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Th1-Inducing Agents in Prophylaxis and Therapy for Paracoccidioidomycosis.

Authors :
da Silva TA
Fernandes FF
Landgraf TN
Panunto-Castelo A
Roque-Barreira MC
Source :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2017; Vol. 1625, pp. 159-167.
Publication Year :
2017

Abstract

Adjuvants and immunomodulatory molecules could be included in the treatment of P. brasiliensis infection. In this context, we reported that the therapeutic and/or prophylactic administration of Th1-inducing agents, such as immunomodulatory lectins and adjuvants, was able to provide protection against experimental paracoccidioidomycosis. Then, we described the protocols to investigate the effect of immunomodulatory agents on the course of P. brasiliensis infection. In this sense, we detailed the measurement of fungal burden and cytokine production, and the histopathological analysis used to evaluate the most effective administration regime.

Details

Language :
English
ISSN :
1940-6029
Volume :
1625
Database :
MEDLINE
Journal :
Methods in molecular biology (Clifton, N.J.)
Publication Type :
Academic Journal
Accession number :
28584990
Full Text :
https://doi.org/10.1007/978-1-4939-7104-6_12