1. Impaired platelet reactivity in patients with septic shock: a proof-of-concept study
- Author
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Giacomo Montanari, Alberto Fogagnolo, Gioconda Ferraro, Riccardo Ragazzi, Gianluca Campo, Jacques Creteur, Andrea Erriquez, Savino Spadaro, Carlo Alberto Volta, Beatrice Capatti, and Fabio Silvio Taccone
- Subjects
platelet reactivity ,Blood Platelets ,Male ,0301 basic medicine ,medicine.medical_specialty ,thrombocytopenia ,Pilot Projects ,030204 cardiovascular system & hematology ,Proof of Concept Study ,Gastroenterology ,NO ,Critical care ,Septic shock ,disseminated intravascular coagulation ,sepsis ,Sepsis ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Distribution (pharmacology) ,Platelet ,In patient ,Mean platelet volume ,Coagulation Disorder ,Aged ,Disseminated intravascular coagulation ,Platelet Count ,business.industry ,Hematology ,General Medicine ,Blood Coagulation Disorders ,Middle Aged ,medicine.disease ,Shock, Septic ,030104 developmental biology ,Female ,business - Abstract
Coagulation disorders and thrombocytopenia are common in patients with septic shock, but only few studies have focused on platelet variables beyond platelet count. The aim of this study was to evaluate whether platelets reactivity predicts sepsis-induced thrombocytopenia in patients with septic shock. We therefore enrolled consecutive patients with septic shock and platelets count >150*103/μL on the day of the diagnosis. Platelets reactivity tests were performed daily from the diagnosis of septic shock until day five; platelet volume distribution and mean platelet volume were also recorded daily. Sepsis-induced thrombocytopenia was defined as a platelet count
- Published
- 2019
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