four P-I-N diodes are engraved into the EBG structures to enable notch band reconfigurability. By switching the operational condition of the four diodes, the UWB antenna can dynamically adjust its notching characteristics to enhance its adaptability to various communication standards and applications. The antenna can be reconfigured as a UWB (3–11.6 GHz) without any notch band, a UWB with a single sharp notch (either at WLAN or 5G), or a UWB with two quasi-perfect notch bands. Moreover, the antenna’s notch bands can also be switched from a traditional notch to a quasi-perfect notch and vice versa. To confirm the validity of the simulated outcomes, the proposed reconfigurable UWB antenna is fabricated and measured. The experimental findings are aligned closely with simulation results, and the antenna offers notch band reconfigurability. The antenna shows a consistently favorable radiation pattern and gain. The dimension of the presented antenna is 20 × 27 × 1.52 mm3 (0.45 λc × 0.33 λc × 0.025 λc, where λc is the wavelength in free space).

An accurate humidity measurement is essential in various industries, including product stability, pharmaceutical and food preservation, environmental control, and precise humidity management in experiments and industrial processes. Crafting effective humidity sensors through precise material selection is crucial for detecting minute humidity levels across various fields, ultimately enhancing productivity and maintaining product quality. Metal–organic frameworks (MOFs), particularly zeolitic imidazolate frameworks (ZIFs), exhibit remarkable properties and offer a wide range of applications in catalysis, sensing, and gas storage due to their structural stability, which resembles zeolites. The previous research on MOF-based humidity sensors have primarily used electrical resistance-based methods. Recently, however, interest has shifted to capacitive-based sensors using MOFs due to the need for humidity sensors at low humidity and the resulting high sensitivity. Nevertheless, further studies are required to optimize particle structure and size. This study analyzes ZIF-8, a stable MOF synthesized in varying particle sizes, to evaluate its performance as a humidity sensor. The structural, chemical, and sensing properties of synthesized ZIF-8 particles ranging from 50 to 200 nanometers were examined through electron microscopy, spectroscopic, and electrochemical analyses. The fabricated copper electrodes combined with these particles demonstrated stable and linear humidity sensing capabilities within the range of 3% to 30% relative humidity (RH).

This study demonstrates the successful 3D printing of dental resin-based composites (DRCs) containing ceramic particles using the digital light processing (DLP) technique. The mechanical properties and oral rinsing stability of the printed composites were evaluated. DRCs have been extensively studied for restorative and prosthetic dentistry due to their clinical performance and aesthetic quality. They are often subjected to periodic environmental stress, and thus can easily undergo undesirable premature failure. Here, we investigated the effects of two different high-strength and biocompatible ceramic additives, carbon nanotube (CNT) and yttria-stabilized zirconia (YSZ), on the mechanical properties and oral rinsing stabilities of DRCs. Dental resin matrices containing different wt.% of CNT or YSZ were printed using the DLP technique after analyzing the rheological behavior of slurries. Mechanical properties such as Rockwell hardness and flexural strength, as well as the oral rinsing stability of the 3D-printed composites, were systematically investigated. The results indicated that a DRC with 0.5 wt.% YSZ exhibits the highest hardness of 19.8 ± 0.6 HRB and a flexural strength flexural strength of 50.6 ± 6 MPa, as well as reasonable oral rinsing steadiness. This study provides a fundamental perspective for designing advanced dental materials containing biocompatible ceramic particles.

Accumulating evidence has shown that sirtuin 7 (SIRT7), a mediator of various cellular activities, plays an important role in the pathogenesis of various immune-mediated inflammatory disorders. However, information remains limited regarding the role of SIRT7 in intestinal inflammation. We used a murine colitis model to investigate the role of SIRT7 in intestinal immunity and whether SIRT7 inhibitors could attenuate the intestinal inflammatory response. Mice were divided into three groups: control, colitis-induced, and SIRT7-inhibitor-treated. A colitis mouse model was established by intraperitoneal injection and nasal challenge with ovalbumin, as in our previous study. Quantitative analyses of inflammatory cytokines and SIRT7 levels in the colonic mucosa were performed to compare the changes in inflammatory responses between the three groups. The colitis group showed increased levels of inflammatory cytokines and SIRT7 in the colonic mucosa. The inflammatory reaction was suppressed in colitis-induced mice administered the SIRT7 inhibitor. The qRT-PCR results showed normalization of inflammatory cytokines in the SIRT7 inhibitor-treated group. Histologic study revealed a decrease in the extent of inflammation after SIRT7 treatment. We also observed that the degree of clinical inflammation was improved in SIRT7-treated mice. Our study demonstrated that SIRT7 inhibition attenuated the inflammatory response in the colon of mice, suggesting a possible role for SIRT7 in the pathogenesis of immune-mediated intestinal inflammation.

Staphylococcal enterotoxin B (SEB) is a potent bacterial toxin that causes inflammatory stimulation and toxic shock, thus it is necessary to detect SEB in food and environmental samples. Here, we developed a sensitive immunodetection system using monoclonal antibodies (mAbs). Our study is the first to employ a baculovirus expression vector system (BEVS) to produce recombinant wild-type SEB. BEVS facilitated high-quantity and pure SEB production from suspension-cultured insect cells, and the SEB produced was characterized by mass spectrometry analysis. The SEB was stable at 4 °C for at least 2 years, maintaining its purity, and was further utilized for mouse immunization to generate mAbs. An optimal pair of mAbs non-competitive to SEB was selected for sandwich enzyme-linked immunosorbent assay-based immunodetection. The limit of detection of the immunodetection method was 0.38 ng/mL. Moreover, it displayed higher sensitivity in detecting SEB than commercially available immunodetection kits and retained detectability in various matrices and S. aureus culture supernatants. Thus, the results indicate that BEVS is useful for producing pure recombinant SEB with its natural immunogenic property in high yield, and that the developed immunodetection assay is reliable and sensitive for routine identification of SEB in various samples, including foods.

Noise radar has become attractive owing to progress in hardware technology. Aside from the low probability of exploitation, the use of noise waveform is likely to grow due to its low interference features, especially in circumstances where multiple radars operate in the same band. In this study, we developed and tested a wideband noise radar for a ground-moving vehicle. It operates in the X-band with an instantaneous bandwidth of 1.5 GHz. The true time delay (TTD) was applied to correct the distortion of the beam pattern by the wide bandwidth, and the correlators were implemented by high-speed parallel processing using a field programmable gate array (FPGA). The outdoor experimental results were presented.

This paper presents a compact two-element MIMO antenna with improved isolation for triple-band applications. The antenna consists of two radiating elements with the shared ground plane and a novel decoupling structure. Each antenna element has three stubs with different lengths, which work as quarter-wavelength monopoles to give a triple-band operation. The decoupling system is made by etching various slots in an inverted H-shape stub attached to two quarter-circles at its lower ends. The simulated and measured results show that the antenna operates (|S11| < −10 dB) at the key frequency bands of 2.4 GHz (2.29–2.47 GHz), 3.5 GHz (3.34–3.73 GHz), and 5.5 GHz (4.57–6.75 GHz) with a stable gain and radiation patterns. Moreover, the MIMO antenna shows good isolation characteristics. The isolation is more than 20 dB, the envelope correlation coefficient is

Neurodegenerative diseases are inseparably linked with aging and increase as life expectancy extends. There are common dysfunctions in various cellular events shared among neurogenerative diseases, such as calcium dyshomeostasis, neuroinflammation, and age-associated decline in the autophagy-lysosome system. However, most of all, the prominent pathological feature of neurodegenerative diseases is the toxic buildup of misfolded protein aggregates and inclusion bodies accompanied by an impairment in proteostasis. Recent studies have suggested a close association between endoplasmic reticulum (ER) stress and neurodegenerative pathology in cellular and animal models as well as in human patients. The contribution of mutant or misfolded protein-triggered ER stress and its associated signaling events, such as unfolded protein response (UPR), to the pathophysiology of various neurodegenerative disorders, including Alzheimer’s, Parkinson’s, and Huntington’s disease, amyotrophic lateral sclerosis, and prion disease, is described here. Impaired UPR action is commonly attributed to exacerbated ER stress, pathogenic protein aggregate accumulation, and deteriorating neurodegenerative pathologies. Thus, activating certain UPR components has been shown to alleviate ER stress and its associated neurodegeneration. However, uncontrolled activation of some UPR factors has also been demonstrated to worsen neurodegenerative phenotypes, suggesting that detailed molecular mechanisms around ER stress and its related neurodegenerations should be understood to develop effective therapeutics against aging-associated neurological syndromes. We also discuss current therapeutic endeavors, such as the development of small molecules that selectively target individual UPR components and address ER stress in general.

An increased life span and accompanying nutritional affluency have led to a rapid increase in diseases associated with aging, such as obesity and type 2 diabetes, imposing a tremendous economic and health burden on society. Pancreatic β-cells are crucial for controlling glucose homeostasis by properly producing and secreting the glucose-lowering hormone insulin, and the dysfunction of β-cells determines the outcomes for both type 1 and type 2 diabetes. As the native structure of insulin is formed within the endoplasmic reticulum (ER), ER homeostasis should be appropriately maintained to allow for the proper metabolic homeostasis and functioning of β-cells. Recent studies have found that cellular senescence is critically linked with cellular stresses, including ER stress, oxidative stress, and mitochondrial stress. These studies implied that β-cell senescence is caused by ER stress and other cellular stresses and contributes to β-cells’ dysfunction and the impairment of glucose homeostasis. This review documents and discusses the current understanding of cellular senescence, β-cell function, ER stress, its associated signaling mechanism (unfolded protein response), and the effect of ER stress on β-cell senescence and dysfunction.

Since the coronavirus disease 2019 (COVID-19) pandemic, most professional sports events have been held without spectators. It is generally believed that home teams deprived of enthusiastic support from their home fans experience reduced benefits of playing on their home fields, thus becoming less likely to win. This study attempts to confirm if this belief is true in four major European football leagues through statistical analysis. This study proposes a Bayesian hierarchical Poisson model to estimate parameters reflecting the home advantage and the change in such advantage. These parameters are used to improve the performance of machine-learning-based prediction models for football matches played after the COVID-19 break. The study describes the statistical analysis on the impact of the COVID-19 pandemic on football match results in terms of the expected score and goal difference. It also shows that estimated parameters from the proposed model reflect the changed home advantage. Finally, the study verifies that these parameters, when included as additional features, enhance the performance of various football match prediction models. The home advantage in European football matches has changed because of the behind-closed-doors policy implemented due to the COVID-19 pandemic. Using parameters reflecting the pandemic’s impact, it is possible to predict more precise results of spectator-free matches after the COVID-19 break.

Mesenchymal stem cells (MSCs) have emerged as a promising therapeutic approach for diverse diseases and injuries. The biological and clinical advantages of human fetal MSCs (hfMSCs) have recently been reported. In terms of promising therapeutic approaches for diverse diseases and injuries, hfMSCs have gained prominence as healing tools for clinical therapies. Therefore, this review assesses not the only biological advantages of hfMSCs for healing human diseases and regeneration, but also the research evidence for the engraftment and immunomodulation of hfMSCs based on their sources and biological components. Of particular clinical relevance, the present review also suggests the potential therapeutic feasibilities of hfMSCs for musculoskeletal disorders, including osteoporosis, osteoarthritis, and osteogenesis imperfecta.

Recent studies on the pathophysiology of irritable bowel syndrome (IBS) have focused on the role of mast cells (MCs) in intestinal mucosal immunity. A link between allergic airway diseases (AADs) and IBS has been suggested because both diseases have similar pathophysiology. We aimed to investigate whether the induction of AAD in mice could lead to inflammation of the colonic mucosa, similar to IBS. We also evaluated whether this inflammatory response could be suppressed by administering a therapeutic agent. Mice were divided into three groups: control, AAD-induced, and salbutamol-treated. An AAD mouse model was established by intraperitoneal injection and nasal challenge with ovalbumin. Mice with AAD were intranasally administered salbutamol. Analyses of cytokine levels, MC count, and tryptase levels in the intestinal mucosa were performed to compare the changes in inflammatory responses among the three groups. Inflammation was observed in the intestinal mucosa of mice in the AAD group. This inflammation in AAD mice was suppressed after salbutamol treatment. Our study demonstrates that AAD induces an inflammatory response similar to that in IBS, suggesting a possible association between IBS and AADs. In patients with IBS with such allergic components, salbutamol may have the potential to alleviate the inflammatory response.

In this article, a layered shell element-based, elastic finite element method for predicting welding distortion in multi-pass welding is developed. The welding distortion generated in each pass can be predicted by employing layer-by-layer equivalent plastic strains as thermal expansion coefficients and using the heat-affected zone (HAZ) width as the mesh size. The final distortion can be expressed as the sum of the distortions for each pass. This study focuses on extraction of the equivalent plastic strain and HAZ width through 3D thermal elastic plastic analysis (TEPA) for each pass. The input variables extracted from each pass can be converted and added to simulate the final distortion of the multi-pass welding. A 10 mm thick, multi-pass butt-welded joint, subjected to three passes, is simulated via the proposed method. The predicted welding distortion is compared with the 3D TEPA results and the measured experimental data. The outcome indicates that good agreement can be obtained.

Recently, the involvement of the nervous system in the pathology of allergic diseases has attracted increasing interest. However, the precise pathophysiological role of enteric neurons in food allergies has not been elucidated. We report the presence of functional high-affinity IgE receptors (FcεRIs) in enteric neurons. FcεRI immunoreactivities were observed in approximately 70% of cholinergic myenteric neurons from choline acetyltransferase-eGFP mice. Furthermore, stimulation by IgE-antigen elevated intracellular Ca2+ concentration in isolated myenteric neurons from normal mice, suggesting that FcεRIs are capable of activating myenteric neurons. Additionally, the morphological investigation revealed that the majority of mucosal mast cells were in close proximity to enteric nerve fibers in the colonic mucosa of food allergy mice. Next, using a newly developed coculture system of isolated myenteric neurons and mucosal-type bone-marrow-derived mast cells (mBMMCs) with a calcium imaging system, we demonstrated that the stimulation of isolated myenteric neurons by veratridine caused the activation of mBMMCs, which was suppressed by the adenosine A3 receptor antagonist MRE 3008F20. Moreover, the expression of the adenosine A3 receptor gene was detected in mBMMCs. Therefore, in conclusion, it is suggested that, through interaction with mucosal mast cells, IgE-antigen-activated myenteric neurons play a pathological role in further exacerbating the pathology of food allergy.

Artemisia argyi is widely used as traditional medicine in East Asia. However, its effects against inflammation and gastric ulcers have not been reported yet. We analyzed anti-inflammatory activity and its molecular mechanisms of A. argyi using RAW264.7 cells line, then evaluated the curative efficacy in rats with acute gastric ulcers. Nitric oxide and IL-6 production was measured using Griess reagent and an ELISA kit. Inducible nitric oxide synthase (iNOS), interleukin (IL)-6, and mucin (MUC)1, MUC5AC, and MUC6 mRNA were determined by SYBR Green or Taqman qRT-PCR methods. The phosphorylation of ERK, JNK, p38, and c-Jun protein were detected by western blotting. RW0117 inhibited LPS-induced NO and IL-6 production. The mRNA levels of iNOS and IL-6 were strongly suppressed. The phosphorylation of ERK, JNK, and c-Jun decreased by treatment with RW0117. Oral administration of RW0117 recovered the amount of mucin mRNA and protein level that was decreased due to gastric ulcers by HCl-EtOH. A. argyi exhibited strong anti-inflammatory effects and contributed to the modulation of HCl-EtOH-induced gastric ulcer in rats.

In this study, modified equivalent load method for welding distortion analysis is suggested to improve its accuracy. To avoid the excessive computational time for welding distortion analysis of large welded structures, shell element-based elastic analysis methods are widely used, applying the inherent deformation approach. Equivalent nodal forces are commonly used in common FE (Finite Element) codes to enter these inherent deformation values. However, the conventional method cannot estimate precise longitudinal bending following the conventional equation. In this study, the problem of the existing equivalent load method is analyzed by a case study, and the modified equivalent load method that can estimate angular distortion, transverse shrinkage, and longitudinal bending is presented based on the FEM principle. The results show that by applying the proposed method, the shell element-based elastic FE approach for the welding distortion analysis can be achieved with improved accuracy.

The effect of deposition pattern on the temperature and global distortion of Direct Metal Tooling (DMT) based Additive Manufactured (AM) is investigated through the experimental results of laser deposited SUS316. DMT is one of the Directed Energy Deposition (DED) processes. In situ temperature measurements were used to monitor the temperature of the substrates and global distortion patterns were analyzed using CMM (coordinate Measuring Machine) after the deposition. Six different patterns combining long raster and short raster patterns were considered for the case studies. The results showed that the deposition pattern affects the temperature gradient and that the peak temperature of each layer can increase or decrease according to the sequence of the deposition pattern. Also, the pattern of the first layer had a dominant influence on the longitudinal bending deflection that occurs. Based on these results, appropriate tool path schedule can be utilized to control not only the distortion but also the peak temperature of the DMT-based AM parts.

Inflammatory bowel disease (IBD) is a chronic relapsing disorder modulated by numerous factors. Recent failures of drugs targeting single factors suggest that multitargeting drugs could be useful for the treatment of IBD. Natural medicines may be an alternative option for the treatment of IBD, owing to the complex nature of the disease. However, most natural medicines have poor in vitro and in vivo translational potential because of inadequate pharmacokinetic study. KM1608, a mixture of the medicinal plants Aucklandia lappa, Terminalia chebula, and Zingiber officinale, was examined for its anti-colitis effects and biodistribution using bioimaging. Dehydrocostus lactone, as a marker compound, was analyzed to assess the biodistribution of KM1608. KM1608 significantly attenuated the disease activity of dextran sodium sulfate-induced colitis in mice and suppressed inflammatory mediators such as myeloperoxidase, proinflammatory cytokines (TNF-α and IL-6), and the Th2-type cytokine IL-4 in the colon. Optical fluorescence imaging revealed that KM1608 was distributed in the intestinal area as a target organ. Collectively, our findings suggest that KM1608 is a potential therapeutic formulation for IBD.

In this work, modified-release solid dosage forms were fabricated by adjusting geometrical properties of solid dosage forms through hot-melt 3D extrusion (3D HME). Using a 3D printer with air pressure driving HME system, solid dosage forms containing ibuprofen (IBF), polyvinyl pyrrolidone (PVP), and polyethylene glycol (PEG) were printed by simultaneous HME and 3D deposition. Printed solid dosage forms were evaluated for their physicochemical properties, dissolution rates, and floatable behavior. Results revealed that IBF content in the solid dosage form could be individualized by adjusting the volume of solid dosage form. IBF was dispersed as amorphous state with enhanced solubility and dissolution rate in a polymer solid dosage form matrix. Due to absence of a disintegrant, sustained release of IBF from printed solid dosage forms was observed in phosphate buffer at pH 6.8. The dissolution rate of IBF was dependent on geometric properties of the solid dosage form. The dissolution rate of IBF could be modified by merging two different geometries into one solid dosage form. In this study, the 3D HME process showed high reproducibility and accuracy for preparing dosage forms. API dosage and release profile were found to be customizable by modifying or combining 3D modeling.

Accompanied by increased life span, aging-associated diseases, such as metabolic diseases and cancers, have become serious health threats. Recent studies have documented that aging-associated diseases are caused by prolonged cellular stresses such as endoplasmic reticulum (ER) stress, mitochondrial stress, and oxidative stress. Thus, ameliorating cellular stresses could be an effective approach to treat aging-associated diseases and, more importantly, to prevent such diseases from happening. However, cellular stresses and their molecular responses within the cell are typically mediated by a variety of factors encompassing different signaling pathways. Therefore, a target-based drug discovery method currently being used widely (reverse pharmacology) may not be adequate to uncover novel drugs targeting cellular stresses and related diseases. The connectivity map (CMap) is an online pharmacogenomic database cataloging gene expression data from cultured cells treated individually with various chemicals, including a variety of phytochemicals. Moreover, by querying through CMap, researchers may screen registered chemicals in silico and obtain the likelihood of drugs showing a similar gene expression profile with desired and chemopreventive conditions. Thus, CMap is an effective genome-based tool to discover novel chemopreventive drugs.

Parkinson’s disease (PD) is a well-known age-related neurodegenerative disorder associated with longer lifespans and rapidly aging populations. The pathophysiological mechanism is a complex progress involving cellular damage such as mitochondrial dysfunction and protein homeostasis. Age-mediated degenerative neurological disorders can reduce the quality of life and also impose economic burdens. Currently, the common treatment is replacement with levodopa to address low dopamine levels; however, this does not halt the progression of PD and is associated with adverse effects, including dyskinesis. In addition, elderly patients can react negatively to treatment with synthetic neuroprotection agents. Recently, natural compounds such as phytochemicals with fewer side effects have been reported as candidate treatments of age-related neurodegenerative diseases. This review focuses on mitochondrial dysfunction, oxidative stress, hormesis, proteostasis, the ubiquitin‒proteasome system, and autophagy (mitophagy) to explain the neuroprotective effects of using natural products as a therapeutic strategy. We also summarize the efforts to use natural extracts to develop novel pharmacological candidates for treatment of age-related PD.

Gami-soyosan is a medicinal herbal formulation prescribed for the treatment of menopausal symptoms, including hot flashes and osteoporosis. Gami-soyosan is also used to treat similar symptoms experienced by patients with breast cancer. The incidence of breast cancer in women receiving hormone replacement therapy is a big burden. However, little is known about the components and their mechanism of action that exhibit these beneficial effects of Gami-soyosan. The aim of this study was to simultaneously analyze compounds of Gami-soyosan, and determine their cytotoxic effects on estrogen receptor (ER)-positive MCF-7 human breast adenocarcinoma cells. We established a simultaneous analysis method of 18 compounds contained in Gami-soyosan and found that, among the various compounds in Gami-soyosan, gallic acid (1), decursin (17), and decursinol angelate (18) suppressed the viability of MCF-7 cells. Gallic acid (1), decursin (17), and decursinol angelate (18) induced apoptotic cell death and significantly increased poly (ADP-ribose) polymerase (PARP) cleavage and the Bcl-2-associated X protein/ B-cell lymphoma 2 (Bax/Bcl-2) ratio. Decursin (17) increased the expression of cleaved caspases-8, -9, -7, and -3. Decursinol angelate (18) increased the expression of cleaved caspase-8 and -7. These three components altered the different apoptosis signal pathways. Collectively, gallic acid (1), decursin (17), and decursinol angelate (18) may be used to inhibit cell proliferation synergistically in patients with ER-positive breast cancer.

Curcumin is a polyphenol compound derived from the rhizomes of Curcuma longa that exhibits antioxidant, anti-inflammatory, anticancer, and antimicrobial properties. However, its low solubility in aqueous solutions, low absorption following oral administration, and rapid degradation limit its use as a functional food material. In this study, a hydroxypropyl methylcellulose-based solid dispersion of curcumin (DW-CUR 20) was prepared and its bioavailability was evaluated. In addition, its therapeutic efficacy as a hepatoprotective agent was investigated using the model of tert-butyl hydroperoxide (t-BHP)-induced hepatocyte damage. The rat plasma pharmacokinetic study showed that the oral curcumin bioavailability of DW-CUR 20 significantly increased compared to that of non-formulated curcumin. DW-CUR 20 showed a concentration-dependent hepatocyte protective effect on t-BHP-induced HepG2 cells. DW-CUR 20 inhibited the release of lactate dehydrogenase and decreased apoptosis-related proteins such as Poly (ADP-ribose) polymerase, cleaved caspase-7 and cleaved caspase-8 on t-BHP-treated HepG2 cells. These findings suggest that DW-CUR 20 could be a promising formulation for enhancing the therapeutic efficiency of curcumin and for improving the safety.

Many medicinal plants have been used traditionally in East Asia for the treatment of gastrointestinal disease and inflammation. The aim of this study was to evaluate the anti-inflammatory activity of 350 extracts (175 water extracts and 175 ethanol extracts) from 71 single plants, 97 mixtures of two plants, and seven formulations based on traditional medicine, to find herbal formulations to treat inflammatory bowel disease (IBD). In the in vitro screening, nitric oxide (NO), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 levels were determined in LPS-treated RAW264.7 cells and the TNF-α induced monocyte-epithelial cell adhesion assay was used for the evaluation of the anti-inflammatory activity of the compounds. Dextran sulfate sodium (DSS)-induced colitis model and 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis model were used to evaluate the therapeutic effect against IBD of the samples selected from the in vitro screening. KM1608, composed of Zingiber officinale, Terminalia chebula and Aucklandia lappa, was prepared based on the screening experiments. The oral administration of KM1608 significantly attenuated the severity of colitis symptoms, such as weight loss, diarrhea, and rectal bleeding, in TNBS-induced colitis. In addition, inflammatory mediators, such as myeloperoxidase, TNF-α, and IL-6 levels decreased in the lysate of colon tissues treated with KM1608. Collectively, KM1608 ameliorated colitis through the regulation of inflammatory responses within the colon, which indicated that KM1608 had potential for the treatment of IBD.

Aucklandia lappa DC., Terminalia chebula Retz and Zingiber officinale Roscoe have been traditionally used in east Asia to treat chronic diarrhea and abdominal pain. This study aimed to evaluated the anti-inflammatory activity of KM1608, which is composed of three natural herbs in a mouse model of dextran sodium sulfate (DSS)-induced ulcerative colitis. The anti-inflammatory activity and underlying mechanism were assessed in vitro using LPS-treated RAW264.7 cells. The in vivo effect of KM1608 on DSS-induced colitis was examined after oral administration in mice. KM1608 significantly inhibited the inflammatory mediators such as nitric oxide, interleukin (IL)-6, monocyte chemotactic protein 1 (MCP-1) and tumor necrosis factor (TNF)-α in LPS-treated RAW264.7 cells. The inhibitory effect of KM1608 was attributed to the reduction of Akt phosphorylation in the LPS-treated cells. In the mouse model, oral administration of KM1608 significantly improved DSS-induced colitis symptoms, such as disease activity index (DAI), colon length, and colon weight, as well as suppressed the expression of IL-6, TNF-α, and myeloperoxidase (MPO) in the DSS-induced colitis tissues. Taken together, KM1608 improved colitis through the regulation of inflammatory responses, suggesting that KM1608 has potential therapeutic use in the treatment of inflammatory diseases.

Solution-processed organic light-emitting diodes (OLEDs) are attractive due to their low-cost, large area displays, and lighting features. Small molecules as well as polymers can be used as host materials within the solution-processed emitting layer. Herein, we report two 3,3′-bicarbazole-based host small molecules, which possess a structural isomer relationship. 9,9′-Di-4-n-butylphenyl-9H,9′H-3,3′-bicarbazole (BCz-nBuPh) and 9,9′-di-4-t-butylphenyl-9H,9′H-3,3′-bicarbazole (BCz-tBuPh) exhibited similar optical properties within solutions but different photoluminescence within films. A solution-processed green phosphorescent OLED with the BCz-tBuPh host exhibited a high maximum current efficiency and power efficiency of 43.1 cd/A and 40.0 lm/W, respectively, compared to the device with the BCz-nBuPh host.

A practical and sustainable method for the synthesis of levocabastine hydrochloride (1), a H1 receptor antagonist for the treatment of allergic conjunctivitis, that can be applied to the industrial production of the compound has been developed. Substantial improvements over the previously reported procedure are achieved via efficient preparation of an optically active key intermediate (5) without chiral resolution and with a more effective detosylation, which complements the previous procedure. Notably, our process requires no chromatographic purification and provides levocabastine hydrochloride in greater than 99.5% purity in a 14.2% overall yield.

In this paper, we study energy harvesting from the mouse click motions of a robot finger and a human index finger using a piezoelectric material. The feasibility of energy harvesting from mouse click motions is experimentally and theoretically assessed. The fingers wear a glove with a pocket for including the piezoelectric material. We model the energy harvesting system through the inverse kinematic framework of parallel joints in a finger and the electromechanical coupling equations of the piezoelectric material. The model is validated through energy harvesting experiments in the robot and human fingers with the systematically varying load resistance. We find that energy harvesting is maximized at the matched load resistance to the impedance of the piezoelectric material, and the harvested energy level is tens of nJ.