13 results on '"Lange, Catharina"'
Search Results
2. Cortical Amyloid Burden Relates to Basal Forebrain Volume in Subjective Cognitive Decline
- Author
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Daamen, Marcel, Scheef, Lukas, Li, Shumei, Grothe, Michel J., Gaertner, Florian C., Buchert, Ralph, Buerger, Katharina, Dobisch, Laura, Drzezga, Alexander, Essler, Markus, Ewers, Michael, Fliessbach, Klaus, Herrera Meléndez, Ana Lucía, Hetzer, Stefan, Janowitz, Daniel, Kilimann, Ingo, Krause, Bernd Joachim, Lange, Catharina, Laske, Christoph, Munk, Matthias H., Peters, Oliver, Priller, Josef, Ramírez, Alfredo, Reimold, Matthias, Rominger, Axel, Rostamzadeh, Ayda, Roeske, Sandra, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Spruth, Eike Jakob, Teipel, Stefan J., Wagner, Michael, Düzel, Emrah, Jessen, Frank, Boecker, Henning, DELCODE Study Group, Daamen, Marcel, Scheef, Lukas, Li, Shumei, Grothe, Michel J., Gaertner, Florian C., Buchert, Ralph, Buerger, Katharina, Dobisch, Laura, Drzezga, Alexander, Essler, Markus, Ewers, Michael, Fliessbach, Klaus, Herrera Meléndez, Ana Lucía, Hetzer, Stefan, Janowitz, Daniel, Kilimann, Ingo, Krause, Bernd Joachim, Lange, Catharina, Laske, Christoph, Munk, Matthias H., Peters, Oliver, Priller, Josef, Ramírez, Alfredo, Reimold, Matthias, Rominger, Axel, Rostamzadeh, Ayda, Roeske, Sandra, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Spruth, Eike Jakob, Teipel, Stefan J., Wagner, Michael, Düzel, Emrah, Jessen, Frank, Boecker, Henning, and DELCODE Study Group
- Abstract
Background: Atrophy of cholinergic basal forebrain (BF) nuclei is a frequent finding in magnetic resonance imaging (MRI) volumetry studies that examined patients with prodromal or clinical Alzheimer’s disease (AD), but less clear for individuals in earlier stages of the clinical AD continuum. Objective: To examine BF volume reductions in subjective cognitive decline (SCD) participants with AD pathologic changes. Methods: The present study compared MRI-based BF volume measurements in age- and sex-matched samples of N = 24 amyloid-positive and N = 24 amyloid-negative SCD individuals, based on binary visual ratings of Florbetaben positron emission tomography (PET) measurements. Additionally, we assessed associations of BF volume with cortical amyloid burden, based on semiquantitative Centiloid (CL) analyses. Results: Group differences approached significance for BF total volume (p = 0.061) and the Ch4 subregion (p = 0.059) only, showing the expected relative volume reductions for the amyloid-positive subgroup. There were also significant inverse correlations between BF volumes and CL values, which again were most robust for BF total volume and the Ch4 subregion. Conclusions: The results are consistent with the hypothesis that amyloid-positive SCD individuals, which are considered to represent a transitional stage on the clinical AD continuum, already show incipient alterations of BF integrity. The negative association with a continuous measure of cortical amyloid burden also suggests that this may reflect an incremental process. Yet, further research is needed to evaluate whether BF changes already emerge at “grey zone” levels of amyloid accumulation, before amyloidosis is reliably detected by PET visual readings.
- Published
- 2023
3. Abnormal Regional and Global Connectivity Measures in Subjective Cognitive Decline Depending on Cerebral Amyloid Status
- Author
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Li, Shumei, Daamen, Marcel, Scheef, Lukas, Gaertner, Florian C., Buchert, Ralph, Buchmann, Martina, Buerger, Katharina, Catak, Cihan, Dobisch, Laura, Drzezga, Alexander, Ertl-Wagner, Birgit, Essler, Markus, Fliessbach, Klaus, Haynes, John Dylan, Incesoy, Enise Irem, Kilimann, Ingo, Krause, Bernd J., Lange, Catharina, Laske, Christoph, Priller, Josef, Ramirez, Alfredo, Reimold, Matthias, Rominger, Axel, Roy, Nina, Scheffler, Klaus, Maurer, Angelika, Schneider, Anja, Spottke, Annika, Spruth, Eike Jakob, Teipel, Stefan J., Tscheuschler, Maike, Wagner, Michael, Wolfsgruber, Steffen, Duzel, Emrah, Jessen, Frank, Peters, Oliver, Boecker, Henning, Li, Shumei, Daamen, Marcel, Scheef, Lukas, Gaertner, Florian C., Buchert, Ralph, Buchmann, Martina, Buerger, Katharina, Catak, Cihan, Dobisch, Laura, Drzezga, Alexander, Ertl-Wagner, Birgit, Essler, Markus, Fliessbach, Klaus, Haynes, John Dylan, Incesoy, Enise Irem, Kilimann, Ingo, Krause, Bernd J., Lange, Catharina, Laske, Christoph, Priller, Josef, Ramirez, Alfredo, Reimold, Matthias, Rominger, Axel, Roy, Nina, Scheffler, Klaus, Maurer, Angelika, Schneider, Anja, Spottke, Annika, Spruth, Eike Jakob, Teipel, Stefan J., Tscheuschler, Maike, Wagner, Michael, Wolfsgruber, Steffen, Duzel, Emrah, Jessen, Frank, Peters, Oliver, and Boecker, Henning
- Abstract
Background: Amyloid-beta accumulation was found to alter precuneus-based functional connectivity (FC) in mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia, but its impact is less clear in subjective cognitive decline (SCD), which in combination with AD pathologic change is theorized to correspond to stage 2 of the Alzheimer's continuum in the 2018 NIA-AA research framework. Objective: This study addresses how amyloid pathology relates to resting-state fMRI FC in SCD, especially focusing on the precuneus. Methods: From the DELCODE cohort, two groups of 24 age- and gender-matched amyloid-positive (SCDA beta+) and amyloidnegative SCD (SCDA beta-) patients were selected according to visual [18F]-Florbetaben (FBB) PET readings, and studied with resting-state fMRI. Local (regional homogeneity [ReHo], fractional amplitude of low-frequency fluctuations [fALFF]) and global (degree centrality [DC], precuneus seed-based FC) measures were compared between groups. Follow-up correlation analyses probed relationships of group differences with global and precuneal amyloid load, as measured by FBB standard uptake value ratios (SUVRFBB). Results: ReHo was significantly higher (voxel-wise p < 0.01, cluster-level p < 0.05) in the bilateral precuneus for SCDA beta+ patients, whereas fALFF was not altered between groups. Relatively higher precuneus-based FC with occipital areas (but no altered DC) was observed in SCDA beta+ patients. In this latter cluster, precuneus-occipital FC correlated positively with global (SCDA beta+) and precuneus SUVRFBB (both groups). Conclusion: While partial confounding influences due to a higher APOE epsilon 4 carrier ratio among SCDA beta+ patients cannot be excluded, exploratory results indicate functional alterations in the precuneus hub region that were related to amyloid-beta load, highlighting incipient pathology in stage 2 of the AD continuum.
- Published
- 2021
4. Brain FDG PET for the Etiological Diagnosis of Clinically Uncertain Cognitive Impairment During Delirium in Remission
- Author
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Mathies, Franziska, primary, Lange, Catharina, additional, Mäurer, Anja, additional, Apostolova, Ivayla, additional, Klutmann, Susanne, additional, and Buchert, Ralph, additional
- Published
- 2020
- Full Text
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5. Impairment of Everyday Spatial Navigation Abilities in Mild Cognitive Impairment Is Weakly Associated with Reduced Grey Matter Volume in the Medial Part of the Entorhinal Cortex.
- Author
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Hallab, Asma, Lange, Catharina, Apostolova, Ivayla, Özden, Cansu, Gonzalez-Escamilla, Gabriel, Klutmann, Susanne, Brenner, Winfried, Grothe, Michel J., Buchert, Ralph, and Alzheimer’s Disease Neuroimaging Initiative
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ENTORHINAL cortex , *MILD cognitive impairment , *SPATIAL ability , *COGNITIVE ability , *ALZHEIMER'S patients , *COGNITIVE testing , *GRAY matter (Nerve tissue) , *RESEARCH , *TEMPORAL lobe , *ANTHROPOMETRY , *RESEARCH methodology , *ACTIVITIES of daily living , *MAGNETIC resonance imaging , *MEDICAL cooperation , *EVALUATION research , *ATROPHY , *COMPARATIVE studies , *RADIOPHARMACEUTICALS , *RESEARCH funding , *DEOXY sugars , *SPACE perception - Abstract
Background: Research in rodents identified specific neuron populations encoding information for spatial navigation with particularly high density in the medial part of the entorhinal cortex (ERC), which may be homologous with Brodmann area 34 (BA34) in the human brain.Objective: The aim of this study was to test whether impaired spatial navigation frequently occurring in mild cognitive impairment (MCI) is specifically associated with neurodegeneration in BA34.Methods: The study included baseline data of MCI patients enrolled in the Alzheimer's Disease Neuroimaging Initiative with high-resolution structural MRI, brain FDG PET, and complete visuospatial ability scores of the Everyday Cognition test (VS-ECog) within 30 days of PET. A standard mask of BA34 predefined in MNI space was mapped to individual native space to determine grey matter volume and metabolic activity in BA34 on MRI and on (partial volume corrected) FDG PET, respectively. The association of the VS-ECog sum score with grey matter volume and metabolic activity in BA34, APOE4 carrier status, age, education, and global cognition (ADAS-cog-13 score) was tested by linear regression. BA28, which constitutes the lateral part of the ERC, was used as control region.Results: The eligibility criteria led to inclusion of 379 MCI subjects. The VS-ECog sum score was negatively correlated with grey matter volume in BA34 (β= -0.229, p = 0.022) and age (β= -0.124, p = 0.036), and was positively correlated with ADAS-cog-13 (β= 0.175, p = 0.003). None of the other predictor variables contributed significantly.Conclusion: Impairment of spatial navigation in MCI is weakly associated with BA34 atrophy. [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
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6. Challenges in Screening and Recruitment for a Neuroimaging Study in Cognitively Impaired Geriatric Inpatients
- Author
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Apostolova, Ivayla, primary, Lange, Catharina, additional, Roberts, Anna, additional, Igel, Hans Joachim, additional, Mäurer, Anja, additional, Liese, Stephanie, additional, Estrella, Melanie, additional, Prasad, Vikas, additional, Stechl, Elisabeth, additional, Lämmler, Gernot, additional, Steinhagen-Thiessen, Elisabeth, additional, and Buchert, Ralph, additional
- Published
- 2017
- Full Text
- View/download PDF
7. Combination of Structural MRI and FDG-PET of the Brain Improves Diagnostic Accuracy in Newly Manifested Cognitive Impairment in Geriatric Inpatients
- Author
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Ritter, Kerstin, primary, Lange, Catharina, additional, Weygandt, Martin, additional, Mäurer, Anja, additional, Roberts, Anna, additional, Estrella, Melanie, additional, Suppa, Per, additional, Spies, Lothar, additional, Prasad, Vikas, additional, Steffen, Ingo, additional, Apostolova, Ivayla, additional, Bittner, Daniel, additional, Gövercin, Mehmet, additional, Brenner, Winfried, additional, Mende, Christine, additional, Peters, Oliver, additional, Seybold, Joachim, additional, Fiebach, Jochen B., additional, Steinhagen-Thiessen, Elisabeth, additional, Hampel, Harald, additional, Haynes, John-Dylan, additional, and Buchert, Ralph, additional
- Published
- 2016
- Full Text
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8. Prediction of Alzheimer's Dementia in Patients with Amnestic Mild Cognitive Impairment in Clinical Routine: Incremental Value of Biomarkers of Neurodegeneration and Brain Amyloidosis Added Stepwise to Cognitive Status.
- Author
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Lange, Catharina, Suppa, Per, Pietrzyk, Uwe, Makowski, Marcus R., Spies, Lothar, Peters, Oliver, Buchert, Ralph, and Alzheimer’s Disease Neuroimaging Initiative
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ALZHEIMER'S disease , *MILD cognitive impairment , *MAGNETIC resonance imaging , *BIOMARKERS , *NEURODEGENERATION , *DIAGNOSIS of dementia , *ALZHEIMER'S disease diagnosis , *AMYLOIDOSIS , *BRAIN , *DEOXY sugars , *LONGITUDINAL method , *NEUROPSYCHOLOGICAL tests , *NERVE tissue proteins , *RADIOPHARMACEUTICALS , *SURVIVAL analysis (Biometry) , *POSITRON emission tomography , *THREE-dimensional imaging , *DISEASE complications ,BRAIN metabolism - Abstract
The aim of this study was to evaluate the incremental benefit of biomarkers for prediction of Alzheimer's disease dementia (ADD) in patients with mild cognitive impairment (MCI) when added stepwise in the order of their collection in clinical routine. The model started with cognitive status characterized by the ADAS-13 score. Hippocampus volume (HV), cerebrospinal fluid (CSF) phospho-tau (pTau), and the FDG t-sum score in an AD meta-region-of-interest were compared as neurodegeneration markers. CSF-Aβ1-42 was used as amyloidosis marker. The incremental prognostic benefit from these markers was assessed by stepwise Kaplan-Meier survival analysis in 402 ADNI MCI subjects. Predefined cutoffs were used to dichotomize patients as 'negative' or 'positive' for AD characteristic alteration with respect to each marker. Among the neurodegeneration markers, CSF-pTau provided the best incremental risk stratification when added to ADAS-13. FDG PET outperformed HV only in MCI subjects with relatively preserved cognition. Adding CSF-Aβ provided further risk stratification in pTau-positive subjects, independent of their cognitive status. Stepwise integration of biomarkers allows stepwise refinement of risk estimates for MCI-to-ADD progression. Incremental benefit strongly depends on the patient's status according to the preceding diagnostic steps. The stepwise Kaplan-Meier curves might be useful to optimize diagnostic workflow in individual patients. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
9. Fully Automatic MRI-Based Hippocampus Volumetry Using FSL-FIRST: Intra-Scanner Test-Retest Stability, Inter-Field Strength Variability, and Performance as Enrichment Biomarker for Clinical Trials Using Prodromal Target Populations at Risk for Alzheimer's Disease.
- Author
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Cavedo, Enrica, Suppa, Per, Lange, Catharina, Opfer, Roland, Lista, Simone, Galluzzi, Samantha, Schwarz, Adam J., Spies, Lothar, Buchert, Ralph, Hampel, Harald, Alzheimer’s Disease Neuroimaging Initiative, and Alzheimer Precision Medicine Initiative (APMI)
- Subjects
HIPPOCAMPUS (Brain) ,CEREBRAL cortex ,LIMBIC system ,ALZHEIMER'S disease ,BRAIN ,COGNITION disorders ,CLINICAL trials - Abstract
Background: MRI-based hippocampus volume is a core clinical biomarker for identification of Alzheimer's disease (AD).Objective: To assess robustness of automatic hippocampus volumetry with the freely available FSL-FIRST software with respect to short-term repeat and across field strength imaging. FSL-FIRST hippocampus volume (FIRST-HV) was also evaluated as enrichment biomarker for mild cognitive impairment (MCI) trials.Methods: Robustness of FIRST-HV was assessed in 51 healthy controls (HC), 74 MCI subjects, and 28 patients with AD dementia from ADNI1, each with two pairs of back-to-back scans, one at 1.5T one at 3T. Enrichment performance was tested in a second sample of 287 ADNI MCI subjects.Results: FSL-FIRST worked properly in all four scans in 147 out of 153 subjects of the first sample (49 HC, 72 MCI, 26 AD). In these subjects, FIRST-HV did not differ between the first and the second scan within an imaging session, neither at 1.5T nor at 3T (p≥0.302). FIRST-HV was on average 0.78% larger at 3T compared to 1.5T (p = 0.012). The variance of the FIRST-HV difference was larger in the inter-field strength setting than in the intra-scanner settings (p < 0.0005). Computer simulations suggested that the additional variability encountered in the inter-field strength scenario does not cause a relevant degradation of FIRST-HV's prognostic performance in MCI. FIRST-HV based enrichment resulted in considerably increased effect size of the 2-years change of cognitive measures.Conclusion: The impact of intra-scanner test-retest and inter-field strength variability of FIRST-HV on clinical tasks is negligible. In addition, FIRST-HV is useful for enrichment in clinical MCI trials. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
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10. Performance of Hippocampus Volumetry with FSL-FIRST for Prediction of Alzheimer's Disease Dementia in at Risk Subjects with Amnestic Mild Cognitive Impairment.
- Author
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Suppa, Per, Hampel, Harald, Kepp, Timo, Lange, Catharina, Spies, Lothar, Fiebach, Jochen B, Dubois, Bruno, Buchert, Ralph, and Alzheimer’s Disease Neuroimaging Initiative
- Abstract
MRI-based hippocampus volume, a core feasible biomarker of Alzheimer's disease (AD), is not yet widely used in clinical patient care, partly due to lack of validation of software tools for hippocampal volumetry that are compatible with routine workflow. Here, we evaluate fully-automated and computationally efficient hippocampal volumetry with FSL-FIRST for prediction of AD dementia (ADD) in subjects with amnestic mild cognitive impairment (aMCI) from phase 1 of the Alzheimer's Disease Neuroimaging Initiative. Receiver operating characteristic analysis of FSL-FIRST hippocampal volume (corrected for head size and age) revealed an area under the curve of 0.79, 0.70, and 0.70 for prediction of aMCI-to-ADD conversion within 12, 24, or 36 months, respectively. Thus, FSL-FIRST provides about the same power for prediction of progression to ADD in aMCI as other volumetry methods. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
11. Optimization of Statistical Single Subject Analysis of Brain FDG PET for the Prognosis of Mild Cognitive Impairment-to-Alzheimer's Disease Conversion.
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Lange, Catharina, Suppa, Per, Frings, Lars, Brenner, Winfried, Spies, Lothar, and Buchert, Ralph
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POSITRON emission tomography , *FLUORODEOXYGLUCOSE F18 , *NEURODEGENERATION , *DEMENTIA research , *COGNITION disorders research , *ALZHEIMER'S disease diagnosis , *RADIOGRAPHY , *BRAIN , *COGNITION disorders diagnosis , *GLUCOSE metabolism , *ALZHEIMER'S disease , *COGNITION disorders , *COMPARATIVE studies , *DEOXY sugars , *DIAGNOSTIC imaging , *LONGITUDINAL method , *RESEARCH methodology , *MEDICAL cooperation , *COMPUTERS in medicine , *PHARMACOKINETICS , *PROGNOSIS , *RADIOPHARMACEUTICALS , *RESEARCH , *EVALUATION research , *RECEIVER operating characteristic curves , *DISEASE progression ,BRAIN metabolism - Abstract
Background: Positron emission tomography (PET) with the glucose analog F-18-fluorodeoxyglucose (FDG) is widely used in the diagnosis of neurodegenerative diseases. Guidelines recommend voxel-based statistical testing to support visual evaluation of the PET images. However, the performance of voxel-based testing strongly depends on each single preprocessing step involved.Objective: To optimize the processing pipeline of voxel-based testing for the prognosis of dementia in subjects with amnestic mild cognitive impairment (MCI).Methods: The study included 108 ADNI MCI subjects grouped as 'stable MCI' (n = 77) or 'MCI-to-AD converter' according to their diagnostic trajectory over 3 years. Thirty-two ADNI normals served as controls. Voxel-based testing was performed with the statistical parametric mapping software (SPM8) starting with default settings. The following modifications were added step-by-step: (i) motion correction, (ii) custom-made FDG template, (iii) different reference regions for intensity scaling, and (iv) smoothing was varied between 8 and 18 mm. The t-sum score for hypometabolism within a predefined AD mask was compared between the different settings using receiver operating characteristic (ROC) analysis with respect to differentiation between 'stable MCI' and 'MCI-to-AD converter'. The area (AUC) under the ROC curve was used as performance measure.Results: The default setting provided an AUC of 0.728. The modifications of the processing pipeline improved the AUC up to 0.832 (p = 0.046). Improvement of the AUC was confirmed in an independent validation sample of 241 ADNI MCI subjects (p = 0.048).Conclusion: The prognostic value of voxel-based single subject analysis of brain FDG PET in MCI subjects can be improved considerably by optimizing the processing pipeline. [ABSTRACT FROM AUTHOR]- Published
- 2016
- Full Text
- View/download PDF
12. Cortical Amyloid Burden Relates to Basal Forebrain Volume in Subjective Cognitive Decline.
- Author
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Daamen M, Scheef L, Li S, Grothe MJ, Gaertner FC, Buchert R, Buerger K, Dobisch L, Drzezga A, Essler M, Ewers M, Fliessbach K, Herrera Melendez AL, Hetzer S, Janowitz D, Kilimann I, Krause BJ, Lange C, Laske C, Munk MH, Peters O, Priller J, Ramirez A, Reimold M, Rominger A, Rostamzadeh A, Roeske S, Roy N, Scheffler K, Schneider A, Spottke A, Spruth EJ, Teipel SJ, Wagner M, Düzel E, Jessen F, and Boecker H
- Subjects
- Humans, Amyloid metabolism, Magnetic Resonance Imaging methods, Positron-Emission Tomography, Amyloidogenic Proteins, Amyloid beta-Peptides metabolism, Basal Forebrain diagnostic imaging, Alzheimer Disease diagnostic imaging, Alzheimer Disease pathology, Cognitive Dysfunction diagnostic imaging, Cognitive Dysfunction pathology
- Abstract
Background: Atrophy of cholinergic basal forebrain (BF) nuclei is a frequent finding in magnetic resonance imaging (MRI) volumetry studies that examined patients with prodromal or clinical Alzheimer's disease (AD), but less clear for individuals in earlier stages of the clinical AD continuum., Objective: To examine BF volume reductions in subjective cognitive decline (SCD) participants with AD pathologic changes., Methods: The present study compared MRI-based BF volume measurements in age- and sex-matched samples of N = 24 amyloid-positive and N = 24 amyloid-negative SCD individuals, based on binary visual ratings of Florbetaben positron emission tomography (PET) measurements. Additionally, we assessed associations of BF volume with cortical amyloid burden, based on semiquantitative Centiloid (CL) analyses., Results: Group differences approached significance for BF total volume (p = 0.061) and the Ch4 subregion (p = 0.059) only, showing the expected relative volume reductions for the amyloid-positive subgroup. There were also significant inverse correlations between BF volumes and CL values, which again were most robust for BF total volume and the Ch4 subregion., Conclusions: The results are consistent with the hypothesis that amyloid-positive SCD individuals, which are considered to represent a transitional stage on the clinical AD continuum, already show incipient alterations of BF integrity. The negative association with a continuous measure of cortical amyloid burden also suggests that this may reflect an incremental process. Yet, further research is needed to evaluate whether BF changes already emerge at "grey zone" levels of amyloid accumulation, before amyloidosis is reliably detected by PET visual readings.
- Published
- 2023
- Full Text
- View/download PDF
13. Abnormal Regional and Global Connectivity Measures in Subjective Cognitive Decline Depending on Cerebral Amyloid Status.
- Author
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Li S, Daamen M, Scheef L, Gaertner FC, Buchert R, Buchmann M, Buerger K, Catak C, Dobisch L, Drzezga A, Ertl-Wagner B, Essler M, Fliessbach K, Haynes JD, Incesoy EI, Kilimann I, Krause BJ, Lange C, Laske C, Priller J, Ramirez A, Reimold M, Rominger A, Roy N, Scheffler K, Maurer A, Schneider A, Spottke A, Spruth EJ, Teipel SJ, Tscheuschler M, Wagner M, Wolfsgruber S, Düzel E, Jessen F, Peters O, and Boecker H
- Subjects
- Aged, Aniline Compounds, Cohort Studies, Female, Humans, Male, Parietal Lobe pathology, Stilbenes, Amyloid beta-Peptides metabolism, Cognitive Dysfunction diagnostic imaging, Magnetic Resonance Imaging
- Abstract
Background: Amyloid-β accumulation was found to alter precuneus-based functional connectivity (FC) in mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia, but its impact is less clear in subjective cognitive decline (SCD), which in combination with AD pathologic change is theorized to correspond to stage 2 of the Alzheimer's continuum in the 2018 NIA-AA research framework., Objective: This study addresses how amyloid pathology relates to resting-state fMRI FC in SCD, especially focusing on the precuneus., Methods: From the DELCODE cohort, two groups of 24 age- and gender-matched amyloid-positive (SCDAβ+) and amyloidnegative SCD (SCDβ-) patients were selected according to visual [18F]-Florbetaben (FBB) PET readings, and studied with resting-state fMRI. Local (regional homogeneity [ReHo], fractional amplitude of low-frequency fluctuations [fALFF]) and global (degree centrality [DC], precuneus seed-based FC) measures were compared between groups. Follow-up correlation analyses probed relationships of group differences with global and precuneal amyloid load, as measured by FBB standard uptake value ratios (SUVR=⫖FBB)., Results: ReHo was significantly higher (voxel-wise p < 0.01, cluster-level p < 0.05) in the bilateral precuneus for SCDAβ+patients, whereas fALFF was not altered between groups. Relatively higher precuneus-based FC with occipital areas (but no altered DC) was observed in SCDAβ+ patients. In this latter cluster, precuneus-occipital FC correlated positively with global (SCDAβ+) and precuneus SUVRFBB (both groups)., Conclusion: While partial confounding influences due to a higher APOE ε4 carrier ratio among SCDAβ+ patients cannot be excluded, exploratory results indicate functional alterations in the precuneus hub region that were related to amyloid-β load, highlighting incipient pathology in stage 2 of the AD continuum.
- Published
- 2021
- Full Text
- View/download PDF
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