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Mobilization of CD34+CXCR4+ stem/progenitor cells and the parameters of left ventricular function and remodeling in 1-year follow-up of patients with acute myocardial infarction.
- Source :
-
Mediators of inflammation [Mediators Inflamm] 2012; Vol. 2012, pp. 564027. Date of Electronic Publication: 2012 Mar 28. - Publication Year :
- 2012
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Abstract
- Mobilization of stem cells in acute MI might signify the reparatory response. Aim of the Study. Prospective evaluation of correlation between CD34+CXCR4+ cell mobilization and improvement of LVEF and remodeling in patients with acute MI in 1-year followup. Methods. 50 patients with MI, 28 with stable angina (SAP), and 20 individuals with no CAD (CTRL). CD34+CXCR4+ cells, SDF-1, G-CSF, troponin I (TnI) and NT-proBNP were measured on admission and 1 year after MI. Echocardiography and ergospirometry were carried out after 1 year. Results. Number of CD34+CXCR4+ cells in acute MI was significantly higher in comparison with SAP and CTRL, but lower in patients with decreased LVEF ≤40%. In patients who had significant LVEF increase ≥5% in 1 year FU the number of cells in acute MI was significantly higher versus patients with no LVEF improvement. Number of cells was positively correlated (r = 0,41, P = 0,031) with absolute LVEF change and inversely with absolute change of ESD and EDD in 1-year FU. Mobilization of CD34+CXCR4+ cells in acute MI was negatively correlated with maximum TnI and NT-proBNP levels. Conclusion. Mobilization of CD34+CXCR4+ cells in acute MI shows significant positive correlation with improvement of LVEF after 1 year.
- Subjects :
- Aged
Chemokine CXCL12 biosynthesis
Echocardiography methods
Female
Follow-Up Studies
Granulocyte Colony-Stimulating Factor biosynthesis
Hematopoietic Stem Cell Mobilization
Humans
Inflammation
Male
Middle Aged
Natriuretic Peptide, Brain biosynthesis
Peptide Fragments biosynthesis
Prognosis
Time Factors
Troponin I biosynthesis
Ventricular Remodeling
Antigens, CD34 biosynthesis
Myocardial Infarction metabolism
Receptors, CXCR4 biosynthesis
Stem Cells cytology
Ventricular Function, Left physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1466-1861
- Volume :
- 2012
- Database :
- MEDLINE
- Journal :
- Mediators of inflammation
- Publication Type :
- Academic Journal
- Accession number :
- 22547906
- Full Text :
- https://doi.org/10.1155/2012/564027