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Abnormal Regional and Global Connectivity Measures in Subjective Cognitive Decline Depending on Cerebral Amyloid Status

Authors :
Li, Shumei
Daamen, Marcel
Scheef, Lukas
Gaertner, Florian C.
Buchert, Ralph
Buchmann, Martina
Buerger, Katharina
Catak, Cihan
Dobisch, Laura
Drzezga, Alexander
Ertl-Wagner, Birgit
Essler, Markus
Fliessbach, Klaus
Haynes, John Dylan
Incesoy, Enise Irem
Kilimann, Ingo
Krause, Bernd J.
Lange, Catharina
Laske, Christoph
Priller, Josef
Ramirez, Alfredo
Reimold, Matthias
Rominger, Axel
Roy, Nina
Scheffler, Klaus
Maurer, Angelika
Schneider, Anja
Spottke, Annika
Spruth, Eike Jakob
Teipel, Stefan J.
Tscheuschler, Maike
Wagner, Michael
Wolfsgruber, Steffen
Duzel, Emrah
Jessen, Frank
Peters, Oliver
Boecker, Henning
Li, Shumei
Daamen, Marcel
Scheef, Lukas
Gaertner, Florian C.
Buchert, Ralph
Buchmann, Martina
Buerger, Katharina
Catak, Cihan
Dobisch, Laura
Drzezga, Alexander
Ertl-Wagner, Birgit
Essler, Markus
Fliessbach, Klaus
Haynes, John Dylan
Incesoy, Enise Irem
Kilimann, Ingo
Krause, Bernd J.
Lange, Catharina
Laske, Christoph
Priller, Josef
Ramirez, Alfredo
Reimold, Matthias
Rominger, Axel
Roy, Nina
Scheffler, Klaus
Maurer, Angelika
Schneider, Anja
Spottke, Annika
Spruth, Eike Jakob
Teipel, Stefan J.
Tscheuschler, Maike
Wagner, Michael
Wolfsgruber, Steffen
Duzel, Emrah
Jessen, Frank
Peters, Oliver
Boecker, Henning
Publication Year :
2021

Abstract

Background: Amyloid-beta accumulation was found to alter precuneus-based functional connectivity (FC) in mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia, but its impact is less clear in subjective cognitive decline (SCD), which in combination with AD pathologic change is theorized to correspond to stage 2 of the Alzheimer's continuum in the 2018 NIA-AA research framework. Objective: This study addresses how amyloid pathology relates to resting-state fMRI FC in SCD, especially focusing on the precuneus. Methods: From the DELCODE cohort, two groups of 24 age- and gender-matched amyloid-positive (SCDA beta+) and amyloidnegative SCD (SCDA beta-) patients were selected according to visual [18F]-Florbetaben (FBB) PET readings, and studied with resting-state fMRI. Local (regional homogeneity [ReHo], fractional amplitude of low-frequency fluctuations [fALFF]) and global (degree centrality [DC], precuneus seed-based FC) measures were compared between groups. Follow-up correlation analyses probed relationships of group differences with global and precuneal amyloid load, as measured by FBB standard uptake value ratios (SUVRFBB). Results: ReHo was significantly higher (voxel-wise p < 0.01, cluster-level p < 0.05) in the bilateral precuneus for SCDA beta+ patients, whereas fALFF was not altered between groups. Relatively higher precuneus-based FC with occipital areas (but no altered DC) was observed in SCDA beta+ patients. In this latter cluster, precuneus-occipital FC correlated positively with global (SCDA beta+) and precuneus SUVRFBB (both groups). Conclusion: While partial confounding influences due to a higher APOE epsilon 4 carrier ratio among SCDA beta+ patients cannot be excluded, exploratory results indicate functional alterations in the precuneus hub region that were related to amyloid-beta load, highlighting incipient pathology in stage 2 of the AD continuum.

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1312208091
Document Type :
Electronic Resource