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Lung cancer is the leading cause of cancer-related deaths in Europe, with low survival rates primarily due to late-stage diagnosis. Early detection can significantly improve survival rates, but lung cancer screening is not currently implemented in Italy. Many countries have implemented lung cancer screening programs for high-risk populations, with studies showing a reduction in mortality. This review aimed to identify key areas for establishing a lung cancer screening program in Italy. A literature search was conducted in October 2022, using the PubMed and Scopus databases. Items of interest included updated evidence, approaches used in other countries, enrollment and eligibility criteria, models, cost-effectiveness studies, and smoking cessation programs. A literature search yielded 61 scientific papers, highlighting the effectiveness of low-dose computed tomography (LDCT) screening in reducing mortality among high-risk populations. The National Lung Screening Trial (NLST) in the United States demonstrated a 20% reduction in lung cancer mortality with LDCT, and other trials confirmed its potential to reduce mortality by up to 39% and detect early-stage cancers. However, false-positive results and associated harm were concerns. Economic evaluations generally supported the cost-effectiveness of LDCT screening, especially when combined with smoking cessation interventions for individuals aged 55 to 75 with a significant smoking history. Implementing a screening program in Italy requires the careful consideration of optimal strategies, population selection, result management, and the integration of smoking cessation. Resource limitations and tailored interventions for subpopulations with low-risk perception and non-adherence rates should be addressed with multidisciplinary expertise. [ABSTRACT FROM AUTHOR]

During the last decade, scientists have given increasingly frequent warnings about global warming, linking it to mycotoxin-producing moulds in various geographical regions across the world. In the future, more pronounced climate change could alter host resilience and host–pathogen interaction and have a significant impact on the development of toxicogenic moulds and the production of their secondary metabolites, known as mycotoxins. The current climate attracts attention and calls for novel diagnostic tools and notions about the biological features of agricultural cultivars and toxicogenic moulds. Since European climate environments offer steadily rising opportunities for Aspergillus flavus growth, an increased risk of cereal contamination with highly toxic aflatoxins shall be witnessed in the future. On top of that, the profile (representation) of certain mycotoxigenic Fusarium species is changing ever more substantially, while the rise in frequency of Fusarium graminearum contamination, as a species which is able to produce several toxic mycotoxins, seen in northern and central Europe, is becoming a major concern. In the following paper, a high-quality approach to a preventative strategy is tailored to put a stop to the toxicogenic mould- and mycotoxin-induced contamination of foods and feeds in the foreseeable future. [ABSTRACT FROM AUTHOR]

Simple Summary: The genus Diopatra is a major driver in sedimentary systems, altering the structure of habitats and changing the frequency of refugia and predator access to prey. It is taken as prey by a variety of shorebirds, crustaceans, and fish and used worldwide as bait. Diopatra are quite charismatic, with iridescent colour patterns and a willingness to be fed by hand by entranced biologists, and their larvae can only be described as 'cute'. One might expect then that given their importance to sedimentary systems, the bait trade, etc. that we would know more than we do about their reproductive modes, physiological tolerances, etc. than we do. The recent discovery that the predominant onuphid of the very well-known Atlantic coast of Europe, D. neapolitana, is a protandric sequential hermaphrodite is startling. This special volume dedicated to Diopatra will hopefully stimulate more investigations and further insights. The annelid genus Diopatra occurs in all major oceans but is best represented in the shallow depths of warmer waters, where it lives in elaborately decorated tubes. This paper provides an introduction to the animals, discussing their history and diversity. We describe and illustrate its morphology and geographic distribution. While they were thought to be predominantly gonochoristic, recent reproductive studies show that several species are protandric simultaneous hermaphrodites. Development is by broadcast spawning with a brief pelagic stage or direct development in the parental tube or egg mass attached to it. Diopatra is a key ecosystem engineer, altering water flow and deposition and increasing the availability of refugia. We also discuss its harvesting as fishing bait, its role as an alien or introduced species, its capacity to regenerate, its therapeutic potential, and its applications as a bioindicator species for climate change, geographic distribution changes, and dispersal. [ABSTRACT FROM AUTHOR]

Digital cadastral maps with accompanying land-related attributes have become a fundamental dataset for many application fields, e.g., spatial planning and development, protecting state lands, securing of land tenure, facilitating land reforms, agriculture, forestry, land management, taxation, etc. In order to fulfil its main objectives, cadastral data needs to be available and accessible, which is, among the others, emphasized also within the United Nations Framework for Effective Land Administration (FELA). This is not only important on the national level but also beyond, including at the European level where use cases and consequently demand for pan-European data sets have evolved in recent years. In order to satisfy these needs, several initiatives regarding cadastral and other geospatial data have been launched in the last 20 years. It started with the Permanent Committee on Cadastre in the European Union, the European Land Information Service, INSPIRE, UN-GGIM Europe and recent European policies on open data and high-value datasets. Our main question is, did those initiatives result in the possibility of building a cadastral map of Europe or not? Is it possible to create a cadastral map of Europe on the desktop or an open online GIS application? Within the paper, we take the opportunity to reflect on the development and implementation of European spatial data infrastructure (INSPIRE) with the main focus on the availability and accessibility of cadastral data. We also take into consideration other European initiatives related to cadastral data. The overall findings show that there is still work to be carried out. Technological developments and recent policy initiatives will certainly be drivers for future improvement. [ABSTRACT FROM AUTHOR]

Maize is one of the most important food and feed sources at the worldwide level. Due to this importance, all the pathogens that can infect this crop can harm both food safety and security. Fungi are the most important pathogens in cultivated maize, and Fusarium spp. are one of the most important families. Reduction in yield and production of dangerous mycotoxins are the main effects of Fusarium spp. infection. Fusarium graminearum (part of the Fusarium graminearum species complex) is one the most important fungi that infect maize, and it is the causative agent of Gibberella ear rot (GER). The main characteristics of this species include its ability to infect various species and its varying infection pressures across different years. This fungus produces various harmful mycotoxins, such as deoxynivalenol, zearalenone, butanolide, and culmorin. Infection can start from silk channels or from ear wounds. In the first case, the environmental conditions are the most important factors, but in the second, a key role is played by the feeding action of lepidopteran larvae (in Europe, Ostrinia nubilalis). All these factors need to be taken into account to develop a successful management strategy, starting from cropping methods that can reduce the source of inoculum to the direct control of the fungus with fungicide, as well as insect control to reduce ear wounds. But, the most important factor that can reduce the effects of this fungus is the use of resistant hybrids. Different studies have highlighted different defensive methods developed by the plant to reduce fungal infections, like fast drying of silk and kernels, chemical compounds produced by the plant after infection, and mechanical protection from insects' wounds. The aim of this paper is to review the scientific evidence of the most important management strategies against GER in maize and to highlight the genetic basis which is behind hybrid resistance to this disease, with a focus on genes and QTLs found in studies conducted across the world and with different types of maize from tropical cultivars to European flint. [ABSTRACT FROM AUTHOR]

To meet the 2050 EU decarbonization goals, there is a need for new and innovative ideas to increase energy efficiency, which includes reducing the energy consumption of buildings and increasing the use of on-site renewable energy sources. One possible solution for achieving efficient thermal energy transition in the building sector is to assign new functionalities to the building envelope. The building envelope can function as a thermal energy storage system, which can help compensate for irregularities in solar energy availability. This can be accomplished by utilizing phase change materials as the energy storage medium in the building envelope. In this paper, two phase change materials with different melting temperatures of 21 °C and 28 °C are compared for their application in a dynamic solar building envelope. Both experimental and numerical studies were conducted within the scope of this study. The laboratory testing involved simulating the conditions of the four seasons through steady-state and dynamic experiments. The performance of the phase change materials was evaluated using a small-scale PASLINK test stand that imitates indoor and outdoor conditions. A numerical model of a small-scale building envelope was created using data from laboratory tests. The purpose of this model was to investigate how the tested phase change materials perform under different climate conditions. The experimental findings show that RT21HC is better at storing thermal energy in the PCM and releasing it into the indoor area than RT28HC. On the other hand, the numerical simulation results demonstrate that RT28HC has an advantage in terms of thermal storage capacity in climates found in Southern Europe, as it prevents overheating of the room. [ABSTRACT FROM AUTHOR]

In this paper, a comprehensive overview of the 'Candidatus Liberibacter solanacearum' presence in Europe was provided. The analyzed findings revealed that, since the first appearance of this pathogen in Finland and Spain in 2008, it has spread to 13 new European countries. Therefore, 'Ca. L. solanacearum' has spread very quickly across the European continent, as evident from the emergence of new host plants within the Apiaceae, Urticaceae, and Polygonaceae families, as well as new haplotypes of this pathogen. Thus far, 5 of the 15 'Ca. L. solanacearum' haplotypes determined across the globe have been confirmed in Europe (haplotypes C, D, E, U, and H). Fully competent 'Ca. L. solanacearum' vectors include Bactericera cockerelli, Trioza apicalis, and B. trigonica; however, only T. apicalis and B. trigonica are presently established in Europe and are very important for plants from the Apiaceae family in particular. Moreover, psyllid species such as B. tremblayi, T. urticae, and T. anthrisci have also been confirmed positive for 'Ca. L. solanacearum'. Constant monitoring of its spread in the field (in both symptomatic and asymptomatic plants), use of sensitive molecular diagnostic techniques, and application of timely management strategies are, therefore, of utmost importance for the control of this destructive pathogen. [ABSTRACT FROM AUTHOR]

This paper aims to analyze factors that influence social performance-related information disclosure in European countries. Specifically, the objective is to investigate the Board's attributes (Diversity, Inclusion, People Development and Controversies). To achieve the goal, an empirical analysis was conducted with 2494 listed companies in Europe as support for the economic year 2021. To measure a possible link between the variables under study, a regression analysis was performed. Our results show that Board Diversity, Inclusion and People Development contribute positively to social performance disclosure, whereas Board Controversies negatively affect the dependent variable. Furthermore, the study results reveal that the country's legal system is relevant to the company's transparency. The model variables determine 62% of the social performance reporting variance. Our Results are useful for all non-financial information users, governments and organizations in developing sustainability reporting standards. [ABSTRACT FROM AUTHOR]

This data article relates to the paper "Review of the cost-optimal methodology implementation in Member States in compliance with the Energy Performance of Buildings Directive". Datasets linked with this article refer to the analysis of the latest national cost-optimal reports, providing an assessment of the implementation of the cost-optimal methodology, as established by the Energy Performance of Building Directive (EPBD). Based on latest national reports, the data provided a comprehensive update to the cost-optimal methodology implementation throughout Europe, which is currently lacking harmonization. Datasets allow an overall overview of the status of the cost-optimal methodology implementation in Europe with details on the calculations carried out (e.g., multi-stage, dynamic, macroeconomic, and financial perspectives, included energy uses, and full-cost approach). Data relate to the implemented methodology, reference buildings, assessed cost-optimal levels, energy performance, costs, and sensitivity analysis. Data also provide insight into energy consumption, efficiency measures for residential and non-residential buildings, nearly zero energy buildings (NZEBs) levels, and global costs. The reported data can be useful to quantify the cost-optimal levels for different building types, both residential (average cost-optimal level 80 kWh/m2y for new, 130 kWh/m2y for existing buildings) and non-residential buildings (140 kWh/m2y for new, 180 kWh/m2y for existing buildings). Data outline weak and strong points of the methodology, as well as future developments in the light of the methodology revision foreseen in 2026. The data support energy efficiency and energy policies related to buildings toward the EU building stock decarbonization goal within 2050. Datasets: Data directly related to this article are provided in the Supplementary Materials. Dataset License: CC-BY 4.0. [ABSTRACT FROM AUTHOR]

This paper endeavors to answer the question of who defines Islam as an academic discipline. Firstly, it discusses the epistemic authority of producers and transmitters of knowledge about Islam. It is argued here that, despite modernization, religious scholars and learning centers in the Muslim world still define, to a certain extent, the main curriculum of texts and interpretations of the Muslim tradition within the discipline of Islamic studies. Furthermore, Western scholars of Islamic studies must navigate between the demands of politics and identity, which put pressure on the discipline. Secondly, this article maps the major models and approaches of Islamic studies at work today. In particular, this section highlights the diversity of research norms and practices in Europe. Finally, multiple critiques produced by decolonial, historicist, and theological views within the field of Islamic studies are shown to be complementary rather than exclusivist. [ABSTRACT FROM AUTHOR]

Current urban mobility systems in Europe, characterized by high car mobility shares, have negative environmental and health impacts but struggle to mitigate these for fear of sacrificing accessibility. Ironically, before the car mobility transition (in the 1950s and 1960s in Western countries and the 1990s in Eastern Europe), most cities were accessible by walking, cycling, public transport, and by the few cars there were. Through a longitudinal case study of a medium-sized urban area in Clermont-Ferrand, France (1950–2022), this paper explores the potential to 'de-transition', i.e., to reverse the urban transition process towards 'accessible, low-car cities' by reshaping infrastructures to constrain car use whilst accommodating walking, cycling, and public transport. We answer the following questions: To what extent can cities reverse the urban car mobility transition? How could such a process be further encouraged? Our analysis adopts a social practices perspective and uses a mixed-methods approach by combining semi-structured interviews, a survey, and a document analysis. On the one hand, our findings highlight the difficulty of an urban modality shift to car alternatives: (1) the limited reach of public transformation networks (in Clermont-Ferrand, the tramline); (2) the fact that many feel unsafe or assume they need excellent health conditions to cycle, which is associated with leisure and sports; and (3) strong convictions concerning the usefulness of vehicle ownership, which is believed to maximise comfort. On the other hand, based on a historic analysis, we offer practical recommendations to de-transition to low-car urban areas: (1) the creation of an extensive regional tramway network; (2) the development of a full cycling network; and (3) the promotion of an extensive car-free city centre. [ABSTRACT FROM AUTHOR]

During the COVID-19 pandemic, most workers had to work from home due to the successive lockdowns across European countries. This constraint posed significant challenges to many workers and companies regarding working conditions and work–life balance. Framed by the job demands–resources model (JD–R), the goal of this paper is to examine the association of perceived organizational support (POS) and individual resilience (IR) with work–life balance (WLB) during the COVID-19 pandemic across European countries. This goal is complemented by assessing the role of work-from-home (WFH) as a mediator. Based on a quantitative approach, data were extracted from the second round of the survey "Living, Working, and COVID-19" from Eurofound. A series of regressions using SEM-PLS tested the hypothesis. Findings reveal that WFH negatively influences WLB. POS positively influences WFH and negatively influences WLB when mediated by WFH. IR negatively influences WFH and positively influences WLB when mediated by WFH. These results have essential theoretical implications related to the relations between individual and organizational resources and WLB and practical implications for the management of WFH, namely, the importance of providing adequate organizational resources and promoting the development of individual resources. [ABSTRACT FROM AUTHOR]

The seismic design of steel systems recently experienced profound changes and progress; in Europe, the research on this topic is very prolific in terms of importance and number of results achieved, even pushed by the recent process of the updating of Eurocode 8. The paper analyzes and discusses the scientific literature on the subject produced approximately over the last twenty years, focusing on both recent research and findings on traditional steel systems and innovative structural types and solutions. The review of the state of the art suggested that most of the authors are now concerned about the numerous criticisms widely encountered in the design of traditional systems according to current Eurocode 8, as well as the difficulty of the application of the relevant detailing rules. The scientific community is also aware of the need to include specific codified design procedures for innovative and promising structural types. Further investigations are needed to deepen the design of moderate-ductile systems and to extend the seismic European prequalification of beam-to-column joints to further typologies. [ABSTRACT FROM AUTHOR]

Despite Brucella suis biovar 2's (BSB2) active circulation in wildlife, no canine infections have been reported. The present paper is the first to describe two cases of BSB2 infections in French dogs. The first case occurred in 2020 and concerned a 13-year-old male neutered Border Collie with clinical signs of prostatitis. The urine culture revealed the excretion of significant levels of Brucella in the sample. The second case concerned a German Shepherd with bilateral orchitis, in which it was possible to detect Brucella colonies following neutering. HRM-PCR and classical biotyping methods classified both isolated strains as BSB2, in contrast to expected B. canis, which is usually the etiological agent of canine brucellosis in Europe. The wgSNP and MLVA analyses highlighted the genetic proximity of two isolates to BSB2 strains originating from wildlife. No pig farms were present in the proximity of either dog's residence, ruling out potential spill over from infected pigs. Nevertheless, the dogs used to take walks in the surrounding forests, where contact with wildlife (i.e., wild boars or hares, or their excrements) was possible. These cases highlight the importance of adopting a One Health approach to control the presence of zoonotic bacteria in wild animals and avoid spillovers into domestic animals and, potentially, humans. [ABSTRACT FROM AUTHOR]

Docosahexaenoic acid (DHA) is a novel mandatory constituent of breast-milk-substitute infant formula in Europe. The aim of the present narrative review was to summarize available data in connection with the background of the novel European mandatory dietary recommendation to add at least 20 mg/100 kcal (4.8 mg/100 kJ) DHA to infant formula. The literature search with the expression "docosahexaenoic acid with (infant or human milk or formula)" revealed nearly 2000 papers, including more than 400 randomized controlled trials (RCTs). DHA is a persistent constituent of human milk (HM) with a worldwide mean level of 0.37% (standard deviation: 0.11%) of all fatty acids in HM. RCTs on supplementing DHA to lactating women showed some indications, though no direct evidence of the beneficial effect of enhanced HM DHA on the development of breastfed infants. The most-recent Cochrane review of RCTs investigating the effect of DHA supplementation to infant formula for full-term infants reported no evidence for recommending supplementation. The controversy between the Cochrane view and the actual recommendation may be related to the numerous hurdles in organizing high-quality studies in this field. On the basis of the official food composition recommendation, today in Europe, DHA should be considered as a fatty acid essential for infants. [ABSTRACT FROM AUTHOR]

Featured Application: Drones can be a very useful tool to help mosquito control tasks in areas where these insects are an important vector of disease transmission. Storing sterile mosquitoes in drones and releasing them in targeted areas where previous suppression of wild populations has been performed can be a major advance in this methodology. This is part of the sterile insect techniques (SIT) which have been demonstrated to be an environmentally friendly solution for the control of insect pests. However, the use of drones in the areas where these operations are foreseen is limited by the fact that we have a regulation that advances at a slower pace than technology. Of particular interest is the case of the suppression of mosquito populations in urban areas below the transmission threshold, where drones and their operating conditions must meet demanding safety requirements. This article presents the current regulatory situation in Europe that affects drone operations and its applicability to the case of the release of sterile mosquitoes to control the population of these insects in two different scenarios: urban and rural areas. In recent years, several countries have developed the use of sterile insect techniques (SIT) to fight against mosquitoes that transmit diseases. From a technical and economic point of view, the use of drones in the aerial release of sterile mosquitoes leads to important improvements in aerial coverage and savings in operational costs due to the requirement of fewer release sites and field staff. However, these operations are under the European drone regulation, one of the most advanced in the world. The main contribution and novelty of this paper with respect to previous work is the analysis of the SIT application with drones under the European risk-based regulation in two scenarios: urban and rural areas. The specific operations risk assessment (SORA) methodology has been applied to assess the risk of drone operations in these scenarios. The paper presents the operational requirements for aerial release of mosquitoes with drones along with the regulatory considerations that must be applied. Finally, an overview of the conditions in operation that could relax risks and mitigation measures is also discussed. [ABSTRACT FROM AUTHOR]

Over the last two decades, the tidal energy industry has laid the groundwork for creating commercially viable tidal power generation projects to strengthen sustainable energy policies around the world. At the end of 2021, the cumulative installation of tidal stream technology that has been deployed in Europe reached 30.2 MW, where the majority of the installations are by small and medium-sized companies. Due to a growing demand among investors related to the global tidal energy industry, the reliability and safety of operational-stage tidal energy systems' components are becoming increasingly important. In this context, companies, universities and research institutes are focusing on conducting large- and small-scale tests of tidal turbine elements to validate their projected design life, and major attention is being given to assessing the structural integrity of turbine blades. This review paper focuses on structural tests that have been reported for axial flow tidal turbine blades manufactured using composite materials around the world, highlighting the testing standards, equipment and instrumentation required. Overall, this review article discusses the state of the art in the structural testing of tidal turbine blades. In addition, it highlights the global concerns and research gaps to ensure the long-term sustainability of axial flow tidal turbine blades. In addition, the information contained in this article will be useful for formulating a smooth and reliable mechanism to enhance the evaluation process of the structural properties of tidal turbine blades in the future. [ABSTRACT FROM AUTHOR]

The gradual reorientation of rural policy paradigms away from competitiveness and economic growth and towards well-being and sustainability creates a need for more appropriate diagnostic tools to assess disparities and policy outcomes. One of the most cited determinants of rural well-being is access to Services of General Interest. Areas with relatively poor access to services can be described as "inner peripheries", and peripherisation literature provides helpful insights into the challenges faced and policy needs. This paper presents a methodology for modelling and mapping access to a suite of ten key services, covering all of Europe at a 2.5 km grid square level. The approach is intrinsically relative, comparing the travel time to services from each grid square with the average for surrounding regions. Maps are provided for 2017 and 2021, and changes between these dates are described. 'Inner peripheries' are found in every country, their configuration being influenced not only by geographical features, but also by service delivery practices. Further analysis explores patterns of risk, identifying areas in which service provision is in a precarious position. The results presented are rich in practical policy implications, not least the suggestion that, in terms of patterns of well-being, local roads are at least as important as trunk infrastructure. [ABSTRACT FROM AUTHOR]

The loss of archaeological heritage continues today, because of both natural disasters and human-made actions. Alarmingly, a significant amount of the destruction is perpetrated by looters and illegal excavations. This problem is not a new one. However, it has increased exponentially in recent years, especially in countries which witnessed internal turmoil (i.e., the Arab Spring) but also throughout Europe. Local authorities struggle to provide adequate controls because of a lack of human resources, budget constraints or technological know-how. This paper describes a multimodal documentation and monitoring workflow applied to an archaeological site for which, due to the sensitivity of the topic, no specific details can be publicly disclosed. The techniques used include UAV aerial surveys, image-based modelling, change detection, relief visualization and GIS mapping. Thanks to the analysis of the multitemporal datasets, it was possible to assess the extension and spatial progression of illegal excavation over a two-year period. [ABSTRACT FROM AUTHOR]

Sinkholes are a severe problem in urban areas located in karstic regions, especially where evaporitic rocks such as gypsum exist. Identification and proposal of mitigation measures are needed to reduce this geo-hazard effect on buildings and social urban living. This paper presents a case study of the town of Alcalá de Ebro (Spain), which is located in the highest sinkhole risk region of Europe. The identification and mitigation of a series of sinkholes that appeared are analyzed. The former involves a geological investigation, including boreholes, field tests and geophysics. The latter is addressed by the use of geogrids, mortar injections and polyurethane injections. A complementary finite element analysis is carried out to set the ground behavior associated with the sinking process and assess its future evolution. The Ebro River appears to be the main cause of sinkholes, and results show that ground treatments applied were successful in their purpose, as there are no apparent deformations indicating that the subsidence or sinking process is still active in the area. The use of different techniques depending on the size of the sinkhole, the objectives pursued and the element affected is discussed. [ABSTRACT FROM AUTHOR]

The question of God is one of the central themes of religious education. Therefore, research in the field of concepts of knowledge and faith can provide a substantial basis for the work of educators and teachers and, thus, for the foundation of Islamic religious education. The following paper presents the results of a qualitative study on Muslim children's relationships with God. The results provide impulses for rethinking Islamic religious education in Europe. [ABSTRACT FROM AUTHOR]

The use of small aircraft for a wide range of missions in urban airspace is expected to increase in the future. In Europe, efforts have been invested into developing a unified system, called U-space, to manage aircraft in dense very-low-level urban airspace. The Metropolis II project aimed to research what degree of centralisation an air traffic management system should use in such airspace. The paper at hand is a follow-up, and investigates improvements that can be brought to the tactical conflict prevention, detection, and resolution module of such a system in order to harmonise these components with an organic high-density U-space environment. The proposed improvements are: the prioritisation of vertical conflict prevention in intersections, the use of intent in detecting and resolving conflicts, and the use of heading-based manoeuvres in open airspace. Results show that the use of intent information in the conflict detection process, as well as the implementation of suitable tactical prevention procedures, can greatly increase airspace safety. Furthermore, the experiments revealed that the effectiveness of conflict resolution algorithms is highly dependent on the airspace rules and structure. This reiterates the potential for increasing the safety and efficiency of operations within constrained airspace if the tactical separation modules are unified with the other components of air traffic management systems for U-space. [ABSTRACT FROM AUTHOR]

The impact of global warming on plant phenology is the subject of a growing number of studies. However, most of these do not focus on woody species, and few examine the entire annual phenological cycle of woody species. In this paper, we explore the phenological pattern of seven woody species native to Europe under ex situ conditions for 3 years, in two urban areas with different mesoclimates. The average temperature differs by 1.81 °C between the two sites. The investigated plants were clonally identical for each species, and the exact same care protocol was kept at both sites. Despite the large variation in the phenological pattern between years, during the study, spring phenophases occurred earlier, while the examined autumn phenophases were delayed at the site observing a higher average temperature. The phenological sensitivity of flowering was significantly higher than that of leaf bud burst. The growing season was 14.8 days longer at the site with a higher average temperature. In most cases, a significant correlation was obtained between the examined phenophases and climatic factors at both sites. Among the autumn phenophases, the strongest correlation was found between the maximum temperature between July and October and the beginning of leaf coloring. [ABSTRACT FROM AUTHOR]

Grazing plays an important role in milk production in most regions of the world. Despite the importance of grazing, current trends in livestock farming in Europe are causing a decline in the popularity of pasture-based feeding of dairy cows. This paper aims to provide an overview of the challenges faced by the pasture feeding system under climate change. Grazing lands provide ecosystem services including regulation and storage of water flows, nutrient cycling, and C sequestration. Livestock grazing is the most important factor shaping and stabilizing pasture biodiversity. Some opportunities for pasture feeding are the health-promoting and nutritional qualities of milk and milk products, especially milk from pasture-fed cows. The beneficial effects of pasture feeding on animal health and welfare are not insignificant. Available organizational innovations can help better manage livestock grazing and, above all, better understand the impact of the grazing process on the environment and climate change. [ABSTRACT FROM AUTHOR]

Internal Combustion Engines (ICE) are experiencing a transition era in which research and innovation are mainly pushed by environmental issues: emission reduction and fuel saving are indispensable requirements of the new technologies, otherwise the end of ICE is proposed in Europe. Modifications, in reality, are under discussion by 2026 but the environmental issues are anyway welcomed. In the transportation sector, today dominated by ICEs, it appears that the reduction in the propulsion power, hybridization at various degrees, and exhaust post-treatment improvements will guarantee technological solutions able to support the transition in the next couple of decades toward full electric propulsion. Waste Heat Recovery (WHR) is a very interesting opportunity since almost two-thirds of fuel energy is not converted into mechanically useful energy. Moreover, the integration with other thermal streams on board (cooling and lubricating mediums, EGR cooling) can add further value to the recovery opportunity as well as the concept of managing the engine thermal management which can produce a sensible contribution that is appreciated mainly during urban driving. A huge scientific effort is underway, and a great expectation is perceptible. More generally, the technological options that can achieve a reduction in overall fuel consumption and, thus, the improvement of global engine efficiency, are the most valuable when they can be introduced without massive changes to the engine layout. This happens in all the energy applications in which ICEs are involved since the recovery unit can be introduced in the exhaust line. The mechanical energy recovered can be easily transformed into electrical energy, so represents an interesting integration with the hybrid propulsion powertrains. In this paper, a review of the most important technologies referred to the WHR is presented, outlining advantages and drawbacks, and setting up the presently available technologies referred to the transportation sector. [ABSTRACT FROM AUTHOR]

Since the industrial revolution, the relationship between unemployment and psychiatric disorders has been a subject of high interest. Currently, regarding the correlation between unemployment and substance-use disorders (SUDs), only older, often isolated and fragmented research results are available in the literature. This review was based on an extensive literature search of the European and North American literature in most relevant databases for "unemployment" and "substance use" related to "drugs", "alcohol", "nicotine", and "tobacco" between November 2022 and January 2023, according to the PRISMA (Preferred Reporting Items for Systematic review and Meta-Analysis) guidelines. A total of 59,117 papers were identified, of which only 33 articles were identified as relevant to the research objective. The literature showed significantly higher prevalence rates of SUDs involving divergent psychotropic substances among unemployed people. Unemployment was found to be a risk factor for SUD, and vice versa. However, the correlation between unemployment and relapses or smoking cessation was inconsistent. In addition, there appeared to be a mild effect of business cycles on SUD. The results showed significant multifaceted correlations between unemployment and SUD, indicating that prevention and early intervention are required to prevent harmful psychosocial consequences, such as social disintegration and severe psychiatric disorders. [ABSTRACT FROM AUTHOR]

Current taxonomical keys are essential for better biodiversity knowledge. Moreover, accurate identification of groups of organisms known to act as disease vectors is vital in today's world of change and the spread of zoonotic disease threats. This is especially relevant to bats and their parasites, given the events of recent years. The available keys of European Nycteribiidae (Diptera) are outdated and do not cover all the species currently known from Europe. Therefore, a summary key of 16 European species is provided in this paper. Based on published data from Europe, a total of 173 host–parasite interactions were observed between 16 European bat fly species and 31 host species (bats). The highest number of associations with different host species and the lowest specialization was observed in Penicillidia (P.) dufourii dufourii, followed by Nycteribia (N.) kolenatii, N. (N.) schmidlii and Phthiridium biarticulatum; most of the other species also had low specialization. Most species are oligoxenous, parasitizing on several families, and three species are stenoxenosus. Only one nycteribiid species, Basilia daganiae, was linked with only one host (Pipistrellus kuhlii). Myotis myotis has 12 associations with different bat fly species, followed by Plecotus auritus and Myotis daubentonii with 12 associations. A relatively high number of bat species were associated with only one bat fly species. In addition, we performed a bipartite analysis complemented by network indices and host specificity at the species and whole network levels, yielding new information in terms of ecology and the host–parasite relationships related to these groups of potential vectors (Nycteribiidae) and sources of zoonoses (bats). The parasite–host network composed of 16 nycteribiid species and 31 bat host species was characterized by a low network level specialization, low modularity, and low nestedness. Our findings also suggest a high probability of associated Nycteribiidae in bat taxa with a similar roosting ecology and phylogenetic relationship. [ABSTRACT FROM AUTHOR]

Digital technology is now a fundamental and indispensable component of daily life. While the great opportunities offered by cyberspace are undoubted, the growing security challenges and threats it brings should not be overlooked. Cyberspace, by its nature transnational and elusive regarding forms of control, is useful to terrorism because it allows not only the propaganda of fundamentalist doctrines but also the creation and manipulation of information; the apology and dissemination of information instrumental to the processes of radicalisation; the use of devices capable of transversally violating the security of technical and virtual infrastructures that are critical to the security of nations; the operational planning of terrorist activities; and the recruitment, financing, and training of recruits. The so-called "new terrorism", religiously motivated, makes extensive use of the digital tool. After an excursus concerning the use of cyberspace by religious fundamentalist groups and the transformation of religiously motivated terrorism, this paper focuses on the analysis of the European legal response and on the need for global and shared European action. [ABSTRACT FROM AUTHOR]

The creation of a Centre for Cultural Witness at Lambeth Palace, to serve the Church of England within an ecumenical partnership that already stretches across Europe, offers an opportune time to reflect upon the place—even the meaning—of "culture" in witness of the church. The analysis presented here identifies three senses in which that term might be applied to witness: as that from which the witness comes, that through which it comes, and that to which it comes. At least in theory, a strong cultural emphasis might (or might not) be placed on each of these dimensions independently. However, while this may prove to be a useful distinction, it risks perpetuating an assumption that churches, and Christians, stand outside the culture of those they address, speaking as if from beyond it. In the second half of this paper, I work, instead, from the recognition that the Christian speaks from a position of a shared creaturehood, shared humanity, and—in myriad ways—a shared culture. Approached that way, the mission of the church can fruitfully be seen as witness to a theologically specific understanding of that which is shared. I conclude with the suggestion that this can be ably resourced from the broad tradition of a Platonic "Christian humanism". [ABSTRACT FROM AUTHOR]

Renewable energy sources (RESs) and electricity demand are not evenly distributed geographically across Europe. Thus, harvesting the wind energy from the north and solar energy from the south and delivering them to the demand in central Europe is a more viable solution. However, the present High-voltage alternating current (HVAC) transmission grids have been sometimes congested; thus, High-voltage direct current (HVDC) provides another possibility along the existing HVAC infrastructure. In this paper, we propose a hybrid HVAC-HVDC grid, allowing a large penetration of concentrated RES in Europe and North Africa. More specifically, the HVDC network is constructed to transfer wind and hydro electricity from northwestern Europe and solar electricity from north Africa, while the HVAC network is used to distribute electricity within each country or among adjacent areas. To quantitatively evaluate the feasibility and relevant performances, multiple dimensions of indicators are designed. Employing several European energy scenarios up to 2050, the performances of the proposed HVAC-HVDC infrastructure are analyzed and compared. The calculation results show that compared with the pure HVAC grid, the integrated HVAC-HVDC grid can significantly reduce greenhouse gas emissions and pollutants, leading to a further reduction in the number of deaths from air pollution. In addition, the HVAC-HVDC grids can accommodate a higher penetration of RES without causing infeasible power flows. [ABSTRACT FROM AUTHOR]

Cowpea (Vigna unguiculata (L.) Walp.) is a legume with a constant rate of cultivation in Southern European countries. Consumer demand for cowpea worldwide is rising due to its nutritional content, while Europe is constantly attempting to reduce the deficit in the production of pulses and invest in new, healthy food market products. Although the climatic conditions that prevail in Europe are not so harsh in terms of heat and drought as in the tropical climates where cowpea is mainly cultivated, cowpea confronts with a plethora of abiotic and biotic stresses and yield-limiting factors in Southern European countries. In this paper, we summarize the main constraints for cowpea cultivation in Europe and the breeding methods that have been or can be used. A special mention is made of the availability plant genetic resources (PGRs) and their potential for breeding purposes, aiming to promote more sustainable cropping systems as climatic shifts become more frequent and fiercer, and environmental degradation expands worldwide. [ABSTRACT FROM AUTHOR]

All over the world, measures were taken to prevent the spread of COVID-19. Social distancing not only had a strong influence on mental health, but also on the organization of care systems. It changed existing practices, as we had to rapidly move from face-to-face contact to remote contact with patients. These changes have prompted research into the attitudes of mental healthcare professionals towards telepsychology. Several factors affect these attitudes: at the institutional and organizational level, but also the collective and personal experience of practitioners. This paper is based on an original European survey conducted by the EFPA (European Federation of Psychologists' Associations) Project Group on eHealth in 2020, which allowed to observe the variability in perceptions of telepsychology between countries and mental healthcare professionals. This study highlights different variables that contributed to the development of attitudes, such as motivations, acquired experience, or training. We found the "feeling of telepresence"—which consists of forgetting to some extent that we are at a distance, in feeling together—and social telepresence in particular as main determinants of the perception and the practice of telepsychology. [ABSTRACT FROM AUTHOR]

Inappropriate forest management activities, above all clear-cutting, are recognized as the major threats to an iconic orchid species—the lady's slipper orchid (Cypripedium calceolus), the flagship species of nature protection in Europe. Although clear-cutting in protected species' localities is strongly regulated in many European countries, salvage logging is allowed in some circumstances (e.g., following windstorms, and insect outbreaks) and can threaten C. calceolus populations. In this paper, we review a database of recently registered populations of this species in the Czech Republic and study historical maps, to better understand the history of local habitat conditions and assess threats to C. calceolus populations by bark beetle outbreaks. We found that about one-third of the C. calceolus populations have suffered in coniferous or mixed tree plantations with a high proportion of spruce trees, which are forests with a high risk of bark beetle infestation. We review bark beetle management measures and distinguish management efforts in areas with known C. calceolus populations that result in no damage to the population and, at times, improve habitat conditions for the species. Thus, the bark beetle—usually understood as the enemy—can be transformed into a savior if smart management measures will replace the panic salvage logging. [ABSTRACT FROM AUTHOR]

The article presents the process of creation of a signals database for the development of a train speed-estimation method for an axle counter system. In the article the authors present the need for information about the train speed on the railway lines and the possible applications for which the information about the train speed may be used, as well as address the concerns related with the evaluation of the information in axle counter systems. The main goal of the paper is to present the creation process of an axle counter signals database and how to emulate the real signals using the laboratory-obtained ones. A database that has been created for a specific wheel detector is available on request. It contains a variety of signals that are necessary for the development and tests of wheel detector algorithms, in particular the estimation of train speed. Signals were generated for the most commonly used rail profile in Europe and the wheels that are defined in the technical specification of interoperability. Furthermore, the signals were transformed to emulate various speeds, the possible accelerations and to include the disturbance observed in the field. [ABSTRACT FROM AUTHOR]

The aviation industry is challenged to reduce its climate impact. The introduction of sustainable aviation fuels (SAF) is, among other policy instruments such as the European Emissions Trading Scheme, an option favored by policymakers in Europe to achieve this objective. These fuels feature substantially reduced carbon life-cycle emissions in comparison to fossil fuels. In Europe, a mandatory quota for the use of sustainable fuels will most likely be introduced, starting in the year 2025. The introduction of a blending mandate by governments and the European Commission is associated with a range of challenges. The purpose of this paper is to discuss the economics of climate change mitigation in aviation and the role SAFs can play. The economic issues associated with the introduction of SAFs are analyzed, with a particular focus on the European Commission's proposal for a blending mandate. Several suggestions for improvement are discussed. Furthermore, alternatives to SAFs are presented and evaluated. [ABSTRACT FROM AUTHOR]

Wild mushroom foraging has a long tradition, especially in the region of Central Europe. Wild mushrooms are a valuable food resource, as they provide nutritional benefits to the European population. They offer a relatively high content of protein and are traditionally used in many European cuisines as a substitute for meat. This is particularly true in times of crisis, such as wars and pandemics. The study presented in this paper shows that wild mushrooms can substitute around 0.2 percent of daily protein intake and contribute around 3% to the agricultural output of the Czech economy, which was selected as a representative for Central Europe. The calculated real price of wild mushrooms indicates their increasing popularity as a source of food protein in Central Europe, while their price seems to be independent of the quantity supplied. [ABSTRACT FROM AUTHOR]

Using airborne drones to monitor water quality in inland, transitional or coastal surface waters is an emerging research field. Airborne drones can fly under clouds at preferred times, capturing data at cm resolution, filling a significant gap between existing in situ, airborne and satellite remote sensing capabilities. Suitable drones and lightweight cameras are readily available on the market, whereas deriving water quality products from the captured image is not straightforward; vignetting effects, georeferencing, the dynamic nature and high light absorption efficiency of water, sun glint and sky glint effects require careful data processing. This paper presents the data processing workflow behind MapEO water, an end-to-end cloud-based solution that deals with the complexities of observing water surfaces and retrieves water-leaving reflectance and water quality products like turbidity and chlorophyll-a (Chl-a) concentration. MapEO water supports common camera types and performs a geometric and radiometric correction and subsequent conversion to reflectance and water quality products. This study shows validation results of water-leaving reflectance, turbidity and Chl-a maps derived using DJI Phantom 4 pro and MicaSense cameras for several lakes across Europe. Coefficients of determination values of 0.71 and 0.93 are obtained for turbidity and Chl-a, respectively. We conclude that airborne drone data has major potential to be embedded in operational monitoring programmes and can form useful links between satellite and in situ observations. [ABSTRACT FROM AUTHOR]

Hybrid Electric Vehicles (HEVs) are a prominent solution for reducing CO2 emissions from transport in Europe. They are equipped with at least two propulsion energy converters, an Internal Combustion Engine (ICE) and one or more Electric Machines (EMs), operated in a way to exploit synergies and achieve fuel efficiency. Because of the variety in configurations and strategies, the use of simulation is essential for vehicle development and characterisation of energy consumption. This paper introduces a novel simulation approach to estimate the CO2 emissions from different hybrid architectures (series, parallel, power-split) and electrification degrees (mild, full, plug-in and range extender) that is relatively simple, flexible and accurate. The approach identifies the optimal power split between the energy converters for any given time in a driving cycle according to three evaluation levels: supervisor, ICE manager and optimiser. The latter relies on the Equivalent Consumption Minimisation Strategy (ECMS) and the limitations imposed by the other two layers. Six light-duty HEVs with different hybrid architectures were tested to support the development of the approach. The results show an indicative accuracy of ±5%, enabling to run assessments of hybrid powertrain solutions and supporting regulatory and consumer information initiatives. [ABSTRACT FROM AUTHOR]

Analyzing data from the Energy Poverty Observatory in Europe, it emerges that more than 50 million households in the EU live in energy poverty (people that cannot heat their homes during winter; cannot make their homes comfortable during the summer; pay their energy bills late). Research studies realized in the last 20 years highlight that making energy demand efficient and effective is the more significant and socially important the more it is able to involve users who are unable to sustain energy demand. The evolution of the research sees a narrowing of the field of investigation by focusing on the user dimension of energy poverty, stressing the role of citizens not only as consumer but also as producers of solutions to tackle energy poverty, real energy communities of agents. The paper aims to provide a systematic literature review highlighting the major findings of the topic, investigating the relationship between spatial and social issues, and looking at the state of energy poverty by addressing the profiling of users and consequently of services useful to overcome their current vulnerable condition. The paper is structured in two core sections. The first one gives the results of a systematic literature review on the energy/fuel poverty topic, the second one deepens the role of communities and individuals need, crucial in defining new design approaches for supportive solutions to tackle energy poverty. [ABSTRACT FROM AUTHOR]

Simple Summary: Endometrial cancer has a high epidemiological impact, and its management is part of everyday clinical practice. International guidelines have been arranged over the years according to major recent discoveries. The application of the guidelines released by different international gynecological societies is still matter of debate as they diverge in many issues. Authors wanted to compare them and point out the differences, aiming to both draw the attention to a need of unification and to provide a useful tool for clinicians. Endometrial cancer is the most common gynecological malignancy in Europe and its management involves a variety of health professionals. In recent years, big discoveries were made concerning the management of patients diagnosed with endometrial cancer, particularly in the field of molecular biology and minimally invasive surgery. This requires the continuous updating of guidelines and protocols over the years. In this paper, we aim to summarize and compare common points and disparities among protocols for management of patients diagnosed with endometrial cancer by leading international gynecological oncological societies. We therefore systematically report the parallel among the guidelines based on the various steps patients with endometrial cancer usually undergo. The comparison between American and European protocols revealed some relevant disparities, in particular regarding surgical staging, molecular biology application as a prognostic tool and follow up regimens. This could possibly cause differences in interpreting and applying protocols in clinical practice in small centers, leading to a lack of adherence to guidelines or even prompting a confusing mix of them. [ABSTRACT FROM AUTHOR]

The recycling of REEs from the end of life (EoL) products, such as nickel metal hydride batteries (NiMH), offers great opportunities for their supply in Europe. In the presented paper, the application of 'green' extractants such as citric (CA), metatartaric (TA), and ethylenediaminedisuccinic acid (EDDS) (also with H2O2 addition) for the recovery of REEs was studied. The studies were conducted considering the effects of the phase contact time, the initial concentration of CA, TA, and EDDS, as well as H2O2, pH, and temperature. It was found that the addition of TA to the CA solution meant that higher rates of metal ion binding and, thus, leaching was observed. The optimal conditions were obtained in the system: CA-TA and H2O2 for the concentration 0.6M-0.3 M-2%. [ABSTRACT FROM AUTHOR]

This paper discusses the risks associated with an aerostat-supported stratospheric (unanchored) balloon mission equipped with a long vertical antenna and a very low frequency radio transmitter. The risks have been grouped into four main types and applicable mitigation methods have been presented to provide a sufficient level of safety and reliability to such a balloon mission. An experimental mission consistent with this analysis, based on the described theoretical VLF propagation approach, has been prepared and launched, and is operating at 14.2 kHz with a vertical antenna of a total length of 400 m and a total payload of max. 4 kg. The maximum altitude reached 29,164 m. The experiment's signal has been registered in numerous locations in Europe; the results are compared with numerical analysis employing a hypothesis of an apparent transmitting frequency decrease with the rise of the transmitter's altitude. The numerical analysis explains the behavior of the experimental signal and remains generally consistent with the hypothesis. [ABSTRACT FROM AUTHOR]

This editorial paper tackles the issue of the consumer attitudes toward energy reduction and changing energy consumption behaviors. This topic is of special relevance today as Europe faces an unprecedented energy crisis as a result of diverting from Russian supplies of oil and gas due to the war in Ukraine. For many years now, Europe has relied upon cheap and affordable Russian oil and gas (in fact, the European Green Deal and the strategy for the decarbonization of the economy by 2030 were indirectly based on it), but the transition to the renewable future now appears to be jeopardized. As energy prices are soaring globally, it is not yet clear whether this would have an effect on significantly changing consumer behavior and increasing energy efficiency and security as many consumers are reluctant to change their old habits and are used to having their energy on demand and for any possible occasion. However, changing energy consumption behaviors would be beneficial not only for handling the current energy crisis but also for setting the long-term trends with respect to energy saving, which is crucial for fighting global warming and climate change while sustaining economic growth. [ABSTRACT FROM AUTHOR]

This systematic study aims at analyzing the differences between the approach of the European healthcare systems to the pharmaceutical market and the American one. This paper highlights the opportunities and the limitations given by the application of managed entry agreements (MEAs) in European countries as opposed to the American market, which does not regulate pharmaceutical prices. Data were collected from the Organisation for Economic Co-operation and Development (OECD), the European Medicines Agency, and the national healthcare agencies of US and European countries. A literature review was undertaken in PubMed, Scopus, MEDLINE, and Google for a period ten years (2010–2019). The period 2020–2021 was considered to compare health expenditure before and after the SARS-CoV-2 pandemic. Scarce information from national agencies has been given in terms of MEAs related to the COVID-19 pandemic. The comparison between the United States approach and the European one shows the importance of a market access regulation to reduce the cost of therapies, increasing the efficiency of national healthcare systems and the advantages in terms of quality and accessibility to the final users: patients. Nevertheless, it seems that the golden age of MEAs for Europe was during the examined period. Except for Italy, countries will move to other forms of reimbursements to obtain higher benefits, reducing the costs of an inefficient implementation and outcomes in the medium term. [ABSTRACT FROM AUTHOR]

Forests cover about 1/3 of Europe's land area and are an important source in providing goods and services such as timber, drinking water, biodiversity, and carbon storage. They are important for a bioeconomy to mitigate climate change effects by reducing greenhouse gas emissions from the combustion of fossil fuels. The purpose of this paper is to assess Europe's potential wood supply by harvesting system. Gridded forest characteristics data are combined with other European spatially-explicit data. A set of eight mechanized harvesting systems is applied to assess the "forest available for wood supply" (FAWS) in Europe. The results show that 74.9% of the total forest area in Europe can be considered FAWS and has the potential to be harvested under the current economic and technical harvesting conditions. The remaining forest area is under legal protection (4.3%) or has limited accessibility with the current mechanized harvesting systems (20.8%). Around 79% of the FAWS can be accessed with ground-based machinery, and another 16% if their operation range is extended using special attachments (e.g., chains or band) or winch-assisted systems. Around 5% of the FAWS is only accessible by cable yarding machinery. With the fully mechanized harvesting systems (i) harvester and forwarder and (ii) winch-assisted harvester and winch-assisted forwarder, about 80% of the harvestable forest area and growing stock can potentially be utilized. [ABSTRACT FROM AUTHOR]

This paper presents a comparative analysis of various capacity mechanisms that are either in force or under approval in key countries/regions in Europe and the US. A detailed analysis on the necessities that led to the establishment of the capacity mechanisms, along with various fundamental technical and operational features associated with the design and operation of different capacity mechanisms, mainly in Europe (Italy, France, Germany, Belgium, Poland, Great Britain, Ireland, Cyprus) and complementarily in the US (PJM, New England), are presented. This analysis is complemented by a real-life application regarding the long-term capacity remuneration mechanism that is expected to be established in Greece in the near future. A detailed simulation of the envisaged capacity mechanism auctions under differentiated scenarios has been performed, regarding the future Greek power system operating conditions during the forthcoming decade (2022–2031). Test results illustrate that the outcome of the auctions is heavily dependent on the future energy generation mix and the market participants' bidding strategy. Whereas, the total cost that will have to be undertaken by the electricity supply companies and, ultimately, by the end-consumers for the financing of the proposed capacity mechanism lies in the range of 5.5–8.7 €/MWh for the entire study period. [ABSTRACT FROM AUTHOR]

Simple Summary: The systematic use of different antiparasitic products over time has led to several problems, such as drug resistances and biodiversity loss, which directly affect extensive livestock farming. Considering the current scenario, alternative approaches for parasite control are needed. This review study presents different Mediterranean tannin-rich plants with anthelmintic effect, which can be used as fodder or voluntarily grazed by livestock as a strategy to reduce the use of antiparasitic drugs. Internal parasites are one of the main causes of health threats in livestock production, especially in extensive livestock farming. Despite the environmental toxic effects (loss of dung beetles, biodiversity, and other issues) and resistance phenomenon derived from their prolonged use, anti-parasitic chemical pharmaceuticals are frequently used, even in organic farming. Such a situation within the context of climate change requires urgent exploration of alternative compounds to solve these problems and apparent conflicts between organic farming objectives regarding the environment, public health, and animal health. This review is focused on some plants (Artemisia spp., Cichorium intybus L., Ericaceae family, Hedysarum coronarium L., Lotus spp., Onobrychis viciifolia Scop.) that are well known for their antiparasitic effect, are voluntarily grazed and ingested, and can be spontaneously found or cultivated in southern Europe and other regions with a Mediterranean climate. The differences found between effectiveness, parasite species affected, in vitro/in vivo experiments, and active compounds are explored. A total of 87 papers where antiparasitic activity of those plants have been studied are included in this review; 75% studied the effect on ruminant parasites, where gastrointestinal nematodes were the parasite group most studied (70%), and these included natural (31%) and experimental (37%) infections. [ABSTRACT FROM AUTHOR]

Temoporfin (mTHPC) is approved in Europe for the photodynamic treatment of head and neck squamous cell carcinoma (HNSCC). Although it has a promising profile, its lipophilic character hampers the full exploitation of its potential due to high tendency of aggregation and a reduced ROS generation that compromise photodynamic therapy (PDT) efficacy. Moreover, for its clinical administration, mTHPC requires the presence of ethanol and propylene glycol as solvents, often causing adverse effects in the site of injection. In this paper we explored the efficiency of a new mTHPC formulation that uses human serum albumin (HSA) to disperse the photosensitizer in solution (mTHPC@HSA), investigating its anticancer potential in two HNSCC cell lines. Through a comprehensive characterization, we demonstrated that mTHPC@HSA is stable in physiological environment, does not aggregate, and is extremely efficient in PDT performance, due to its high singlet oxygen generation and the high dispersion as monomolecular form in HSA. This is supported by the computational identification of the specific binding pocket of mTHPC in HSA. Moreover, mTHPC@HSA-PDT induces cytotoxicity in both HNSCC cell lines, increasing intracellular ROS generation and the number of γ-H2AX foci, a cellular event involved in the global response to cellular stress. Taken together these results highlight the promising phototoxic profile of the complex, prompting further studies to assess its clinical potential. [ABSTRACT FROM AUTHOR]

Sap sucking heteropteran cereal bugs—members of the Eurygaster and Aelia genus—are serious pests of wheat. Moreover, they feed on a variety of gramineous plant species, including rye, barley, oat, maize, and millet. They are widely distributed in the European continent. The purpose of this review paper is two-fold; it summarizes the currently available data on the biological characteristics, the inflicted damage, and their European distribution and, in addition, we aimed to determine their economic importance, based on data available in the current literature. For the most important cereal bug species, we have collected data on their occurrence in Europe to provide a comprehensive picture of their distribution, and characterized them according to their temperature requirements at different life stages. We have also determined the degree of their attachment to wheat as their host plant, examining the synchronization between the pests and the life cycle of the plant. Finally, we compared their migration characteristics. All the above-mentioned characteristics were merged, in order to assess and rank the damage potential of each species. [ABSTRACT FROM AUTHOR]