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Ethyl 6-Methyl-2-oxo-4-{4-[(1-phenyl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-1,2,3,4-tetrahydropyrimidine-5-carboxylate
- Source :
- Molbank, Vol 2019, Iss 3, p M1076 (2019)
- Publication Year :
- 2019
- Publisher :
- MDPI AG, 2019.
-
Abstract
- The Biginelli reaction is an acid-catalyzed, three-component reaction between an aldehyde, a hydrogen methylene active compound, and urea (or its analogue) and constitutes a rapid and easy synthesis of highly functionalized heterocycles. Synthesis of ethyl 6-methyl-2-oxo-4-{4-[(1-phenyl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-1,2,3,4-tetrahydropyrimidine-5-carboxylate, identified by our laboratory code LaSOM® 293, was achieved using the Biginelli reaction as the key step, followed by the Huisgen 1,3-dipolar cycloaddition in a convergent four-step route. The product LaSOM® 293 was obtained with a yield of 84%.
Details
- Language :
- English
- ISSN :
- 14228599
- Volume :
- 2019
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Molbank
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.3afb649ed13422e8275b39c7b3a29f2
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/M1076