1. New Insights in Therapy for Food Allergy
- Author
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Mayorga, Cristobalina, Palomares, Francisca, Cañas, José A., Pérez-Sánchez, Natalia, Núñez, Rafael, Torres, María José, Gómez, Francisca, [Mayorga,C, Palomares,F, Cañas,JA, Núñez,R] Allergy Research Group, Instituto de Investigación Biomédica de Málaga (IBIMA),Málaga, Spain. [Mayorga,C, Pérez-Sánchez,N, Torres,MJ, Gomez,F] Allergy Clinical Unit, Hospital Regional Universitario de Málaga, Málaga, Spain. [Torres,MJ] Medicine Department, Universidad de Málaga-UMA, Málaga, Spain., This research was funded by grants from the Institute of Health 'Carlos III' (ISCIII) of the Ministry of Economy and Competitiveness: PI17/01318 and PI18/00288. RETICS ARADyAL (RD16/0006/0001) and Sara Borrell (CD20/00085) Program. Andalusian Regional Ministry of Health (PE-0039-2018, and RH-0085-2020 and PI-0099-2020), Senior Clinical Researcher Program (B-0005-2019), and Nicolas Monardes Program (RC-0004-2021). Roche Pharma S.A. 'Stop Fuga de Cerebros' Program (SFC-0002-2020). Grants were co-funded by the European Regional Development Fund (ERDF). 'Una manera de hacer Europa' 'Andalucía se mueve con Europa'.
- Subjects
Microbiota ,Specific immunotherapy ,Nanopartículas ,Non-specific therapy ,Hypoallergens ,Chemicals and Drugs::Complex Mixtures::Biological Products [Medical Subject Headings] ,Hipersensibilidad a los alimentos ,Phenomena and Processes::Microbiological Phenomena::Microbiota [Medical Subject Headings] ,Food allergy ,Nanoparticles ,Inmunoterapia ,Diseases::Immune System Diseases::Hypersensitivity::Hypersensitivity, Immediate::Food Hypersensitivity [Medical Subject Headings] ,Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Immunoglobulin Isotypes::Immunoglobulin E [Medical Subject Headings] ,Technology and Food and Beverages::Technology, Industry, and Agriculture::Manufactured Materials::Nanostructures::Nanoparticles [Medical Subject Headings] - Abstract
Food allergy is an increasing problem worldwide, with strict avoidance being classically the only available reliable treatment. The main objective of this review is to cover the latest information about the tools available for the diagnosis and treatment of food allergies. In recent years, many efforts have been made to better understand the humoral and cellular mechanisms involved in food allergy and to improve the strategies for diagnosis and treatment. This review illustrates IgE-mediated food hypersensitivity and provides a current description of the diagnostic strategies and advances in different treatments. Specific immunotherapy, including different routes of administration and new therapeutic approaches, such as hypoallergens and nanoparticles, are discussed in detail. Other treatments, such as biologics and microbiota, are also described. Therefore, we conclude that although important efforts have been made in improving therapies for food allergies, including innovative approaches mainly focusing on efficacy and safety, there is an urgent need to develop a set of basic and clinical results to help in the diagnosis and treatment of food allergies. Yes
- Published
- 2021