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Systemic Inflammation and Lung Function Impairment in Morbidly Obese Subjects with the Metabolic Syndrome.
- Source :
-
Journal of Obesity . 2013, Vol. 2013, p1-8. 8p. 6 Charts. - Publication Year :
- 2013
-
Abstract
- Background. Obesity and asthma are associated. There is a relationship between lung function impairment and the metabolic syndrome. Whether this relationship also exists in the morbidly obese patients is still unknown. Hypothesis. Low-grade systemic inflammation associated with the metabolic syndrome causes inflammation in the lungs and, hence, lung function impairment. Methods. This is cross-sectional study of morbidly obese patients undergoing preoperative screening for bariatric surgery. Metabolic syndrome was assessed according to the revised NCEP-ATP III criteria. Results. A total of 452 patients were included. Patients with the metabolic syndrome (n = 293) had significantly higher blood monocyte (mean 5.3 versus 4.9, P = 0.044) and eosinophil percentages (median 1.0 versus 0.8, P = 0.002), while the total leukocyte count did not differ between the groups. The FEV1/FVC ratio was significantly lower in patients with the metabolic syndrome (76.7% versus 78.2%, P = 0.032). Blood eosinophils were associated with FEV1/FVC ratio (adj. B .0.113, P = 0.018). Conclusion. Although the difference in FEV1/FVC ratio between the groups is relatively small, in this cross-sectional study, and its clinical relevance may be limited, these data indicate that the presence of the metabolic syndrome may influence lung function impairment, through the induction of relative eosinophilia. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ASTHMA risk factors
*GASTROESOPHAGEAL reflux diagnosis
*HEART disease risk factors
*LUNG diseases
*LUNG physiology
*SLEEP apnea syndromes
*SMOKING
*METABOLIC syndrome diagnosis
*BARIATRIC surgery
*ANTHROPOMETRY
*ASTHMA
*BLOOD pressure measurement
*CHI-squared test
*CHOLESTEROL
*INFLAMMATION
*LIPOPROTEINS
*MEDICAL screening
*METABOLISM
*OBESITY
*PREOPERATIVE care
*PULMONARY function tests
*T-test (Statistics)
*U-statistics
*DATA analysis
*BODY mass index
*MORBID obesity
*CROSS-sectional method
*VITAL capacity (Respiration)
*DISEASE complications
*DIAGNOSIS
*DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 20900708
- Volume :
- 2013
- Database :
- Academic Search Index
- Journal :
- Journal of Obesity
- Publication Type :
- Academic Journal
- Accession number :
- 90188510
- Full Text :
- https://doi.org/10.1155/2013/131349