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Your search keyword '"3,4-dihydropyrimidinone"' showing total 2 results
Start Over Descriptor "3,4-dihydropyrimidinone" Publisher mdpi ag
2 results on '"3,4-dihydropyrimidinone"'

1. Ethyl 6-Methyl-2-oxo-4-{4-[(1-phenyl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Author

Itamar Luís Gonçalves, Gabriel Oliveira de Azambuja, Leonardo Davi, Guilherme Arraché Gonçalves, Luciano Porto Kagami, Gustavo Machado das Neves, João Pedro Silveira, Rômulo Faria Santos Canto, and Vera Lucia Eifler-Lima

Subjects
Biginelli reaction, 3,4-dihydropyrimidinone, triazole, LaSOM® 293, Inorganic chemistry, QD146-197
Abstract

The Biginelli reaction is an acid-catalyzed, three-component reaction between an aldehyde, a hydrogen methylene active compound, and urea (or its analogue) and constitutes a rapid and easy synthesis of highly functionalized heterocycles. Synthesis of ethyl 6-methyl-2-oxo-4-{4-[(1-phenyl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-1,2,3,4-tetrahydropyrimidine-5-carboxylate, identified by our laboratory code LaSOM® 293, was achieved using the Biginelli reaction as the key step, followed by the Huisgen 1,3-dipolar cycloaddition in a convergent four-step route. The product LaSOM® 293 was obtained with a yield of 84%.

Published
2019
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2. Ethyl 6-Methyl-2-oxo-4-{4-[(1-phenyl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Author

Gustavo Machado das Neves, Itamar Luís Gonçalves, Luciano Porto Kagami, Guilherme Arraché Gonçalves, Gabriel Oliveira de Azambuja, Leonardo Davi, João Pedro Silveira, Vera Lucia Eifler-Lima, and Rômulo Faria Santos Canto

Subjects
chemistry.chemical_classification, 3,4-dihydropyrimidinone, 010405 organic chemistry, Organic Chemistry, Biginelli reaction, Triazole, LaSOM® 293, 010402 general chemistry, 01 natural sciences, Biochemistry, Aldehyde, Medicinal chemistry, lcsh:QD146-197, Cycloaddition, 0104 chemical sciences, triazole, chemistry.chemical_compound, chemistry, Yield (chemistry), lcsh:Inorganic chemistry, Urea, Carboxylate, Physical and Theoretical Chemistry, Methylene
Abstract

The Biginelli reaction is an acid-catalyzed, three-component reaction between an aldehyde, a hydrogen methylene active compound, and urea (or its analogue) and constitutes a rapid and easy synthesis of highly functionalized heterocycles. Synthesis of ethyl 6-methyl-2-oxo-4-{4-[(1-phenyl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-1,2,3,4-tetrahydropyrimidine-5-carboxylate, identified by our laboratory code LaSOM® 293, was achieved using the Biginelli reaction as the key step, followed by the Huisgen 1,3-dipolar cycloaddition in a convergent four-step route. The product LaSOM® 293 was obtained with a yield of 84%.

Published
2019

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