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BACKGROUND: The muscle protein synthetic response to food intake is reduced in aging, contributing to a progressive muscle loss. This anabolic resistance results from a decreased sensitivity to anabolic signals, especially leucinemia, a potent activator of protein synthesis. Nutritional strategies are needed to reach the anabolic threshold of leucinemia and stimulate muscle anabolism. OBJECTIVES: This study sought to evaluate the effect of supplementing meals with soluble milk proteins (SMP) on postprandial leucinemia in elders. METHODS: During 3 successive experimental sessions, 6 healthy older men (66.7±0.7y) consumed a standardized lunch (27 g of proteins; 2.2 g of leucine) supplemented with a beverage containing 0 g, 5 g or 8.2 g of SMP (0 g, 0.6 g and 1.1 g of leucine, respectively). RESULTS: The supplementation with 5 g or 8.2 g of SMP induced an increase of 1.9? and 2.5? in plasma leucine levels, compared to the control meal (without additional SMP). The leucine area under the curve over 3h20 had an increase of 2.1? and 2.3?, respectively, as compared to the control meal. CONCLUSIONS: Ingesting SMP in addition to a meal strongly increased postprandial plasma leucine, and could be an effective strategy to reach anabolic thresholds and optimize the anabolic effect of each meal. [ABSTRACT FROM AUTHOR]

The French ministry of Health is setting up the Personal Medical Record (PMR). This innovative tool has long been expected by French Health Authorities, Associations of Patients, other Health's associations, those defending Individual Liberties and the French National Data Protection Authority. The PMR will lead to improvements in many areas such as Diagnosis (Research and monitoring) Healthcare (Management of emergencies, urgent situations, Temporal health monitoring and evaluation), Therapy (Cohorts of patients for Clinical trials and epidemiological studies). The PMR will foster safe healthcare management, clinical research and epidemiological studies. Nevertheless, it raises many important questions regarding duplicates and the quality, precision and coherence of the linkage with other health data coming from different sources. The currently planned identifying process raises many questions with regard to its ability to deal with potential duplicates and to perform data linkage with other health data sources. Through this article, using the electronic health records, we develop and propose an identification process to improve the French PMR. Our proposed unique patient identifier will guarantee the security, confidentiality and privacy of the personal data, and will prove to be particularly useful for health planning, health policies and research as well as clinical and epidemiological studies. Finally, it will certainly be interoperable with other European health information systems. We propose here an alternative identification procedure that would allow France to broaden the scope of its PMR project by making it possible to contribute to public health research and policy while increasing interoperability with European health information systems and preserving the confidentiality of the data. [ABSTRACT FROM AUTHOR]

The French ministry of Health is setting up the personal medical record (PMR or DMP for Dossier Medical Personnel in French). This innovating tool is highly expected and will be extremely useful for the therapeutic follow-up as well as for epidemiological studies on which public health policies are based. Therefore the currently planned identifying process should prevent any epidemiological use of these data. Numerous scientific organisations have alerted government powers about the threat that this impairment represents, and they wish to promote some secure procedures that exist, which have already proved their efficiency at the national and international level. [ABSTRACT FROM AUTHOR]