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This paper integrated size-based filtration and negative depletion (SF-ND) to improve the rare circulating tumor cells enrichment from the undiluted whole blood. The whole blood was firstly filtrated by a carefully designed micropore array filter. The captured cells were then released off and mixed with CD45 Dynabeads. CD45+ white blood cells were removed by a magnet and left target cells with a high purity. All operations were conducted in a home-made gadget. The preliminary performance of the SF-ND system showed a high purity (80.48 ± 0.87%) along with the acceptable recovery rate 57.83 ± 10.62% by treating 1 mL whole blood with spiked 104 lung cancer cells (A549s).

In this study, a PI flexible hollow microneedle(HMN) array made by optimized dual-moulding processes is proposed. For the hollow microneedle array reported in the literature, most of the materials are silicon and metal, which are costly and complex, cannot be practically applied to human skin. The needle material used in this design is Polyimide (PI), which has the advantages of biocompatibility and good toughness, and is simple to prepare with low cost. The HMN array shows ability to penetrate porcine skin in the in vitro experiment. Most importantly, it possesses good drug delivery ability by adopting water flow experiment and Rhodamine B as a drug analogue. Due to the advantages of this hollow microneedle array, it has a good application prospect and research value.

In this study, we propose a novel method for the preparation of dissolvable microneedle (DMN) patch directly attached on a medical adhesive tape for transdermal drug delivery. The fabrication process is simple and time-saving without second curing procedures and the fabricated DMN patch exhibits high flexibility and dosage accuracy owing to the property of the medical adhesive tape. Sodium carboxymethyl cellulose (SCMC) was adopted as matrix material due to its biodegradability and mechanical hardness. The MN patch shows great ability to penetrate skin ex vivo and in vivo by utilizing porcine skin and the living mouse. Most importantly, it possesses good capacity to carry drugs and locally release drug molecules into mouse skin by adopting Rhodamine B as the drug analog.

This paper presents the thermal effect of piezoelectric micromachined ultrasonic transducer (PMUT) and expects to apply it to heat dissipation of power electronics. Experiment results have shown that resonant frequency of PMUT does not change much with different external heat flow disturbance (400μm: 2.28kHz for 150°C temperature difference; 2500μm: 8.82kHz for 150°C temperature difference). Therefore, when a voltage with a certain frequency is applied to the PMUT, it will resonate and form a determined distribution of acoustic streaming on the surface, which enhances heat transfer from the heat source to the adjacent air. Simulation and experiment results have shown that the longer the side length of PMUT, the smaller the frequency of it. Further, as the resonant frequency increases, the maximum acoustic streaming velocity also increases. It has been confirmed by experiment that the PMUT has a cooling effect, which varies with the input power.

In a conventional optical resonator, the resonance transmission spectrum is always a Lorentz line shape, which is symmetrical with respect to the resonant wavelength. Recently, different configurations based on ring resonators [1], surface plasmons [2] and photonic crystal cavities [3] have been demonstrated to have asymmetric line shape, i.e., Fano resonance. Asymmetric profile in Fano resonance has sharper features than normal Lorentz line shape, which leads to a smaller shift of the resonant wavelength required for the same variation of optical power. Compared to other structures possessing Fano resonance, PhC cavities are superior with the advantages of ultra-high Q factors, small effective mode volumes and high integrabilities with optical circuits. In this work, we design and demonstrate a high Q 1D PhC cavity which can obtain tunable Fano line shape filtering. It is designed for fabrication on SilicononInsulator (SOI) wafer. The cavity is formed by two periodic arrays of circular air holes etched on a silicon strip waveguide. By utilizing a deterministic design method, we obtain a high calculated Q-factor of 1.03 × 106 for the fundamental resonant mode. Fig. 1(a) shows the SEM image of the fabricated device, the inset is the grating coupler integrated with the cavity. Experimental results show that, the cavity not only possesses transmission spectrum of Lorentz line shape, it can also obtain asymmetric sharp Fano line shape. By shifting the input fiber from the center relative to the grating coupler in the lateral direction, we can get tunable and asymmetric Fano line shapes. The two typical Fano spectrums are shown in Fig. 1(b), we can see that the Fano spectrums are asymmetric and very sharp around the resonant wavelength. Besides, our designed 1D PhC cavity has a small footprint of 14 × 0.56 µm2. It has great potential in the applications of efficient and compact optical modulators and sensors.

We present a novel optical sensor based on a one-dimensional photonic crystal slot nanobeam cavity. An ultra-high quality factor of 174,000 is obtained. The sensor possesses an estimated very high sensitivity of 851 nm/RIU.