1. Polymorphism of IL-1 receptor antagonist gene: role in cancer.
- Author
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Sehouli J, Mustea A, Könsgen D, Katsares I, and Lichtenegger W
- Subjects
- Alleles, Female, Humans, Interleukin 1 Receptor Antagonist Protein, Prognosis, Sialoglycoproteins biosynthesis, Sialoglycoproteins physiology, Stomach Neoplasms metabolism, Uterine Cervical Neoplasms metabolism, Polymorphism, Genetic, Sialoglycoproteins genetics, Stomach Neoplasms genetics, Uterine Cervical Neoplasms genetics
- Abstract
Background: IL-1-cytokines are strongly involved in carcinogenesis and tumor genesis. In this systematic review we will describe the role of IL-1 RA within the cytokine network and its predictive and prognostic value in cancer., Materials and Methods: We analysed preclinical and clinical studies., Results: A polymorphism is present in intron 2 of the human IL-1RA gene. The IL-1RA allele 2 has an influence on the IL-1RA plasma level. The IL-1 beta level is elevated at the homozygous for IL-1RA, allele 2 (IL-1RN*2). The IL-1 gene cluster polymorphism is associated with gastric cancer. Carriers of IL-1 1B- 511T and IL-1RN*2 homozygotes have an increased risk of developing gastric cancer. Patients with a heterozygosity of allele 2 for IL-1 RA (IL-RA1/2) have an increased risk of cervical cancer. There are negative associations between IL-1 RA polymorphism and the occurrence of ovarian cancer., Conclusion: The polymorphism of IL-1RA seems to be involved in the induction of different solid tumors. more...
- Published
- 2002