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The aims of this research were to evaluate the current nutritional status, dietary intake, and level of physical activity and assess the need for intervention. This was a cross-sectional study with 2724 participating children aged 6–9 years old. Nutritional status was assessed using nutrimetry, dietary intake with a 3-day food-recall questionnaire and physical activity with an ad hoc questionnaire. The nutricode with the highest prevalence was healthy weight/normal stature, with 51.3% of the sample. For the BMI for age Z-score, those in the overweight/obesity category represented 37.5% of the sample, while the thinness category included 7.6%. Intake of calories, proteins, sugar, lipids, SFA, MUFA, and cholesterol were significantly higher than recommended. The thinness groups consumed a significantly higher amount of excess calories while the overweight/obesity groups had the lowest mean excess calorie intake. Children in the thinness category presented the highest rates at both ends of the spectrum for sedentary activities. This study showed the high prevalence of malnutrition in schoolchildren. The results for the risk of thinness and overweight/obesity according to individual nutrient intake should be carefully interpreted. Lifestyle is a fundamental aspect to consider when combating malnutrition, especially at the level of dietary and physical activity habits, to combine various methods of intervention to improve nutritional status. [ABSTRACT FROM AUTHOR]

The most promising treatment options for severe uncontrolled asthma (SUA) have emerged in recent years with the development of monoclonal antibodies for blocking selective targets responsible for the underlying inflammation, such as mepolizumab and benralizumab. However, there is variability in treatment response that is not fully controlled. The variability of the response to mepolizumab and benralizumab could be influenced by single-nucleotide polymorphisms (SNPs), and it would be useful to detect these and use them as predictive biomarkers of response. We conducted a retrospective observational cohort study of 72 Caucasian patients recruited from a tertiary hospital with severe uncontrolled eosinophilic asthma treated with mepolizumab and benralizumab. Polymorphisms in the IL5 (rs4143832, rs17690122), RAD50 (rs11739623, rs4705959), IL1RL1 (rs1420101, rs17026974, rs1921622), GATA2 (rs4857855), IKZF2 (rs12619285), FCGR2A (rs1801274), FCGR2B (rs3219018, rs1050501), FCGR3A (rs10127939, rs396991), FCER1A (rs2251746, rs2427837), FCER1B (rs1441586, rs573790, rs569108), and ZNF415 (rs1054485) genes were analyzed by real-time polymerase chain reaction (PCR) using Taqman probes. The response was analyzed after 12 months of treatment. In patients under mepolizumab treatment, a treatment response defined as a reduction in exacerbations was associated with ZNF415 rs1054485-T (p = 0.042; OR = 5.33; 95% CI = 1.06–30.02), treatment response defined as a reduction in oral corticosteroids use was associated with the number of exacerbations in the previous year (p = 0.029; OR = 3.89; 95% CI = 1.24–14.92), and treatment response defined as improvement in lung function was associated with the age at the beginning of biological therapy (p = 0.002; OR = 1.10; 95% CI = 1.04–1.18), FCER1B rs569108-AA (p < 0.001; OR = 171.06; 95% CI = 12.94–6264.11), and FCER1A rs2427837-A (p = 0.021; OR = 8.61; 95% CI = 1.71–76.62). On the other hand, in patients under benralizumab treatment, treatment response, defined as a reduction in exacerbations, was associated with ZNF415 rs1054485-T (p = 0.073; OR = 1.3 × 108; 95% CI = 1.8 × 10−19–NA), FCER1B rs569108-AA (p = 0.050; OR = 11.51; 95% CI = 1.19–269.78), allergies (p = 0.045; OR = 4.02; 95% CI = 1.05–16.74), and sex (p = 0.028; OR = 4.78; 95% CI = 1.22–20.63); and treatment response defined as improvement in lung function was associated with polyposis (p = 0.027; OR = 9.16; 95% CI = 1.58–91.4), IKZF2 rs12619285-AA (p = 0.019; OR = 9.1; 95% CI = 1.7–75.78), IL5 rs4143832-T (p = 0.017; OR = 11.1; 95% CI = 1.9–112.17), and FCER1B rs1441586-C (p = 0.045; OR = 7.81; 95% CI = 1.16–73.45). The results of this study show the potential influence of the studied polymorphisms on the response to mepolizumab and benralizumab and the clinical benefit that could be obtained by defining predictive biomarkers of treatment response. [ABSTRACT FROM AUTHOR]

Pseudomonas aeruginosa (P. aeruginosa) poses a significant threat as a nosocomial pathogen due to its robust resistance mechanisms and virulence factors. This study integrates subtractive proteomics and ensemble docking to identify and characterize essential proteins in P. aeruginosa, aiming to discover therapeutic targets and repurpose commercial existing drugs. Using subtractive proteomics, we refined the dataset to discard redundant proteins and minimize potential cross-interactions with human proteins and the microbiome proteins. We identified 12 key proteins, including a histidine kinase and members of the RND efflux pump family, known for their roles in antibiotic resistance, virulence, and antigenicity. Predictive modeling of the three-dimensional structures of these RND proteins and subsequent molecular ensemble-docking simulations led to the identification of MK-3207, R-428, and Suramin as promising inhibitor candidates. These compounds demonstrated high binding affinities and effective inhibition across multiple metrics. Further refinement using non-covalent interaction index methods provided deeper insights into the electronic effects in protein–ligand interactions, with Suramin exhibiting superior binding energies, suggesting its broad-spectrum inhibitory potential. Our findings confirm the critical role of RND efflux pumps in antibiotic resistance and suggest that MK-3207, R-428, and Suramin could be effectively repurposed to target these proteins. This approach highlights the potential of drug repurposing as a viable strategy to combat P. aeruginosa infections. [ABSTRACT FROM AUTHOR]

Investigating the contribution of mindfulness training to psychological well-being and quality of life in the university setting is of interest. The objective of the study is to present a comparative analysis of the scores in the variables of self-efficacy, resilience, coping strategies, and communication skills before and after the application of an intervention program based on mindfulness. An ex post facto cross-sectional design and a convenience sample of participants were adopted. The participants were students belonging to Education Sciences who benefited from the activities of the program. Instruments were administered to assess mindfulness, self-efficacy, resilience, coping strategies, and communication skills. The correlations of the mindfulness variable with the other psychoeducational variables evaluated were also analyzed. The results indicate an increase in the scores in the selected variables of mindfulness, resilience, communication skills, and some of the coping strategies considered productive or functional such as problem solving, self-criticism, emotional expression, desiderative thinking, social support, and cognitive restructuring. Statistically significant correlations were also observed between the variable mindfulness and those of perceived self-efficacy, resilience, coping strategies, and communication skills. The development of mindfulness training programs in the university setting is necessary to contribute to the improvement of more adaptive coping skills and the promotion of resilience. [ABSTRACT FROM AUTHOR]

Electropolishing is a common treatment in the industry; however, how it behaves in the mouth and what benefits it can bring over metal dental attachments have not yet been established. Thus, the aim of this study was to determine the levels of corrosion, the released metal ions, and the changes in structural composition in metallic orthodontic appliances following electropolishing treatment. This study included 56 orthodontic brackets and 28 archwires. The samples were subjected to a pH cycle to simulate an oral environment. Using UV–Vis spectrophotometry, the release of metallic particles was evaluated, and using scanning electron microscopy, the structural and composition changes were evaluated. Groups were compared using Student's t-tests with a value of p ≤ 0.05. The cyclical pH solutions showed variations between groups and days (1, 3, 5, 7 and 15), reaching the highest acidification in the self-ligating brackets; the absorbance between solutions did not differ significantly. As seen from the SEM results, the experimental group showed minor irregularities compared with the control groups. The experimental brackets decreased in iron and increased in chromium after electropolishing, while for the NiTi archwires, they decreased in nickel. Therefore, electropolishing treatments in metallic orthodontic attachments improve their surface structure and corrosion resistance could reduce the risk of metal hypersensitivity, mainly from nickel. [ABSTRACT FROM AUTHOR]

Background: The integration of Artificial Intelligence (AI) into various aspects of daily life has sparked growing interest in understanding public attitudes toward this technology. Despite advancements in tools to assess these perceptions, there remains a need for culturally adapted instruments, particularly in specific contexts like that of Peruvian nurses. Objective: To evaluate the psychometric properties of the AIAS-4 in a sample of Peruvian nurses. Methods: An instrumental design was employed, recruiting 200 Peruvian nurses. The Attitude toward Artificial Intelligence in Spanish (AIAS-S), a cultural and linguistic adaptation of the AIAS-4, involved data analysis using descriptive statistics, confirmatory factor analysis (CFA), and invariance tests. Results: The Confirmatory Factor Analysis (CFA) confirmed a unidimensional factor structure with an excellent model fit (χ2 = 0.410, df = 1, p = 0.522, CFI = 1.00, TLI = 1.00, RMSEA = 0.00, SRMR = 0.00). The scale demonstrated high internal consistency (α = 0.94, ω = 0.91). Tests of invariance from configural to strict confirmed that the scale is stable across different demographic subgroups. Conclusions: The AIAS-S proved to be a psychometrically solid tool for assessing attitudes toward AI in the context of Peruvian nurses, providing evidence of validity, reliability, and gender invariance. This study highlights the importance of having culturally adapted instruments to explore attitudes toward emerging technologies in specific groups. [ABSTRACT FROM AUTHOR]

The article discusses a special issue on the sustainable development of food waste biorefineries. The issue includes research papers covering various aspects of biorefinery processes, such as fermentation, sustainability assessment, and the production of valuable bioproducts from food waste. The papers highlight the benefits of biorefineries in reducing food waste, conserving natural resources, and promoting sustainable behaviors. However, there are challenges in terms of technological development, biomass supply, and economic competitiveness. The authors express their appreciation to the contributing authors for their valuable work and identify research gaps in the field. [Extracted from the article]

To update the record of mosquito diversity in the state of Morelos, Mexico, mosquito collections were conducted in both physiographical regions of Morelos: the Neo-volcanic Axis and the South Mountain Range. Immature stages were collected from aquatic habitats, while adult mosquitoes were collected using CDC light traps, Shannon traps and approaching/landing on the collecting personnel. All specimens were identified using taxonomic keys and the mitochondrial cytochrome C oxidase subunit 1 (COI). Following Mexico State, this is the second study of mosquito taxonomy of a complete Mexican state using COI barcoding. In Morelos, a total of 58 species of mosquito occurs, of which we report 12 for first time (Aedes vexans, Ae. euplocamus, Ae. vargasi, Psorophora cilipes, Ps. lineata, Culex restrictor, Cx. interrogator, Cx. nigripalpus, Cx. tarsalis, Cx. sandrae, Cx. lactator and Toxorhynchites moctezuma). Morelos now ranks sixth in mosquito diversity among Mexican states. Phylogenetic trees were constructed for 32 species, including Ae. shannoni, which is a new record for GenBank databases. Additionally, we report COI barcode sequences of Culiseta dugesi Dyar and Knab, which is resurrected from the synonymy of Cs. particeps (Adams). Fourth-instar larvae and adult females of Cs. dugesi were redescribed. This brings the number of mosquito species in Mexico to 248. Ecological and distributional notes for the new records, the medical importance of mosquito species in Morelos, and an identification key for larvae and females of the known Culiseta species occurring in Mexico are also included. [ABSTRACT FROM AUTHOR]

Water effluent pollution in the Ecuadorian Amazon occurs mainly due to the lack of sewage infrastructure, wastewater treatment plants in urban and rural areas, and agricultural and livestock activities. Consequently, understanding water quality is crucial because of its dynamic nature, influenced by various activities along its course. We evaluated and compared the water quality status of the El Salvador River with the current standards of the Ministry of the Environment, Water, and Ecological Transition in Ecuador and with Decree No. 115/2003 on water quality and water pollution management. The water quality index was determined through random sampling at seven locations along the river. The results show good water quality, with contamination indices ranging from 84 to 87. When comparing the results with the standards, all water quality parameters met the standards for recreational purposes. However, considering the river's uses for agricultural activities, we compared the water with additional standards from legislation outlined by the Environment Ministry and found that the nitrate content exceeded permissible limits due to runoff from the surrounding crops, causing a potential risk to human health. Therefore, incorporating helophyte plants is a promising option that would promote the health of this aquatic ecosystem and others. [ABSTRACT FROM AUTHOR]

Background: Medical education represents a complex field of study, influenced by various psychological, demographic, and contextual factors. Academic motivation, essential for educational success, has been linked to critical decisions in medical careers and can be modulated by contextual elements such as socioeconomic and geographical environments. The theory of self-determination has provided a solid framework for understanding the multidimensional nature of motivation. Objective: To evaluate the psychometric properties of a Spanish version of the Short Scale of Academic Motivation among Peruvian medical students. Methods: Using an instrumental design, the factorial structure, reliability, and gender invariance of the SAMS-S were assessed. A confirmatory factor analysis (CFA) was conducted to validate the scale's structure based on seven dimensions. Additionally, reliability was assessed through Cronbach's alpha coefficient and omega coefficient, and gender invariance was determined through multi-group confirmatory factor analysis. Results: The Peruvian version of the SAMS-S showed a good fit in the CFA with satisfactory goodness-of-fit indices. However, challenges in discriminant validity among certain dimensions were detected, suggesting the presence of a second-order factor. The proposed second-order model yielded an adequate fit (χ2 = 198.26, df = 70, CFI = 0.92, TLI = 0.90, RMSEA = 0.08 [90% CI: 0.07–0.1], SRMR = 0.07), validating the factorial structure of the SAMS-S. The scale's reliability and its subscales were within acceptable ranges. Furthermore, the gender invariance of the SAMS-S was confirmed at all levels, from configural to strict. Conclusions: The second-order model of the SAMS-S presents as a valid and reliable tool for measuring academic motivation among medical students in Peru. Its robustness and adaptability make it relevant for future research in similar educational contexts and can serve as a basis for interventions aimed at improving academic motivation in this specific group. [ABSTRACT FROM AUTHOR]

This work explores efficiency improvements in the copper flotation stage, a complex nonlinear, multivariable process subject to numerous perturbations. The primary objective is to design a fractional-order PID (FOPID) control strategy and a fractional-order model reference adaptive control (FOMRAC) system. The parameters for these controllers are optimized using the particle swarm optimization (PSO) algorithm with an objective function tailored to the control goals. This study employs models of both a bank series of five flotation cells and a flotation column. Their performance results are compared against traditional controllers, such as an integer-order PID and MRAC. The findings reveal that fractional-order controllers offer notable advantages over their integer-order counterparts, showing improved performance metrics with minimal changes to the existing control framework. This research highlights the effectiveness of fractional control in enhancing flotation processes and introduces a novel application of fractional control techniques in this area. [ABSTRACT FROM AUTHOR]

This work aims to provide the hardware (HW) design of the optoelectronics interfaces for a visible-light communication (VLC) system that can be employed for several use cases. Potential applications include the transmission of ultra-high-definition (UHD) streaming video through existing reading lamps installed in passenger vans. In this use case, visible light is employed for the downlink, while infrared light is used for the uplink channel, acting as a remote controller. Two primary components -a Light Fidelity (LiFi) router and a USB dongle—were designed and implemented. The 'LiFi Router', handling the downlink channel, comprises components such as a visible Light-Emitting Diode (LED) and an infrared receiver. Operating at a supply voltage of 12 V and consuming current at 920 mA, it is compatible with standard voltage buses found in transport vehicles. The 'USB dongle', responsible for the uplink, incorporates an infrared LED and a receiver optimized for visible light. The USB dongle works at a supply voltage of 5 V and shows a current consumption of 1.12 A, making it well suited for direct connection to a universal serial bus (USB) port. The bandwidth achieved for the downlink is 11.66 MHz, while the uplink's bandwidth is 12.27 MHz. A system competent at streaming UHD video with the feature of being single-input multiple-output (SIMO) was successfully implemented via the custom hardware design of the optical transceivers and optoelectronics interfaces. To ensure the system's correct performance at a distance of 110 cm, the minimum signal-to-noise ratio (SNRmin) for both optical links was maintained at 10.74 dB. We conducted a proof-of-concept test of the VLC system in a passenger van and verified its optimal operation, effectively illustrating its performance in a real operating environment. Exemplifying potential implementations possible with the hardware system designed in this work, a bit rate of 15.2 Mbps was reached with On–Off Keying (OOK), and 11.25 Mbps was obtained with Quadrature Phase Shift Keying (QPSK) using Orthogonal Frequency-Division Multiplexing (OFDM) obtaining a bit-error rate (BER) of 3.3259 × 10−5 in a passenger van at a distance of 72.5 cm between the LiFi router and the USB dongle. As a final addition, a solar panel was installed on the passenger van's roof to power the user's laptop and the USB dongle via a power bank battery. It took 13.4 h to charge the battery, yielding a battery life of 22.3 h. This characteristic renders the user's side of the system entirely self-powered. [ABSTRACT FROM AUTHOR]

Type 2 diabetes mellitus (T2DM) is a complex chronic disease characterized by decreased insulin secretion and the development of insulin resistance. Previous genome-wide association studies demonstrated that single-nucleotide polymorphisms (SNPs) present in genes coding for ion channels involved in insulin secretion increase the risk of developing this disease. We determined the association of 16 SNPs found in CACNA1D, KCNQ1, KCNJ11, and CACNA1E genes and the increased probability of developing T2DM. In this work, we performed a case-control study in 301 Mexican adults, including 201 cases with diabetes and 100 controls without diabetes. Our findings indicate a moderate association between T2DM and the C allele, and the C/C genotype of rs312480 within CACNA1D. The CAG haplotype surprisingly showed a protective effect, whereas the CAC and CGG haplotypes have a strong association with T2DM. The C allele and C/C genotype of rs5219 were significantly associated with diabetes. Also, an association was observed between diabetes and the A allele and the A/A genotype of rs3753737 and rs175338 in CACNA1E. The TGG and CGA haplotypes were also found to be significantly associated. The findings of this study indicate that the SNPs examined could serve as a potential diagnostic tool and contribute to the susceptibility of the Mexican population to this disease. [ABSTRACT FROM AUTHOR]

We assessed the impact of environmental conditions and agronomic traits on maize grain quality parameters. The study was conducted using genotypes with distinct genetic constitutions developed specifically for late sowing in semi-arid environments. We evaluated the agronomic, physical, and chemical characteristics of eight maize open-pollinated varieties, six inbred lines, and three commercial hybrids. The yield of the open-pollinated varieties showed a positive correlation with protein content (r = 0.33), while it exhibited a negative correlation with the carbohydrate percentage (r = −0.36 and −0.42) in conjunction with the inbred lines. The flotation index of the hybrids was influenced primarily by the environmental effect (50.15%), whereas in the inbred lines it was nearly evenly divided between the genotype effect (45.51%) and the environmental effect (43.15%). In the open-pollinated varieties, the genotype effect accounted for 35.09% and the environmental effect for 42.35%. The characteristics of plant structure were associated with grain quality attributes relevant for milling, including hardness and test weight. Inbred lines exhibited significant genotype contributions to grain hardness, protein, and carbohydrate content, distinguishing them from the other two germplasm types. These associations are crucial for specific genotypes and for advancing research and development of cultivars for the food industry. [ABSTRACT FROM AUTHOR]

Storing ground beef at frozen temperatures prior to refrigerated display when using thermoforming vacuum packaging is not a common manufacturing practice. However, limited data on thermoforming packaging film and its interaction with meat quality suggests that more information is needed. The current study aimed to identify the influences of thermoforming packaging on the surface color and lipid oxidation of ground beef. Ground beef was portioned into 454 g bricks and packaged into one of three thermoforming films: T1 (150 µ polyethylene/EVOH/polyethylene coextrusion), T2 (175 µ polyethylene /EVOH/polyethylene coextrusion), and T3 (200 µ polyethylene/EVOH/polyethylene coextrusion), stored for 21 days at −20.83 °C (±1.50 °C), and displayed for 42 days at 3.0 °C ± 1.5 °C. There were no statistical differences for the packaging treatment of lipid oxidation (p = 0.0744), but oxidation increased throughout storage day (p < 0.0001). The main effects of treatment and day resulted in altered (p < 0.05) surface lightness (L*), redness (a*), yellowness, hue angle (°), red-to-brown (RTB), and relative myoglobin for met-myoglobin (MET), deoxymyoglobin (DMB), and oxymyoglobin (OMB). Surprisingly, there was an interaction between treatment and day for the calculated relative values of chroma (p = 0.0321), Delta E (p = 0.0155), and the ratio of a*:b* (p < 0.0001). These results indicate that thermoforming vacuum packaging can reduce the rate of deterioration that occurs to ground beef color and the rate of oxidation. [ABSTRACT FROM AUTHOR]

The storage duration of fresh meat products is a contributing factor leading to increased waste and loss at the retail counter. Losses of fresh pork can be linked to packaging methods that do not protect the attributes of color, taste, and odors consumers use in determining wholesome meat. Boneless pork loins (N = 63) were fabricated into 2.54-cm-thick chops and assigned to one of three vacuum treatments (VacA, VacB, VacC) or a fourth polyvinyl chloride overwrap (PVC) treatment to assess objective fresh color, cook loss, Warner–Bratzler shear force (WBSF), and lipid oxidation. Pork chops (n = 882) were evaluated at 5-day intervals (D 0, 5, 10, 15) in a randomized complete block design. Pork chop surface color was lighter (L*; p < 0.0001) when stored in a vacuum compared to PVC-packaged loin chops, regardless of storage duration. Redness (a*) values were greater (p < 0.0001) for loin chops stored in PVC than all other vacuum packaging treatments throughout the entire 15-day display period. Relative values for chroma on PVC-packaged loin chops were greater (p < 0.0001) throughout the simulated retail display period. An interaction of day and packaging treatment (p < 0.0343) occurred for WBSF. Lipid oxidation for pork chops packaged using PVC was significantly greater (p < 0.0001) from Day 10 through the completion of the storage period. Results indicate that vacuum packaging limits the deterioration of fresh pork loin chops, whereas traditional overwrapping expedites the color and lipid oxidation during refrigerated storage. [ABSTRACT FROM AUTHOR]

Simple Summary: Crocodiles are one of nature's most successful predators. Their prey varies according to their size. Adults are known to consume different types of vertebrates; juveniles have a similar diet, although their prey is smaller. However, hatchlings have a diet based mainly on insects. This study aimed to know the diet of hatchling Morelet's crocodiles (Crocodylus moreletii) at a growth stage corresponding to their transition to the juvenile stage. Therefore, it is important to know which vertebrate prey are beginning to appear during this developmental change in crocodiles. To find out, we captured and washed the stomachs of 31 hatchling crocodiles in the Laguna de las Ilusiones in Tabasco, Mexico. Our results showed that crocodiles have a generalist diet, with prey ranging from invertebrates (mainly coleoptera and hemipterans) to some vertebrates (mostly fish and birds). It is important to know these changes in the diet of crocodilians as they develop to help us better interpret their natural history and propose better strategies for their study. The relationship between diet and behavior is essential to understanding an animal's strategies to obtain food, considering ontogenical changes. In reptiles, there is a relationship between the length of the individual and the size of the prey it consumes. Studies have focused on the ontogenetic changes in reptile diets from hatchling to adult, but only a few studies have focused on the transition from hatchling to juvenile. We aimed to describe and analyze the composition, variation, diversity, and overlap in the diet of hatchling Morelet's crocodiles (Crocodylus moreletii) for three size intervals during the hatchling–juvenile transition. We captured 31 hatchling Morelet's crocodiles in an urbanized lagoon in Tabasco. We performed stomach-flushing to determine the diet. Additionally, we estimated the volume, frequency of occurrence, and relative importance of diet items and analyzed the relationship between prey type and the total length of the individuals. The diversity of the hatchling prey suggests a generalist diet. We observed two items not previously described in the diet of hatchling crocodiles. In addition, we found differences in diet between the initial and final size intervals, as increases in the length of prey appeared that they did not consume when they were hatchlings. Our results contribute new information to the dietary changes that occur during the hatchling–juvenile transition. [ABSTRACT FROM AUTHOR]

Simple Summary: In male rats, the major pelvic ganglion is the principal component of the pelvic plexus and plays a crucial role in regulating various physiological functions such as urination, defecation, erection, ejaculation, and glandular secretion. This ganglion is considered mixed, as it receives both sympathetic and parasympathetic innervation through the hypogastric and pelvic nerves, respectively. Homologous structures with similar functions are present in other species, including cats, dogs, and pigs; however, differences exist in nomenclature, anatomical complexity, and functionality. Although anatomical, histological, and immunohistochemical studies have been conducted on these structures across various species, the major pelvic ganglion of the rat has been the most extensively studied due to its ease of identification and manipulation. This review provides a comprehensive analysis of the pelvic plexus and its regulation across various mammalian species, including rats, cats, dogs, and pigs. The pelvic and hypogastric nerves play crucial roles in regulating pelvic functions such as micturition, defecation, and erection. The anatomical organization of these nerves varies, forming either well-defined ganglia or complex plexuses. Despite these variations, the neurons within these structures are consistently regulated by key neurotransmitters, norepinephrine and acetylcholine. These neurons also possess receptors for testosterone and prolactin, particularly in rats, indicating the significant role of these hormones in neuronal function and development. Moreover, neuropeptides such as vasoactive intestinal peptide (VIP), substance P, neuropeptide Y (NPY), somatostatin (SOM), galanin (GAL), and calcitonin gene-related peptide (CGRP) are co-released with neurotransmitters to modulate pelvic functions. This review highlights the complex interplay between neurotransmitters, neuropeptides, and hormones in regulating pelvic physiology and emphasizes the importance of hormonal regulation in maintaining the functionality and health of the pelvic plexus across different species. [ABSTRACT FROM AUTHOR]

This experimental study explores the mitigation of membrane fouling in membrane bioreactors (MBRs) through the combined use of granular activated carbon (GAC) and powdered activated carbon (PAC). The research assesses the impact of these materials on the fouling resistance, critical flux, and permeate quality using various mixed liquor suspended solids concentrations and carbon dosages. The results indicate that the GAC-PAC combination significantly reduces the total filtration resistance, particularly the cake layer resistance, by 11.7% to 13.6% compared to setups without activated carbon or with the individual carbon types. The study also reveals that this combination decreased the fouling rate by 15% to 24% at critical flux steps, demonstrating substantial improvements in fouling mitigation and operational efficiency. Furthermore, the GAC-PAC combination, which produces an adsorption process, enhances the permeate quality, achieving the near-complete removal of organic matter, total nitrogen, and turbidity, with total phosphorus removal reaching 99%. These findings demonstrate that the combined use of GAC and PAC not only reduces membrane fouling but also improves the overall MBR performance, making it a viable strategy for enhancing the efficiency of wastewater treatment processes. [ABSTRACT FROM AUTHOR]

Introduction/Aim: Vitamin D plays a crucial role in immune modulation, which may influence the development of graft-versus-host disease (GvHD) in patients undergoing hematopoietic stem cell transplantation (HSCT). This study aims to evaluate the impact of vitamin D levels and supplementation on the incidence of GvHD in HSCT patients. Methods: A narrative review was conducted across PubMed/Medline, Cochrane Library, CINAHL, and Embase databases. Results: The reviewed studies indicated widespread vitamin D deficiency among HSCT patients, with baseline levels ranging from 12.8 to 29.2 ng/mL. Supplementation protocols varied significantly, with dosages ranging from 1000 IU/day to 60,000 IU/week. Post-supplementation levels improved in some studies. Studies exploring the relationship between vitamin D and GvHD showed mixed results. Lower baseline vitamin D levels were associated with an increased risk of acute GvHD in some studies, while others found no significant correlation. However, a significant association between low levels of vitamin D and the incidence of chronic GvHD was observed. Conclusion: Vitamin D deficiency is prevalent in HSCT patients and may influence the risk of developing chronic GvHD. Future research should focus on larger and more rigorous studies to determine the optimal role of vitamin D as an adjuvant therapy in the context of HSCT. [ABSTRACT FROM AUTHOR]

Background: Current treatment for chronic kidney disease (CKD) focuses on improving manifestations and delaying progression. Nutritional approaches play a crucial role in CKD management, and various supplements have become available. Ketoanalogues of amino acids (KAs), calcium citrate, and inulin have been proposed as suitable supplements, yet their widespread use has been limited due to insufficient evidence. This study aimed to generate general guidance statements on the appropriateness of these supplements through a RAND/UCLA consensus process. Methods: A RAND/UCLA consensus panel was convened to evaluate the appropriateness of these supplements in different clinical scenarios. In this study, we present a subgroup analysis focusing on a panel of eleven clinical nephrologists from among the experts. Results: Supplementation of low-protein diets (LPDs) and very low-protein diets (VLPDs) with KA was considered appropriate to reduce manifestations and delay CKD outcomes, supplementation with calcium citrate is considered appropriate to reduce CKD manifestations, and supplementation with inulin is considered appropriate to delay CKD outcomes and manage comorbidities. Conclusions: Based on a combination of clinical experience and scientific evidence, the panel reached a consensus that KA supplementation of LPD and VLPD, calcium citrate, and inulin are appropriate in patients with CKD across various scenarios. [ABSTRACT FROM AUTHOR]

Migraine-related stigma is a pervasive issue impacting nearly half of chronic migraine patients, with significant consequences for their quality of life, disability and mental health. Despite its profound effects, migraine stigma remains under-recognised in both clinical practice and research. This narrative review explores the three primary types of stigmas affecting migraine patients: public, structural and internalised. Public stigma involves negative societal attitudes and stereotypes that trivialise the condition. Structural stigma is reflected in policies that restrict access to necessary care and resources. Internalised stigma occurs when patients absorb these negative views, leading to self-blame and diminished self-worth. Addressing these different types of stigmas is crucial for improving the understanding, diagnosis and treatment of migraine. Educational efforts, advocacy and policy reform are essential strategies in this context. A deep understanding of stigma is vital for developing effective interventions that enhance clinical management and patient quality of life. Ultimately, reducing stigma can lead to better health outcomes and a more comprehensive approach to migraine care. [ABSTRACT FROM AUTHOR]

The implementation of Industry 4.0 has integrated manufacturing, electronics, and engineering materials, leading to the creation of smart parts (SPs) that provide information on production system conditions. However, SP development faces challenges due to limitations in manufacturing processes and integrating electronic components. This systematic review synthesizes scientific articles on SP fabrication using additive manufacturing (AM), identifying the advantages and disadvantages of AM techniques in SP production and distinguishing between SPs and smart spare parts (SSPs). The methodology involves establishing a reference framework, formulating SP-related questions, and applying inclusion criteria and keywords, initially resulting in 1603 articles. After applying exclusion criteria, 70 articles remained. The results show that while SP development is advancing, widespread application of AM-manufactured SP is recent. SPs can anticipate production system failures, minimize design artifacts, and reduce manufacturing costs. Furthermore, the review highlights that SSPs, a subcategory of SPs, primarily differs by replacing conventional critical parts in the industry, offering enhanced functionality and reliability in industrial applications. The study concludes that continued research and development in this field is essential for further advancements and broader adoption of these technologies. [ABSTRACT FROM AUTHOR]

In the present work, short glass fiber is superficially modified with different concentrations of polyhedral oligomeric silsesquioxanes (Trisilanol–Isobutyl, TSI-POSS) for processing as a filler in a polypropylene matrix (PP). It is observed that increasing the amount of TSI-POSS increases the fracture point and tensile strength; the opposite is the case for the strength impact property. The behaviors of both dynamic mechanical and thermal analyses are also observed. The flame behavior, i.e., the burning rate, decreases with increasing TSI-POSS in the polymers. [ABSTRACT FROM AUTHOR]

Zinc (Zn) is an essential trace element; it exhibits a plethora of physiological properties and biochemical functions. It plays a pivotal role in regulating the cell cycle, apoptosis, and DNA organization, as well as in protein, lipid, and carbohydrate metabolism. Among other important processes, Zn plays an essential role in reproductive health. The ZIP and ZnT proteins are responsible for the mobilization of Zn within the cell. Zn is an inert antioxidant through its interaction with a variety of proteins and enzymes to regulate the redox system, including metallothioneins (MTs), metalloenzymes, and gene regulatory proteins. The role of Zn in the reproductive system is of great importance; processes, such as spermatogenesis and sperm maturation that occur in the testicle and epididymis, respectively, depend on this element for their development and function. Zn modulates the synthesis of androgens, such as testosterone, for these reproductive processes, so Zn deficiency is related to alterations in sperm parameters that lead to male infertility. [ABSTRACT FROM AUTHOR]

Cancer is the leading cause of disease-related death among children. Vincristine (VCR), a key component of childhood cancer treatment protocols, is associated with the risk of peripheral neuropathy (PN), a condition that may be reversible upon drug discontinuation but can also leave lasting sequelae. Single nucleotide polymorphism (SNP) in genes involved in VCR pharmacokinetics and pharmacodynamics have been investigated in relation to an increased risk of PN. However, the results of these studies have been inconsistent. A retrospective cohort study was conducted to investigate the potential association of drug transporter genes from the ATP-binding cassette (ABC) family and the centrosomal protein 72 (CEP72) gene with the development of PN in 88 Caucasian children diagnosed with cancer and treated with VCR. Genotyping was performed using real-time PCR techniques for the following SNPs: ABCB1 rs1128503, ABCC1 rs246240, ABCC2 rs717620, and CEP72 rs924607. The results indicated that age at diagnosis (OR = 1.33; 95% CI = 1.07–1.75) and the ABCC1 rs246240 G allele (OR = 12.48; 95% CI = 2.26–100.42) were associated with vincristine-induced peripheral neuropathy (VIPN). No association was found between this toxicity and CEP72 rs924607. Our study provides insights that may contribute to optimizing childhood cancer therapy in the future by predicting the risk of VIPN [ABSTRACT FROM AUTHOR]

Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a novel class of incretin mimetics for treating type 2 diabetes (T2D). This study evaluated the impact of semaglutide, the first oral GLP-1RA, on glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), and body composition and anthropometric parameters. Additionally, the effects on cardiovascular risk factors and quality of life (QoL) in T2D patients were assessed. Methods: A prospective observational study with a six-month follow-up was conducted. Clinical parameters, including HbA1c, FPG, anthropometric measurements, blood pressure, cardiovascular risk factors, Diabetes Treatment Satisfaction Questionnaire (DTSQ) responses, and Short Form (36) Health Survey (SF-36) responses, were collected at baseline (T0) and at six months (T1). Results: Sixty-one subjects were enrolled, with there being an average T2D duration of 4.67 ± 3.93 years. Significant decreases were observed in HbA1c (µ = −1.24; SD = 1.33; p < 0.05), FPG (µ = −31.01 mg/dL; SD = 41.71; p < 0.05), body composition and anthropometric parameters (p < 0.05), and cardiovascular risk factors (p < 0.05), with an increase in DTSQ scores (p < 0.05). Conclusions: The administration of 14 mg/day oral semaglutide improved several clinical parameters after six months of treatment. These findings suggest semaglutide is effective in improving glycemic control, weight management, and some cardiovascular risk factors in T2D patients. [ABSTRACT FROM AUTHOR]

Background/Objectives: To analyze the best noninvasive tests prognosis marker in patients with diabetic foot ulcer (DFU) who underwent endovascular revascularization based on clinical outcomes, such as healing rate, time to heal, and free amputation survival after at least a six-month follow-up. Methods: A multicentric prospective observational study was performed with 28 participants with ischemic or neuroischemic DFU who came to the participant centers and underwent endovascular revascularization between January 2022 and March 2023. Toe systolic pressure (TP), ankle systolic pressure (AP), the ankle brachial pressure index (ABPI), the toe brachial pressure index (TBPI), transcutaneous pressure of oxygen (TcPO2), and skin perfusion pressure (SPP) were evaluated using PeriFlux 6000 System, Perimed, Sweden, before (Visit 0) and four weeks after revascularization (Visit 1). The primary clinical outcome was an evaluation of the clinical evolution of noninvasive tests comparing Visit 0 and Visit 1, estimating the sensitivity for predicting wound healing of noninvasive tests at six months following initial recruitment. Results: After six months, 71.43% (n = 20) of DFU healed, four patients (14.3%) received major amputations, and one (3.5%) died. The two tests that best predicted wound healing after revascularization according to the ROC curve were TcPO2 and TP with sensitivities of 0.89 and 0.70 for the cut-off points of 24 mmHg and 46 mmHg, respectively. Conclusions: TcPO2 and TP were the two tests that best predicted wound healing in patients who underwent endovascular revascularization. Clinicians should consider the importance of the evaluation of microcirculation in the healing prognosis of patients with diabetic foot ulcers. [ABSTRACT FROM AUTHOR]

Ecuador is grappling with a severe energy crisis, marked by frequent power outages. A recent study explored solar energy efficiency in the coastal city of Manta using an IoT real-time monitoring system to compare static photovoltaic (PV) systems with two single-axis solar tracking systems: one based on astronomical programming and the other using light-dependent resistor (LDR) sensors. Results showed that both tracking systems outperformed the static PV system, with net gains of 31.8% and 37.0%, respectively. The astronomical-programming-based system had a slight edge, operating its stepper motor intermittently for two minutes per hour, while the LDR system required continuous motor energization. The single-axis tracker using astronomical programming demonstrated notable advantages in energy efficiency and complexity, making it suitable for equatorial regions like Manta. The study also suggested potential further gains by adjusting solar positioning at shorter intervals, such as every 15 or 30 min. These findings enhance our understanding of solar tracking performance in equatorial environments, offering valuable insights for optimizing solar energy systems in regions with high solar radiation. By emphasizing customized solar tracking mechanisms, this research presents promising solutions to Ecuador's energy crisis and advances sustainable energy practices. [ABSTRACT FROM AUTHOR]

Simple Summary: Advances in the treatment of acute lymphoblastic leukemia (ALL) have led to a marked improvement in the survival rate of patients. Nevertheless, these patients may develop adverse effects during and after treatment, such as bone abnormalities and vitamin D deficiency. Bone remodeling allows for bone volume and structure to be maintained, which is controlled by the receptor activator of the nuclear factor-kB (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) system-determining pathway in the balance between bone formation and resorption. Some reports have explored the role of corticosteroids in modulating the RANKL and OPG levels and RANKL/OPG ratio in pediatric patients. Nevertheless, studies evaluating the role of RANKL and OPG in the bone health of pediatric ALL patients during treatment are limited. During remission, we observed an increase in the RANKL/OPG ratio, increased RANKL levels, and decreased OPG levels in ALL patients. These changes may predispose such patients to the development of bone health disorders in their adult lives. Background: The receptor activator of the nuclear factor-kB (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) pathway is a determining pathway in the balance between bone formation and resorption, and disruptions in this complex can affect bone metabolism. Methods: This study analyzes the changes in RANKL, OPG, and 25(OH)D levels; the RANKL/OPG ratio; and other bone turnover markers (BTMs) from diagnosis to complete remission in children with acute lymphoblastic leukemia (ALL). This is a prospective observational cohort study, carried out at the Instituto Mexicano del Seguro Social, Mexico City, including 33 patients (4–17 years) with newly diagnosed B-cell ALL. The patients were treated with the HP09 chemotherapy protocol. Children who had previously been treated with corticosteroids were excluded. A peripheral blood sample at diagnosis and remission was collected to determine the 25(OH)D and BTM concentrations. Results: Increased RANKL (p = 0.001) and osteocalcin (p < 0.001) levels and RANKL/OPG ratio (<0.001) and a decreased OPG level (p = 0.005) were observed at remission, predominantly in the high-risk (HR) relapse and vitamin D deficiency groups. A negative association between RANKL and OPG (r = −0.454, p = 0.008) was observed. Conclusions: we suggest that the RANKL/OPG ratio could serve as a bone remodeling marker in ALL patients. [ABSTRACT FROM AUTHOR]