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The Value of In Vitro Tests to DiminishDrug Challenges.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2017 Jun 07; Vol. 18 (6). Date of Electronic Publication: 2017 Jun 07. - Publication Year :
- 2017
-
Abstract
- Drug hypersensitivity reactions have multiple implications for patient safety and health system costs, thus it is important to perform an accurate diagnosis. The diagnostic procedure includes a detailed clinical history, often unreliable; followed by skin tests, sometimes with low sensitivity or unavailable; and drug provocation testing, which is not risk-free for the patient, especially in severe reactions. In vitro tests could help to identify correctly the responsible agent, thus improving the diagnosis of these reactions, helping the physician to find safe alternatives, and reducing the need to perform drug provocation testing. However, it is necessary to confirm the sensitivity, specificity, negative and positive predictive values for these in vitro tests to enable their implementation in clinical practice. In this review, we have analyzed these parameters from different studies that have used in vitro test for evaluating drug hypersensitivity reactions and estimated the added value of these tests to the in vivo diagnosis.<br />Competing Interests: The authors declare no conflict of interest.
- Subjects :
- Drug Hypersensitivity metabolism
Humans
Hypersensitivity, Delayed diagnosis
Hypersensitivity, Delayed immunology
Hypersensitivity, Delayed metabolism
Hypersensitivity, Immediate diagnosis
Hypersensitivity, Immediate immunology
Hypersensitivity, Immediate metabolism
Immunoglobulin E blood
Immunoglobulin E immunology
T-Lymphocytes immunology
T-Lymphocytes metabolism
Diagnostic Tests, Routine methods
Diagnostic Tests, Routine standards
Drug Hypersensitivity diagnosis
Drug Hypersensitivity immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 18
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 28590437
- Full Text :
- https://doi.org/10.3390/ijms18061222