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Patterns of Aging Changes in Bodyweight May Predict Alzheimer's Disease.
- Source :
- Journal of Alzheimer's Disease; 2024, Vol. 97 Issue 1, p163-170, 8p
- Publication Year :
- 2024
-
Abstract
- Relationships between patterns of aging-changes in bodyweight and AD are not fully understood. We compared mean age-trajectories of weight between those who did and did not develop late-onset-AD, and evaluated impact of age at maximum weight (AgeMax), and slope of decline in weight, on AD risk. Women with late-onset-AD had lower weight three or more decades before AD onset, and ∼10 years younger AgeMax, compared to AD-free women. APOE4 carriers had younger AgeMax and steeper slope. Older AgeMax and flatter slope predicted lower AD risk. Premature decline in weight could be a sign of accelerated physical aging contributing to AD. [ABSTRACT FROM AUTHOR]
- Subjects :
- ALZHEIMER'S disease
AGING
APOLIPOPROTEIN E
APOLIPOPROTEIN E4
Subjects
Details
- Language :
- English
- ISSN :
- 13872877
- Volume :
- 97
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Alzheimer's Disease
- Publication Type :
- Academic Journal
- Accession number :
- 174658236
- Full Text :
- https://doi.org/10.3233/JAD-220998