1. Patterns of Aging Changes in Bodyweight May Predict Alzheimer's Disease.
- Author
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Ukraintseva, Svetlana, Duan, Hongzhe, Holmes, Rachel, Bagley, Olivia, Wu, Deqing, Yashkin, Arseniy, Kulminski, Alexander, Akushevich, Igor, Whitson, Heather, Stallard, Eric, Yashin, Anatoliy, and Arbeev, Konstantin
- Subjects
ALZHEIMER'S disease ,AGING ,APOLIPOPROTEIN E ,APOLIPOPROTEIN E4 - Abstract
Relationships between patterns of aging-changes in bodyweight and AD are not fully understood. We compared mean age-trajectories of weight between those who did and did not develop late-onset-AD, and evaluated impact of age at maximum weight (AgeMax), and slope of decline in weight, on AD risk. Women with late-onset-AD had lower weight three or more decades before AD onset, and ∼10 years younger AgeMax, compared to AD-free women. APOE4 carriers had younger AgeMax and steeper slope. Older AgeMax and flatter slope predicted lower AD risk. Premature decline in weight could be a sign of accelerated physical aging contributing to AD. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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