1. Mobilization of CD34+CXCR4+ stem/progenitor cells and the parameters of left ventricular function and remodeling in 1-year follow-up of patients with acute myocardial infarction.
- Author
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Wyderka R, Wojakowski W, Jadczyk T, Maślankiewicz K, Parma Z, Pawłowski T, Musiałek P, Majka M, Król M, Kuczmik W, Dworowy S, Korzeniowska B, Ratajczak MZ, and Tendera M
- Subjects
- Aged, Chemokine CXCL12 biosynthesis, Echocardiography methods, Female, Follow-Up Studies, Granulocyte Colony-Stimulating Factor biosynthesis, Hematopoietic Stem Cell Mobilization, Humans, Inflammation, Male, Middle Aged, Natriuretic Peptide, Brain biosynthesis, Peptide Fragments biosynthesis, Prognosis, Time Factors, Troponin I biosynthesis, Ventricular Remodeling, Antigens, CD34 biosynthesis, Myocardial Infarction metabolism, Receptors, CXCR4 biosynthesis, Stem Cells cytology, Ventricular Function, Left physiology
- Abstract
Mobilization of stem cells in acute MI might signify the reparatory response. Aim of the Study. Prospective evaluation of correlation between CD34+CXCR4+ cell mobilization and improvement of LVEF and remodeling in patients with acute MI in 1-year followup. Methods. 50 patients with MI, 28 with stable angina (SAP), and 20 individuals with no CAD (CTRL). CD34+CXCR4+ cells, SDF-1, G-CSF, troponin I (TnI) and NT-proBNP were measured on admission and 1 year after MI. Echocardiography and ergospirometry were carried out after 1 year. Results. Number of CD34+CXCR4+ cells in acute MI was significantly higher in comparison with SAP and CTRL, but lower in patients with decreased LVEF ≤40%. In patients who had significant LVEF increase ≥5% in 1 year FU the number of cells in acute MI was significantly higher versus patients with no LVEF improvement. Number of cells was positively correlated (r = 0,41, P = 0,031) with absolute LVEF change and inversely with absolute change of ESD and EDD in 1-year FU. Mobilization of CD34+CXCR4+ cells in acute MI was negatively correlated with maximum TnI and NT-proBNP levels. Conclusion. Mobilization of CD34+CXCR4+ cells in acute MI shows significant positive correlation with improvement of LVEF after 1 year.
- Published
- 2012
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