Polymorphism of IL-1 receptor antagonist gene: role in cancer.

Authors :: Sehouli J
Mustea A
Könsgen D
Katsares I
Lichtenegger W
Source :: Anticancer research [Anticancer Res] 2002 Nov-Dec; Vol. 22 (6A), pp. 3421-4.
Publication Year :: 2002
Abstract: Background: IL-1-cytokines are strongly involved in carcinogenesis and tumor genesis. In this systematic review we will describe the role of IL-1 RA within the cytokine network and its predictive and prognostic value in cancer.<br />Materials and Methods: We analysed preclinical and clinical studies.<br />Results: A polymorphism is present in intron 2 of the human IL-1RA gene. The IL-1RA allele 2 has an influence on the IL-1RA plasma level. The IL-1 beta level is elevated at the homozygous for IL-1RA, allele 2 (IL-1RN*2). The IL-1 gene cluster polymorphism is associated with gastric cancer. Carriers of IL-1 1B- 511T and IL-1RN*2 homozygotes have an increased risk of developing gastric cancer. Patients with a heterozygosity of allele 2 for IL-1 RA (IL-RA1/2) have an increased risk of cervical cancer. There are negative associations between IL-1 RA polymorphism and the occurrence of ovarian cancer.<br />Conclusion: The polymorphism of IL-1RA seems to be involved in the induction of different solid tumors.