183 results on '"Amy, L."'
Search Results
2. How Have Patient Out-of-pocket Costs for Common Outpatient Orthopaedic Foot and Ankle Surgical Procedures Changed Over Time? A Retrospective Study From 2010 to 2020.
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Goldfarb, Sarah I., Xu, Amy L., Gupta, Arjun, Mun, Frederick, Durand, Wesley M., Gonzalez, Tyler A., and Aiyer, Amiethab A.
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OPERATIVE surgery , *PREFERRED provider organizations (Medical care) , *SURGICAL clinics , *ANKLE , *VARIABLE costs - Abstract
Background Out-of-pocket (OOP) costs can be substantial financial burdens for patients and may even cause patients to delay or forgo necessary medical procedures. Although overall healthcare costs are rising in the United States, recent trends in patient OOP costs for foot and ankle orthopaedic surgical procedures have not been reported. Fully understanding patient OOP costs for common orthopaedic surgical procedures, such as those performed on the foot and ankle, might help patients and professionals make informed decisions regarding treatment options and demonstrate to policymakers the growing unaffordability of these procedures. Questions/purposes (1) How do OOP costs for common outpatient foot and ankle surgical procedures for commercially insured patients compare between elective and trauma surgical procedures? (2) How do these OOP costs compare between patients enrolled in various insurance plan types? (3) How do these OOP costs compare between surgical procedures performed in hospital-based outpatient departments and ambulatory surgical centers (ASCs)? (4) How have these OOP costs changed over time? Methods This was a retrospective, comparative study drawn from a large, longitudinally maintained database. Data on adult patients who underwent elective or trauma outpatient foot or ankle surgical procedures between 2010 and 2020 were extracted using the MarketScan Database, which contains well-delineated cost variables for all patient claims, which are particularly advantageous for assessing OOP costs. Of the 1,031,279 patient encounters initially identified, 41% (427,879) met the inclusion criteria. Demographic, procedural, and financial data were recorded. The median patient age was 50 years (IQR 39 to 57); 65% were women, and more than half of patients were enrolled in preferred provider organization insurance plans. Approximately 75% of surgical procedures were classified as elective (rather than trauma), and 69% of procedures were performed in hospital-based outpatient departments (rather than ASCs). The primary outcome was OOP costs incurred by the patient, which were defined as the sum of the deductible, coinsurance, and copayment paid for each episode of care. Monetary data were adjusted to 2020 USD. A general linear regression, the Kruskal-Wallis test, and the Wilcoxon-Mann-Whitney test were used for analysis, as appropriate. Alpha was set at 0.05. Results For foot and ankle indications, trauma surgical procedures generated higher median OOP costs than elective procedures (USD 942 [IQR USD 150 to 2052] versus USD 568 [IQR USD 51 to 1426], difference of medians USD 374; p < 0.001). Of the insurance plans studied, high-deductible health plans had the highest median OOP costs. OOP costs were lower for procedures performed in ASCs than in hospital-based outpatient departments (USD 645 [IQR USD 114 to 1447] versus USD 681 [IQR USD 64 to 1683], difference of medians USD 36; p < 0.001). This trend was driven by higher coinsurance for hospital-based outpatient departments than for ASCs (USD 391 [IQR USD 0 to 1136] versus USD 337 [IQR USD 0 to 797], difference of medians USD 54; p < 0.001). The median OOP costs for common outpatient foot and ankle surgical procedures increased by 102%, from USD 450 in 2010 to USD 907 in 2020. Conclusion Rapidly increasing OOP costs of common foot and ankle orthopaedic surgical procedures warrant a thorough investigation of potential cost-saving strategies and initiatives to enhance healthcare affordability for patients. In particular, measures should be taken to reduce underuse of necessary care for patients enrolled in highdeductible health plans, such as shorter-term deductible timespans and placing additional regulations on the implementation of these plans. Moreover, policymakers and physicians could consider finding ways to increase the proportion of procedures performed at ASCs for procedure types that have been shown to be equally safe and effective as in hospital-based outpatient departments. Future studies should extend this analysis to publicly insured patients and further investigate the health and financial effects of highdeductible health plans and ASCs, respectively. Level of Evidence Level III, economic and decision analysis. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Patient Removal of Urinary Catheters After Urogynecologic Surgery.
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Askew, Amy L., Margulies, Samantha L., Agu, Ijeoma, LeCroy, Katie M., Geller, Elizabeth, and Wu, Jennifer M.
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URINARY catheters , *UROGYNECOLOGIC surgery , *MEDICAL offices , *MEDICAL care use , *PELVIC organ prolapse , *MEDICAL slings , *IMPLANTABLE catheters - Abstract
OBJECTIVE: To compare postoperative urinary retention rates in the early postoperative period between home and office catheter removal. Secondary outcomes included pain, difficulty, satisfaction, likelihood to use again, and health care utilization. METHODS: We conducted a nonblinded, randomized controlled, noninferiority trial of women undergoing surgery for stress incontinence and prolapse from March 2021 to June 2022. Exclusion criteria were preoperative voiding dysfunction (need for self-catheterization or postvoid residual [PVR] greater than 150 mL), urethral bulking, and need for prolonged postoperative catheterization. Participants discharged with indwelling catheters because of an initial failed void trial were randomized 1:1 to home compared with office removal on postoperative day 3-4. For home removal, participants were instructed to remove the catheter at 7 am and to drink two glasses of water. If they had difficulty voiding 5 hours after catheter removal, they came to the office for a void trial. For office removal, participants returned for a backfill void trial with PVR assessment. Our primary outcome was rate of early postoperative urinary retention, defined as confirmed retention (PVR greater than half the voided volume) after catheter removal. Secondary outcomes were assessed at a 2-week call. Health care utilization (telephone calls and office visits) related to catheter issues was also assessed. At 80% power and a=0.05, we needed 100 participants (50/group) to detect a noninferiority margin of 11%. RESULTS: Among 117 participants, the home (n=59) and office (n=58) removal groups were similar in mean age (60 years vs 61 years), mean body mass index (29 vs 30), pelvic organ prolapse quantification system stage 3 or 4, and proportion who underwent hysterectomy or apical suspension. Sling procedures were more common in the office group (45.8% vs 77.6%). For our primary outcome, the rate of early postoperative retention was 11.9% in the home group and 22.4% in the office group (P=.13). Our predetermined noninferiority margin was greater than the upper bound of our 95% CI;thus, we conclude non-inferiority of home removal. For secondary outcomes, the home removal group was more likely to report "no pain" (P=.02) and "very likely" to use this method again (P=.004). There were no differences in difficulty or satisfaction between groups. Number of nursing calls was not different (P=.66);however, number of office visits was higher in the office group (median 0 [interquartile range 0-1] vs 1 [1-1], PC001). CONCLUSION: Postoperative urinary catheter removal by the patient at home was noninferior to office removal when early urinary retention rates were compared. Participants in the home removal group had fewer office visits and reported low pain, low difficulty, and high satisfaction. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Feasibility and reliability of a quantitative sensory testing protocol in youth with acute musculoskeletal pain postsurgery or postinjury.
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Li, Rui, Holley, Amy L., Palermo, Tonya M., Ohls, Olivia, Edwards, Robert R., and Rabbitts, Jennifer A.
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MUSCULOSKELETAL pain , *HISPANIC American youth , *PAIN tolerance , *PAIN threshold , *CHRONIC pain - Abstract
Supplemental Digital Content is Available in the Text. A brief quantitative sensory testing protocol tested in youth with acute musculoskeletal pain is feasible and shows reliability for multisite research. Quantitative sensory testing (QST) is increasingly used in pediatric chronic pain; however, assessment in youth with acute musculoskeletal (MSK) pain is limited. This study evaluated the feasibility, reliability, and sources of variability of a brief QST protocol in 2 clinical samples of youth with acute MSK pain. Participants were 277 youth (Mage = 14.5 years, SD = 2.0, range = 11-18 years, 59% female, 81% non-Hispanic) across 3 geographic study sites who completed a QST protocol assessing pressure and thermal pain sensitivity, temporal summation of pain, and conditioned pain modulation 8 weeks after MSK surgery (n = 100) or within 4 weeks after an acute MSK injury (n = 177). High feasibility was demonstrated by protocol completion rates ranging from 97.5% to 100% for each task, with 95.3% of youth completing all tasks. Reliability was high, with reliability coefficients of >0.97 for 7 out of 8 QST parameters and minimal influence of examiner or participating site effects. Younger youth had lower pressure and heat pain thresholds (11-12 vs 13-18 years, d = −0.80 to −0.56) and cold pain tolerance (d = −0.33). Hispanic youth had higher pressure and heat pain thresholds (d = 0.37-0.45) and pain ratings for cold pain tolerance (d = 0.54) compared with non-Hispanic youth. No significant differences were observed in QST values by sex or personal contextual factors at the time of assessment (momentary pain, menstrual period, use of pain medications). Overall findings demonstrate feasibility of a brief QST protocol with youth with diverse acute MSK pain and data provide initial support for the reliability of this QST protocol for multisite research studies. [ABSTRACT FROM AUTHOR]
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- 2023
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5. Cannabis update: Anxiety disorders and post-traumatic stress disorder.
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Haycraft, Amy L.
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MEDICAL marijuana laws , *DRUG tolerance , *POST-traumatic stress disorder , *MEDICAL marijuana , *ANXIETY disorders , *PATIENT safety , *THERAPEUTICS - Abstract
The development of anxiety disorders and post-traumatic stress disorder (PTSD) is complex. Both delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are of potential therapeutic use. Evidence suggests that cannabis has a beneficial effect on neural circuitry involved in fear regulation. In the United States, cannabis is considered either medical or recreational and can contain pure THC or CBD or any combination thereof. The numerous cannabis compounds of various administration routes, with variable pharmacokinetics, further affect the cannabis conundrum. Despite being federally unregulated, medical cannabis has received increased attention socially, and at present, 37 states, four territories, and the District of Columbia have legalized medical cannabis for use in specific health conditions. Patients are increasingly inquiring about cannabis, and clinicians must educate themselves with reliable cannabinoid information for patient education. In adults with anxiety disorders and PTSD, evidence supports a relatively safe profile for medical cannabis; however, conclusive scientific evidential support of its therapeutic properties is limited, resulting in a lack of standardization and Food and Drug Administration approval. [ABSTRACT FROM AUTHOR]
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- 2023
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6. Building the Roadmap to Health Equity Research: Extracorporeal Membrane Oxygenation Health Disparities*.
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Roswell, Robert O. and Dzierba, Amy L.
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HEALTH equity , *EXTRACORPOREAL membrane oxygenation , *COVID-19 pandemic , *SOCIAL determinants of health , *INSTITUTIONAL racism - Abstract
Even though this roadmap for health equity research centers around ECMO disparities, it can be used as an exemplar for health equity research throughout critical care and medicine ( B b ). Keywords: disparities; extracorporeal membrane oxygenation; intensive care unit; race; structural inequalities; systemic review EN disparities extracorporeal membrane oxygenation intensive care unit race structural inequalities systemic review 964 966 3 06/19/23 20230701 NES 230701 In this issue of I Critical Care Medicine i , Moynihan et al ([1]) report the results of a scoping review investigating neonatal, pediatric, and adult extracorporeal membrane oxygenation (ECMO) use and associated outcomes across social determinants of health (SDoH). [Extracted from the article]
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- 2023
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7. A Five-Year Cost-Utility Analysis Comparing Synthetic Cage Versus Allograft Use in Anterior Cervical Discectomy and Fusion Surgery for Cervical Spondylotic Myelopathy.
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Raad, Micheal, Xu, Amy L., Ortiz-Babilonia, Carlos, Marrache, Majd, Durand, Wesley M., Greenberg, Marc, and Jain, Amit
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CERVICAL spondylotic myelopathy , *COST effectiveness , *PRICE indexes , *MONTE Carlo method , *HOMOGRAFTS , *DISCECTOMY - Abstract
Study Design.: Retrospective cost-utility analysis. Objective.: To conduct a cost-analysis comparing synthetic cage (SC) versus allograft (Allo) over a five-year time horizon. Summary of Background Data.: SC and Allo are two commonly used interbody choices for anterior cervical discectomy and fusion (ACDF) surgery. Previous analyses comparative analyses have reached mixed conclusions regarding their cost-effectiveness, yet recent estimates provide high-quality evidence. Materials and Methods.: A decision-analysis model comparing the use of Allo versus SC was developed for a hypothetical 60-year-old patient with cervical spondylotic myelopathy undergoing single-level ACDF surgery. A comprehensive literature review was performed to estimate probabilities, costs (2020 USD) and quality-adjusted life years (QALYs) gained over a five-year period. A probabilistic sensitivity analysis using a Monte Carlo simulation of 1000 patients was carried out to calculate incremental cost-effectiveness ratio and net monetary benefits. One-way deterministic sensitivity analysis was performed to estimate the contribution of individual parameters to uncertainty in the model. Results.: The use of Allo was favored in 81.6% of the iterations at a societal willing-to-pay threshold of 50,000 USD/QALY. Allo dominated (higher net QALYs and lower net costs) in 67.8% of the iterations. The incremental net monetary benefits in the Allo group was 2650 USD at a willing-to-pay threshold of 50,000 USD/QALY. One-way deterministic sensitivity analysis revealed that the cost of the index surgery was the only factor which significantly contributed to uncertainty. Conclusion.: Cost-utility analysis suggests that Allo maybe a more cost-effective option compared with SCs in adult patients undergoing ACDF for cervical spondylotic myelopathy. [ABSTRACT FROM AUTHOR]
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- 2023
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8. Trends in pelvic pain symptoms over 2 years of follow-up among adolescents and young adults with and without endometriosis.
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Sasamoto, Naoko, Shafrir, Amy L., Wallace, Britani M., Vitonis, Allison F., Fraer, Cameron J., Sadler Gallagher, Jenny, DePari, Mary, Ghiasi, Marzieh, Laufer, Marc R., Sieberg, Christine B., DiVasta, Amy D., Schrepf, Andrew, As-Sanie, Sawsan, Terry, Kathryn L., and Missmer, Stacey A.
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PELVIC pain , *YOUNG adults , *ENDOMETRIOSIS , *TEENAGERS , *WOMEN'S health - Abstract
Supplemental Digital Content is Available in the Text. Pelvic pain characteristics, including severity, differed by pain type and endometriosis status across 2 years, supporting the importance of assessing multidimensional features of pelvic pain. We described trends in pelvic pain characteristics over 2 years of follow-up among adolescents and adults with and without endometriosis participating in the longitudinal observational cohort of the Women's Health Study: From Adolescence to Adulthood, using data reported at baseline and at years 1 and 2 of follow-up. Participants completed a questionnaire at baseline (between November 2012 and May 2019) and annually thereafter that included validated measures of severity, frequency, and life interference of dysmenorrhea, acyclic pelvic pain, and dyspareunia. Our study population included 620 participants with surgically confirmed endometriosis (rASRM stage I/II = 95%) and 671 community-based and hospital-based controls, with median age = 19 and 24 years, respectively. The proportion reporting hormone use varied across the 3 years ranging from 88% to 92% for cases and 56% to 58% for controls. At baseline, endometriosis cases were more likely to report severe, frequent, and life-interfering dysmenorrhea, acyclic pelvic pain, and dyspareunia compared with controls. Among cases, frequency and severity of dysmenorrhea and dyspareunia were relatively static across 2 years. However, acyclic pelvic pain improved. Severe acyclic pain decreased from 69% at baseline to 46% at year 2. Daily pain decreased from 28% to 14%, and life interference from 68% to 38%. Trends among controls remained fairly stable across 2 years. Among endometriosis cases who completed the questionnaire at all 3 time points, 18% reported persistent, severe acyclic pelvic pain at all 3 time points. Over time, different trends were observed by pelvic pain type among endometriosis cases and controls, supporting the importance of assessing multidimensional features of pelvic pain. [ABSTRACT FROM AUTHOR]
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- 2023
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9. Oxygen saturation probe-related pressure injury prevention in children on an inpatient pediatric unit: a best practice implementation project.
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Carroll, Amy L., Palokas, Michelle, and Linnell, Shelbi
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AUDITING , *PROFESSIONAL practice , *TEAMS in the workplace , *OXIMETRY , *PRESSURE ulcers , *CHILDREN'S hospitals , *STAKEHOLDER analysis , *OXYGEN saturation , *EVIDENCE-based medicine , *HUMAN services programs , *MEDICAL protocols , *DOCUMENTATION , *QUALITY assurance , *ELECTRONIC health records , *HOSPITAL care of children , *CHILDREN - Abstract
Objectives: The aim of this project was to increase compliance with rotation and documentation of rotation of oxygen saturation probes to reduce medical-device-related pressure injuries in children on a pediatric inpatient unit. Introduction: There are a multitude of factors that place hospitalized children at an increased risk for medicaldevice-related pressure injuries. Evidence supports the rotation of medical devices, if appropriate, at least twice daily to minimize the risk of medical-device-related pressure injuries in hospitalized children. Methods: The project used JBI's Practical Application of Clinical Evidence System and Getting Research into Practice audit tool for encouraging evidence-based practices. A baseline audit was conducted, followed by the implementation of targeted strategies. The project was completed with a follow-up audit to determine change in practice. Results: The baseline audit revealed significant deficits in two of the seven audit criteria. Barriers to the rotation of oxygen saturation probes and the assessment of skin under oxygen saturation probes were identified by the project team and an electronic health record (EHR) documentation change was implemented. Follow-up audits were not conducted on the five criteria that showed high compliance at baseline. For the remaining two audit criteria, data revealed no improvement in one of the criteria (3% compliance at both baseline and follow-up audits) and an increase from 0% compliance to 43% compliance in the second criterion. Conclusion: Optimizing EHR documentation, specifically ease and efficiency of EHR documentation, has the potential to positively impact clinical practice. Key words: evidence-based practice, hospitalized, implementation project, medical-device-related pressure injuries, pediatrics. [ABSTRACT FROM AUTHOR]
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- 2023
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10. A new cardiovascular disease risk factor for young adults: Preterm birth.
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Brewer, Pamela L., D'Agata, Amy L., and Sullivan, Mary C.
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CARDIOVASCULAR diseases risk factors , *HYPERTENSION , *PREMATURE infants , *MEDICAL protocols , *ADULTS ,CARDIOVASCULAR disease related mortality - Abstract
Adults born preterm (birth <37 weeks' gestation) have a two-fold increased risk of early cardiovascular mortality. With 10% of the U.S. population born prematurely and perinatal advancements dramatically improving survival rates, millions of survivors are now reaching adulthood. This phenomenon has introduced a whole new population of individuals with a history of preterm birth. Although the prevailing notion has been that preterm birth is a condition confined only to infancy and early childhood, we now know preterm birth is a risk for lifelong chronic health conditions. Despite almost a decade of epidemiological evidence showing increased cardiovascular risk for those born preterm, this has not yet been translated into clinical practice. As a result, clinicians are caring for adults born prematurely without screening and treatment guidelines for this at-risk population and few inquire about birth history during clinical encounters. This brief report presents growing evidence about disrupted cardiogenesis and consequential structural and functional modifications. By asking the question "Were you born preterm?," nurse practitioners can take the first step of increasing their awareness of this at-risk population and mitigate adverse cardiovascular outcomes by using preterm birth as a risk factor when determining health promotion and treatment decisions. [ABSTRACT FROM AUTHOR]
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- 2022
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11. A Protocol to Assess Adult Outcomes at 30 Years Following Preterm Birth.
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Sullivan, Mary C., D'Agata, Amy L., Stanley, Zachary, Brewer, Pamela, and Kelly, Michelle M.
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PREMATURE infants , *HEALTH status indicators , *DISEASES , *PSYCHOLOGICAL adaptation , *EPIGENOMICS , *PSYCHOLOGICAL stress , *PSYCHOLOGICAL resilience , *ADULTS - Abstract
Background: Among the most intense adversity experiences for infants is premature birth. Early birth marks the beginning of a life course that broadly affects families, healthcare, education, social systems, and the survivors themselves. For many, the transition to adulthood is challenging and often hampered by cognitive, physical and mental health, and motor and independence difficulties. Objectives: The aim of this study was to share a comprehensive protocol of a 10th follow-up study of premature infants in their 30s. The protocol accounts for stress during the neonatal period, the cumulative context (risk and protection) of development, biological and epigenetic mechanisms, and individual resilience. Methods: The prospective, five-group longitudinal design includes 215 term-born and preterm-born individuals with various neonatal morbidities at ages 30–35 years. Adult outcomes include health, adaptive, executive function, work, and social competence. Novel measures are four system indicators of allostatic load (AL) and epigenetics. Contextual measures include socioeconomic risk and individual resilience. All measures were selected based on coherence with constructs of the scientific aims, strong psychometrics, continuity for repeated measures, and minimal subject burden. Objective assessments include body composition imaging, exercise testing, blood and saliva collection, and actigraphy. The two-phase protocol takes approximately 8 hours. Discussion: After an 11-month COVID-19 pause, participant response has been strong. As of May 2022, 75 participants have completed the full protocol, and 99 have consented to participate. When socioeconomic risk is controlled, we hypothesize that life course trajectories in physical and psychological health, adaptive function, and executive function will differ between term and preterm neonatal morbidity groups. AL will vary across groups and contribute to outcomes. We expect proximal protection and resilience to mediate the cumulative medical and socioeconomic risk and AL. Epigenome-wide DNA methylation, with estimates of age acceleration, will be examined across groups and explored in longitudinal associations with medical risk, socioeconomic status, and protection. To our knowledge, this is the only U.S. study of premature infants aged 30–35 years. With millions of preterm-born individuals reaching adulthood, the protocol incorporates molecular and genetic biomarkers in a life course developmental examination to inform the timing and content of interventions. [ABSTRACT FROM AUTHOR]
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- 2022
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12. Surgery in Pregnancy.
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Lightner, Amy L. and Mathis, Kellie L.
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APPENDICITIS , *APPENDECTOMY , *FETAL surgery , *PREGNANCY , *ABORTION , *BILIOUS diseases & biliousness - Abstract
Nonobstetric surgery during pregnancy is of important concern for both the pregnant patient and the fetus. In a series of 25 peripartum patients, symptomatic relief was obtained in 24/25 patients with morbidity reported in only 1 patient (significant postoperative hemorrhage). In general, a pregnant patient should never be denied medically necessary surgery or have life-threatening or urgent surgery delayed, regardless of trimester. Regarding the pregnant patient, surgery for major trauma should proceed as clinically indicated because delaying surgery can often be life-threatening, and without surgical intervention, both the pregnant patient and fetus remain at risk in such cases. [Extracted from the article]
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- 2022
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13. Ethical Considerations Surrounding Surgeon Ownership of Ambulatory Surgery Centers.
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Xu, Amy L, Jain, Amit FACS, Humbyrd, Casey Jo E, Jain, Amit, and Humbyrd, Casey Jo
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As surgical care continues to transition to an outpatient setting, ambulatory surgery centers (ASCs) present favorable options for physician investment. As of 2017, more than 90% of ASCs have at least some physician ownership, with 64% solely physician-owned. Yet, physician ownership creates an inherent conflict of interest known as dual agency, where clinicians have a personal financial stake in addition to their obligation towards patient well-being. Here, we assess the ethical considerations surrounding dual agency in the setting of ASCs through the lens of beneficence, nonmaleficence, autonomy, and justice. We further propose strategies for appropriate navigation of such situations, including disclosure of ownership status, instruction on unfamiliar techniques, and adherence to accepted clinical practice guidelines for materials selection and surgical indications. [ABSTRACT FROM AUTHOR]
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- 2022
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14. Association of an Obstetric Surgical Closing Protocol With Infection After Cesarean Delivery.
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Wyatt, Michelle A., Weaver, Amy L., Jensen, Claire, Yelsa, Isabel, Rangel Latuche, Laureano J., Sharpe, Emily E., and Rivera-Chiauzzi, Enid Y.
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CESAREAN section , *SURGICAL gloves , *SURGICAL site infections , *MEDICAL protocols , *SURGICAL instruments , *OPERATIVE surgery , *RETROSPECTIVE studies - Abstract
Objective: To examine surgical site infection rates before and after the addition of a closing protocol to an existing surgical site infection risk-reduction bundle used during cesarean delivery.Methods: We conducted a single-center retrospective cohort study to review the association of a closing protocol with rates of surgical site infection after cesarean delivery. The closing protocol included fresh surgical instruments and physician and scrub nurse glove change before fascia closure. Surgical site infections were defined using Centers for Disease Control and Prevention criteria. Eligible patients underwent cesarean delivery at our institution from July 1, 2013, through December 31, 2015 (n=1,708; preimplementation group), or from June 1, 2016, through April 30, 2018 (n=1,228; postimplementation group).Results: The surgical site infection rate was 2.3% preimplementation and 2.7% postimplementation (difference 0.4%, 95% CI -1.6 to 0.7%]. The mean [SD] duration of the surgical procedure was longer postimplementation (59.6 [23.7] vs 55.6 [21.5] minutes; P<.001).Conclusion: Addition of a closing tray and glove change to our existing surgical site infection risk-reduction bundle was not associated with a reduction in the frequency of postcesarean surgical site infection but was associated with longer operating times. [ABSTRACT FROM AUTHOR]- Published
- 2022
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15. Discordance Between Respiratory Drive and Sedation Depth in Critically Ill Patients Receiving Mechanical Ventilation.
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Dzierba, Amy L., Khalil, Anas M., Derry, Katrina L., Madahar, Purnema, and Beitler, Jeremy R.
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ARTIFICIAL respiration , *CRITICALLY ill , *ADULT respiratory distress syndrome , *EXPIRATORY flow , *NEUROMUSCULAR diseases , *ADULTS , *RETROSPECTIVE studies , *CATASTROPHIC illness , *RESEARCH funding , *RESPIRATORY mechanics , *LONGITUDINAL method - Abstract
Objectives: In mechanically ventilated patients, deep sedation is often assumed to induce "respirolysis," that is, lyse spontaneous respiratory effort, whereas light sedation is often assumed to preserve spontaneous effort. This study was conducted to determine validity of these common assumptions, evaluating the association of respiratory drive with sedation depth and ventilator-free days in acute respiratory failure.Design: Prospective cohort study.Setting: Patients were enrolled during 2 month-long periods in 2016-2017 from five ICUs representing medical, surgical, and cardiac specialties at a U.S. academic hospital.Patients: Eligible patients were critically ill adults receiving invasive ventilation initiated no more than 36 hours before enrollment. Patients with neuromuscular disease compromising respiratory function or expiratory flow limitation were excluded.Interventions: Respiratory drive was measured via P0.1, the change in airway pressure during a 0.1-second airway occlusion at initiation of patient inspiratory effort, every 12 ± 3 hours for 3 days. Sedation depth was evaluated via the Richmond Agitation-Sedation Scale. Analyses evaluated the association of P0.1 with Richmond Agitation-Sedation Scale (primary outcome) and ventilator-free days.Measurements and Main Results: Fifty-six patients undergoing 197 bedside evaluations across five ICUs were included. P0.1 ranged between 0 and 13.3 cm H2O (median [interquartile range], 0.1 cm H2O [0.0-1.3 cm H2O]). P0.1 was not significantly correlated with the Richmond Agitation-Sedation Scale (RSpearman, 0.02; 95% CI, -0.12 to 0.16; p = 0.80). Considering P0.1 terciles (range less than 0.2, 0.2-1.0, and greater than 1.0 cm H2O), patients in the middle tercile had significantly more ventilator-free days than the lowest tercile (incidence rate ratio, 0.78; 95% CI, 0.65-0.93; p < 0.01) or highest tercile (incidence rate ratio, 0.58; 95% CI, 0.48-0.70; p < 0.01).Conclusions: Sedation depth is not a reliable marker of respiratory drive during critical illness. Respiratory drive can be low, moderate, or high across the range of routinely targeted sedation depth. [ABSTRACT FROM AUTHOR]- Published
- 2021
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16. Depression After Open Heart Surgery: Influences of Optimism, Sex, and Event-Related Medical Factors.
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Ai, Amy L. and Smyth, Susan S.
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Abstract: Postoperative depression is a multifaceted condition that can limit quality of life and potentially decrease the survival benefits of open heart surgery (OHS). We postulated that sex, pre-event character strengths, medical, and certain surgery indicators would predict post-event/myocardial infarction depression. To identify predictors, we collected three-wave survey data from 481 OHS patients at a large academic referral institution (age, 62+; female, 42%) and included key medical and surgical information. The final model (F[7, N = 293] = 28.15, p < 0.001, R2 = 0.408) accounted for over two fifths of the variance in post-OHS depression. Pre-event/OHS optimism mitigated post-OHS depression. Being female, older, living alone, longer surgical perfusion time, absence of left main disease greater than 50%, and pre-OHS depression were associated with the increased likelihood of post-OHS depression. Our findings suggest that teaching optimism to OHS patients might be beneficial in reducing the risk of postoperative depression and that female patients should be monitored more closely for the development of depression through an interdisciplinary approach. [ABSTRACT FROM AUTHOR]- Published
- 2021
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17. Examining Disparities in Route of Surgery and Postoperative Complications in Black Race and Hysterectomy.
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Alexander, Amy L. MD, MS, Strohl, Anna E. MD, MA, Rieder, Stephanie MD, PhD, Holl, Jane MD, MPH, Barber, Emma L. MD, MS, Alexander, Amy L, Strohl, Anna E, Rieder, Stephanie, Holl, Jane, and Barber, Emma L
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SURGICAL complications , *HYSTERECTOMY , *BODY mass index , *RACE , *BLACK women , *VAGINAL hysterectomy - Abstract
Objective: To estimate the associations among race, route of hysterectomy, and postoperative complications among women undergoing hysterectomy for benign indications.Methods: A cohort study was performed. All patients undergoing hysterectomy for benign indications, recorded in the National Surgical Quality Improvement Program and its targeted hysterectomy file in 2015, were identified. The primary exposure was patient race. The primary outcome was route of hysterectomy and the secondary outcome was postoperative complication. Associations were examined using both bivariable tests and logistic regression.Results: Of 15,136 women who underwent hysterectomy for benign indications, 75% were white and 25% were black. Black women were more likely to undergo an open hysterectomy than white women (50.1% vs 22.9%; odds ratio [OR] 3.36, 95% CI 3.11-3.64). Black women had larger uteri (median 262 g vs 123 g; 60.7% vs 25.6% with uterus greater than 250 g), more prior pelvic surgery (58.5% vs 53.2%), and higher body mass indices (32.7 vs 30.4). After adjusting for these and other clinical factors, black women remained more likely to undergo an open hysterectomy (adjusted OR 2.02, 95% CI 1.85-2.20). Black women experienced more major complications than white women (4.1% vs 2.3%; P<.001) and more minor complications (11.4% vs 6.7%; OR 1.78, P<.001). Again these disparities persisted with adjustment (major adjusted OR 1.56, 95% CI 1.25-1.95; minor adjusted OR 1.27, 95% CI 1.11-1.47).Conclusions: Black women undergo a higher proportion of open hysterectomy and experience more major and minor postoperative complications. These differences persisted even after adjusting for confounding medical, surgical, and gynecologic factors. [ABSTRACT FROM AUTHOR]- Published
- 2019
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18. Preoperative Optimism Related to Low Anxiety in Patients 1 Month After Open Heart Surgery.
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Ai, Amy L., McMullen, Colleen A., and Smyth, Susan S.
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ANXIETY , *CARDIAC surgery , *CORONARY artery bypass , *PREOPERATIVE period , *SURGICAL complications , *HEART valve surgery , *PROSTHETIC heart valves , *RESEARCH funding , *HEART diseases - Abstract
Anxiety can contribute to poor prognosis in cardiac patients. Few studies have examined the role of optimism in anxiety after open heart surgery (OHS). This study investigated the influence of preoperative optimism on post-OHS anxiety, adjusting cardiac indices used by cardiac surgeons. Data were collected before and 1 month after OHS in 481 patients (58% men; age, 62.4 ± 11.94 years). Optimism was measured using the Life Orientation Test. Anxiety was measured using the Trait Anxiety Inventory. Medical and cardiac indices were retrieved from the Society of Thoracic Surgeon's national database. Multiple regression analyses showed that greater pre-OHS optimism was associated with lower levels of post-OHS anxiety (F[6, N = 306] = 50.18, p < 0.001, R = 0.502). No other factors showed similar protection. Pre-OHS anxiety, younger age, and minority status were associated with anxiety in the critical recovery month. The findings demonstrate the potential benefit of optimism against post-OHS anxiety, which may have clinical implications for improving disease management. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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19. Quantitative somatosensory testing of the abdomen: establishing initial reference values across developmental age and biological sex.
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Sieberg, Christine B., Lunde, Claire E., Shafrir, Amy L., Meints, Samantha M., Madraswalla, Mehnaz, Huntley, Devon, Olsen, Hannah, Wong, Cindy, DiVasta, Amy D., Missmer, Stacey A., and Sethna, Navil
- Subjects
- *
SEX (Biology) , *REFERENCE values , *INFLAMMATORY bowel diseases , *ABDOMEN , *YOUNG adults , *IRRITABLE colon , *PELVIC pain - Abstract
Abdominal pain is a common symptom of several debilitating conditions (eg, inflammatory bowel disease, irritable bowel syndrome, and endometriosis) and affects individuals throughout their lifespan. Quantitative sensory testing (QST) reference values exist for many body sites but not the abdomen. Using a QST battery adapted from the German Research Network on Neuropathic Pain, we collected QST data on the upper and lower abdomen in 181 pain-free participants, ages 12 to 50 years, to establish reference values by age and biological sex. The normative values are presented as medians for each QST measure by sex (male, n = 63; female, n = 118) and across 3 age categories (adolescents: 12-19 years, n = 48; young adults: 20-30 years, n = 87; and adults: 31-50 years, n = 46). Evaluating the sensory functioning of the abdomen and characterizing ranges of QST measures is an essential first step in understanding and monitoring the clinical course of sensory abnormalities in patients with underlying diseases affecting the abdomen and pelvis. The impact of age and development on sensory functioning is necessary, given age-related changes in pain perception and modulation. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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- View/download PDF
20. Brief Report: HIV Drug Resistance Assessment Among Women Who Seroconverted During the MTN-025/HOPE Open-Label Extension Dapivirine Vaginal Ring Trial.
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Parikh, Urvi M., Penrose, Kerri J., Heaps, Amy L., Sethi, Rahil, Goetz, B. Jay, Szydlo, Daniel, Chandran, Uma, Palanee-Phillips, Thesla, Mgodi, Nyaradzo M., Baeten, Jared M., and Mellors, John W.
- Abstract
Background: Clinical trials of dapivirine (DPV) vaginal ring have shown it is safe, effective, and desired by women as an HIV prevention option. The risk of drug resistance is a potential concern for DPV ring users who acquire HIV. We conducted a comprehensive resistance evaluation of plasma samples from the women who seroconverted during the Microbicide Trials Network-025/HIV Open-label Prevention Extension (HOPE) study of DPV ring. Methods: Plasma collected on the visit at which seroconversion was detected was tested by next-generation sequencing with unique molecular identifiers for non-nucleoside reverse transcriptase inhibitor (NNRTI) drug resistance mutations (DRM) present at ≥1% frequency. Bulk-cloned plasma-derived recombinant HIV was phenotyped in a TZM-bl–based assay for susceptibility to DPV and other NNRTI. HIV-1 RNA was retrospectively quantified in plasma samples collected before HIV seroconversion. Results: Among 38 participants who seroconverted in HOPE, 7 (18%) had NNRTI DRM detected by next-generation sequencing with unique molecular identifiers including A98G, K103N, V106M, E138A, and V179D. Six of 7 samples with NNRTI DRM had <3-fold reduction in susceptibility to DPV. Only 1 sample with K103N and V179I polymorphism had 9-fold reduction in susceptibility to DPV, but this genotype occurred in an individual who did not use DPV ring, likely indicating transmitted resistance. Detection of NNRTI resistance was not higher in individuals who remained on DPV ring >3 months after acquiring HIV infection. Conclusions: NNRTI resistance among women who seroconverted during HOPE was infrequent and selection of DPV-specific mutations was not detected. DPV ring is considered a safe and effective option for HIV prevention in women. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
21. Vanishing Twins Conceived Through Fresh In Vitro Fertilization: Obstetric Outcomes and Placental Pathology.
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Harris, Amy L., Sacha, Caitlin R., Basnet, Kristen M., James, Kaitlyn E., Freret, Taylor S., Kaimal, Anjali J., Yeh, John, Souter, Irene, Roberts, Drucilla J., and Toth, Thomas L.
- Subjects
- *
FETOFETAL transfusion , *FERTILIZATION in vitro , *ANATOMICAL pathology , *TWINS , *FISHER exact test , *CLINICAL pathology , *PREMATURE infants , *MISCARRIAGE , *RETROSPECTIVE studies , *GESTATIONAL age , *PERINATAL death , *EMBRYO transfer , *PREGNANCY outcomes , *PLACENTA , *HUMAN reproductive technology , *BIRTH weight , *LOGISTIC regression analysis , *MULTIPLE pregnancy - Abstract
Objective: To characterize the obstetric outcomes and placental pathology in live births arising from vanishing twin pregnancies compared with nonreduced in vitro fertilization (IVF) pregnancies.Methods: This is a retrospective cohort study of live births resulting from fresh embryo transfers after IVF cycles with autologous oocytes from 2004 through 2017 at a large academic fertility center. Clinical information and pathology reports were reviewed. Placental diagnoses were coded using established nosology by expert placental pathologists. Analysis of variance, Kruskal-Wallis, Pearson's χ, and Fisher exact tests were used, as appropriate, to compare pathology categories between pregnancy outcomes. Mixed effects logistic regression models were generated to reveal the association between pregnancy outcome and placenta pathology, controlling for pregnancies arising in the same woman and various suspected confounders.Results: Of 905 fresh autologous IVF cycles with placental pathology available for review, we identified 73 vanishing twin pregnancies (8.1%), 556 singleton pregnancies (61.4%), and 276 twin pregnancies (30.5%). Vanishing twin syndrome was not associated with preterm delivery, route of delivery, growth restriction or other obstetric outcomes as compared with IVF singleton pregnancies. However, vanishing twin syndrome pregnancies showed distinctive placental pathologies including an increased rate of small placentas (less than the 10th percentile by weight), with more anatomical abnormalities than IVF singleton pregnancies (odds ratio 1.73, 95% CI 0.94-3.19; adjusted odds ratio 2.15, 95% CI 1.08-4.28). The frequency of placental vascular and inflammatory pathologies associated with IVF vanishing twin syndrome pregnancies were similar to that of IVF singleton pregnancies. Loss of a twin after 8 weeks of gestation was not associated with greater risks of placental pathologies.Conclusion: In vitro fertilization pregnancies affected by vanishing twin syndrome did not have significant differences in obstetric or perinatal outcomes as compared with twin or singleton gestations. However, early twin loss was potentially associated with differences in placental development associated with a higher rate of small placentas and other anatomic pathologies. [ABSTRACT FROM AUTHOR]- Published
- 2020
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22. An Introduction to Causal Diagrams for Anesthesiology Research.
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Gaskell, Amy L. and Sleigh, Jamie W.
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- *
RESEARCH , *MEDICAL illustration , *ANESTHESIOLOGY , *RESEARCH methodology , *EVALUATION research , *MEDICAL cooperation , *COMPARATIVE studies , *ATTRIBUTION (Social psychology) , *MEDICAL research - Abstract
Making good decisions in the era of Big Data requires a sophisticated approach to causality. We are acutely aware that association ≠ causation, yet untangling the two remains one of our greatest challenges. This realization has stimulated a Causal Revolution in epidemiology, and the lessons learned are highly relevant to anesthesia research. This article introduces readers to directed acyclic graphs; a cornerstone of modern causal inference techniques. These diagrams provide a robust framework to address sources of bias and discover causal effects. We use the topical question of whether anesthetic technique (total intravenous anesthesia vs. volatile) affects outcome after cancer surgery as a basis for a series of example directed acyclic graphs, which demonstrate how variables can be chosen to statistically control confounding and other sources of bias. We also illustrate how controlling for the wrong variables can introduce, rather than eliminate, bias; and how directed acyclic graphs can help us diagnose this problem.This is a rapidly evolving field, and we cover only the most basic elements. The true promise of these techniques is that it may become possible to make robust statements about causation from observational studies-without the expense and artificiality of randomized controlled trials. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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23. Compensatory Motion of the Subtalar Joint Following Tibiotalar Arthrodesis: An in Vivo Dual-Fluoroscopy Imaging Study.
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Lenz, Amy L., Nichols, Jennifer A., Roach, Koren E., Foreman, K. Bo, Barg, Alexej, Saltzman, Charles L., and Anderson, Andrew E.
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- *
SUBTALAR joint , *ARTHRODESIS , *FLUOROSCOPY , *RANGE of motion of joints , *JOINT hypermobility , *DIAGNOSTIC imaging , *MOTION capture (Human mechanics) , *ANKLEBONE surgery , *TIBIA surgery , *RETROSPECTIVE studies , *SURGICAL complications , *OSTEOARTHRITIS , *WALKING , *RESEARCH funding , *LONGITUDINAL method - Abstract
Background: Tibiotalar arthrodesis is a common treatment for end-stage tibiotalar osteoarthritis, and is associated with a long-term risk of concomitant subtalar osteoarthritis. It has been clinically hypothesized that subtalar osteoarthritis following tibiotalar arthrodesis is the product of compensatory subtalar joint hypermobility. However, in vivo measurements of subtalar joint motion following tibiotalar arthrodesis have not been quantified. Using dual-fluoroscopy motion capture, we tested the hypothesis that the subtalar joint of the limb with a tibiotalar arthrodesis would demonstrate differences in kinematics and increased range of motion compared with the subtalar joint of the contralateral, asymptomatic, untreated ankle.Methods: Ten asymptomatic patients who had undergone unilateral tibiotalar arthrodesis at a mean (and standard deviation) of 4.0 ± 1.8 years previously were evaluated during overground walking and a double heel-rise task. The evaluation involved markerless tracking with use of dual fluoroscopy integrated with 3-dimensional computed tomography, which allowed for dynamic measurements of subtalar and tibiotalar dorsiflexion-plantar flexion, inversion-eversion, and internal-external rotation. Range of motion, stance time, swing time, step length, and step width were also measured.Results: During the early stance phase of walking, the subtalar joint of the limb that had been treated with arthrodesis was plantar flexed (-4.7° ± 3.3°), whereas the subtalar joint of the untreated limb was dorsiflexed (4.6° ± 2.2°). Also, during the early stance phase of walking, eversion of the subtalar joint of the surgically treated limb (0.2° ± 2.3°) was less than that of the untreated limb (4.5° ± 3.2°). During double heel-rise, the treated limb exhibited increased peak subtalar plantar flexion (-7.1° ± 4.1°) compared with the untreated limb (0.2° ± 1.8°).Conclusions: A significant increase in subtalar joint plantar flexion was found to be a primary compensation during overground walking and a double heel-rise activity following tibiotalar arthrodesis.Clinical Relevance: Significant subtalar joint plantar flexion compensations appear to occur following tibiotalar arthrodesis. We found an increase in subtalar plantar flexion and considered the potential relationship of this finding with the increased rate of subtalar osteoarthritis that occurs following ankle arthrodesis. [ABSTRACT FROM AUTHOR]- Published
- 2020
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24. Clinical Documentation for Intensivists: The Impact of Diagnosis Documentation.
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Sanderson, Amy L. and Burns, Jeffrey P.
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- *
ELECTRONIC health records , *DOCUMENTATION , *CRITICAL care medicine , *MEDICAL societies , *DATA extraction , *INFORMATION retrieval standards , *DIAGNOSIS related groups , *INTENSIVE care units , *MEDICAL coding - Abstract
Objectives: The aim of this review is to describe the interaction of clinical documentation with patient care, measures of patient acuity, quality metrics, research database accuracy, and healthcare reimbursement in order to highlight potential areas of improvement for intensivists.Data Sources: An online search of PubMed was undertaken as well as review of resources published by the American Academy of Pediatrics, the Society of Critical Care Medicine, the American Medical Association, and the Association of Clinical Documentation Improvement Specialists.Study Selection: Selected publications included those that described coding, medical record documentation, healthcare reimbursement, quality metrics, administrative databases, Clinical Documentation Improvement programs, medical scribe programs, and various payment models.Data Extraction: Relevant information was extracted to highlight the impact of diagnosis documentation on patient care, perceived patient severity of illness, quality metrics, and healthcare reimbursement. Query data from our hospital's Clinical Documentation Improvement program were reviewed to highlight areas of improvement within our own Division of Critical Care Medicine. Additionally, interventions to improve clinical documentation were incorporated into this review.Data Synthesis: Available data in the literature indicate that documentation of precise diagnoses in the medical record has a positive impact on quality metrics, accuracy of administrative databases, hospital reimbursement, and perceived patient complexity. However, there is insufficient data to make conclusions regarding documentation of specific diagnoses and effects on patient care. Administrative responsibilities associated with documentation have been increasing, especially with the introduction of electronic medical records.Conclusions: Documentation of specific diagnoses in the medical record is important in the broad context of our existing medical system but there is an associated burden in doing so. Widespread implementation of electronic medical record systems has inadvertently led to clinician dissatisfaction and burnout. Research is needed to further evaluate the impact of documentation on patient care as well as steps to decrease the associated burden. [ABSTRACT FROM AUTHOR]- Published
- 2020
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- View/download PDF
25. Office-based Approach to Evaluation and Management of Abnormal Uterine Bleeding.
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GARCIA, AMY L.
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- *
UTERINE hemorrhage treatment , *DIAGNOSTIC imaging , *HYSTEROSCOPY , *ULTRASONIC imaging , *UTERINE hemorrhage , *WOMEN'S health , *DISEASE management , *ABLATION techniques - Abstract
Evaluation and management of abnormal uterine bleeding (AUB) are possible in the office. Approaching AUB evaluation from an etiology-based perspective allows the gynecologist to focus evaluation efforts on the most probable causes of AUB for a particular patient and therefore customize the management accordingly. Developing skills with imaging such as transvaginal ultrasound, saline infusion sonography, and diagnostic hysteroscopy are important for AUB etiology diagnosis. Operative hysteroscopy experience can be developed for AUB management in the office and endometrial ablation provides a minimally invasive solution for some patients. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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26. Chronic stress-associated visceral hyperalgesia correlates with severity of intestinal barrier dysfunction.
- Author
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Creekmore, Amy L., Shuangsong Hong, Shengtao Zhu, Jing Xue, Wiley, John W., Hong, Shuangsong, Zhu, Shengtao, and Xue, Jing
- Subjects
- *
PSYCHOLOGICAL stress , *HYPERALGESIA , *ANIMAL models in research , *VISCERAL pain , *PERMEABILITY , *GASTROINTESTINAL disease diagnosis , *ANIMAL experimentation , *GASTROINTESTINAL diseases , *INTESTINAL mucosa , *RATS , *RESEARCH funding , *SEVERITY of illness index - Abstract
In humans, chronic psychological stress is associated with increased intestinal paracellular permeability and visceral hyperalgesia, which is recapitulated in the chronic intermittent water avoidance stress (WAS) rat model. However, it is unknown whether enhanced visceral pain and permeability are intrinsically linked and correlate. Treatment of rats with lubiprostone during WAS significantly reduced WAS-induced changes in intestinal epithelial paracellular permeability and visceral hyperalgesia in a subpopulation of rats. Lubiprostone also prevented WAS-induced decreases in the epithelial tight junction protein, occludin (Ocln). To address the question of whether the magnitude of visceral pain correlates with the extent of altered intestinal permeability, we measured both end points in the same animal because of well-described individual differences in pain response. Our studies demonstrate that visceral pain and increased colon permeability positively correlate (0.6008, P = 0.0084). Finally, exposure of the distal colon in control animals to Ocln siRNA in vivo revealed that knockdown of Ocln protein inversely correlated with increased paracellular permeability and enhanced visceral pain similar to the levels observed in WAS-responsive rats. These data support that Ocln plays a potentially significant role in the development of stress-induced increased colon permeability. We believe this is the first demonstration that the level of chronic stress-associated visceral hyperalgesia directly correlates with the magnitude of altered colon epithelial paracellular permeability. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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27. CORR Insights®: What Demographic and Clinical Characteristics Correlate With Expectations With Trapeziometacarpal Arthritis?
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Ladd, Amy and Ladd, Amy L
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- *
OSTEOARTHRITIS treatment , *OSTEOARTHRITIS , *THUMB , *TYPE 2 diabetes , *DISEASES , *PATIENTS - Abstract
The article reports the study by Kang et al. about the expectations that patients have with regards to the treatment of thumb trapeziometacarpal osteoarthritis. Topics include the importance of the trapeziometacarpal joint, the occurrence of arthritis in the thumb joint, and the accuracy of the treatment.
- Published
- 2017
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28. Variability in Acuity in Acute Care.
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Garcia, Amy L.
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HEART failure , *ANALYSIS of variance , *CONCEPTUAL structures , *CRITICAL care medicine , *LENGTH of stay in hospitals , *WORKING hours , *LONGITUDINAL method , *MATHEMATICAL models , *RESEARCH methodology , *MEDICAL quality control , *NOSOLOGY , *NURSING , *HEALTH outcome assessment , *PROBABILITY theory , *STATISTICS , *MATHEMATICAL variables , *THEORY , *STATISTICAL power analysis , *DATA analysis , *EFFECT sizes (Statistics) , *INTER-observer reliability , *REPEATED measures design , *RETROSPECTIVE studies , *ELECTRONIC health records , *DESCRIPTIVE statistics , *DIAGNOSIS - Abstract
OBJECTIVE: This study was designed to describe variable acuity among 1 population of acute care patients. BACKGROUND: Acuity, defined as the individual patient need for nursing care, can inform level of care, nurse staffing, and the nurse-to-patient assignment. Nurse-generated data in the electronic health record can be mined and analyzed for decision support. METHODS: This study used a descriptive, retrospective analysis of repeated measures of acuity generated from 28 739 nursing assessments of 405 consecutive subjects treated for heart failure (HF) in a 455-bed southern hospital. RESULTS: Patients treated for HF have variable care needs throughout the course of treatment. Univariate analysis of variance and post hoc analysis found that gender, age, type of unit, and length of stay (LOS) had a significant impact on acuity, P < .01, with a very small effect of less than 1%, indicating that acuity should be measured instead of assumed. Patients in medical-surgical and step-down units had highly variable acuity, ranging from ready to discharge to acuity levels consistent with critical care. Across the LOS, the mean acuity stabilized at 12 hours after admission, decreased until 88 hours, then increased steadily through discharge. CONCLUSIONS: Understanding the variability in acuity within an individual patient, or a specific patient population, will contribute to decision support levels of patient care, staffing, nurse-patient assignments, and the cost of care. Frequent, sequential, and real-time measures of acuity may be valuable for tracking patient progress or measuring response to nursing interventions. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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29. Low-Force Muscle Activity Regulates Energy Expenditure after Spinal Cord Injury.
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Woelfel, Jessica R., Kimball, Amy L., Chu-Ling Yen, and Shields, Richard K.
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ADIPOSE tissues , *ELECTRIC stimulation , *ENERGY metabolism , *MUSCULOSKELETAL system physiology , *SPINAL cord injuries , *HAMSTRING muscle , *QUADRICEPS muscle , *BODY mass index , *OXYGEN consumption , *DESCRIPTIVE statistics - Abstract
Reduced physical activity is a primary risk factor for increased morbidity and mortality. People with spinal cord injury (SCI) have reduced activity for a lifetime, as they cannot volitionally activate affected skeletal muscles. We explored whether low-force and low-frequency stimulation is a viable strategy to enhance systemic energy expenditure in people with SCI. Purpose: This study aimed to determine the effects of low stimulation frequency (1 and 3 Hz) and stimulation intensity (50 and 100 mA) on energy expenditure in people with SCI. We also examined the relationship between body mass index and visceral adipose tissue on energy expenditure during low-frequency stimulation. Methods: Ten individuals with complete SCI underwent oxygen consumption monitoring during electrical activation of the quadriceps and hamstrings at 1 and 3 Hz and at 50 and 100 mA. We calculated the difference in energy expenditure between stimulation and rest and estimated the number of days that would be necessary to burn 1 lb of body fat (3500 kcal) for each stimulation protocol (1 vs 3 Hz). Results: Both training frequencies induced a significant increase in oxygen consumption above a resting baseline level (P G 0.05). Energy expenditure positively correlated with stimulus intensity (muscle recruitment) and negatively correlated with adiposity (reflecting the insulating properties of adipose tissue). We estimated that 1 lb of body fat could be burned more quickly with 1 Hz training (58 d) as compared with 3 Hz training (87 d) if an identical number of pulses were delivered. Conclusion: Low-frequency stimulation increased energy expenditure per pulse and may be a feasible option to subsidize physical activity to improve metabolic status after SCI. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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30. Reassessment of Cardiac Function and Implantable Cardioverter-Defibrillator Use Among Medicare Patients With Low Ejection Fraction After Myocardial Infarction.
- Author
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Pokorney, Sean D., Miller, Amy L., Chen, Anita Y., Thomas, Laine, Fonarow, Gregg C., de Lemos, James A., Al-Khatib, Sana M., Velazquez, Eric J., Peterson, Eric D., and Wang, Tracy Y.
- Subjects
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MYOCARDIAL infarction treatment , *IMPLANTABLE cardioverter-defibrillators , *TREATMENT effectiveness , *TREATMENT of acute coronary syndrome , *REVASCULARIZATION (Surgery) , *COMPUTED tomography , *DATABASES , *HEART ventricles , *MAGNETIC resonance imaging , *MEDICARE , *MYOCARDIAL revascularization , *SURVIVAL , *ULTRASONIC imaging , *ACQUISITION of data , *PROPORTIONAL hazards models , *RETROSPECTIVE studies , *STROKE volume (Cardiac output) ,MYOCARDIAL infarction-related mortality - Abstract
Background: Guidelines recommend that patients with low ejection fraction (EF) after myocardial infarction (MI) have their EF reassessed 40 days after MI for implantable cardioverter-defibrillator (ICD) candidacy. This study examines rates of EF reassessment and their association with 1-year ICD implantation in post-MI patients with low EF.Methods: We examined rates of postdischarge EF reassessment and ICD implantation among 10 289 Medicare-insured patients ≥65 years of age with an EF≤35% during the index MI admission from January 2007 through September 2010 in ACTION Registry-GWTG (Acute Coronary Treatment and Intervention Outcomes Network Registry-Get With The Guidelines). Multivariable Cox models tested the association between time-dependent EF reassessment and 1-year ICD implantation, stratified by revascularization status during the index MI admission.Results: Among patients with EF ≤35% during the index MI admission, 66.8% (95% confidence interval [CI], 65.9-67.8) had EF reassessment within the next year. Revascularized patients were more likely to have EF reassessment (76.9% [95% CI, 75.8-78.0)] versus 53.7% [95% CI, 52.2-55.2]; P<0.001) and had shorter times to EF reassessment (median, 67 versus 84 days; P<0.001) than nonrevascularized patients. Among patients with EF reassessment, only 11% received an ICD within 1 year. Reassessment of EF was associated with a higher likelihood of ICD implantation for both revascularized (unadjusted, 12.1% versus 2.4%, P<0.001; adjusted hazard ratio, 10.6, 95% CI, 7.7-14.8) and nonrevascularized (unadjusted, 10.0% versus 1.7%, P<0.001; adjusted hazard ratio, 6.1, 95% CI, 4.1-9.2) patients.Conclusions: In US practice, EF reassessments are commonly performed among patients with MI with an initially reduced EF. Although 1-year EF reassessment is associated with increased likelihood of ICD implantation, 1-year ICD implantation rates remain very low even among patients with EF reassessment, regardless of revascularization status. [ABSTRACT FROM AUTHOR]- Published
- 2017
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31. Clinician Perceptions of Teamwork in the Emergency Department.
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Weaver, Amy L., Hernandez, Susan, and Olson, Daiwai M.
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ACADEMIC medical centers , *COMMUNICATION , *HOSPITAL emergency services , *LEADERSHIP , *LONGITUDINAL method , *NURSE practitioners , *NURSES , *NURSES' attitudes , *SENSORY perception , *PHYSICIANS , *PHYSICIANS' assistants , *QUESTIONNAIRES , *SURVEYS , *WORK environment , *TEAMS in the workplace , *SAMPLE size (Statistics) , *PHYSICIANS' attitudes - Abstract
OBJECTIVE: This study was intended to determine whether positioning emergency department (ED) physicians, physician assistants, and nurse practitioners at the same workstations as registered nurses (RNs) improved communication and teamwork. BACKGROUND: Historically in this organization, providers and staff had separate physical locations (workstations). Construction of a new ED provided the opportunity to redesign the physical layout and to study whether a new design improved the perception of communication and teamwork among medical providers. METHODS: A prospective, self-administered presurvey-postsurvey using the TeamSTEPPS Teamwork Perceptions Questionnaire (TPQ) was completed at 2 medical centers with the same staff premove and postmove but different ED designs. The presurvey was conducted while the staff were at the older facility with a more linear floor design and separated nurse and physician stations. The postsurvey was conducted 3 months after employees and physicians were relocated to a new hospital with a pod design and communal workstations in the ED. RESULTS: Forty-six staff members completed both the presurvey and the postsurvey. There was a statistically significant improvement in the total TPQ scores (P = .0009) and 4 of the 5 components of the TPQ: team structure (P = .0283), situation monitoring (P = .0006), mutual support (P < .0001), and communication (P < .0001). There was no change in the leadership component (P = .4519). CONCLUSIONS: Adopting a more communal physical layout was associated with improved overall TPQ scores and most of the TPQ components. The lack of change in the leadership component was explained by the lack of change in leadership structure. The physical placement of medical providers and RNs in an ED is important and can increase the perception of communication and teamwork and thereby improve patient outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
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32. Predicting Injurious Falls in the Hospital Setting: Implications for Practice.
- Author
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Hester, Amy L., Pao-Feng Tsai, Rettiganti, Mallik, and Mitchell, Anita
- Subjects
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ACCIDENTAL fall prevention , *RISK factors of falling down , *CHI-squared test , *CONCEPTUAL structures , *CONFIDENCE intervals , *STATISTICAL correlation , *HOSPITALS , *MULTIVARIATE analysis , *RISK assessment , *STATISTICS , *T-test (Statistics) , *LOGISTIC regression analysis , *BODY mass index , *CONTINUING education units , *RETROSPECTIVE studies , *ODDS ratio - Abstract
Background: Despite years of research and increasingly evidence-based practice, falls continue to be the most commonly reported adverse events experienced by hospitalized adults. Yet a majority of the relevant research has focused on predicting and preventing falls in general; there has been little focus on injurious falls. Purpose: The purpose of this retrospective study was to determine which patient factors are associated with injurious falls in hospitalized adults. Methods: The study site's adverse event reporting database was used to identify 1,369 patients who fell between January 1, 2006, and October 31, 2013. Of these, 381 (27.8%) subjects suffered injurious falls. Variables of interest included age, sex, fall history, use of diuretics, use of central nervous system medications, cognitive impairment, primary discharge diagnoses, abnormal laboratory values, impaired mobility, and body mass index. Findings: Bivariate analysis revealed a statistically significant association between injurious falls and having a primary discharge diagnosis of "symptoms, signs, and ill-defined conditions." Having this discharge diagnosis was a significant predictor of injurious falls. Conclusions: Findings from this study may help hospital clinicians to better identify which patients are most at risk for injurious falls and to create better fall-related injury prevention interventions. [ABSTRACT FROM AUTHOR]
- Published
- 2016
33. COMPARISON OF ...O2PEAK PERFORMANCE ON A MOTORIZED VS. A NONMOTORIZED TREADMILL.
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MORGAN, AMY L., LAURENT, C. MATTHEW, and FULLENKAMP, ADAM M.
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CARDIOPULMONARY system , *EXERCISE tests , *HEART beat , *PROBABILITY theory , *TREADMILLS , *OXYGEN consumption - Abstract
Despite growing popularity of nonmotorized treadmills (NMTs), little data exist regarding responses during exercise testing using this equipment, which is important when providing an appropriate exercise prescription. The purpose of this study was to evaluate physiological and perceptual responses during peak graded exercise tests (GXTs) on a motorized treadmill (MT) vs. NMT. Volunteers (12 men and 12 women aged 18-35 years) performed 2 peak GXT sessions (1 MT and 1 NMT). Respiratory gases and heart rate (HR) were collected each minute; perceptual response was estimated (Borg's 6-20 rating of perceived exertion [RPE] scale) during the final 10 seconds of each stage. Peak values (i.e., ...o2, HR, speed) were determined during the final 10 seconds of each test; ventilatory threshold (VT) was assessed using the V-slope method. Paired t-tests matching variables measured at each stage of the GXT identified significantly higher values on the NMT for ...o2 83% of the time, HR 67% of the time, and RPE 25% of the time. Interestingly though, neither peak ...o2 (48.6 ± 9.2 ml·kg·min-1 vs. 47.8 ± 8.9 ml·kg·min-1), peak HR (185 ± 9 b·min-1 vs. 188 ± 10 b·min-1; p = 0.90), nor VT (72.7 ± 5.7% vs. 73.8 ± 5.4%) were significantly different on the NMT vs. the MT. However, significant differences were identified between NMT and MT tests for time to exhaustion (9:55 ± 1:49 vs. 12:05 ± 2:48; p < 0.01) and peak speed (8.0 ± 0.9 mph vs. 9.2 ± 1.4 mph; p < 0.01). Thus, although peak values obtained were similar between testing sessions on the NMT and MT, the majority of submaximal data were significantly different between trials. These differences are important when designing exercise prescriptions using submaximal values from NMT testing that may be inappropriately high or low at corresponding intensities during training. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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34. Return of Voice for Ventilated Tracheostomy Patients in ICU: A Randomized Controlled Trial of Early-Targeted Intervention.
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Freeman-Sanderson, Amy L., Togher, Leanne, Elkins, Mark R., and Phipps, Paul R.
- Subjects
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TRACHEOTOMY patients , *ARTIFICIAL respiration , *HOSPITAL care , *CLINICAL trials , *URBAN hospitals , *RANDOMIZED controlled trials , *CONTROL groups , *SPEECH therapy , *ARTIFICIAL respiration equipment , *COMPARATIVE studies , *CONVALESCENCE , *LENGTH of stay in hospitals , *INTENSIVE care units , *LONGITUDINAL method , *RESEARCH methodology , *MEDICAL cooperation , *QUALITY of life , *RESEARCH , *SPEECH disorders , *TIME , *TRACHEOTOMY , *HUMAN voice , *EVALUATION research - Abstract
Objectives: A cuffed tracheostomy tube facilitates prolonged mechanical ventilation and weaning but usually leads to prolonged voicelessness, which can be one of the most negative experiences of hospitalization. No randomized trials have examined the effects of targeted early communication intervention for the restoration of voice in ventilated tracheostomy patients in the ICU.Design: A prospective randomized clinical trial.Setting: The trial was conducted in the ICU of an urban tertiary level hospital.Patients: Thirty adult participants enrolled, with 15 randomly allocated to the intervention and control groups.Interventions: The early intervention group received early cuff deflation and insertion of an in-line speaking valve during mechanical ventilation. The control group received standard cuff deflation and a speaking valve during self-ventilation. A speech-language pathologist provided all treatments.Measurements and Main Results: The primary outcome measure was time from tracheostomy insertion to phonation. Early intervention significantly hastened return to phonation (median difference = 11 d; hazard ratio = 3.66; 95% CI, 1.54-8.68) with no significant effect on duration of tracheostomy cannulation (hazard ratio = 1.40; 95% CI, 0.65-3.03), duration of mechanical ventilation in days from tracheostomy insertion (hazard ratio = 1.19; 95% CI, 0.58-2.51), length of stay in ICU (hazard ratio = 1.16; 95% CI, 0.54-2.52), or time to return to oral intake (hazard ratio = 2.35; 95% CI, 0.79-6.98). Adverse events were low and equal in both groups. There was no significant change in measures of quality of life.Conclusions: Focused early intervention for communication during mechanical ventilation allows the restoration of phonation significantly sooner than standard treatment, with no increase in complications in a small patient cohort. Although these results are favorable, further research is needed to determine whether the effects on any of the secondary outcomes are statistically significant and clinically important. [ABSTRACT FROM AUTHOR]- Published
- 2016
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- View/download PDF
35. Gendered Innovations in Orthopaedic Science: Hollywood and Orthopaedics: Through the Glass Ceiling-Darkly.
- Author
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Ladd, Amy and Ladd, Amy L
- Subjects
- *
ORTHOPEDICS , *GLASS ceiling (Employment discrimination) , *GENDER inequality , *TECHNOLOGICAL innovations , *DIVERSITY in the workplace , *SOCIETIES - Abstract
The author discusses the sex and gender similarities and differences in orthopaedics. She states that lack of talents, accessibility and flexibility were the reasons for economic and leadership between men and women in the society. And reflects on the orthopedic workforce of the diverse patient population.
- Published
- 2016
- Full Text
- View/download PDF
36. THE EFFECTS OF NOVEL INGESTION OF SODIUM BICARBONATE ON REPEATED SPRINT ABILITY.
- Author
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MILLER, PETER, ROBINSON, AMY L., SPARKS, S. ANDY, BRIDGE, CRAIG A., BENTLEY, DAVID J., and MCNAUGHTON, LARS R.
- Subjects
- *
ATHLETIC ability , *BUFFER solutions , *COMPARATIVE studies , *CYCLING , *HYDROGEN-ion concentration , *LACTATES , *PROBABILITY theory , *SODIUM bicarbonate , *ERGOGENIC aids - Abstract
This work examined the influence of an acute dose of sodium bicarbonate (NaHCO3) on buffering capacity and performance during a repeated sprint ability (RSA) protocol. Eleven (mean±SD: age 24.6±6.1 years; mass 74.9±5.7 kg; height 1 77.2±6.7 cm) participated in the study, undertaking 4 test sessions. On the first visit to the laboratory, each participant ingested 300 mg⋅kg-1 of NaHCO3 (in 450 ml of flavored water) and blood samples were obtained at regular intervals to determine the individual times peak pH and HCO3-. In subsequent visits, participants ingested 300 mg⋅kg-1 of NaHCO3, 270 mg⋅kg-1 body mass (BM) of NaCI, or no drink followed by a RSA cycling protocol (10 x 6 seconds sprints with 60 seconds recovery), which commenced at each individuals predetermined ingestion peak pH response time. Blood samples were obtained before exercise and after the first, fifth, and 10th sprint to determine the blood pH, HCO3-, and lactate (La-) responses. Total work completed during the repeated sprint protocol was higher (p ≤ 0.05) in the NaHCO3 condition (69.8±11.7 kJ) compared with both the control (59.6±12.2 kJ) and placebo (63.0±8.3 kJ) conditions. Peak power output was similar (p > 0.05) between the 3 conditions. Relative to the control and placebo conditions, NaHCO3 ingestion induced higher (p ≤ 0.05) blood pH and HCO3- concentrations before exercise and during the bouts, and higher lactate concentrations (p ≤ 0.05) after the final sprint. Results suggest that NaHCO3- improves the total amount of work completed during RSA through enhanced buffering capacity. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
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37. Gendered Innovations in Orthopaedic Science: Sex, Lies, and Stereotype: In Praise of the Systematic Review.
- Author
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Ladd, Amy and Ladd, Amy L
- Subjects
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ORTHOPEDICS , *MEDICAL innovations , *SYSTEMATIC reviews , *STEREOTYPES , *BONE densitometry , *GUIDELINES , *HEALTH services accessibility , *HEALTH status indicators , *LITERATURE , *ORTHOPEDIC surgery , *SEX distribution , *EVIDENCE-based medicine , *HEALTH equity - Abstract
In the article, the author discusses studies regarding sex and gender considered as a variable in scientific research. Topics discussed include guidelines from the U.S. National Institutes of Health for consideration of the same in research grants applications, its consideration in orthopaedics research, use of stereotype in typography, application of gender and sex variable consideration in measurement of bone density in osteoporos, and involvement of guidelines in systematic reviews.
- Published
- 2016
- Full Text
- View/download PDF
38. Implementing a Communication Coaching Program for Students with Autism Spectrum Disorders in Postsecondary Education.
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Weiss, Amy L. and Rohland, Pamela
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AUTISM , *COGNITION , *PSYCHOLOGY of college students , *COLLEGE teachers , *COMMUNICATION education , *COUNSELORS , *EMPLOYMENT , *SOCIAL skills education , *STUDENT assistance programs , *UNIVERSITIES & colleges , *AFFINITY groups , *ELIGIBILITY (Social aspects) , *TEACHING methods , *HUMAN services programs , *EDUCATIONAL outcomes , *TRANSITIONAL programs (Education) , *EXECUTIVE function - Abstract
This article describes the operation of a Communication Coaching Program, which was designed to provide supports for students with autism spectrum disorders (ASDs) attending the University of Rhode Island. To succeed in college programs, many students with ASDs need access to specialized programming and personnel who are able to foster their success in both social and academic venues. The Communication Coaching Program has utilized the principles of individualization, evolution, and relevance over the 5 years of its existence. Disability counselors, along with communication coaches and peer coaches, provide students with ASDs opportunities to receive the explicit teaching and guided practice of social-communication and executive functioning skill sets that are keys to successful retention and graduation from postsecondary education. Insights gleaned from 5 years of programming are discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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39. Physical Activity Patterns Of College Students During The Early Stages Of The Covid-19 Pandemic.
- Author
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Morgan, Amy L., Ludy, Mary-Jon, Nieschwitz, Natalie C., Huzyak, Madelyn G., Chen Du, and Tucker, Robin M.
- Subjects
- *
COLLEGE students , *CONFERENCES & conventions , *PHYSICAL activity , *COVID-19 pandemic - Abstract
Prior to the COVID-19 pandemic, two-thirds of college students met aerobic physical activity (PA) recommendations and one-third reported that stress affected their academic performance. As regular PA has been demonstrated to reduce stress and positively influence academic performance, the impact of the pandemic on PA is of interest. PURPOSE: To describe levels of PA, stress, and academic performance in college students during the early stages of the COVID-19 pandemic. METHODS: College students (N = 803, age 22.6 ± 5.8 years, BMI 26.5 ± 6.5 kg/m², 72.4% female, 79.6% undergraduate) completed a survey in April/May 2020. Questionnaires included the International Physical Activity Questionnaire (long form) and Perceived Stress Scale (PSS-10). Students indicated whether PA, stress, and academic performance were more, less, or the same as prior to the pandemic and associated shutdown. Participants also answered an open ended question about concerns related to the pandemic that were not covered in the survey. RESULTS: Respondents reported less PA, more stress, and poorer academic performance. Students engaged in 1256.6 ± 3525.4 total MET min/wk (457.3 ± 1524.9 walking, 352.4 ± 1202.1 moderate, and 446.9 ± 1898.7 vigorous MET min/wk). Compared to before the pandemic and associated shutdown, 54.2% of respondents reported exercising less time while 47.9% exercised less intensely. Concurrently, 77.6% reported more stress and 40.4% reported worse academic performance. Concerns related to overall mental and physical well-being and financial issues, such as insurance coverage. There were also larger concerns over COVID-19, including worry about contracting the virus and receiving consistent information. CONCLUSION: During the early stages of the COVID-19 pandemic, college students participated in less PA while experiencing additional stress. Strategies to help students maintain/increase PA throughout the pandemic may help to reduce stress and maintain academic performance. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
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40. The Science of Being a Study Participant: FEM-PrEP Participants' Explanations for Overreporting Adherence to the Study Pills and for the Whereabouts of Unused Pills.
- Author
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Corneli, Amy L., McKenna, Kevin, Perry, Brian, Ahmed, Khatija, Micro, MMed, Agot, Kawango, Malamatsho, Fulufhelo, Skhosana`, Joseph, Odhiambo, Jacob, and Van Damme, Lut
- Published
- 2015
- Full Text
- View/download PDF
41. Gendered innovations in orthopaedic science: Title IX education: book learnin' and bone mendin'.
- Author
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Ladd, Amy L
- Published
- 2014
- Full Text
- View/download PDF
42. FEM-PrEP.
- Author
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Corneli, Amy L., Deese, Jennifer, Wang, Meng, Taylor, Doug, Ahmed, Khatija, Agot, Kawango, Lombaard, Johan, Manongi, Rachel, Kapiga, Saidi, Kashuba, Angela, and Van Damme, Lut
- Abstract
Several clinical trials have demonstrated the safety and effectiveness of oral tenofovir disoproxil fumarate (TDF), with or without emtricitabine (FTC), as pre-exposure prophylaxis (PrEP) for reducing the risk of HIV acquisition. Adherence to the study product was insufficient to demonstrate the effectiveness of FTC/TDF in 2 PrEP clinical trials conducted among women (FEM-PrEP and the Vaginal and Oral Interventions to Control the Epidemic study), but further analyses of adherence in these studies may inform PrEP demonstration projects and future HIV prevention clinical trials.We randomly selected a subcohort of 150 participants randomized to FTC/TDF in 3 FEM-PrEP sites (Bondo, Kenya; Bloemfontein, South Africa; and Pretoria, South Africa) to examine adherence levels over time and to assess factors associated with adherence, based on plasma tenofovir and intracellular tenofovir diphosphate drug concentrations in specimens collected at 4-week visit intervals.We observed drug concentrations consistent with good adherence in 28.5% of all visit intervals when drug was available to use, but only 12% of participants achieved good adherence throughout their study participation. In multivariate analysis, the Bloemfontein site [odds ratio (OR): 2.43; 95% confidence interval (CI): 1.32 to 4.48] and liking the pill color (OR: 2.93; 95% CI: 1.18 to 7.27) were positively associated with good adherence, whereas using oral contraceptive pills at enrollment was negatively associated with good adherence (OR: 0.37; 95% CI: 0.18 to 0.74).Most participants did not regularly adhere to the study product throughout their trial participation, although a small minority did. Few factors associated with good adherence to the study product were identified in FEM-PrEP. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
43. The sports bra, the ACL, and Title IX--the game in play.
- Author
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Ladd, Amy L
- Published
- 2014
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44. Guest editorial: The Robert's view: a historical and clinical perspective.
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Ladd, Amy L
- Published
- 2014
- Full Text
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45. Clinical characteristics and surgical outcomes of phacoemulsification in true exfoliation syndrome.
- Author
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Wong, Amy L., Chan, Tommy C.Y., Fong, Angie H.C., Lam, Ben N.M., and Yuen, Hunter K.L.
- Subjects
- *
PHACOEMULSIFICATION , *HEALTH outcome assessment , *EXFOLIATION syndrome , *TREATMENT of eye diseases , *OPHTHALMIC surgery , *CATARACT surgery - Abstract
Purpose: To review the clinical characteristics and surgical outcomes of patients with true exfoliation syndrome of the lens capsule having phacoemulsification cataract surgery. Setting: Hong Kong Eye Hospital, Kowloon, Hong Kong. Design: Case series. Methods: Eyes of patients with true exfoliation syndrome diagnosed clinically or intraoperatively had standard phacoemulsification and intraocular lens (IOL) implantation. The anterior capsules removed during capsulorhexis were sent for histological confirmation. Results: Twenty-four eyes of 18 patients were included. All eyes were confirmed to have true exfoliation syndrome by histological examination of the anterior lens capsule. Seven eyes (29.2%) had preexisting chronic glaucoma; 5 (20.8%) had laser iridotomy before the diagnosis. During phacoemulsification, all eyes had a continuous curvilinear capsulorhexis without complications. Trypan blue staining was used during capsulorhexis in 11 eyes (45.8%). Posterior capsule rupture occurred during lens chopping in 1 eye (4.2%). No loose zonular fibers or radial extension of capsulorhexis occurred. Capsular bag IOL implantation was successfully performed in all cases except the 1 with a posterior capsule rupture, in which an anterior chamber IOL was implanted. Conclusions: Phacoemulsification was safely performed in eyes with true exfoliation syndrome. Trypan blue staining can be used to facilitate capsulorhexis creation. Ultrasound biomicroscopy or anterior segment optical coherence tomography may be useful in preoperative assessment of such cases. The disease may be associated with glaucoma and laser iridotomy. Financial Disclosure: No author has a financial or proprietary interest in any material or method mentioned. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
46. Dexamethasone Administration Decreases Opioid Usage After Posterior Spinal Fusion in Patients with Adolescent Idiopathic Scoliosis: Commentary on article by Nicholas D. Fletcher, MD, et al.: "Postoperative Dexamethasone Following Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis".
- Author
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McIntosh, Amy L.
- Subjects
- *
ORTHOPEDIC braces , *ADOLESCENT idiopathic scoliosis , *SPINAL fusion , *DEXAMETHASONE , *OPIOIDS , *THERAPEUTIC use of narcotics , *ANALGESICS , *KYPHOSIS , *SCOLIOSIS - Published
- 2020
- Full Text
- View/download PDF
47. Letter to the Editor: Art in Science: The 'Pygmy' Chair and the Tenodesis Effect.
- Author
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Kwong, Jeffrey W and Ladd, Amy L
- Subjects
- *
ORTHOPEDIC surgery , *NEUROSURGERY , *PLASTIC surgery , *TENODESIS , *GROWTH disorders - Published
- 2020
- Full Text
- View/download PDF
48. Visual outcomes and subjective experience after bilateral implantation of a new diffractive trifocal intraocular lens
- Author
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Sheppard, Amy L., Shah, Sunil, Bhatt, Uday, Bhogal, Gurpreet, and Wolffsohn, James S.
- Subjects
- *
INTRAOCULAR lenses , *VISUAL acuity , *VISUAL accommodation , *CONTRAST sensitivity (Vision) , *SCOTOMA , *HEALTH outcome assessment , *COHORT analysis - Abstract
Purpose: To assess clinical outcomes and subjective experience after bilateral implantation of a diffractive trifocal intraocular lens (IOL). Setting: Midland Eye Institute, Solihull, United Kingdom. Design: Cohort study. Methods: Patients had bilateral implantation of Finevision trifocal IOLs. Uncorrected distance visual acuity, corrected distance visual acuity (CDVA), and manifest refraction were measured 2 months postoperatively. Defocus curves were assessed under photopic and mesopic conditions over a range of +1.50 to −4.00 diopters (D) in 0.50 D steps. Contrast sensitivity function was assessed under photopic conditions. Halometry was used to measure the angular size of monocular and binocular photopic scotomas arising from a glare source. Patient satisfaction with uncorrected near vision was assessed using the Near Activity Visual Questionnaire (NAVQ). Results: The mean monocular CDVA was 0.08 logMAR ± 0.08 (SD) and the mean binocular CDVA, 0.06 ± 0.08 logMAR. Defocus curve testing showed an extended range of clear vision from +1.00 to −2.50 D defocus, with a significant difference in acuity between photopic conditions and mesopic conditions at −1.50 D defocus only. Photopic contrast sensitivity was significantly better binocularly than monocularly at all spatial frequencies. Halometry showed a glare scotoma of a mean size similar to that in previous studies of multifocal and accommodating IOLs; there were no subjective complaints of dysphotopsia. The mean NAVQ Rasch score for satisfaction with near vision was 15.9 ± 10.7 logits. Conclusions: The trifocal IOL implanted binocularly produced good distance visual acuity and near and intermediate visual function. Patients were very satisfied with their uncorrected near vision. Financial Disclosure: No author has a financial or proprietary interest in any material or method mentioned. [Copyright &y& Elsevier]
- Published
- 2013
- Full Text
- View/download PDF
49. EMLA Application Exceeding Two Hours Improves Pediatric Emergency Department Venipuncture Success.
- Author
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Baxter, Amy L., Ewing, Philip H., Young, Ginger B., Ware, Amy, Evans, Neil, and Manworren, Renee C. B.
- Subjects
- *
PAIN , *PREVENTIVE medicine , *THERAPEUTIC complications , *CHI-squared test , *CHILDREN'S hospitals , *CLASSIFICATION , *CONFIDENCE intervals , *CONTENT analysis , *EMERGENCY nursing , *EMLA (Anesthetics) , *EPIDEMIOLOGY , *LENGTH of stay in hospitals , *LONGITUDINAL method , *NURSING , *NURSING records , *HEALTH outcome assessment , *PARENTS , *PATIENT satisfaction , *PATIENTS , *PROBABILITY theory , *STATISTICAL sampling , *SCALE analysis (Psychology) , *SCALES (Weighing instruments) , *T-test (Statistics) , *MEDICAL triage , *U-statistics , *VENOUS puncture , *DATA analysis , *PAIN measurement , *RANDOMIZED controlled trials , *TREATMENT effectiveness , *DESCRIPTIVE statistics , *CHILDREN , *PREVENTION - Abstract
The article presents a study that investigates the efficacy of the Eutectic Mixture of Local Anesthetics (EMLA) in boosting success of venipuncture practice of the emergency department (ED) of hospitals in the U.S. Researchers did the study on 37 weeks gestational age children to 18 years-old individuals who need venipuncture to reduce the pain associated with triage. They found that venipuncture is effective in reducing the pain experienced by patients.
- Published
- 2013
- Full Text
- View/download PDF
50. Clinical outcomes after implantation of a new hydrophobic acrylic toric IOL during routine cataract surgery
- Author
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Sheppard, Amy L., Wolffsohn, James S., Bhatt, Uday, Hoffmann, Peter C., Scheider, Andreas, Hütz, Werner W., and Shah, Sunil
- Subjects
- *
HEALTH outcome assessment , *CATARACT surgery , *ROUTINE diagnostic tests , *INTRAOCULAR lenses , *HYDROPHOBIC compounds , *CORNEA diseases , *ASTIGMATISM , *PATIENTS - Abstract
Purpose: To assess the clinical outcomes after implantation of a new hydrophobic acrylic toric intraocular lens (IOL) to correct preexisting corneal astigmatism in patients having routine cataract surgery. Setting: Four hospital eye clinics throughout Europe. Design: Cohort study. Methods: This study included eyes with at least 0.75 diopter (D) of preexisting corneal astigmatism having routine cataract surgery. Phacoemulsification was performed followed by insertion and alignment of a Tecnis toric IOL. Patients were examined 4 to 8 weeks postoperatively; uncorrected distance visual acuity (UDVA), corrected distance visual acuity, manifest refraction, and keratometry were measured. Individual patient satisfaction with uncorrected vision and the surgeon’s assessment of ease of handling and performance of the IOL were also documented. The cylinder axis of the toric IOL was determined by dilated slitlamp examination. Results: The study enrolled 67 eyes of 60 patients. Four to 8 weeks postoperatively, the mean UDVA was 0.15 logMAR ± 0.17 (SD) and the UDVA was 20/40 or better in 88% of eyes. The mean refractive cylinder decreased significantly postoperatively, from −1.91 ± 1.07 D to −0.67 ± 0.54 D. No significant change in keratometric cylinder was observed. The mean absolute IOL misalignment from the intended axis was 3.4 degrees (range 0 to 12 degrees). The good UDVA resulted in high levels of patient satisfaction. Conclusion: Implantation of the new toric IOL was an effective, safe, and predictable method to manage corneal astigmatism in patients having routine cataract surgery. Financial Disclosure: No author has a financial or proprietary interest in any material or method mentioned. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
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