1. Th1-Inducing Agents in Prophylaxis and Therapy for Paracoccidioidomycosis.
- Author
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da Silva TA, Fernandes FF, Landgraf TN, Panunto-Castelo A, and Roque-Barreira MC
- Subjects
- Adjuvants, Immunologic, Animals, Cytokines metabolism, Disease Models, Animal, Immunomodulation drug effects, Male, Mice, Paracoccidioidomycosis metabolism, Paracoccidioidomycosis prevention & control, Paracoccidioidomycosis therapy, Th1 Cells metabolism, Blastomyces immunology, Immunologic Factors pharmacology, Paracoccidioidomycosis immunology, Th1 Cells drug effects, Th1 Cells immunology
- Abstract
Adjuvants and immunomodulatory molecules could be included in the treatment of P. brasiliensis infection. In this context, we reported that the therapeutic and/or prophylactic administration of Th1-inducing agents, such as immunomodulatory lectins and adjuvants, was able to provide protection against experimental paracoccidioidomycosis. Then, we described the protocols to investigate the effect of immunomodulatory agents on the course of P. brasiliensis infection. In this sense, we detailed the measurement of fungal burden and cytokine production, and the histopathological analysis used to evaluate the most effective administration regime.
- Published
- 2017
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