1. Systemic Inflammation and Lung Function Impairment in Morbidly Obese Subjects with the Metabolic Syndrome.
- Author
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van Huisstede, Astrid, Castro Cabezas, Manuel, Birnie, Erwin, van de Geijn, Gert-Jan M., Rudolphus, Arjan, Mannaerts, Guido, Njo, Tjin L., Hiemstra, Pieter S., and Braunstahl, Gert-Jan
- Subjects
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ASTHMA risk factors , *GASTROESOPHAGEAL reflux diagnosis , *HEART disease risk factors , *LUNG diseases , *LUNG physiology , *SLEEP apnea syndromes , *SMOKING , *METABOLIC syndrome diagnosis , *BARIATRIC surgery , *ANTHROPOMETRY , *ASTHMA , *BLOOD pressure measurement , *CHI-squared test , *CHOLESTEROL , *INFLAMMATION , *LIPOPROTEINS , *MEDICAL screening , *METABOLISM , *OBESITY , *PREOPERATIVE care , *PULMONARY function tests , *T-test (Statistics) , *U-statistics , *DATA analysis , *BODY mass index , *MORBID obesity , *CROSS-sectional method , *VITAL capacity (Respiration) , *DISEASE complications , *DIAGNOSIS , *DISEASE risk factors - Abstract
Background. Obesity and asthma are associated. There is a relationship between lung function impairment and the metabolic syndrome. Whether this relationship also exists in the morbidly obese patients is still unknown. Hypothesis. Low-grade systemic inflammation associated with the metabolic syndrome causes inflammation in the lungs and, hence, lung function impairment. Methods. This is cross-sectional study of morbidly obese patients undergoing preoperative screening for bariatric surgery. Metabolic syndrome was assessed according to the revised NCEP-ATP III criteria. Results. A total of 452 patients were included. Patients with the metabolic syndrome (n = 293) had significantly higher blood monocyte (mean 5.3 versus 4.9, P = 0.044) and eosinophil percentages (median 1.0 versus 0.8, P = 0.002), while the total leukocyte count did not differ between the groups. The FEV1/FVC ratio was significantly lower in patients with the metabolic syndrome (76.7% versus 78.2%, P = 0.032). Blood eosinophils were associated with FEV1/FVC ratio (adj. B .0.113, P = 0.018). Conclusion. Although the difference in FEV1/FVC ratio between the groups is relatively small, in this cross-sectional study, and its clinical relevance may be limited, these data indicate that the presence of the metabolic syndrome may influence lung function impairment, through the induction of relative eosinophilia. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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