57 results on '"Edward Araujo Júnior"'
Search Results
2. Kisspeptin as a predictor of miscarriage: a systematic review
- Author
-
Pedro Henrique Alcântara da Silva, Lourena Guedes de Melo Romão, Natércia Paula Alves de Freitas, Thiago Ribeiro Carvalho, Maria Eduarda Mendes Pontes Porto, Edward Araujo Júnior, and Marcelo Borges Cavalcante
- Subjects
Pediatrics, Perinatology and Child Health ,Obstetrics and Gynecology - Published
- 2023
3. Evaluation of ultrasound measurements of abdominal fat for the prediction of gestational diabetes in the first and second trimesters of pregnancy
- Author
-
Fernanda Teixeira Benevides, Edward Araujo Júnior, Carla Soraya Costa Maia, Sammya Bezerra Maia e Holanda Moura, Renan Magalhães Montenegro Junior, and Francisco Herlânio Costa Carvalho
- Subjects
Blood Glucose ,Diabetes, Gestational ,Pregnancy Trimester, First ,Pregnancy ,Pregnancy Trimester, Second ,Pediatrics, Perinatology and Child Health ,Pregnancy Outcome ,Humans ,Obstetrics and Gynecology ,Female ,Prospective Studies ,Intra-Abdominal Fat - Abstract
To evaluate whether ultrasound abdominal fat measurements in the first and second trimesters can predict adverse gestational outcomes, particularly gestational diabetes mellitus (GDM), and identify early patients at higher risk for complications.A prospective cohort study of 126 pregnant women at 11-14 and 20-24 weeks of gestation with normal fasting glucose levels during early pregnancy. From 126 participants with complete data, 13.5% were diagnosed with GDM, based on the cutoffs established for the peripherical blood glucose. Subcutaneous, visceral, and maximum preperitoneal abdominal fat were measured using ultrasound techniques. GDM status was determined by oral glucose tolerance test (OGTT) with 75 g glucose overload, and the following values were considered abnormal: fasting glucose ≥92 mg/dl and/or 1 h after overload ≥180 mg/dl and/or 2 h after overload ≥153 mg/dl. The receiver operator characteristic (ROC) curve was used to determine the optimal threshold to predict GDM.Maximum preperitoneal fat measurement was predictive of GDM, and subcutaneous and visceral abdominal fat measurements did not show significant differences in the prediction of GDM. According to the ROC curve, a threshold of 45.25 mm of preperitoneal fat was identified as the optimal cutoff point, with 87% sensitivity and 41% specificity to predict GDM. The raw and adjusted odds ratios for age and pre-pregnancy body mass index were 0.730 (95% confidence interval [CI], 0.561-0.900) and 0.777 (95% CI, 0.623-0.931), respectively.The use of a 45.25 mm threshold for maximum preperitoneal fat, measured by ultrasound to predict the risk of GDM, appears to be a feasible, inexpensive, and practical alternative to incorporate into clinical practice during the first trimester of pregnancy.
- Published
- 2022
4. Adverse perinatal outcomes in fetuses with severe late-onset fetal growth restriction
- Author
-
Fernanda Campos da Silva, Edward Araujo Júnior, Renato Augusto Moreira de Sá, Guillermo Coca Velarde, and Maria Luiza Rozo Bahia
- Subjects
medicine.medical_specialty ,Hemorrhage ,Gestational Age ,Late onset ,Ultrasonography, Prenatal ,Umbilical Arteries ,law.invention ,Fetus ,Pregnancy ,Enterocolitis, Necrotizing ,law ,Fetal growth ,Humans ,Medicine ,Prospective Studies ,reproductive and urinary physiology ,Retrospective Studies ,Fetal Growth Retardation ,business.industry ,Obstetrics ,Infant, Newborn ,Pregnancy Outcome ,Obstetrics and Gynecology ,Ultrasonography, Doppler ,Intensive care unit ,humanities ,embryonic structures ,Pediatrics, Perinatology and Child Health ,Female ,business ,Cohort study - Abstract
To evaluate perinatal outcomes in fetuses with severe late-onset fetal growth restriction.This was a retrospective and observational cohort study in which pregnant women diagnosed with late-onset fetal growth restriction assisted at perinatal maternity birth from 2010 to 2017 were included. The outcomes were intensive care unit (ICU) admission and perinatal complications, such as neonatal death, intraventricular hemorrhage, periventricular leukomalacia, hypoxic-ischemic encephalopathy, necrotizing enterocolitis, bronchopulmonary dysplasia, and sepsis.We selected 277 pregnant women, of whom 124 newborns (44.76%) went to the ICU. The chance of a newborn needing ICU decreases by 62, 7, and 9% according to an increase of one gestational week, 1 cm of the abdominal circumference, or 1 cm of the amniotic fluid index, respectively. Oligohydramnios increases the risk of going to the ICU by 2.13 times. The increase in the umbilical artery pulsatility index (PI) Doppler increases the chance of ICU admission by 7.9 times. The normal middle cerebral artery PI Doppler and the normal cerebroplacental ratio reduce the risk of ICU admission.The estimated fetal weight, abdominal circumference, and amniotic fluid index diagnosed severe late-onset fetal growth restriction. With the decrease in middle cerebral artery PI Doppler, there is a greater probability of admission to the ICU, with the most common complications being intraventricular hemorrhage and necrotizing enterocolitis.
- Published
- 2021
5. Heterotaxy Syndrome with Increased Nuchal Translucency and Normal Karyotype Associated with Complex Systemic Venous Return. Ultrasound Diagnosis with Autopsy Correlation
- Author
-
Maria Paola Bonasoni, Gianpaolo Grisolia, Gabriele Tonni, Maria Bellotti, and Edward Araujo Júnior
- Subjects
medicine.medical_specialty ,Vena Cava, Superior ,Karyotype ,Autopsy ,Prenatal diagnosis ,Heterotaxy Syndrome ,Ultrasonography, Prenatal ,Pathology and Forensic Medicine ,Pulmonary vein ,Pregnancy ,Internal medicine ,medicine ,Humans ,Persistent left superior vena cava ,Increased nuchal translucency ,Coronary sinus ,business.industry ,General Medicine ,medicine.disease ,Dissection ,Pediatrics, Perinatology and Child Health ,cardiovascular system ,Cardiology ,Female ,Nuchal Translucency Measurement ,business ,Venous return curve - Abstract
Background: Prenatal ultrasound (US) detection of heterotaxy syndrome can be challenging, especially in identifying cardiovascular and associated anomalies. We present a new case of heterotaxy syndrome with anomalous systemic venous return (ASVR) fully displayed at autopsy. Case report: Left heterotaxy syndrome was diagnosed in a 19 weeks' of gestation fetus with right-sided stomach. The heart showed both ventricles with left morphology, a large ventricular septal defect, persistent left superior vena cava draining into the coronary sinus, ASVR with interrupted inferior vena cava (IVC) and azygous continuation. Autopsy dissection further identified the azygous draining into the left lower pulmonary vein (LLPV). Prenatal a-CGH on villous sampling showed 22q13.1 microduplication inherited from the father, not contributory to the phenotype. Conclusion/discussion: Heterotaxy syndrome requires US accuracy for anomaly identification, as they allow legal termination of pregnancy. Our case is unusual as IVC drained into the azygous vein and then into the LLPV.
- Published
- 2021
6. Doppler abnormalities and perinatal outcomes in pregnant women with early-onset fetal growth restriction
- Author
-
Edward Araujo Júnior, Beatriz Frota Dias, Júlio Augusto Gurgel Alves, Paula Vitória Pereira Motoyama, Cesaltina Soares Muniz, Camila Timbó Catunda Almeida, and Francisco Edson de Lucena Feitosa
- Subjects
medicine.medical_specialty ,Fetal Growth Retardation ,business.industry ,Obstetrics ,Placenta ,Obstetrics and Gynecology ,Ultrasonography, Doppler ,Placental Insufficiency ,Umbilical Arteries ,Ultrasonography, Prenatal ,humanities ,Fetal hypoxia ,Pregnancy ,Pediatrics, Perinatology and Child Health ,Fetal growth ,Humans ,Medicine ,Female ,Pregnant Women ,business ,High risk pregnancy ,Retrospective Studies ,Early onset ,Cohort study - Abstract
To compare Doppler alterations and perinatal outcomes in pregnant women who evolved with early- and late-onset fetal growth restriction (FGR).A retrospective, observational cohort study with pregnant women who evolved with FGR treated between January 2018 and April 2019, in which all live births from singleton pregnancies, over 24 weeks, with FGR ultrasound diagnosis and under 2700 g weight were included in the study.Pregnancies with early-onset FGR were more associated with hypertensive disorders (Early-onset FGR had a lower prevalence but was associated with higher maternal and fetal morbidity and mortality than late-onset FGR.
- Published
- 2021
7. Cervical pessary plus vaginal progesterone in a singleton pregnancy with a short cervix: an experience-based analysis of cervical pessary’s efficacy
- Author
-
Edward Araujo Júnior, Antonio Fernandes Moron, Valter Lacerda de Andrade Junior, Marcelo Santucci França, David Baptista da Silva Pares, Stephanno Gomes Pereira Sarmento, Julio Elito Júnior, Rosiane Mattar, A. R. Hatanaka, Tatiana K. Hamamoto, and Jader Cruz
- Subjects
Cervical pessary ,medicine.medical_specialty ,Singleton pregnancy ,Cervix Uteri ,macromolecular substances ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,medicine ,Humans ,Pessary insertion ,030212 general & internal medicine ,Progesterone ,030219 obstetrics & reproductive medicine ,Obstetrics ,business.industry ,Infant, Newborn ,Obstetrics and Gynecology ,Pessaries ,Administration, Intravaginal ,Short cervix ,Cervical Length Measurement ,Pediatrics, Perinatology and Child Health ,Premature Birth ,Female ,Progestins ,business - Abstract
Several studies were published about cervical pessary, with controversial results. These studies demonstrated that the patient follow-up after pessary insertion is very different between the study centers and the number of pessary insertions per center was often30 cases. This study aims to determine cervical pessary performance in singleton pregnancies with a short cervix based on a single center learning curve.Between 2011 and 2018, 128 singleton pregnancies between 18 and 24 gestational weeks with a short cervix (25 mm) were referred to our clinic. All cases were treated with progesterone, and when available in our supplies (due to low resources) cervical pessary was also offered. Three groups were created for statistical analysis: Group 1 (The learning curve was performed with all cases of pessary plus progesterone, and 30 patients were obtained as the number needed for learning, in our study with two operators. The PTB rate34 weeks was 27.3, 20, and 4.6% in groups 1, 2, and 3, respectively. There was no significant difference between Group 1 and 2 (OR 1.1; 95% CI 0.066 - 18.45;Learning curve and cumulative sum analysis determined that the application and surveillance of at least 30 patients is required to see significant improvements in the primary outcome of PTB34 weeks.
- Published
- 2021
8. Increased pulsatility index of uterine artery Doppler between 26 and 28 weeks of gestation and adverse perinatal outcomes
- Author
-
Daniela Rocha Ramos, Fernando Felix Dulgheroff, Caetano Galvão Petrini, Taciana Mara Rodrigues da Cunha Caldas, Edward Araujo Júnior, and Alberto Borges Peixoto
- Subjects
Normalization (statistics) ,medicine.medical_specialty ,030204 cardiovascular system & hematology ,Pulsatility index ,Ultrasonography, Prenatal ,03 medical and health sciences ,0302 clinical medicine ,Pre-Eclampsia ,Pregnancy ,Internal medicine ,Birth Weight ,Humans ,Medicine ,Retrospective Studies ,030219 obstetrics & reproductive medicine ,business.industry ,Uterus ,Uterine artery doppler ,Pregnancy Outcome ,Obstetrics and Gynecology ,Ultrasonography, Doppler ,humanities ,Uterine Artery ,Pediatrics, Perinatology and Child Health ,Cardiology ,Gestation ,Female ,business - Abstract
To compare adverse perinatal outcomes in pregnant women with or without normalization of the mean pulsatility index (PI) uterine artery Doppler between 24 and 28 weeks of gestation.Retrospective cohort which pregnant women were divided into three groups: normal uterine artery Doppler between 20-24 and 26-28 weeks (controls), abnormal uterine artery Doppler between 20-24 and normal between 26-28 weeks (anUtA), and abnormal uterine artery Doppler between 20-24 and 26-28 weeks (aaUtA). To compare adverse perinatal results between the groups Chi-square test was used. Binary logistic regression was used to assess the ability of uterine artery Doppler to predict birthweight10th and composite perinatal outcomes.Birthweight was significantly lower in the aaUtA compared to anUtA (2687 vs 3248 grams,Maintenance of altered uterine artery Doppler during the 3rd trimester was associated with higher prevalence of composite perinatal outcomes and lower birthweight compared to its late normalization. Although modest, uterine artery Doppler in the 3rd trimester proved to be predictor of birthweight10th.
- Published
- 2021
9. Ultrasound evaluation of subcutaneous and visceral abdominal fat as a predictor of gestational diabetes mellitus: a systematic review
- Author
-
Francisco Herlânio Costa Carvalho, Renan Magalhães Montenegro Júnior, Fernanda Teixeira Benevides, Edward Araujo Júnior, and Carla Soraya Costa Maia
- Subjects
medicine.medical_specialty ,endocrine system diseases ,Intra-Abdominal Fat ,Subcutaneous Fat ,Gestational Age ,030209 endocrinology & metabolism ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,medicine ,Abdominal fat ,Humans ,Ultrasonography ,030219 obstetrics & reproductive medicine ,business.industry ,Ultrasound ,nutritional and metabolic diseases ,Obstetrics and Gynecology ,medicine.disease ,Gestational diabetes ,Diabetes, Gestational ,Pregnancy Trimester, First ,Pregnancy Trimester, Second ,Pediatrics, Perinatology and Child Health ,Female ,Radiology ,business - Abstract
Studies of subcutaneous and visceral abdominal fat thickness evaluated by ultrasound as a predictor of gestational diabetes mellitus (GDM) have been published, but the best technique and standardization are unknown. To identify, critically evaluate, and analyze studies using subcutaneous and visceral abdominal fat as a model for predicting GDM in the first and second trimesters of pregnancy and evaluate their methodological quality.PubMed, Scopus, and Web of Science databases were searched from May to July 2019. We included studies of any sample size performed for any duration and in any configuration. Model development and validation studies were eligible for inclusion. Two authors independently performed the eligibility assessment of the studies by reviewing the titles and abstracts. Data on study design, gestational age, diagnostic criteria for GDM, device, ultrasound fat measurement technique, and cutoff point for GDM prediction were extracted.The electronic search resulted in 1331 articles, of which 14 were eligible for systematic review. Different criteria for diagnosing GDM and fat measurement techniques were used. The cutoff point for subcutaneous, visceral, and total abdominal fat for predicting GDM in the first and second trimesters varied between the studies.No study validated the model for predicting GDM using subcutaneous and visceral abdominal fat measurements. External validation studies are recommended to improve the generalization of this GDM predictor in clinical practice.
- Published
- 2020
10. Performance of local reference curve on the diagnosis of large for gestational age fetuses in diabetic pregnant women
- Author
-
Edward Araujo Júnior, Rafael Frederico Bruns, Natália Roberta Andrade Dalla Costa, Liziane Lorusso, and Daniel Massamatsu Pianovski Kato
- Subjects
medicine.medical_specialty ,Gestational Age ,Infant, Newborn, Diseases ,Ultrasonography, Prenatal ,03 medical and health sciences ,Fetus ,0302 clinical medicine ,Pregnancy ,Diabetes Mellitus ,medicine ,Birth Weight ,Humans ,Intergrowth 21st ,030212 general & internal medicine ,Fetal Growth Retardation ,030219 obstetrics & reproductive medicine ,Obstetrics ,business.industry ,Significant difference ,Infant, Newborn ,Large gestational age ,Obstetrics and Gynecology ,Gestational age ,Fetal weight ,medicine.disease ,Gestational diabetes ,Fetal Weight ,Infant, Small for Gestational Age ,Pediatrics, Perinatology and Child Health ,Female ,Pregnant Women ,business - Abstract
Objective: To evaluate the performance of a local fetal weight curve based on the prediction for large gestational age (LGA) newborns in diabetic pregnant women and to compare it to reference curves established for other populations.Method: A reference model for estimated fetal weight was created from a local sample of 2211 singleton low-risk pregnancies. The estimated fetal weight from 194 women with gestational diabetes mellitus was then plotted on this curve, and the results were compared to those obtained by Intergrowth 21st and Hadlock curves.Results: The sensitivity of the proposed model to predict LGA fetuses was 55.6%, the specificity was 82.1%, and the accuracy was 74.7%. The sensitivity, specificity, and accuracy for the Intergrowth 21st curve were 46.3%, 87.9%, and 76.3%, respectively, and no statistically significant difference was observed compared to the proposed model. Conversely, significant differences were observed for the Hadlock curve, which presented a lower sensitivity (24.1%), higher specificity (97.1%), and similar accuracy (76.8%).Conclusion: The sensitivity of the proposed model was higher compared to the Hadlock curve for the screening of LGA newborns in diabetic pregnant women. However, no significant differences were observed in comparison to the Intergrowth 21st curve.
- Published
- 2020
11. Transperineal three-dimensional ultrasound for analyzing the effects of perineal stretching with EPI-NO® in women with multiple pregnancies: a pilot study
- Author
-
Miriam Raquel Diniz Zanetti, Edward Araujo Júnior, Juliana Sayuri Kubotani, Julio Elito Júnior, and Jurandir Piassi Passos
- Subjects
Three dimensional ultrasound ,medicine.medical_specialty ,030219 obstetrics & reproductive medicine ,Pelvic floor ,business.industry ,Obstetrics and Gynecology ,Surgery ,body regions ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Vaginal dilator ,Pediatrics, Perinatology and Child Health ,medicine ,sense organs ,030212 general & internal medicine ,Muscle stretching ,business - Abstract
Objective: To compare the changes in the pelvic floor of women with twin pregnancies who practiced muscle stretching with the EPI-NO® vaginal dilator, as assessed using transperineal three-dimensio...
- Published
- 2020
12. Perinatal outcomes of fetal intra-abdominal umbilical vein varix: a multicenter cohort study
- Author
-
Sherif A. Shazly, Laura F. Sutton, Heron Werner, Edward Araujo Júnior, Victoria Novoa, Federico Prefumo, Eniola R. Ibirogba, Gabriele Tonni, Mari Charisse Trinidad, Waldo Sepulveda, and Rodrigo Ruano
- Subjects
Adult ,Umbilical Veins ,medicine.medical_specialty ,Prenatal diagnosis ,Ultrasonography, Prenatal ,Umbilical vein ,030218 nuclear medicine & medical imaging ,Varicose Veins ,03 medical and health sciences ,Fetus ,0302 clinical medicine ,Pregnancy ,Humans ,Medicine ,thrombosis ,reproductive and urinary physiology ,Retrospective Studies ,umbilical vein ,prenatal diagnosis ,030219 obstetrics & reproductive medicine ,business.industry ,Obstetrics ,Infant, Newborn ,Obstetrics and Gynecology ,Retrospective cohort study ,medicine.disease ,Thrombosis ,humanities ,Fetal ultrasound ,embryonic structures ,Pediatrics, Perinatology and Child Health ,Umbilical vein varix ,Female ,business ,Cohort study - Abstract
To investigate the perinatal outcomes of fetuses with antenatal diagnoses of intra-abdominal umbilical vein varix (UVV).A multicenter retrospective study was conducted in four countries on fetuses diagnosed with intra-abdominal UVV between 2012 and 2019. Collected data included gestational age (GA), UVV maximum diameter at diagnosis and delivery, associated anatomical and chromosomal anomalies, birth weight, and neonatal outcomes.Twenty fetuses were identified, of which 20% had associated chromosomal and/or anatomical abnormalities, most resulting in poor outcomes (either intrauterine fetal death or pregnancy termination). Mean maternal age was 34.1 ± 7.0 years, UVV was diagnosed at 26.5 ± 4.5 weeks of GA on average with a maximum diameter of 12.0 ± 4.0 mm. Mean GA at delivery was 35.4 ± 5.6 weeks. Survival rate was 85%.Our study shows a satisfactory outcome when intra-abdominal UVV is an isolated finding, with minimal obstetrical and perinatal consequences. The prognosis is worse when UVV is associated with other anomalies.
- Published
- 2019
13. Device to predict pelvic floor integrity during vaginal delivery: an intra- and interrater reliability study of the Epi-no distensibility measurement
- Author
-
Carla Dellabarba Petricelli, Miriam Raquel Diniz Zanetti, Edward Araujo Júnior, Sandra Maria Alexandre, Mary Uchiyama Nakamara, and Aline Paschoal
- Subjects
Adult ,medicine.medical_specialty ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,medicine ,Humans ,Prospective Studies ,030212 general & internal medicine ,Reliability (statistics) ,Observer Variation ,Reproducibility ,030219 obstetrics & reproductive medicine ,Pelvic floor ,business.industry ,Vaginal delivery ,Reproducibility of Results ,Obstetrics and Gynecology ,Pelvic Floor ,Delivery, Obstetric ,body regions ,Inter-rater reliability ,medicine.anatomical_structure ,Vagina ,Pediatrics, Perinatology and Child Health ,Physical therapy ,Female ,Observational study ,business - Abstract
To determine the test-retest reliability of the pelvic floor distensibility evaluation with Epi-noProspective, blinded observational study with 32 women pregnant from 35 gestational weeks. An Epi-noFrom a total of 32 included pregnant women, 28 were analyzed; they were 29.3 (±5.97) years old, were at 37 (±1.3) weeks' gestation and presented a mean Epi-noEpi-no
- Published
- 2019
14. Intrahepatic bile ductal ectasia in autosomal recessive polycystic kidney disease evaluated by fetal magnetic resonance imaging: a more frequent complication
- Author
-
Tatiana Fazecas, Heron Werner, Pedro Henrique Zubcich Caiado de Castro, A.P. Matos, Edward Araujo Júnior, and Edson Marchiori
- Subjects
Fetal magnetic resonance imaging ,Pathology ,medicine.medical_specialty ,Magnetic Resonance Spectroscopy ,Prenatal diagnosis ,digestive system ,03 medical and health sciences ,Fetus ,0302 clinical medicine ,Pregnancy ,030225 pediatrics ,Ectasia ,Bile ,Humans ,Medicine ,Polycystic Kidney, Autosomal Recessive ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Obstetrics and Gynecology ,Magnetic resonance imaging ,Magnetic Resonance Imaging ,Autosomal Recessive Polycystic Kidney Disease ,Pediatrics, Perinatology and Child Health ,Female ,030211 gastroenterology & hepatology ,business ,Complication ,Dilatation, Pathologic - Abstract
This study aimed to evaluate liver malformations and intrahepatic bile ductal ectasia and dilatation (IBDED) in cases of prenatal diagnosis of autosomal recessive polycystic kidney disease (ARPKD) using magnetic resonance imaging (MRI).This retrospective study involved 209 cases referred for fetal MRI studies (f-MRI) from March 2004 and December 2019, suspicious of congenital renal disease. Fetuses that met the criteria for ARPKD were selected.Six cases were diagnosed as ARPKD (2.8%). The median gestational age at MRI examination was 28 weeks (24-36 weeks). IBDED was observed in 84% of cases. Moreover, 66% presented multilobar liver lesions, and 33% exhibited monolobar lesions. The "central dot sign" (CDS) was found in half of the cases.In this case series of prenatal diagnosis of ARPKD using f-MRI, IBDED was present in the majority of the cases, and the CDS was noted in half of the cases.
- Published
- 2020
15. Reference ranges for the left ventricle modified myocardial performance index, respective time periods, and atrioventricular peak velocities between 20 and 36 + 6 weeks of gestation
- Author
-
Wellington P. Martins, Alberto Borges Peixoto, Antonio Fernandes Moron, Rosiane Mattar, Edward Araujo Júnior, and Nathalie Jeanne Bravo-Valenzuela
- Subjects
medicine.medical_specialty ,Fetus ,business.industry ,Heart Ventricles ,Reproducibility of Results ,Obstetrics and Gynecology ,Gestational Age ,Fetal heart ,Ultrasonography, Prenatal ,Cross-Sectional Studies ,Fetal Heart ,medicine.anatomical_structure ,Pregnancy ,Reference Values ,Ventricle ,Internal medicine ,Pediatrics, Perinatology and Child Health ,medicine ,Cardiology ,Humans ,Gestation ,Female ,Prospective Studies ,Myocardial Performance Index ,business - Abstract
Objective: To establish reference ranges for the fetal left ventricle (LV) modified myocardial performance index (Mod-MPI), respective time periods, and right and left atrioventricular peak velocit...
- Published
- 2019
16. Prediction of birth weight in twin pregnancies using fractional limb volumes by three-dimensional ultrasonography
- Author
-
Antonio Braga, Julio Elito Júnior, Vivian Melo Corrêa, and Edward Araujo Júnior
- Subjects
medicine.medical_specialty ,Birth weight ,Gestational Age ,Ultrasonography, Prenatal ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Birth Weight ,Humans ,Medicine ,Prospective Studies ,030212 general & internal medicine ,Twin Pregnancy ,Ultrasonography ,Fetus ,030219 obstetrics & reproductive medicine ,business.industry ,Obstetrics ,Significant difference ,Ultrasound ,Obstetrics and Gynecology ,Gestational age ,Pediatrics, Perinatology and Child Health ,Pregnancy, Twin ,Female ,Three dimensional ultrasonography ,business ,Cohort study - Abstract
Objective To predict birth weight using fetal fractional limb volumes (FLVs) by three-dimensional (3D) ultrasonography in twin pregnancies. Method This prospective observational cohort study evaluated 51 twin pregnancies, including 28 dichorionic and 23 monochorionic pregnancies. Ultrasound examinations were performed up to 5 d before delivery. Birth weight prediction models were developed using the fractional arm volume (FAV), fractional thigh volume (FTV), and Hadlock's formula and were compared with the actual birth weight. Results The mean gestational age at the time of ultrasound examination was 35.3 weeks. The mean birth weight was slightly higher in dichorionic than in monochorionic pregnancies 2391.2 versus 2352.4 g. The measurements using FTV were the closest to actual birth weights. For the total group, the Hadlock formula had mean percentage change of 7.18% while the FTV model presented mean percentage change of 6.62% in relation to birth weight. However, no significant difference was noted between Hadlock's formula and FTV p = .363 and .678 for dichorionic and monochorionic pregnancies, respectively. Conclusions FTV accurately predicted birth weight in twin monochorionic and dichorionic pregnancies. However, Hadlock's formula should still be used.
- Published
- 2019
17. Prenatal diagnosis of cervical masses by magnetic resonance imaging and 3D virtual models: perinatal and long-term follow-up outcomes
- Author
-
Pedro Teixeira Castro, Luciana de Barros Duarte, Tatiana Fazecas, A.P. Matos, Edward Araujo Júnior, Pedro Daltro, Heron Werner, Adauto Dutra Moraes Barbosa, and Renata Nogueira
- Subjects
Adult ,Male ,medicine.medical_specialty ,Long term follow up ,Gestational Age ,Prenatal diagnosis ,Ultrasonography, Prenatal ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Cervical masses ,Imaging, Three-Dimensional ,0302 clinical medicine ,Pregnancy ,medicine ,Humans ,Retrospective Studies ,Fetus ,Lymphatic Abnormalities ,medicine.diagnostic_test ,business.industry ,Infant, Newborn ,Teratoma ,Obstetrics and Gynecology ,Magnetic resonance imaging ,Magnetic Resonance Imaging ,Head and Neck Neoplasms ,030220 oncology & carcinogenesis ,Pediatrics, Perinatology and Child Health ,Female ,Radiology ,business - Abstract
Objective: To assess perinatal and long-term follow-up outcomes of fetal cervical masses diagnosed by three-dimensional (3D) magnetic resonance imaging (MRI) and 3D virtual models.Methods: This ret...
- Published
- 2018
18. TRAP Sequence in Monochorionic/Monoamniotic (MC/MA) Discordant Twins: Two Cases Treated with Fetoscopic Laser Surgery
- Author
-
Suonavy Khung-Savatovsky, Federico Prefumo, Fabien Guimiot, Gabriele Tonni, Mathilde Lefebvre, Paola Bonasoni, Anna Fichera, Jonathan Rosenblatt, Edward Araujo Júnior, Paolo Zampriolo, and Gianpaolo Grisolia
- Subjects
Laser surgery ,Cristal and Realistic Vue ,fetal pathology ,fetoscopic laser photocoagulation ,monochorionic/monoamiotic twins ,TRAP sequence ,Female ,Fetofetal Transfusion ,Fetoscopy ,Humans ,Laser Coagulation ,Laser Therapy ,Pregnancy ,Twins, Monozygotic ,medicine.medical_treatment ,Twins ,Umbilical cord ,Monozygotic ,Pathology and Forensic Medicine ,Trap (computing) ,03 medical and health sciences ,0302 clinical medicine ,medicine ,030212 general & internal medicine ,030219 obstetrics & reproductive medicine ,business.industry ,Interstitial laser ,General Medicine ,Ablation ,medicine.anatomical_structure ,Acardiac twin ,Pediatrics, Perinatology and Child Health ,TRAP Sequence ,business ,Nuclear medicine - Abstract
Ablation of the acardiac twin umbilical cord in the TRAP protects the normal donor twin.Two case descriptions, one of interstitial laser photocoagulation and one of laser umbilical cord occlusion (L-UCO) of the acardiac twin in monochorionic monoamniotic pregnancies are reported.L-UCO in two pregnancies with TRAP syndrome in the second trimester resulted in intrauterine fetal death in both cases after 1 month. Case 1 had no detectable cause of fetal death. Case 2 had rupture of the amniotic sac causing anhydramnios and acute chorioamnionitis. A groove on the umbilical cord of the normal twin indicated a cord stricture due to cord entanglement.Our experience confirms that the best timing and optimal treatment of MC/MA twins complicated by TRAP sequence still remains a controversial clinical issue. Cord entanglement may continue be a potential clinical risk factor for adverse perinatal outcome even after ablation therapy.
- Published
- 2018
19. Coronavirus and pregnancy: How can three-dimensional printing laboratories help?
- Author
-
Flávia Paiva Lopes, Gerson Ribeiro, Edward Araujo Júnior, Jorge Lopes, and Heron Werner
- Subjects
Pregnancy ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Obstetrics and Gynecology ,Outbreak ,medicine.disease ,medicine.disease_cause ,Coronavirus ,Pneumonia ,Three dimensional printing ,Pediatrics, Perinatology and Child Health ,Pandemic ,Printing, Three-Dimensional ,Obstetrics and Gynaecology ,medicine ,Humans ,Female ,Medical emergency ,Pediatrics, Perinatology, and Child Health ,business ,Coronavirus Infections ,Laboratories - Abstract
Sir,The coronavirus infection (COVID-19) outbreak has been upgraded to a pandemic. The first case of COVID-19 pneumonia was reported in Wuhan, China, in December 2019 [1]. In Brazil, many efforts a...
- Published
- 2020
- Full Text
- View/download PDF
20. Late umbilical cord clamping does not increase rates of jaundice and the need for phototherapy in pregnancies at normal risk
- Author
-
Francisco Herlânio Costa Carvalho, Matheus Costa Carvalho Augusto, Edward Araujo Júnior, Antônio Brazil Viana Júnior, Ocilia Maria Costa Carvalho, Hesly Martins Pereira Lima, and Maxsuênia Queiroz Medeiros
- Subjects
Adult ,medicine.medical_specialty ,Adolescent ,Birth weight ,Population ,Gestational Age ,Umbilical cord ,Umbilical Cord ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Risk Factors ,030225 pediatrics ,Statistical significance ,medicine ,Humans ,030212 general & internal medicine ,education ,Retrospective Studies ,education.field_of_study ,business.industry ,Obstetrics ,Infant, Newborn ,Obstetrics and Gynecology ,Retrospective cohort study ,Phototherapy ,Jaundice ,Delivery, Obstetric ,Surgical Instruments ,Constriction ,Jaundice, Neonatal ,Exact test ,Cross-Sectional Studies ,medicine.anatomical_structure ,Pediatrics, Perinatology and Child Health ,Gestation ,Female ,medicine.symptom ,business - Abstract
Objective: To verify the relationship between the time of clamping of the umbilical cord and the development of neonatal jaundice, the dosage of bilirubin and the need for phototherapy. Methods: Cross-sectional, retrospective study with 398 parturients at normal risk (single term gestation, no complications during gestation or delivery, birth weight between 2500 and 4499 g). The population was divided into three groups regarding the time of cord clamping: 3 min(53, 13.3%). Sociodemographic, clinical and obstetric characteristics, birth and delivery data, and maternal and perinatal outcomes were evaluated. Pearson's chi-square test, Fisher's exact test and the Kruskal-Wallis test were used for comparison between the groups. Statistical significance was considered p 3 min: 16.6 versus 1%) (p
- Published
- 2018
21. Tuboperitoneal fistula, ectopic pregnancy, and remnants of fallopian tube: a confocal microtomography analysis and 3D reconstruction of human fallopian tube pathologies
- Author
-
Haimon Diniz Lopes Alves, A.S. Machado, Pedro Teixeira Castro, Osvaldo Luiz Aranda, A.P. Matos, Ricardo Tadeu Lopes, Edward Araujo Júnior, Edson Marchiori, and Heron Werner
- Subjects
Fistula ,Confocal ,Surgical sterilization ,Peritoneal Diseases ,03 medical and health sciences ,Imaging, Three-Dimensional ,0302 clinical medicine ,Pregnancy ,medicine ,Humans ,Fallopian Tubes ,Ultrasonography ,030219 obstetrics & reproductive medicine ,Biological studies ,Tissue segmentation ,Ectopic pregnancy ,business.industry ,Obstetrics and Gynecology ,X-Ray Microtomography ,medicine.disease ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Pediatrics, Perinatology and Child Health ,Female ,Pregnancy, Tubal ,Nuclear medicine ,business ,Fallopian tube - Abstract
Objective: The aim of this study was to provide a three-dimensional (3D) microscopic reconstruction of morphological modifications of the fallopian tube (FT) following surgical sterilization (including tuboperitoneal fistula) and ectopic pregnancy (EP) using confocal microtomography (micro-CT). Methods: Six specimens of FT from elective and emergency surgeries were selected: three remnants of the FT (RFT) from surgical sterilization, including one presenting tuboperitoneal fistula, and three FTs with EP. The specimens were fixed in formalin and stained with Lugol solution. Micro-CT studies were conducted on the specimens using protocols adapted from biological studies. Results: Three RFTs from surgical sterilization and three FTs affected by EPs were successfully scanned using micro-CT. There was good contrast impregnation, allowing tissue segmentation and analysis of different sections of the FTs. Three FT specimens from EP exhibited considerable distortion of the tubal anatomy, mainly from the blood clot in the tubal abortion. Three RFT specimens exhibited some features observed in traditional microscopy, such as tubal distension and loss of normal anatomical characteristics of a normal FT, and indicated the presence of a tuboperitoneal fistula in one of the three specimens. Conclusion: Micro-CT can identify morphological characteristics of FT pathologies previously described in a microscopic scale, with tissue contrast and the possibility of 3D reconstruction. Micro-CT is also useful in guiding traditional sectioning of specimens for histopathological studies.
- Published
- 2018
22. Anatomically corrected malposition of the great arteries: a challenging fetal diagnosis
- Author
-
Edward Araujo Júnior, Alberto Borges Peixoto, Nathalie Jeanne Bravo-Valenzuela, Marilim de Souza Bezerra, and Milene Carvalho Carrilho
- Subjects
Adult ,Male ,Transposition of Great Vessels ,Ventricular outflow tract obstruction ,030204 cardiovascular system & hematology ,03 medical and health sciences ,Fatal Outcome ,Fetal Heart ,0302 clinical medicine ,Pregnancy ,medicine ,Humans ,030219 obstetrics & reproductive medicine ,medicine.diagnostic_test ,business.industry ,Infant, Newborn ,Obstetrics and Gynecology ,Anatomy ,Coronary arteries ,medicine.anatomical_structure ,Great vessels ,Echocardiography ,Great arteries ,Pediatrics, Perinatology and Child Health ,Female ,Fetal diagnosis ,medicine.symptom ,business ,Fetal echocardiography - Abstract
Anatomically corrected malposed great arteries are uncommon and benign entity. Basically, this occurs with ventriculoarterial concordance in which the great vessels arise parallel instead of a twisting fashion. In this manuscript, we described two cases in which the antenatal diagnosis of anatomically corrected malposition of great arteries was suspected and confirmed during the postnatal period. During the fetal life, this diagnosis remains a challenge and this condition is often misdiagnosed as the transposition of the great arteries (TGA). Differently to TGA, anatomically corrected malposition of the great arteries may not require any cardiac surgical intervention depending on the associated cardiac anomalies. Indeed, postnatal examination for concerns related to anomalies that can be associated with this condition, such as anomalous origins of coronary arteries and left ventricular outflow tract obstruction, should be performed.
- Published
- 2018
23. Is there any possible link between COVID-19 and human infertility?
- Author
-
Arlley Cleverson Belo da Silva, Ricardo Barini, Edward Araujo Júnior, Marcelo Borges Cavalcante, and Manoel Sarno
- Subjects
0301 basic medicine ,Infertility ,medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,MEDLINE ,medicine.disease_cause ,World health ,03 medical and health sciences ,0302 clinical medicine ,Obstetrics and Gynaecology ,medicine ,Humans ,Pediatrics, Perinatology, and Child Health ,Coronavirus ,business.industry ,COVID-19 ,Obstetrics and Gynecology ,Outbreak ,medicine.disease ,030104 developmental biology ,030220 oncology & carcinogenesis ,Family medicine ,Pediatrics, Perinatology and Child Health ,business - Abstract
Currently, we are facing a new outbreak of coronavirus infection that started in December 2019 in China and is already present in more than sixty other countries. The World Health Organization (WHO...
- Published
- 2020
24. Reference ranges of fetal adrenal gland and fetal zone volumes between 24 and 37 + 6 weeks of gestation by three-dimensional ultrasound
- Author
-
Amarilis Aparecida de Castro Maldonado, Edward Araujo Júnior, Ana Carolina Rabachini Caetano, Liliam Cristine Rolo, Tatiana K. Hamamoto, Nayana Alves de Brito Melo Okasaki, Antonio Fernandes Moron, Ana Cristina Perez Zamarian, Vinicius Fernando Calsavara, T.M. Helfer, and Luciano Marcondes Machado Nardozza
- Subjects
Adult ,Coefficient of determination ,Intraclass correlation ,Gestational Age ,Ultrasonography, Prenatal ,030218 nuclear medicine & medical imaging ,Fetal Development ,Young Adult ,03 medical and health sciences ,Fetus ,Imaging, Three-Dimensional ,0302 clinical medicine ,Pregnancy ,Reference Values ,Adrenal Glands ,Humans ,Medicine ,Prospective Studies ,030219 obstetrics & reproductive medicine ,Fetal adrenal ,business.industry ,Ultrasound ,Reproducibility of Results ,Obstetrics and Gynecology ,Gestational age ,Organ Size ,Anatomy ,Repeatability ,Cross-Sectional Studies ,Pediatrics, Perinatology and Child Health ,Gestation ,Female ,business ,Biomarkers - Abstract
Objective: To establish reference ranges of the fetal adrenal gland (AG) and fetal zone (FZ) volumes using three-dimensional ultrasound (3DUS).Methods: We performed a prospective cross-sectional study with 204 normal singleton pregnancies between 24 and 37 + 6 weeks of gestation. The fetal AG and FZ volumes were obtained using the virtual organ computer-aided analysis method with a 30° rotation. To establish reference ranges as the function of gestational age (GA), quantile regression was performed with the adjusted coefficient of determination (R2). Intra- and inter-observer repeatability was performed using the intraclass correlation coefficient (ICC).Results: The mean results of fetal AG and FZ values were 0.42 cm3 (0.04–1.22) and 0.10 cm3 (0.02–0.47), respectively. The best-fit quantile regression models for fetal AG and FZ volumes as the function of GA were in first-degree models: AG = −0.937 + 0.041 × GA (R2 = 0.124) and FZ = −0.201 + 0.009 × GA (R2 = 0.127), respectively. We observed good i...
- Published
- 2016
25. Delivery prediction in pregnant women with spontaneous preterm birth using fetal adrenal gland biometry
- Author
-
Francisco Edson de Lucena Feitosa, João Gabriel Damasceno Pereira, Rosa Maria Salani Mota, Aline Pinto Lemos, Francisco Herlânio Costa Carvalho, Helvécio Neves Feitosa, and Edward Araujo Júnior
- Subjects
Adult ,Male ,medicine.medical_specialty ,Biometry ,Time Factors ,Adolescent ,Gestational Age ,Cervix Uteri ,Sensitivity and Specificity ,Statistics, Nonparametric ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Adrenal Glands ,medicine ,Humans ,Prospective Studies ,030212 general & internal medicine ,Prospective cohort study ,Gynecology ,Fetus ,030219 obstetrics & reproductive medicine ,Receiver operating characteristic ,Obstetrics ,business.industry ,Infant, Newborn ,Obstetrics and Gynecology ,Gestational age ,Delivery, Obstetric ,medicine.disease ,Cervical Length Measurement ,Cross-Sectional Studies ,ROC Curve ,Premature birth ,Pediatrics, Perinatology and Child Health ,Premature Birth ,Gestation ,Female ,business - Abstract
To assess the prediction of delivery within 7 days in pregnant women who showed symptoms of spontaneous preterm birth (PB) by means of fetal adrenal gland biometry and to compare these predictions with the cervical length (CL) measurement.We performed a prospective cross-sectional study with 53 pregnant women between 24 and 36 weeks of gestation. An ultrasound exam was performed for each participant to obtain the CL measurement (transvaginal route) and fetal adrenal gland biometry on day 1 of their hospital admission because of symptoms of spontaneous PB. The main outcome measure was the time between the ultrasound exam and delivery, which was classified into two groups: delivery ≤7 days and delivery 7 days. A receiver operating characteristics (ROC) curve was performed to define the cutoffs for sensitivity and specificity.The prevalence of delivery within 7 days was 35.8%, which showed a statistically significant difference from the depth of the central zone of the fetal adrenal gland (p = 0.036). The cutoff for the depth of the central zone of the fetal adrenal gland was 7.2 mm (sensitivity 66.7%, specificity 61.8% and accuracy 63.5%). These values were not significantly different than the cutoffs for cervical length measurement: 20 mm (p = 0.267) and 9 mm (p = 0.118).The biometry for the central zone of the fetal adrenal gland predicted delivery within 7 days in pregnant women with spontaneous PB and had a predictive accuracy similar to that of CL measurement.
- Published
- 2016
26. Maternal risks and predictor factors for the termination of pregnancy in fetuses with severe congenital anomaly: experience from a single reference center in Brazil
- Author
-
Flavia Westphal, Suzete Maria Fustinoni, Edward Araujo Júnior, and Anelise Riedel Abrahão
- Subjects
Adult ,Risk ,medicine.medical_specialty ,Logistic regression ,Choice Behavior ,Statistics, Nonparametric ,Congenital Abnormalities ,Nuclear Family ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Humans ,Medicine ,030212 general & internal medicine ,Young adult ,Retrospective Studies ,Analysis of Variance ,Fetus ,030219 obstetrics & reproductive medicine ,business.industry ,Obstetrics ,Medical record ,Obstetrics and Gynecology ,Retrospective cohort study ,medicine.disease ,Pregnancy Complications ,Pediatrics, Perinatology and Child Health ,Female ,Analysis of variance ,business ,Abortion, Eugenic ,Brazil ,Postpartum period - Abstract
To assess the maternal complications in pregnant women with fetuses with several congenital anomaly as well as the predictor variables for the termination of pregnancy.We performed a retrospective cohort study with 94 medical records of pregnant women with fetal infeasibility confirmed in the postnatal period by clinical, radiological or anatomopathological exams. To compare the categorical variables regarding the termination and nontermination of pregnancy, we used analysis of variance (ANOVA) and the Mann-Whitney U-test. To assess the variables that were more associated with the judicial request for the termination of pregnancy, we used logistic regression.The termination of pregnancy was performed in 41 (43.6%) and nontermination of pregnancy in 53 (56.4%) pregnant women. Pregnant women who did not terminate the pregnancy had more complications in the gestational period (p 0.0001) and in the postpartum period (p = 0.0088). After multiple logistic regressions, the following variables influenced the decision to terminate the pregnancy: type of congenital anomaly (OR: 18.59; 95%CI: 1.96; 175.87) and living children (OR: 0.45; 95%CI: 0.25; 0.80).Most of the pregnant women with fetal infeasibility opted for nontermination of pregnancy and these patients had more obstetrical complications. The type of congenital anomaly and living children were the factors most associated with the choice for the termination of pregnancy.
- Published
- 2016
27. Preterm at birth is not associated with greater cardiovascular risk in adolescence
- Author
-
Francisco Herlânio Costa Carvalho, Ana Ciléia Pinto Teixeira Henriques, Priscila de Jesus dos Santos Alves, and Edward Araujo Júnior
- Subjects
Male ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Urban Population ,Birth weight ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Risk Factors ,030225 pediatrics ,medicine ,Humans ,030212 general & internal medicine ,Family history ,Retrospective Studies ,Obstetrics ,business.industry ,Obstetrics and Gynecology ,Retrospective cohort study ,Anthropometry ,medicine.disease ,Cardiovascular Diseases ,Premature birth ,Pediatrics, Perinatology and Child Health ,Cohort ,Premature Birth ,Gestation ,Female ,business ,Brazil - Abstract
To determine the effects of preterm birth and gender on subsequent cardiovascular risk factors among urban adolescents in a capital in the Brazilian northeast and to compare them with a group of adolescents term at birth.In a retrospective double cohort, data of birth weight were extracted from hospital registers of children born in a same day of birth, between 1992 and 2002. We classified the preterm as a unique group born before 37 weeks of gestation. A total of 134 adolescents, aged 10-20 years were found and investigated. We measured anthropometric and clinical data, blood lipid profile and glucose after overnight fasting.Preterm subjects had less years of scholar education, especially between females (p = 0.01). Preterm females also had lower height (p = 0.00) and waist-hip circumference ratio (p = 0.01). Preterm males had lower cesarean delivery (p = 0.05) and greater family history of cardiovascular disease (p = 0.05). Although the differences on clinical or laboratorial measurements were small and non-significant for cardiovascular risk factors, systolic blood pressure (SBP) and diastolic blood pressure (DBP) tended to be higher in preterm groups, especially for females (SBP = 4.1 mmHg and DBP = 1.6 mmHg, p = 0.12 and p = 0.38, respectively).Premature did not increase cardiovascular risk adolescents in this sample. The lower association between premature and poor health outcomes among adolescents in a low average socioeconomic status population from a capital in the Brazilian northeast corroborates previous findings in other countries.
- Published
- 2016
28. Unconditional reference values for the amniotic fluid index measurement between 26w0d and 41w6d of gestation in low-risk pregnancies
- Author
-
Wellington P. Martins, Alberto Borges Peixoto, Fabricio da Silva Costa, Edward Araujo Júnior, and Taciana Mara Rodrigues da Cunha Caldas
- Subjects
Adult ,medicine.medical_specialty ,Amniotic fluid ,Adolescent ,Umbilicus (mollusc) ,Umbilical cord ,Linea nigra ,Young Adult ,ULTRASSONOGRAFIA ,Pregnancy ,Reference Values ,Interquartile range ,medicine ,Humans ,Amniotic fluid index ,Retrospective Studies ,business.industry ,Obstetrics ,Obstetrics and Gynecology ,Gestational age ,Middle Aged ,Amniotic Fluid ,Cross-Sectional Studies ,medicine.anatomical_structure ,Pediatrics, Perinatology and Child Health ,Gestation ,Female ,business - Abstract
To establish reference values for the amniotic fluid index (AFI) measurement between 26w0d and 41w6d of gestation in a Brazilian population.We performed a cross-sectional study with 1984 low-risk singleton pregnant women between 26w0d and 41w6d of gestation. AFI was measured according to the technique proposed by Phelan et al. Maternal abdomen was divided into four quadrants using the umbilicus and linea nigra as landmarks. Single vertical pocket in each quadrant was measured and the AFI was generated by the sum of these four values without umbilical cord or fetal parts. All ultrasound exams were performed by only two experienced examiners. AFI was expressed as median, interquartile range, mean and ranges in each gestational age (GA) interval. Polynomial regressions were performed to obtain the best fit with adjustment by the determination coefficient (R(2)).Mean of AFI ranged from 14.0 ± 4.1 cm (range, 9.7-14.0) at 26w0d to 8.3 ± 4.7 cm (range, 1.9-16.5) at 41w6d, respectively. The best polynomial regression fit curve was a first-degree: AFI = 16.29-0.125*GA (R(2) = 0.01). According the scatterplot, AFI values practically did not vary with advancing GA.Reference values for the AFI measurement between 26w0d and 41w6d of gestation in a low-risk Brazilian population were established.
- Published
- 2015
29. Reference ranges for the uterine arteries Doppler and cervical length measurement at 11–13(+6) weeks of gestation in a Brazilian population
- Author
-
Julio José Alvarenga Barros, Wellington P. Martins, Taciana Mara Rodrigues da Cunha Caldas, Edward Araujo Júnior, Alberto Borges Peixoto, Anna Bárbara Ribeiro Lima, Gabriele Tonni, and Francisco Herlânio Costa Carvalho
- Subjects
Adult ,medicine.medical_specialty ,Gestational Age ,Cervix Uteri ,03 medical and health sciences ,symbols.namesake ,0302 clinical medicine ,Pregnancy ,Reference Values ,Humans ,Medicine ,030212 general & internal medicine ,Cervical length ,Retrospective Studies ,Gynecology ,Fetus ,030219 obstetrics & reproductive medicine ,business.industry ,Obstetrics and Gynecology ,Gestational age ,ULTRASSONOGRAFIA DOPPLER ,Cervical Gland ,Sagittal plane ,Cervical Length Measurement ,Pregnancy Trimester, First ,Uterine Artery ,medicine.anatomical_structure ,Pediatrics, Perinatology and Child Health ,symbols ,Gestation ,Female ,business ,Doppler effect ,Brazil - Abstract
To establish references ranges for the uterine arteries (UtA) Doppler and cervical length (CL) measurements at 11-13(+6) weeks of gestation in a Brazilian population.We performed a retrospective cross-sectional study with singleton low-risk pregnant women who underwent first trimester ultrasound exams of fetuses with crown-rump length (CRL) ranging from 45 to 84 mm. The mean UtA Doppler and CL measurements were performed by transvaginal route. The mean pulsatility index (PI) of uterine arteries was obtained with color Doppler at the level of cervico-corporeal junction. The CL was obtained in a sagittal view using the cervical gland area as landmark. We determined mean ± standard deviation (SD), ranges for mean PI of UtA and CL in each gestational age. Polynomial regression was performed to establish reference values.We have assessed 598 first-trimester pregnancies: the CL measurement was obtained from 497, while the mean PI UtA Doppler was available in 450 pregnant women. The mean CL ranged from 33.41 to 35.58 mm while the PI UtA Doppler ranged from 1.89 to 1.45. The best fit curves were: CL = 30.790 + 0.057 × CRL and UtA PI = 2.411-0.011 × CRL.References ranges for the mean UtA PI Doppler and CL measurement at 11-13(+6) weeks of gestation in a Brazilian population were established.
- Published
- 2015
30. Prenatal diagnosis of gastric and small bowel atresia: a case series and review of the literature
- Author
-
Gianpaolo Grisolia, Edward Araujo Júnior, Gabriele Tonni, Annamaria Giacobbe, Jurandir Piassi Passos, Roberta Granese, and Marcello Napolitano
- Subjects
Adult ,Pediatrics ,medicine.medical_specialty ,Birth weight ,Intestinal Atresia ,Prenatal diagnosis ,Ultrasonography, Prenatal ,Duodenal atresia ,Pregnancy ,Intestine, Small ,medicine ,Humans ,gastrointestinal obstructions ,Pylorus ,Gastric Outlet Obstruction ,business.industry ,outcome ,postnatal surgery ,small bowel atresia ,Obstetrics and Gynecology ,Ileal Atresia ,Gestational age ,medicine.disease ,Fetal Diseases ,Atresia ,Pediatrics, Perinatology and Child Health ,Gestation ,Female ,business - Abstract
To describe seven cases of gastrointestinal tract (GIT) obstructions and to report a skewed review of the literature.We performed a search of our permanent perinatal database about cases with prenatal ultrasound and MRI diagnosis of gastrointestinal tract obstructions between 2006 and 2013. All cases were followed until hospital discharge and pre-natal diagnosis were confirmed by fetal MRI, postnatal imaging and/or intra-operative findings. Maternal age, parity, gestational age at diagnosis, ultrasound findings, gestational age at delivery, Apgar scores at 1 and 5 min and postnatal outcome have been recorded.We identified seven cases of gastric and small bowel atresia. Karyotype was normal in six cases and abnormal in one co-twin [46,XY dup (20) (qq13.1q13.3)dn] of a dichorionic-diamniotic pregnancy. The mean ± SD for maternal age, gestational age at diagnosis, gestational at delivery, birth weight and Apgar scores at 1 and 5 min were 30.8 ± 4.8 years, 29.8 ± 3.7 weeks, 2507.5 ± 727.5 g and 5.6 ± 2.1, 7.6 ± 1.6, respectively. All fetuses' undergone surgical procedures in the postnatal period and all of them were discharged live from the hospital.Prompted antenatal detection of gastrointestinal tract obstruction using ultrasound proved to be diagnostic in all cases. Fetal MRI aid was a useful complementary diagnostic investigation. Correct pre-natal diagnosis allows adequate counseling, delivery planning and management care by a multidisciplinary team.
- Published
- 2015
31. Reference range for the pulsatility index ductus venosus Doppler measurement between 11 and 13 + 6 weeks of gestation in a Brazilian population
- Author
-
Alberto Borges Peixoto, Polyana Costa Ferreira, Taciana Mara Rodrigues da Cunha Caldas, Wellington P. Martins, Fabricio da Silva Costa, Edward Araujo Júnior, and Luciano Marcondes Machado Nardozza
- Subjects
Umbilical Veins ,medicine.medical_specialty ,Percentile ,Pulsatile flow ,Reference range ,Ultrasonography, Prenatal ,VEIA CAVA ,symbols.namesake ,Pregnancy ,Reference Values ,Linear regression ,Humans ,Medicine ,Retrospective Studies ,Polynomial regression ,business.industry ,Obstetrics ,Obstetrics and Gynecology ,Ultrasonography, Doppler ,Cross-Sectional Studies ,Pulsatile Flow ,Pediatrics, Perinatology and Child Health ,cardiovascular system ,symbols ,Gestation ,Female ,business ,Nuclear medicine ,Doppler effect ,Ductus venosus - Abstract
To establish reference range for the pulsatility index (PI) ductus venosus (DV) Doppler measurement between 11 and 13 + 6 weeks of gestation in a Brazilian population.A retrospective cross-sectional study was performed with 430 singleton pregnancies. The PI DV Doppler measurement was performed as routine during the first trimester screening. DV was identified by color Doppler and the pulsed Doppler gate was placed in the distal portion of the umbilical sinus. When at least three typical DV waveforms were obtained, PI DV was measured manually in one waveform. Polynomial regression was used to obtain the best fit using PI DV Doppler measurement and crown-rump length (CRL) with adjustments by the determination coefficient (R(2)). 5th, 50th and 95th percentiles for the PI DV Doppler measurements at each gestational were determined.The mean of PI DV Doppler measurement was 1.1 ± 0.2 (range 0.8-3.7). The linear regression was the best fit: PI DV measurement = 1.288-0.0034*CRL (R(2 )= 0.03).Reference range for the PI DV Doppler measurement between 11 and 13 + 6 weeks of gestation in a Brazilian population was established.
- Published
- 2015
32. Reference values for the fetal lateral ventricle atrium measurement in the second and third trimesters of pregnancy in a Brazilian population
- Author
-
Edward Araujo Júnior, Alberto Borges Peixoto, Marcelle Flausino Barbosa, Wellington P. Martins, Ludimila dos Anjos Teixeira Romão, and Taciana Mara Rodrigues da Cunha Caldas
- Subjects
Adult ,Adolescent ,Pregnancy Trimester, Third ,Ultrasonography, Prenatal ,Young Adult ,Lateral ventricles ,Pregnancy ,Reference Values ,Lateral Ventricles ,ULTRASSOM ,Humans ,Medicine ,Atrium (heart) ,Retrospective Studies ,Fetus ,business.industry ,Transventricular ,Obstetrics and Gynecology ,Gestational age ,Anatomy ,medicine.disease ,Cross-Sectional Studies ,medicine.anatomical_structure ,Ventricle ,Pregnancy Trimester, Second ,Pediatrics, Perinatology and Child Health ,Female ,Choroid plexus ,business ,Brazil - Abstract
To establish reference values for the fetal atrium lateral ventricle measurements in the second and third trimesters of pregnancy in a Brazilian population.A retrospective cross-sectional study was performed with low-risk pregnant women who underwent ultrasound examination at 16-41 weeks of gestation. The atrium of lateral ventricle measurement was performed in the transventricular plane at the end of choroid plexus. We assessed reference curves (percentiles 5th, 50th and 95th) for the atrium of lateral ventricle measurement with gestational age (GA), using the best-fit polynomial equation, and determination coefficient (R(2)) and modeling the variability.The fetal atrium of lateral ventricle measurements was assessed in 519 singleton pregnancies. However, seven fetuses were excluded because of central nervous system malformations, and therefore data from 512 pregnancies were included in the analysis. The mean ± standard deviation (range) of the fetal atrium lateral ventricle measurement (mm) was 5.1 ± 1.4 (1.6-9.7). A best-fit curve was a first-degree polynomial regression: atrium lateral ventricle = 6.455 - 0.049 × GA (R(2) = 0.05).Reference values for the fetal atrium lateral ventricle measurements in the second and third trimesters of pregnancy in a Brazilian population were established.
- Published
- 2015
33. Maternal–fetal attachment in blind women using physical model from three-dimensional ultrasound and magnetic resonance scan data: six serious cases
- Author
-
Jorge Lopes, Gabriele Tonni, Edward Araujo Júnior, and Heron Werner
- Subjects
Adult ,Male ,Models, Anatomic ,medicine.medical_specialty ,Pathology ,Blindness ,Ultrasonography, Prenatal ,Imaging, Three-Dimensional ,Pregnancy ,medicine ,Humans ,Maternal fetal ,3D ultrasound ,Prospective Studies ,Fetus ,Three dimensional ultrasound ,medicine.diagnostic_test ,business.industry ,Obstetrics ,Infant, Newborn ,Obstetrics and Gynecology ,Gestational age ,Magnetic resonance imaging ,Magnetic Resonance Imaging ,Object Attachment ,Cross-Sectional Studies ,Pediatrics, Perinatology and Child Health ,Female ,Observational study ,business - Abstract
The objective of this study is to assess the maternal-fetal attachment (MFA) in six blind pregnant women by means three-dimensional (3D) physical models from 3D ultrasound and magnetic resonance imaging (MRI) scan data.We performed a prospective observational cross-sectional study with six blind pregnant women who performed 3D ultrasound and MRI exams to build 3D physical models for their fetuses. The MFA was assessed quantitatively by means a questionnaire of three questions, each one with a score ranging from 0 to 3. We considered MFA values ≥ 7 to each pregnant woman. The descriptive data were expressed by mean ± standard deviation (SD).The mean (±SD) maternal age was 32 ± 2.7 years. The mean gestational age at 3DUS and MRI exams were 23.1 ± 3.7 and 21.3 ± 0.9 weeks, respectively. The mean of gestational age at delivery was 36.5 ± 4.7 weeks and all of them were cesarean sections. The mean newborn weight was 2615.8 ± 871.9 g and the gender was 50% both female and male. The MFA was quantitatively observed in all pregnant women, with maximum value (9) in all of them.The MFA was quantitatively observed in all blind pregnant women using 3D physical models.
- Published
- 2015
34. Predicting small for gestational age in the first trimester of pregnancy using maternal ophthalmic artery Doppler indices
- Author
-
Júlio Augusto Gurgel Alves, Fabricio da Silva Costa, Gabriele Tonni, Edward Araujo Júnior, Wellington P. Martins, and Sammya Bezerra Maia e Holanda Moura
- Subjects
Adult ,medicine.medical_specialty ,Percentile ,Mothers ,030204 cardiovascular system & hematology ,Ultrasonography, Prenatal ,Preeclampsia ,Ophthalmic Artery ,Young Adult ,03 medical and health sciences ,IDADE GESTACIONAL ,0302 clinical medicine ,Predictive Value of Tests ,Pregnancy ,medicine.artery ,medicine ,Humans ,Uterine artery ,reproductive and urinary physiology ,Fetal Growth Retardation ,030219 obstetrics & reproductive medicine ,Receiver operating characteristic ,Obstetrics ,business.industry ,Infant, Newborn ,Obstetrics and Gynecology ,Ultrasonography, Doppler ,Prognosis ,medicine.disease ,female genital diseases and pregnancy complications ,Confidence interval ,Pregnancy Trimester, First ,Uterine Artery ,Pulsatile Flow ,Ophthalmic artery ,Infant, Small for Gestational Age ,Pediatrics, Perinatology and Child Health ,Small for gestational age ,Female ,business - Abstract
To assess the capacity of maternal ophthalmic Doppler indices for predicting small for gestational age (SGA) newborns in the first trimester of pregnancy.We performed a prospective observational cohort study involving 499 singleton pregnancies during the first trimester scan (11-14 weeks). The following maternal ophthalmic Doppler indices were assessed: pulsatility index (PI), first diastolic peak velocity (PD1) and peak ratio (PR) = PD1/peak systolic velocity. We considered SGA all newborns with weight below 10th percentile. We used chi-square test (χ(2)) to compare the groups. We used area under receiver operating characteristics (ROC) curves with 95% confidence intervals (CI) and detection rate of 5% of false positive of each maternal ophthalmic Doppler index and the mean uterine artery PI for prediction SGA.27 (5.4%) patients delivered SGA newborns, 12 (2.4%) patients developed preeclampsia (PE) and delivered SGA newborns, and 460 had uneventful pregnancies (controls). We observed significant difference of PI and PR between SGA (SGA and SGA+PE) and control groups, p = 0.043 and p = 0.014, respectively. To 5% of false positive, the detection rate of SGA (SGA and SGA+PE groups) using PI, PD1 and PR were 14.8, 3.7, 14.8, 16.7, 16.7 and 16.7%, respectively. Mean uterine PI was significantly higher in the SGA+PE group (p = 0.003).The isolated use of maternal ophthalmic Doppler indices or in combination with uterine artery Doppler, in the first trimester of pregnancy, was not efficient to predict SGA newborns.
- Published
- 2015
35. Neonatal neuronal apoptosis after betamethasone administration in pregnant Wistar rats
- Author
-
Carolina B. Jaqueta, Antonio Fernandes Moron, David Parés, Luiz E. Mello, Edward Araujo Júnior, Marcelo Santucci França, Marcelo Avedissian, and Luciano Marcondes Marchado Nardozza
- Subjects
Male ,medicine.medical_specialty ,Apoptosis ,Cell Count ,Hippocampal formation ,Placebo ,Betamethasone ,Hippocampus ,03 medical and health sciences ,0302 clinical medicine ,Therapeutic index ,Pregnancy ,Internal medicine ,Animals ,Medicine ,Hippocampus (mythology) ,030212 general & internal medicine ,Rats, Wistar ,Neurons ,TUNEL assay ,business.industry ,Dentate gyrus ,Obstetrics and Gynecology ,Rats ,Endocrinology ,Animals, Newborn ,Prenatal Exposure Delayed Effects ,Dentate Gyrus ,Pediatrics, Perinatology and Child Health ,Female ,Analysis of variance ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
To analyze the apoptosis of cortical and hippocampal neurons in newborn following the intramuscular administration of betamethasone in pregnant Wistar rats.Betamethasone or placebo was administered to 10 pregnant rats. Subsequently, 98 newborns were analyzed in three different groups: therapeutic dose (TD, 20 mg/kg), triple therapeutic dose (3TD, 60 mg/kg), and nine times TD (9TD, 180 mg/kg). Forty-four newborns were injected with placebo (control subjects--CTR). Neuronal apoptosis was measured by immunofluorescence using the TUNEL assay. The one-way analysis of variance, Tukey-Kramer (parametric) test and Kruskal-Wallis (non-parametric) test were used for statistical analysis.The CA1 area of the hippocampus of TD and 3TD groups showed significant differences from that of the CTR group (p0.001). Compared to the CTR group, there was increased neuronal apoptosis in the dentate gyrus (DG) of animals in TD and 3TD groups (p0.0001). There were no significant differences in CA2 and CA3 regions as well as in amygdala and cortex.Prenatal administration of betamethasone leads to significant changes in neuronal apoptosis in CA1 and DG regions.
- Published
- 2015
36. Postnatal outcomes of infants with gastroschisis: a 5-year follow-up in a tertiary referral center in Brazil
- Author
-
Luciano Marcondes Machado Nardozza, Antonio Fernandes Moron, Liliam Cristine Rolo, Edward Araujo Júnior, Natália da Silva Carvalho, Tatiane Boute, P.O. Serni, O. Terasaka, and T.M. Helfer
- Subjects
Adult ,Pediatrics ,medicine.medical_specialty ,Neonatal intensive care unit ,Adolescent ,Birth weight ,Umbilical cord ,Tertiary Care Centers ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Sepsis ,030225 pediatrics ,parasitic diseases ,Humans ,Medicine ,Retrospective Studies ,Gastroschisis ,Fetus ,030219 obstetrics & reproductive medicine ,business.industry ,Obstetrics ,Infant, Newborn ,Infant ,Obstetrics and Gynecology ,Gestational age ,Retrospective cohort study ,medicine.disease ,Neonatal infection ,medicine.anatomical_structure ,Pediatrics, Perinatology and Child Health ,Female ,business ,Brazil ,Follow-Up Studies - Abstract
The aim of this study was to evaluate postnatal outcomes in fetuses with gastroschisis.This is a retrospective study (2009-2013) of patients with gastroschisis at the Hospital São Paulo (Federal University of São Paulo, Brazil).A total of 44 infants with gastroschisis were examined. The mean maternal age was 21.1 years and mean gestational age at delivery was 36.1 weeks. Delivery occurred before 34 weeks in 13.6%, between 34 and 36 weeks and 6 d in 40.9%, and after 37 weeks in 45.5%. The mean birth weight was 2349 g, with 37.2% small-for-gestational age infants. The mean umbilical cord blood pH was 7.32. Bowel resection and delayed fascial closure was performed in 14.6% and 19.5%, respectively. The mean hospitalization time in the neonatal intensive care unit was 52.7 d. Neonatal infection was detected in 52.4%, with a positive blood culture; 77.3% of those cases were coagulase negative staphylococci. The overall rate of mortality was 25%; 18.2% before birth, 45.4% during the neonatal period, and 36.4% in infants. The main cause of postnatal death was septicemia (55.5%).Despite advances in perinatal care and surgical techniques, infants with gastroschisis still present high rates of complications and death.
- Published
- 2015
37. Oestrogen receptor alpha expression in neovaginal tissue of women following modified Abbé-McIndoe technique and in premenopausal women
- Author
-
Marair Gracio Ferreira Sartori, Edward Araujo Júnior, Liliam Cristine Rolo, Zsuzsanna Ilona Katalin de Jármy Di Bella, Rodrigo Aquino Castro, Gustavo Rubino de Azevedo Focchi, Manoel João Batista Castello Girão, Marcio Masashi Kajikawa, Luciana Campanatti Crema, Claudia Cristina Takano, and Juliane Dornelas
- Subjects
Adult ,medicine.medical_specialty ,Stromal cell ,46, XX Disorders of Sex Development ,Adolescent ,Biopsy ,Endocrinology, Diabetes and Metabolism ,Alpha (ethology) ,Quantitative Evaluations ,Biology ,Congenital Abnormalities ,Hospitals, University ,Young Adult ,Basal (phylogenetics) ,Gynecologic Surgical Procedures ,Endocrinology ,Stroma ,medicine ,Humans ,Cellulose, Oxidized ,Prospective Studies ,Oestrogen receptor ,Mullerian Ducts ,Gynecology ,Mucous Membrane ,Tissue Scaffolds ,Guided Tissue Regeneration ,Estrogen Receptor alpha ,Vertical distance ,Obstetrics and Gynecology ,Epithelium ,medicine.anatomical_structure ,Gene Expression Regulation ,Premenopause ,Case-Control Studies ,Vagina ,Female ,Atrophy ,Stromal Cells ,Brazil ,Follow-Up Studies - Abstract
The aim of the study was to compare the expression of oestrogen receptor alpha (ERα) in neovaginal tissue of patients with vaginal agenesis following neovaginoplasty using regenerated, oxidised cellulose in premenopausal women. A prospective, observational case-control study was performed on eight patients with vaginal agenesis following modified Abbé-McIndoe neovaginoplasty and 10 control premenopausal women following benign gynaecologic surgery. 6F11 monoclonal antibody was used to determine ERα expression in the vaginal mucosa. Quantitative and qualitative evaluations were performed, respectively, in vaginal epithelium and stroma. The thickness of the vaginal epithelium was determined as the vertical distance between the basal layer cells and the apical surface of the superficial layer. The percentage of ERα-expressing cells was higher in the control group, except in the superficial zone of the epithelium. In the stromal tissue, ERα was detected in only one patient from the neovagina group compared with nine women in the control group. The neovagina group had a statistically thinner epithelium. Our study suggests that women with vaginal agenesis following modified Abbé-McIndoe neovaginoplasty using regenerated oxidised, cellulose experience relatively local hypo-oestrogenism in the first year after surgery, with repercussion in vaginal trophism.
- Published
- 2015
38. Evaluation of inflammatory mediators in the deciduas of pregnant women with pre-eclampsia/eclampsia
- Author
-
Denise Bertulucci Rocha Rodrigues, Eumenia Costa da Cunha Castro, Virmondes Rodrigues Junior, Alberto Borges Peixoto, Edward Araujo Júnior, João Ulisses Ribeiro, and Taciana Mara Rodrigues da Cunha Caldas
- Subjects
Adult ,0301 basic medicine ,medicine.medical_specialty ,Adolescent ,030204 cardiovascular system & hematology ,Nitric oxide ,Andrology ,Young Adult ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Pregnancy ,Griess test ,Decidua ,medicine ,Humans ,In patient ,Nitrite ,Th1-Th2 Balance ,Nitrites ,Eclampsia ,business.industry ,Obstetrics ,Interleukins ,Obstetrics and Gynecology ,Trophoblast ,Hypertension, Pregnancy-Induced ,Hypoxia (medical) ,medicine.disease ,030104 developmental biology ,medicine.anatomical_structure ,chemistry ,Solubilization ,Case-Control Studies ,Pediatrics, Perinatology and Child Health ,Female ,medicine.symptom ,business - Abstract
The objective was to evaluate some inflammatory mediators, i.e. cytokines that induce and inhibit nitric oxide (NO) synthase, in pregnant women with pre-eclampsia/eclampsia (PE/E) compared to clinically normal patients.Placental fragments were collected from 46 pregnant patients, including 30 clinically normal subjects and 16 women with PE/E, and stored in NP40-containing phosphate buffer in a freezer at -70 °C until the time of solubilization. Cytokines IL-4, IL-10, IL-13, TNF-α and IFN-γ were assayed by ELISA and NO was estimated by the Griess reaction after reduction.Patients with PE/E presented significantly lower placental levels of IL-10 and IL-3 than the control group (p 0.05). On the other hand, IL-4, TNF-α and IFN-γ levels were similar on the two groups, whereas nitrite/nitrate levels were significantly lower in the PE/E group. A higher inflammatory balance was observed in patients with PE/E compared to normal subjects (p 0.05).Patients with PE/E present lower levels of Th2 cytokines associated with a pro-inflammatory balance as evaluated by the IL-10/TNF-α ratio, as well as lower nitrite/nitrate levels, than controls.
- Published
- 2014
39. Reproducibility of placental maturity grade classification using a dynamic ultrasonography
- Author
-
Edward Araujo Júnior, Rafael Frederico Bruns, Liliam Cristine Rolo, and Ricardo Ditzel Delle Donne
- Subjects
medicine.medical_specialty ,Placenta ,media_common.quotation_subject ,Ultrasonography, Prenatal ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,medicine ,Humans ,media_common ,Observer Variation ,Gynecology ,Reproducibility ,030219 obstetrics & reproductive medicine ,Obstetrics ,business.industry ,Infant, Newborn ,Reproducibility of Results ,Obstetrics and Gynecology ,Placentation ,Maturity (psychological) ,Cross-Sectional Studies ,Research Design ,Pediatrics, Perinatology and Child Health ,Female ,Ultrasonography ,business ,Kappa - Abstract
To evaluate the agreement between ultrasonographers in classifying placental maturity grade using examination videos.A prospective, cross-sectional study was conducted using 25 videos of ultrasonographic examinations of single, healthy pregnancies ≥ 34 + 0 weeks. The Grannum (grades 0, I, II and III) and Julio (grades 0, 1, 2A, 2B and 3) classifications were used for placental maturity grade. The videos were evaluated on two occasions by 10 experienced ultrasonographers. Intra- and inter-observer agreements were evaluated using the Kappa (k) coefficient of agreement.According to the Grannum classification, the inter-observer agreement coefficients were good for grades III and 0 (k = 0.69 and 0.738, respectively) and moderate for grades I and II (k = 0.401 and 0.593, respectively) placentas. According to the Julio classification, the inter-observer agreement coefficients were good for grades 0 and 3 (k = 0.738 and 0.651, respectively), moderate for grades 1 and 2A (0.401 and 0.413, respectively) and poor for grade 2B (k = 0.161). Intra-observer coefficients for the Grannum and Julio classifications ranged from 0.567 to 0.890 and from 0.446 to 0.790, respectively.Placental maturity grading using the Grannum and Julio classifications demonstrated moderate/good intra- and inter-observer agreements on examination videos evaluation.
- Published
- 2016
40. Trans-Pacific tele-ultrasound image transmission of fetal central nervous system structures
- Author
-
Adilson Cunha Ferreira, Fabricio da Silva Costa, Simon Meagher, Edward Araujo Júnior, Antonio Hélio Oliani, Wellington P. Martins, and João Francisco Jordão
- Subjects
Adult ,Central Nervous System ,Pathology ,medicine.medical_specialty ,Adolescent ,education ,Video Recording ,Ultrasonography, Prenatal ,Mean difference ,Standard deviation ,Fetal Development ,Young Adult ,Pregnancy ,Humans ,Medicine ,Single-Blind Method ,CLIPS ,EQUIPAMENTOS DE TRANSMISSÃO ,Ultrasound image ,computer.programming_language ,Internet ,business.industry ,Ultrasound ,Australia ,Obstetrics and Gynecology ,Telemedicine ,Cross-Sectional Studies ,Transmission (telecommunications) ,Pediatrics, Perinatology and Child Health ,Female ,Video streaming ,Ultrasonography ,business ,Nuclear medicine ,computer ,Brazil - Abstract
Objective: To assess the quality of images and video clips of fetal central nervous (CNS) structures obtained by ultrasound and transmitted via tele-ultrasound from Brazil to Australia. Methods: In this cross-sectional study, 15 normal singleton pregnant women between 20 and 26 weeks were selected. Fetal CNS structures were obtained by images and video clips. The exams were transmitted in real-time using a broadband internet and an inexpensive video streaming device. Four blinded examiners evaluated the quality of the exams using the Likert scale. We calculated the mean, standard deviation, mean difference, and p values were obtained from paired t tests. Results: The quality of the original video clips was slightly better than that observed by the transmitted video clips; mean difference considering all observers ¼ 0.23 points. In 47/60 comparisons (78.3%; 95% CI ¼ 66.4–86.9%) the quality of the video clips were judged to be the same. In 182/240 still images (75.8%; 95% CI ¼ 70.0–80.8%) the scores of transmitted image were considered the same as the original. Conclusion: We demonstrated that long distance tele-ultrasound transmission of fetal CNS structures using an inexpensive video streaming device provided images of subjective good quality.
- Published
- 2014
41. The utility of ultrasound in late pregnancy compared with clinical evaluation in detecting small and large for gestational age fetuses in low-risk pregnancies
- Author
-
Deborah Friedman, Edward Araujo Júnior, Ahmed Al-Amin, Costa Fabrício Da Silva, Peter Mayall, and Tania Hingston
- Subjects
Percentile ,medicine.medical_specialty ,Pregnancy Trimester, Third ,Gestational Age ,Ultrasonography, Prenatal ,Fetal Macrosomia ,Predictive Value of Tests ,Pregnancy ,Risk Factors ,medicine ,Humans ,Retrospective Studies ,Fetus ,Diagnostic Tests, Routine ,Obstetrics ,business.industry ,Medical record ,Ultrasound ,Infant, Newborn ,Obstetrics and Gynecology ,Gestational age ,Retrospective cohort study ,medicine.disease ,Late pregnancy ,Infant, Small for Gestational Age ,Pediatrics, Perinatology and Child Health ,Small for gestational age ,Female ,business - Abstract
To determine the utility of ultrasound (US) in late pregnancy for identifying fetuses with growth disturbances.This study was designed as a retrospective study of birth weights over a 12-month period at the Royal Hobart Hospital (RHH) and Barwon Health (BH). Data were collected from the discharge summaries and medical records at both hospitals targeting abnormal fetal weight below 10th percentile (small for gestational age - SGA) and above 90th percentile (large for gestational age - LGA).There were 4079 study patients from both hospitals. After weight adjustment by gender and gestational age, an abnormal fetal weight was detected in 741 cases (babies over the 90th percentile or below 10th percentile). One hundred and twenty-eight patients with high-risk pregnancies were excluded. Therefore, a total of 613 patients remained that were considered to be low-risk pregnancies with abnormal foetal growth; 305 patients from RHH and 308 from BH. The antenatal detection rate for LGA was 35.9%, at RHH by combination of US and clinical evaluation, while for BH it was 34.8% by clinical evaluation alone (p = 0.910). The antenatal detection rate for SGA was 36.8% via US and clinical evaluation at RHH and 54.5% by clinical evaluation alone at BH (p = 0.006).This study shows no benefit in the use of routine US for the antenatal diagnosis of LGA compared with clinical evaluation in low-risk pregnancies. US evaluation was inferior to clinical evaluation in the antenatal diagnosis of SGA in low-risk pregnancies.
- Published
- 2014
42. Fetal cardiac interventricular septum: volume assessment by 3D/4D ultrasound using spatio-temporal image correlation (STIC) and virtual organ computer-aided analysis (VOCAL)
- Author
-
Fabricio da Silva Costa, Priscila Henriques da Silva, Eduardo Felix Martins Santana, Luciano Marcondes Machado Nardozza, Liliam Cristine Rolo, Gabriele Tonni, Edward Araujo Júnior, and Antonio Fernandes Moron
- Subjects
medicine.medical_specialty ,Coefficient of determination ,Correlation coefficient ,Echocardiography, Three-Dimensional ,Gestational Age ,Ventricular Septum ,Ultrasonography, Prenatal ,Correlation ,Fetal Heart ,Spatio-Temporal Analysis ,Pregnancy ,Reference Values ,Image Interpretation, Computer-Assisted ,medicine ,Humans ,Prospective Studies ,Interventricular septum ,Echocardiography, Four-Dimensional ,Observer Variation ,Polynomial regression ,Fetus ,Models, Statistical ,business.industry ,Obstetrics and Gynecology ,Gestational age ,Cross-Sectional Studies ,medicine.anatomical_structure ,Pediatrics, Perinatology and Child Health ,Female ,Radiology ,Nuclear medicine ,business ,Volume (compression) - Abstract
To determine reference values for fetal interventricular septum (IVS) volume by 3D/4D ultrasound using spatio-temporal image correlation (STIC) and virtual organ computer-aided analysis (VOCAL).A prospective cross-sectional study was conducted on 200 consecutive normal low-risk pregnant women at a gestational age ranging from 18w0d to 33w6d. The volume data sets of the fetal heart were acquired by applying STIC to a four-chamber plane. IVS volume was calculated offline using VOCAL with rotation of 30° (six planes). To assess the correlation of fetal IVS volume as a function of gestational age (GA), Pearson's correlation coefficient (r) and polynomial regression models with adjustments through the coefficient of determination (R(2)) were calculated. The intra-class coefficient (ICC) was used to evaluate intra- and inter-observer reproducibility.A good correlation between GA and fetal IVS volume (r = 0.827) was observed. The mean fetal IVS volume ranged from 0.13 ± 0.03 cm(3) (0.08-0.18 cm(3)) at 18wd0 of gestation to 1.33 ± 0.37 cm(3) (0.41-1.98 cm(3)) at 33w6d. The best correlation between fetal IVS volume and GA was exponential: fetal IVS volume = 0.11e(0.139×GA) (R(2 )= 0.785). A good intra- and inter-observer reliability were observed, with ICC = 0.999 and 0.991, respectively.Reference values for fetal IVS volume using STIC and VOCAL by 3D/4D ultrasound between 18w0d and 33w6d of gestation were determined and showed to be reliable and concordant.
- Published
- 2014
43. Fetal thigh and upper-arm volumes by three-dimensional ultrasound to predict low postnatal body mass index
- Author
-
Wellington P. Martins, Daniela Cristina Nacaratto, Ana Carolina Rabachini Caetano, R. Cavalcante, Antonio Fernandes Moron, Edward Araujo Júnior, Luciano Marcondes Machado Nardozza, and T.M. Helfer
- Subjects
Adult ,Male ,Percentile ,Thigh ,Ultrasonography, Prenatal ,Body Mass Index ,Young Adult ,Imaging, Three-Dimensional ,Pregnancy ,medicine ,Humans ,Prospective Studies ,Fetus ,Three dimensional ultrasound ,Receiver operating characteristic ,business.industry ,Infant, Newborn ,Obstetrics and Gynecology ,Anatomy ,Infant, Low Birth Weight ,Cross-Sectional Studies ,medicine.anatomical_structure ,ROC Curve ,Pediatrics, Perinatology and Child Health ,Arm ,Gestation ,Female ,PESOS E MEDIDAS CORPORAIS ,Ultrasonography ,business ,Nuclear medicine ,Body mass index ,Algorithms - Abstract
To assess the usefulness of estimating fetal upper arm and thigh volumes as predictors of low postnatal body mass index (BMI) using three-dimensional ultrasonography (3DUS) with extended imaging virtual organ computer-aided analysis (XI VOCAL).This prospective cross-sectional study analyzed 300 singleton pregnancies between 33 and 41 weeks of gestation. The Hadlock 4 formula was used to estimate fetal weight. The XI VOCAL 10 planes method was used to assess fetal upper arm and thigh volumes. After delivery, the newborns' BMI was evaluated and considered low (≤10th percentile) or normal (10th percentile). We determined receiver operating characteristics (ROC) curves and respective areas under the curves for the percentiles of fetal weight and fetal thigh and upper arm volumes.Of the 300 newborns, BMI was ≤10th percentile for 21 and10th percentile for 279 newborns. The area under the ROC curve for fetal weight, obtained using the Hadlock formula, and fetal upper arm and thigh volumes, obtained by 3DUS, were 0.801, 0.930 and 0.924, respectively. We determined the sensitivity and specificity of the three parameters for predicting low postnatal BMI and found values of 85.70% and 65.60%, respectively, for fetal weight, 90.48% and 88.17%, respectively, for fetal thigh volume, and 76.19% and 92.47%, respectively, for fetal upper arm volume.Fetal upper arm and thigh volumes estimated using 3DUS with XI VOCAL were effective predictors of low postnatal BMI.
- Published
- 2014
44. Early indicators of cervical insufficiency assessed using magnetic resonance imaging of the cervix during pregnancy
- Author
-
S. Y. Sun, Jacob Szejnfeld, Rosiane Mattar, Sergio Aron Ajzen, Viviane Vieira Francisco Habib, Dirceu Faggion Júnior, and Edward Araujo Júnior
- Subjects
Adult ,medicine.medical_specialty ,Cervical insufficiency ,Adolescent ,Amniotic sac ,Cervix Uteri ,Young Adult ,Pregnancy ,Prenatal Diagnosis ,medicine ,Humans ,Cervix ,medicine.diagnostic_test ,Obstetrics ,business.industry ,Obstetrics and Gynecology ,Magnetic resonance imaging ,medicine.disease ,Magnetic Resonance Imaging ,Early Diagnosis ,medicine.anatomical_structure ,Cervical Length Measurement ,Case-Control Studies ,Pediatrics, Perinatology and Child Health ,Female ,Uterine Cervical Incompetence ,business - Abstract
To establish the main characteristics of the cervix in pregnant women with cervical insufficiency, by means of magnetic resonance imaging (MRI).A prospective observational case-control study was conducted among 59 pregnant women with cervical insufficiency and 10 normal pregnant women, between their 10th and 28th weeks. The parameters analyzed in the MRI examinations were: precise identification of the cervix; presence of hyposignal at the internal orifice of the cervix; loss of definition of the periendocervical stromal zone (PESZ); presence of hyposignal content inside the amniotic sac (sludge sign) and anatomical and functional biometry of the cervix.Peripheral hyposignal was found in 41 (85.4%) and loss of definition of the PESZ was observed in 36 pregnant women (73.5%) with cervical insufficiency. Sludge was observed in 46 pregnant women with cervical insufficiency, and this was seen on MRI in 27 cases (58.7%). The mean anatomical and functional lengths of the cervix on MRI in the pregnant women with cervical insufficiency were 3.5 ± 0.8 cm (0.8-4.9 cm) and 28.7 ± 6.3 mm (9-41 mm). None of the normal pregnant women presented hyposignal loss of the PESZ and the sludge sign.MRI may be useful for evaluating the cervix and for early identification of signs of cervical insufficiency during pregnancy.
- Published
- 2014
45. Conservative management of cervical pregnancy with embryonic heart activity by ultrasound-guided local injection: an eight case series
- Author
-
Jair Luiz Fava, Julio Elito Júnior, Rubens Bermudes Musiello, Edward Araujo Júnior, Eduardo Almeida Guerzet, Luiz Camano, and Eduardo Soares de Souza
- Subjects
Adult ,medicine.medical_specialty ,Cervical pregnancy ,Potassium Chloride ,Uterine Cervical Diseases ,Pregnancy ,medicine ,Humans ,Ultrasonography, Interventional ,Retrospective Studies ,Abortifacient Agents, Nonsteroidal ,Series (stratigraphy) ,Embryonic heart ,business.industry ,Ultrasound ,Obstetrics and Gynecology ,Retrospective cohort study ,medicine.disease ,Pregnancy, Ectopic ,Surgery ,Methotrexate ,Pediatrics, Perinatology and Child Health ,Female ,business ,medicine.drug - Abstract
To evaluate the efficacy of conservative management of cervical pregnancy with embryonic heart activity by ultrasound-guided local injection.Retrospective case series at University tertiary care Hospital. Eight patients diagnosed with cervical pregnancy with embryonic heart activity managed conservatively. The intervention was ultrasound-guided local injection of methotrexate (1 mg/kg) and potassium chloride (2 meq/mL). Measurements were occurrence of morbidity, necessity for further intervention, the initial titers of beta-hCG, interval of time in which the levels of beta-hCG became negative, period for regression of cervical pregnancy at ultrasound and future pregnancy.All patients were treated successfully. The initial levels of beta-hCG ranged from 3013 to 71199 mUI/mL. One case evaluated with infection. There was no need for additional intervention in our series study. The interval of time for the levels of beta-hCG becomes negative range from 2 to 12 weeks. The period for the regression of the cervical pregnancy at ultrasound range from 3 to 14 weeks. In two cases intrauterine pregnancies occurred after the treatment.Conservative management of cervical pregnancy with embryonic heart activity by ultrasound-guided injection is an effective treatment avoiding the need of further intervention.
- Published
- 2013
46. Reference range of fetal nasal bone length between 18 and 24 weeks of pregnancy in an unselected Brazilian population: experience from a single service
- Author
-
Antonio Fernandes Moron, Edward Araujo Júnior, Claudio Rodrigues Pires, Wellington P. Martins, and Sebastião Marques Zanforlin Filho
- Subjects
Adult ,medicine.medical_specialty ,Adolescent ,Reference range ,Ultrasonography, Prenatal ,Fetal nasal bone ,Young Adult ,Pregnancy ,Reference Values ,medicine ,Humans ,Nasal Bone ,Child ,Nose ,Retrospective Studies ,Fetus ,business.industry ,Obstetrics ,Obstetrics and Gynecology ,Gestational age ,ESTUDOS TRANSVERSAIS ,Middle Aged ,Nasal bone ,medicine.disease ,Cross-Sectional Studies ,medicine.anatomical_structure ,Pregnancy Trimester, Second ,Pediatrics, Perinatology and Child Health ,Gestation ,Female ,business ,Brazil - Abstract
Objective: To determine reference range of fetal nasal bone length (NBL) during the second trimester of pregnancy in a Brazilian population.Methods: This was a retrospective cross-sectional study with 2681 normal singleton pregnancies between 18 and 24 weeks of gestation. The NBL was obtained in the mid-sagittal plane of the fetal face profile using the following landmarks: nasal bone, overlying skin and the tip of the nose. The NBL was measured by placing the calipers in the out-to-out position. To assess the correlation between NBL and gestational age (GA), polynomial equations were calculated, with adjustments by coefficient of determination (R2).Results: The mean of NBL ranged from 5.72 ± 0.87 mm at 18–18 + 6 weeks to 7.45 ± 1.23 mm at 24–24+6 weeks of pregnancy. We observed a good correlation between NBL and GA, best represented by a linear equation: NBL = 0.080+0.276*GA (R2 = 0.16).Conclusion: We established a reference range of fetal NBL in the second trimester of pregnancy in a Brazilian p...
- Published
- 2013
47. Reference range of fetal cisterna magna volume by three-dimensional ultrasonography using the VOCAL method
- Author
-
Luciano Marcondes Machado Nardozza, Antonio Fernandes Moron, Ana Paula Passos, Edward Araujo Júnior, and Rafael Frederico Bruns
- Subjects
Male ,Coefficient of determination ,Correlation coefficient ,Pregnancy Trimester, Third ,Reference range ,Cisterna magna ,Ultrasonography, Prenatal ,Fetal Development ,Imaging, Three-Dimensional ,Pregnancy ,Reference Values ,Cisterna Magna ,Image Interpretation, Computer-Assisted ,Humans ,Medicine ,Prospective Studies ,Observer Variation ,Fetus ,business.industry ,Reproducibility of Results ,Obstetrics and Gynecology ,Gestational age ,Organ Size ,Anatomy ,Cross-Sectional Studies ,Pregnancy Trimester, Second ,Pediatrics, Perinatology and Child Health ,Female ,Three dimensional ultrasonography ,business ,Algorithms ,Volume (compression) - Abstract
To determine reference values for the fetal cisterna magna volume by three-dimensional ultrasonography (3DUS) using the virtual organ computer-aided analysis (VOCAL) method.A cross-sectional study was conducted with 224 healthy pregnant women between 17 and 29 completed weeks. Measurement of the fetal cisterna magna volume was performed in the standard axial plane of the transverse diameter of the cerebellum through the VOCAL method with a 30° angle. For the determination of reference values, polynomial regressions with adjustments by the coefficient of determination (R(2)) were held. The reliability and agreement were made by the intra-class correlation coefficient (ICC) and limits of agreement of the Bland-Altman graph.The average of the fetal cisterna magna volume ranged from 0.73 ± 0.25 to 3.79 ± 1.10 cm(3) between 17 and 29 weeks, respectively. Correlation was observed between the fetal cisterna magna volume and the gestational age (GA), best represented by a quadratic equation: -1.918+0.0284 × GA + 0.0065 × GA(2) (R(2 )= 0.67). It was observed good reliability and intra-observer agreement, with ICC = 0.92 and 95% limits of agreement (-49.7; 48.4). There was low inter-observer reliability and agreement, with ICC = 0.58 and 95% limits of agreement (-114.0; 80.2).Reference values for the fetal cisterna magna volume by 3DUS using the VOCAL method were determined and showed good agreement and intra-observer reliability.
- Published
- 2013
48. Fetal thigh and upper arm volumes by 3D-sonography: comparison between multiplanar and XI VOCAL methods
- Author
-
Antonio Fernandes Moron, Edward Araujo Júnior, Liliam Cristine Rolo, R. Cavalcante, and Luciano Marcondes Machado Nardozza
- Subjects
Adult ,3d sonography ,Gestational Age ,Thigh ,Ultrasonography, Prenatal ,Young Adult ,Fetus ,Imaging, Three-Dimensional ,Pregnancy ,Humans ,Medicine ,Three dimensional ultrasound ,Anatomy, Cross-Sectional ,business.industry ,Ultrasound ,Obstetrics and Gynecology ,Gestational age ,Organ Size ,Anatomy ,Volume measurements ,Cross-Sectional Studies ,medicine.anatomical_structure ,Pediatrics, Perinatology and Child Health ,Arm ,Female ,Ultrasonography ,business - Abstract
Objective. To compare fetal upper arm and thigh volume measurements acquired by three-dimensional (3D) ultrasound using the multiplanar and the eXtended Imaging Virtual Organ Computer-aided AnaLysis (XI VOCAL) methods with different number of sectional planes.Methods. This study enrolled 40 healthy pregnant women between 20 and 40 weeks of gestation. The volume of fetal limbs was calculated using the multiplanar (with 5.0 mm intervals) and the XI VOCAL (with 5, 10, 15, and 20 slice planes) methods. Comparison between the techniques was made by analysis of variance and Bonferroni statistical tests.Results. Mean fetal upper arm volume measured by the 15 sectional planes XI VOCAL method was lower than the same method using 5 and 10 planes instead (p = 0.025 and 0.039, respectively). Fetal thigh volume showed no statistically significant differences among all studied methods.Conclusion. The XI VOCAL using 15 sectional planes method underestimated the fetal upper arm volume by 5 and 10 planes XI VOCAL ...
- Published
- 2011
49. Fetal cerebral ventricle volumetry: comparison between 3D ultrasound and magnetic resonance imaging in fetuses with ventriculomegaly
- Author
-
Antonio Fernandes Moron, K. K. Haratz, P. S. Oliveira, Edward Araujo Júnior, Luciano Mm Nardozza, E. Q. Barreto, Liliam Cristine Rolo, Hérbene José Figuinha Milani, and Sergio Aron Ajzen
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Intraclass correlation ,Ultrasonography, Prenatal ,Cerebral Ventricles ,Lateral ventricles ,Pregnancy ,medicine ,Humans ,3D ultrasound ,Fetus ,medicine.diagnostic_test ,business.industry ,Obstetrics and Gynecology ,Magnetic resonance imaging ,Prognosis ,medicine.disease ,Magnetic Resonance Imaging ,Cross-Sectional Studies ,medicine.anatomical_structure ,Ventricle ,Pediatrics, Perinatology and Child Health ,Cerebral ventricle ,Female ,Radiology ,business ,Hydrocephalus ,Ventriculomegaly - Abstract
The aim of this study was to evaluate feasibility of fetal lateral ventricle (LV) volumetry in fetuses with ventriculomegaly and to compare measurements performed by 3D sonographic method virtual organ computer-aided analysis (VOCAL) with those obtained by magnetic resonance imaging (MRI).This cross-sectional study evaluated 30 fetuses with atrial width (AW) between 10 and 30 mm, from 20 to 36 gestational weeks. Fifty-nine ventricles were measured by two observers. Sonographic volumetric measurements using VOCAL 30° were performed with an ACCUVIX XQ machine (Medison, Korea) and MRI assessments with a Sonata system using ARGUS software (Siemens, Germany). Agreement between both techniques was assessed by intraclass correlation coefficient (ICC) calculation, and proportionate Bland-Altman plots were constructed.A high degree of reliability was observed between VOCAL and MRI measurements (ICC 0.928, 95%CI [0.876;0.958]). Bland-Altman plots confirmed the high correlation (mean of differences: 1.62 cm(3) and standard deviation: ± 8.41 cm(3)).Three-dimensional volumetry of fetal LVs by VOCAL method has good agreement with fetal MRI in fetuses with ventriculomegaly and may be used as an additional tool in patient counseling and prognosis prediction.
- Published
- 2011
50. Fetal lung volume in fetuses with urinary tract malformations: Comparison by 2D-, 3D-sonography and magnetic resonance imaging
- Author
-
Edward Araujo Júnior, Liliam Cristine Rolo, Luciano Marcondes Machado Nardozza, Christiane Simioni, Susan Menasce Goldman, P. S. Oliveira, Antonio Fernandes Moron, and Jacob Szejnfeld
- Subjects
medicine.medical_specialty ,Intraclass correlation ,Urinary system ,Gestational Age ,Ultrasonography, Prenatal ,Pregnancy ,medicine ,Humans ,Lung volumes ,Urinary Tract ,Lung ,Fetus ,medicine.diagnostic_test ,business.industry ,Obstetrics and Gynecology ,Gestational age ,Magnetic resonance imaging ,Magnetic Resonance Imaging ,Fetal Diseases ,Cross-Sectional Studies ,medicine.anatomical_structure ,Pediatrics, Perinatology and Child Health ,Female ,Radiology ,business ,Volume (compression) - Abstract
To evaluate the concordance between two-dimensional ultrasonography (2DUS), three-dimensional ultrasonography (3DUS) and magnetic resonance imaging (MRI) in the assessment of lung volume in fetuses with urinary tract malformations (UTM).This was a cross-sectional study involving 12 pregnancies between 19 and 34 weeks, with various fetal UTM. Pulmonary volume was obtained by 2DUS using the following equation: total lung volume = [right lung antero-posterior diameter (X) x transverse diameter (Y) x cranial-caudal diameter x 0.152 + left lung (X1) x (Y1) x (Z1) x 0.167]. Pulmonary volume by 3DUS was obtained using the virtual organ computer-aided analysis (VOCAL) method with a 30 degrees (VOL30), 18 degrees (VOL18) and 12 degrees (VOL12) rotation. A fast sequence of transverse lung section was also obtained by MRI. The intraclass correlation coefficient was used to evaluate the correlation between the three methods. The paired student t-test was used to compare the means.There was a strong correlation between the three methods, and the highest correlations were between MRI and VOL18 for the right (ICC = 0.913) and left (ICC = 0.947) lungs. A strong correlation was also found between the lung volumes obtained through MRI and VOL12 as well as VOL18 (p = 0.544 and 0.286, respectively). However, for the left lung there was only a correlation between MRI and VOL12 (p = 0.49).There is a good concordance between 3DUS (VOL12) and MRI in the evaluation of lung volume in fetuses with UTM.
- Published
- 2009
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.