1. Influence of wortmannin of aggregation ability of neutrophylic granulocytes under type 1 diabetes mellitus
- Author
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O. Vovk, I. V. Brodyak, U. Urbanovich, Mykola Zdioruk, Natalia Sybirna, and M. L. Barska
- Subjects
medicine.medical_specialty ,Type 1 diabetes ,QH301-705.5 ,business.industry ,medicine.disease ,Wortmannin ,chemistry.chemical_compound ,Endocrinology ,chemistry ,Internal medicine ,sialic containing glycoprotein ,medicine ,lectin induced aggregation ,neutrohylic granulocytes ,Biology (General) ,business ,type 1 diabetes mellitus - Abstract
The determination wortmanin influence on aggregation ability of neutrophylic granulocytes induced by specific lectins such as WGA, SNA and MAA was conducted. Distinct functional changes of the leucocytes under type 1 diabetes mellitus contingently by quantitative increasing of plasmatic membrane sialic containing glycoprotein receptors which contain in their structure NeuNAc(α2→6)DGal/DgalNAc carbohydrate, but not NeuNAc(α2→3)DGal/DgalNAc carbohydrate were revealed. Enhanced ability of neutrophylic granulocytes aggregation under influence of specific lectins at type 1 diabetes mellitus and weak answer of wortmanin inhibition may used as test system for determination of dearrangements in functional changes of the leukocytes under type 1 diabetes mellitus.
- Published
- 2009