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Your search keyword '"You-Kai Xu"' showing total 4 results
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4 results on '"You-Kai Xu"'

1. Limonoids from the Fruits of Khaya ivorensis

Author

Xiao-Ling Zheng, Shang-Gao Liao, Zhi Na, You-Kai Xu, Ping Zhang, Hua-Bin Hu, and Kai-Long Ji

Subjects
Limonins, Khaya ivorensis, Pharmaceutical Science, Tumor cells, Article, limonoids, 14,15-didehydroruageanin A, Analytical Chemistry, lcsh:QD241-441, Inhibitory Concentration 50, lcsh:Organic chemistry, Cell Line, Tumor, Drug Discovery, Humans, Physical and Theoretical Chemistry, Meliaceae, Cytotoxicity, Nuclear Magnetic Resonance, Biomolecular, biology, Traditional medicine, Molecular Structure, Chemistry, Organic Chemistry, biology.organism_classification, Chemistry (miscellaneous), Fruit, Molecular Medicine, 3-O-methylbutyryl- seneganolide A, cytotoxicity
Abstract

Two new limonoids, namely 14,15-didehydroruageanin A (1) and 3-O-methyl- butyrylseneganolide A (2), were isolated from the fruits of Khaya ivorensis along with six known limonoids: seneganolide A (3), 1,3-dideacetylkhivorin (4), 7-deacetylkhivorin (5), 3-deacetylkhivorin (6), 1-deacetylkhivorin (7), and 3-deacetyl-7-oxokhivorin (8). All the compounds were evaluated for their cytotoxicity against five tumor cell lines.

Published
2014

2. Uncarilic Acid and Secouncarilic Acid, Two New Triterpenoids from Uucaria sessilifructus

Author

Bing Liu, De-Qiang Feng, Kai-Long Ji, You-Kai Xu, Yan Li, Mao-Juan Zhang, and Shang-Gao Liao

Subjects
Lipopolysaccharides, Stereochemistry, Uncaria sessilifructus, Pharmaceutical Science, Nitric Oxide, Article, Analytical Chemistry, Nitric oxide, Cell Line, lcsh:QD241-441, chemistry.chemical_compound, Structure-Activity Relationship, Triterpenoid, lcsh:Organic chemistry, Drug Discovery, Organic chemistry, Humans, Secosteroids, Physical and Theoretical Chemistry, Oleanolic Acid, Inflammation, Molecular Structure, Chemistry, uncarilic acid, Macrophages, Organic Chemistry, secouncarilic acid, triterpenoids, Triterpenes, Uncaria, Chemistry (miscellaneous), Molecular Medicine, Derivative (chemistry)
Abstract

Two new compounds, the 6-oxo oleanane-type triterpenoid uncarilic acid, and its 5,6-secotriterpenoid derivative, secouncarilic acid, were isolated from the hooks and stems of Uucaria sessilifructus together with seven known ursane-type triterpenoids. Uncarilic acid is the second 6-oxo oleanane-type triterpenoid ever reported, while secouncarilic acid is the first oleanane-type 5,6-secotriterpenoid. A plausible biosynthetic pathway from uncarilic acid to secouncarilic acid was also postulated. The inhibitory activities of all the nine compounds against LPS-induced nitric oxide production in RAW264.7 macrophages were evaluated.

Published
2013

3. Limonoids from the Fruits of Khaya ivorensis.

Author

Kai-Long Ji, Shang-Gao Liao, Xiao-Ling Zheng, Zhi Na, Hua-Bin Hu, Ping Zhang, and You-Kai Xu

Subjects
LIMONOIDS, FRUIT, TUMORS, CANCER cells, CHEMICALS
Abstract

Two new limonoids, namely 14,15-didehydroruageanin A (1) and 3-O-methylbutyrylseneganolide A (2), were isolated from the fruits of Khaya ivorensis along with six known limonoids: seneganolide A (3), 1,3-dideacetylkhivorin (4), 7-deacetylkhivorin (5), 3-deacetylkhivorin (6), 1-deacetylkhivorin (7), and 3-deacetyl-7-oxokhivorin (8). All the compounds were evaluated for their cytotoxicity against five tumor cell lines. [ABSTRACT FROM AUTHOR]

Published
2014
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4. Uncarilic Acid and Secouncarilic Acid, Two New Triterpenoids from Uucaria sessilifructus.

Author

Mao-Juan Zhang, Bing Liu, Shang-Gao Liao, You-Kai Xu, De-Qiang Feng, Kai-Long Ji, and Yan Li

Subjects
TRITERPENOIDS, BIOSYNTHESIS, INHIBITORY postsynaptic potential, NITRIC oxide synthesis, MACROPHAGE activation
Abstract

Two new compounds, the 6-oxo oleanane-type triterpenoid uncarilic acid, and its 5,6-secotriterpenoid derivative, secouncarilic acid, were isolated from the hooks and stems of Uucaria sessilifructus together with seven known ursane-type triterpenoids. Uncarilic acid is the second 6-oxo oleanane-type triterpenoid ever reported, while secouncarilic acid is the first oleanane-type 5,6-secotriterpenoid. A plausible biosynthetic pathway from uncarilic acid to secouncarilic acid was also postulated. The inhibitory activities of all the nine compounds against LPS-induced nitric oxide production in RAW264.7 macrophages were evaluated. [ABSTRACT FROM AUTHOR]

Published
2013
Full Text
View/download PDF

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