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Appropriateness of Ketoanalogues of Amino Acids, Calcium Citrate, and Inulin Supplementation for CKD Management: A RAND/UCLA Consensus.

Authors :
Saavedra-Fuentes, Nadia
Carmona-Montesinos, Enrique
Castañeda-Hernández, Gilberto
Campos, Israel
Castillo-Salinas, Juan Carlos
Castillo-Tapia, Javier Alberto
Del Castillo-Loreto, Karla Guadalupe
Falcón-Martínez, Juan Carlos
Fuentes-García, Raquel
García de León Guerrero, Miguel Ángel
García-García, Victor
Gómez-García, Erika F.
González-Toledo, Rafael
Jaime, Angélica
Rely, Kely
Lerma, Claudia
Morales-Buenrostro, Luis E.
Quilantan-Rodriguez, Mateo
Rodriguez-Matías, Adrián
Rojas-Rodriguez, Felipe Octavio
Source :
Nutrients; Sep2024, Vol. 16 Issue 17, p2930, 12p
Publication Year :
2024

Abstract

Background: Current treatment for chronic kidney disease (CKD) focuses on improving manifestations and delaying progression. Nutritional approaches play a crucial role in CKD management, and various supplements have become available. Ketoanalogues of amino acids (KAs), calcium citrate, and inulin have been proposed as suitable supplements, yet their widespread use has been limited due to insufficient evidence. This study aimed to generate general guidance statements on the appropriateness of these supplements through a RAND/UCLA consensus process. Methods: A RAND/UCLA consensus panel was convened to evaluate the appropriateness of these supplements in different clinical scenarios. In this study, we present a subgroup analysis focusing on a panel of eleven clinical nephrologists from among the experts. Results: Supplementation of low-protein diets (LPDs) and very low-protein diets (VLPDs) with KA was considered appropriate to reduce manifestations and delay CKD outcomes, supplementation with calcium citrate is considered appropriate to reduce CKD manifestations, and supplementation with inulin is considered appropriate to delay CKD outcomes and manage comorbidities. Conclusions: Based on a combination of clinical experience and scientific evidence, the panel reached a consensus that KA supplementation of LPD and VLPD, calcium citrate, and inulin are appropriate in patients with CKD across various scenarios. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20726643
Volume :
16
Issue :
17
Database :
Complementary Index
Journal :
Nutrients
Publication Type :
Academic Journal
Accession number :
179648404
Full Text :
https://doi.org/10.3390/nu16172930