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1. Coupling the Yoccoz-Birkeland population model with price dynamics: chaotic livestock commodities market cycles

Author: Stefano Marmi, Duccio Papini, Sylvain Arlot, Laboratoire de Mathématiques d'Orsay (LMO), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Sélection de modèles en apprentissage statistique (SELECT-POST), Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Scuola Normale Superiore di Pisa (SNS), Dipartimento di Matematica e Informatica - Universita Udine (DIMI), Università degli Studi di Udine - University of Udine [Italie], This work was started during a visit of SA to the Scuola Normale Superiore in Pisa and to the Complex Systems Center of the University of Siena, the hospitality of which is gratefully acknowledged. The authors acknowledge the support of the Centro di Ricerca Matematica Enniode Giorgi and of UniCredit Bank R&D group for financial support through the 'Dynamics and Information Theory Institute' at the Scuola Normale Superiore. Most of this work was done while SA was a researcher at CNRS (Département d’Informatique / Ecole Normale Supérieure, UMR8548 CNRS/ENS/INRIA), 45, rue d’Ulm, F-75230 PARIS Cedex 05, France). DP was supported by the INdAM-GNAMPA project 'Proprietà qualitative di alcuni problemi ai limiti'. We are also grateful to Paolo Nistri for contributing to the initial formulation of the model and to Nicola Zanda for useful discussions on livestocks farming (in particular Cinta Senese and pig)., Laboratoire de Mathématiques d'Orsay ( LMO ), Université Paris-Saclay-Centre National de la Recherche Scientifique ( CNRS ), Model selection in statistical learning ( SELECT ), Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ) -Laboratoire de Mathématiques d'Orsay ( LMO ), Université Paris-Saclay-Centre National de la Recherche Scientifique ( CNRS ) -Université Paris-Saclay-Centre National de la Recherche Scientifique ( CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Scuola Normale Superiore di Pisa ( SNS ), Scuola Normale Superiore di Pisa, Department of Mathematical and Computer Science, University of Udine, Arlot, S., Marmi, S., and Papini, D.
Subjects: Spot contract, Population dynamics, Differential equation, Population, [ MATH.MATH-DS ] Mathematics [math]/Dynamical Systems [math.DS], [MATH.MATH-DS]Mathematics [math]/Dynamical Systems [math.DS], Chaotic, Chaotic livestock commodities cycles, General Physics and Astronomy, Dynamical Systems (math.DS), Population dynamic, 01 natural sciences, Delays dynamical systems, Strange attractor, Supply and demand, Attractor, FOS: Mathematics, Econometrics, Quantitative Biology::Populations and Evolution, 0101 mathematics, Mathematics - Dynamical Systems, education, Quantitative Biology - Populations and Evolution, Settore MAT/07 - Fisica Matematica, Mathematical Physics, Mathematics, education.field_of_study, Applied Mathematics, [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], 010102 general mathematics, Populations and Evolution (q-bio.PE), Delays dynamical system, Statistical and Nonlinear Physics, Integral equation, 010101 applied mathematics, [ SDV.BID.EVO ] Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], Population model, Chaotic livestock commodities cycle, FOS: Biological sciences
Abstract: We propose a new model for the time evolution of livestock commodities which exhibits endogenous deterministic stochastic behaviour. The model is based on the Yoccoz-Birkeland integral equation, a model first developed for studying the time-evolution of single species with high average fertility, a relatively short mating season and density dependent reproduction rates. This equation is then coupled with a differential equation describing the price of a livestock commodity driven by the unbalance between its demand and supply. At its birth the cattle population is split into two parts: reproducing females and cattle for butchery. The relative amount of the two is determined by the spot price of the meat. We prove the existence of an attractor and we investigate numerically its properties: the strange attractor existing for the original Yoccoz-Birkeland model is persistent but its chaotic behaviour depends also from the price evolution in an essential way., 26 pages, 19 figures
Published: 2018

2. Development of the ClinESSDAI: a clinical score without biological domain. A tool for biological studies

Author: Seror, Raphaèle, Meiners, Petra, Baron, Gabriel, Bootsma, Hendrika, Bowman, Simon J, Vitali, Claudio, Gottenberg, Jacques-Eric, Theander, Elke, Tzioufas, Athanasios, De Vita, Salvatore, Ramos-Casals, Manel, Dörner, Thomas, Quartuccio, Luca, Ravaud, Philippe, Mariette, Xavier, Bartoloni, Elena, Gerli, Roberto, Bombardieri, Stefano, Kallenberg, Cees, Brun, Johan G, Caporali, Roberto, Devauchelle, Valerie, Saraux, Alain, Fauchais, Anne-Laure, Gottenberg, Jacques Eric, Hachulla, Eric, Kruize, Aike A, Mandl, Thomas, Demoulins, Frederic, Bicêtre, Le Kremlin, Montecucco, Carlomaurizio, Ng, Wan-Fai, Praprotnik, Sonja, Tomsic, Matija, Casals, Manel Ramos, Scofield, Hal, Sivils, Kathy L., Laqué, Roser Solans, Sumida, Takayuki, Nishiyama, Sumusu, Valesini, Guido, Valim, Valeria, Vollenweider, Cristina, CHU Cochin [AP-HP], Departement of Oral and Maxillofacial Surgery, Groningen, Univesity of Medical Center Groningen, Education Discours Apprentissages (EDA - EA 4071), Université Paris Descartes - Paris 5 (UPD5), Department of Rheumatology and Clinical Immunology Groningen, University Medical Center Groningen [Groningen] (UMCG), Department of Internal Medicine and section of Rheumatology, Villamarina Hospital, Immuno-Rhumatologie Moléculaire, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Rheumatology, Lund University [Lund], Department of Pathophysiology, Medical School, University of Athens, University of Udine and University Hospital of Udine, Laboratory of Autoimmune Diseases Josep Font Barcelona, CELLEX-IDIBAPS Department of Autoimmune Diseases, Barcelona, Klinik für Dermatologie, Venerologie und Allergologie, University of Udine and University Hospital- Udine, Università degli Studi di Udine - University of Udine [Italie], Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Régulation de la réponse immune, infection VIH-1 et autoimmunité, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Service de Médecine interne A et polyclinique médicale [CHU Limoges], CHU Limoges, Homéostasie Cellulaire et Pathologies (HCP), Université de Limoges (UNILIM)-CHU Limoges-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503), Service de médecine interne, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Department of biomedical sciences, Universita degli Studi di Padova, University of Northumbria at Newcastle [United Kingdom], University Medical Centre, Faculty of Chemistry and Chemical Technology, University of Ljubjana, University of Tsukuba, Department of Internal Medicine, Lupus Clinic, Sapienza University [Rome], Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Strasbourg (UNISTRA), Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques (U738 / UMR_S738), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), Université de Limoges (UNILIM)-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-CHU Limoges, Université de Tsukuba = University of Tsukuba, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Translational Immunology Groningen (TRIGR), Education Discours Apprentissages ( EDA - EA 4071 ), Université Paris Descartes - Paris 5 ( UPD5 ), University Medical Center Groningen, Université de Strasbourg ( UNISTRA ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Paris Diderot - Paris 7 ( UPD7 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Immunologie et Pathologie ( EA2216 ), Université de Brest ( UBO ) -IFR148, CHRU Brest - Service de Rhumatologie ( CHU - BREST - Rhumato ), Centre Hospitalier Régional Universitaire de Brest ( CHRU Brest ), Homéostasie Cellulaire et Pathologies ( HCP ), Université de Limoges ( UNILIM ) -Génomique, Environnement, Immunité, Santé, Thérapeutique ( GEIST FR CNRS 3503 ) -CHU Limoges, and Centre Hospitalier Régional Universitaire [Lille] ( CHRU Lille )
Subjects: Genetics and Molecular Biology (all), Male, Multivariate statistics, Psychometrics, Intraclass correlation, INDEXES ESSPRI, Biochemistry, Severity of Illness Index, B-LYMPHOCYTE STIMULATOR, RESPONSIVENESS, 0302 clinical medicine, [ SDV.IMM ] Life Sciences [q-bio]/Immunology, Immunology and Allergy, Disease Activity, Outcomes research, Sjøgren's Syndrome, Rheumatology, Immunology, Biochemistry, Genetics and Molecular Biology (all), 030212 general & internal medicine, SYSTEMIC-LUPUS-ERYTHEMATOSUS, ComputingMilieux_MISCELLANEOUS, MINIMAL DISEASE-ACTIVITY, Sjogren's Syndrome, Cohort, SjÃ¸gren's Syndrome, Female, Humans, Reproducibility of Results, Sensitivity and Specificity, [SDV.IMM]Life Sciences [q-bio]/Immunology, medicine.medical_specialty, PRIMARY SJOGRENS-SYNDROME, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Internal medicine, Severity of illness, medicine, Journal Article, Validation Studies, 030203 arthritis & rheumatology, business.industry, HEALTH-STATUS INSTRUMENTS, Gold standard (test), RHEUMATOID-ARTHRITIS, Clinical trial, DEFINITION, Physical therapy, business, ESSDAI
Abstract: ObjectiveTo develop and validate ClinESSDAI (Clinical European League Against Rheumatism Sjögren's Syndrome Disease Activity Index), ie, ESSDAI without the biological domain.Patients and methodsThe 702 fictive vignettes derived from 96 real cases of primary Sjögren's syndrome of the ESSDAI development study were used. As for ESSDAI development, the physician assessment of disease activity (0–10 scale) was used as the ‘gold standard’ in a multivariate model for weighting domains, after removing the biological domain. The reliability, assessed by intraclass correlation coefficient (ICC) between ClinESSDAI and ESSDAI, explored if ClinESSDAI was equivalent to ESSDAI. Its psychometric (ie, measurement) properties were compared with that of ESSDAI in an independent cohort. Also, its use was evaluated on data of two clinical trials.ResultsIn multivariate modelling, all 11 domains remained significantly associated with disease activity, with slight modifications of some domain weights. Reliability between clinESSDAI and ESSDAI was excellent (ICC=0.98 and 0.99). Psychometric properties of clinESSDAI, disease activity levels and minimal clinically important improvement thresholds and its ability to detect change over time in clinical trials were very close to that of ESSDAI.ConclusionsClinESSDAI appears valid and very close to the original ESSDAI. This score provides an accurate evaluation of disease activity independent of B-cell biomarkers. It could be used in various circumstances: (i) in biological/clinical studies to avoid data collinearity, (ii) in clinical trials, as secondary endpoint, to detect change independent of biological effect of the drug, (iii) in clinical practice to assess disease activity for visits where immunological tests have not been done.
Published: 2016
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3. Neuromorphic object localization using resistive memories and ultrasonic transducers

Author: Filippo Moro, Emmanuel Hardy, Bruno Fain, Thomas Dalgaty, Paul Clémençon, Alessio De Prà, Eduardo Esmanhotto, Niccolò Castellani, François Blard, François Gardien, Thomas Mesquida, François Rummens, David Esseni, Jérôme Casas, Giacomo Indiveri, Melika Payvand, Elisa Vianello, Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Département Systèmes et Circuits Intégrés Numériques (DSCIN), Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Università degli Studi di Udine - University of Udine [Italie], Université de Tours (UT), Universität Zürich [Zürich] = University of Zurich (UZH), Institute for Neuroinformatics, Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), European Project: 871371,meM-scales, European Project: 101043854,DIVERSE, University of Zurich, Moro, Filippo, and Vianello, Elisa
Subjects: 1000 Multidisciplinary, Multidisciplinary, Computers, [PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], Transducers, General Physics and Astronomy, 1600 General Chemistry, Genetics and Molecular Biology, General Chemistry, General Biochemistry, Genetics and Molecular Biology, Electrical and electronic engineering, 3100 General Physics and Astronomy, NEMS, Electronic devices, Semiconductors, 1300 General Biochemistry, Genetics and Molecular Biology, General Biochemistry, 570 Life sciences, biology, Ultrasonics, 10194 Institute of Neuroinformatics
Abstract: Real-world sensory-processing applications require compact, low-latency, and low-power computing systems. Enabled by their in-memory event-driven computing abilities, hybrid memristive-Complementary Metal-Oxide Semiconductor neuromorphic architectures provide an ideal hardware substrate for such tasks. To demonstrate the full potential of such systems, we propose and experimentally demonstrate an end-to-end sensory processing solution for a real-world object localization application. Drawing inspiration from the barn owl's neuroanatomy, we developed a bio-inspired, event-driven object localization system that couples state-of-the-art piezoelectric micromachined ultrasound transducer sensors to a neuromorphic resistive memories-based computational map. We present measurement results from the fabricated system comprising resistive memories-based coincidence detectors, delay line circuits, and a full-custom ultrasound sensor. We use these experimental results to calibrate our system-level simulations. These simulations are then used to estimate the angular resolution and energy efficiency of the object localization model. The results reveal the potential of our approach, evaluated in orders of magnitude greater energy efficiency than a microcontroller performing the same task., Nature Communications, 13 (1), ISSN:2041-1723
Published: 2022
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4. K-Fibonacci sequences and minimal winning quota in Parsimonious game

Author: Pressacco, Flavio, Plazzotta, Giacomo, Ziani, Laura, DIES - Dept. of Economics and Statistics (DIES), Università degli Studi di Udine - University of Udine [Italie], Department of Mathematics [Imperial College London], Imperial College London, and We acknowledge financial support of MedioCredito Friuli Venezia Friuli through the 'Bonaldo Stringher' Laboratory of Finance, Department of Finance, University of Udine.
Subjects: JEL: C - Mathematical and Quantitative Methods, Computer Science::Computer Science and Game Theory, Mathematics - Number Theory, [MATH.MATH-DS]Mathematics [math]/Dynamical Systems [math.DS], Dynamical Systems (math.DS), minimal winning quota, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, [MATH.MATH-NT]Mathematics [math]/Number Theory [math.NT], parsimonious games, Homogeneous weighted majority games, Fibonacci polynomials, JEL: C - Mathematical and Quantitative Methods/C.C7 - Game Theory and Bargaining Theory, Fibonacci polynomials,Homogeneous weighted majority games,parsimonious games,minimal winning quota,k-Fibonacci sequence,Fibonacci polynomials, FOS: Mathematics, k-Fibonacci sequence, Number Theory (math.NT), Mathematics - Dynamical Systems
Abstract: Parsimonious games are a subset of constant sum homogeneous weighted majority games unequivocally described by their free type representation vector. We show that the minimal winning quota of parsimonious games satisfies a second order, linear, homogeneous, finite difference equation with nonconstant coefficients except for uniform games. We provide the solution of such an equation which may be thought as the generalized version of the polynomial expansion of a proper k-Fibonacci sequence. In addition we show that the minimal winning quota is a symmetric function of the representation vector; exploiting this property it is straightforward to prove that twin Parsimonious games, i.e. a couple of games whose free type representations are each other symmetric, share the same minimal winning quota.
Published: 2014

5. Landscape Agronomy: background concepts and emerging challenges to address agri-food system design beyond the farm level

Author: Rizzo, Davide, Marraccini, Elisa, Thenail, Claudine, Moonen, Anna-Camilla, Debolini, Marta, Lardon, Sylvie, Laboratoire d'étude des Interactions Sol - Agrosystème - Hydrosystème (UMR LISAH), Institut de Recherche pour le Développement (IRD)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Dipartimento di Scienze Agrarie e Ambientali (DiSA), Università degli Studi di Udine - University of Udine [Italie], Biodiversité agroécologie et aménagement du paysage (UMR BAGAP), Ecole supérieure d'Agricultures d'Angers (ESA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Rennes Angers, Scuola Universitaria Superiore Sant'Anna [Pisa] (SSSUP), Environnement Méditerranéen et Modélisation des Agro-Hydrosystèmes (EMMAH), Avignon Université (AU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Euro-Mediterranean Center on Climate Change (CMCC), Territoires (Territoires), AgroParisTech-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Farming System Design, and ANR-22-CPJ1-0050,CPJ1-0050,Chaire de Professeur Junior en Géoagronomie
Subjects: Farming system, System approach, Landscape agronomy, [SDV.SA.AGRO]Life Sciences [q-bio]/Agricultural sciences/Agronomy, Conceptual model, [SHS.GEO]Humanities and Social Sciences/Geography, Interdisciplinary research
Abstract: The aim of this communication is to present the landscape agronomy framework and how it addresses spatially explicit natural resource management in agriculture. Based on a summary of the scientific background and state of the art on how agriculture is addressed at the landscape level, the result is a conceptual model that provides a framework for observing, understanding, and supporting the actions of actors involved in the dynamics of agricultural landscapes and the design of agri-food systems. The landscape agronomy conceptual model was developed to integrate assessment and monitoring beyond the farm level and across multiple temporal and spatial scales. It was introduced in a seminal paper by Benoît and colleagues (Landscape Ecology, 27(10):2012), which highlighted the importance of an integrated approach to describing and understanding farming practices, natural resources, and landscape patterns. The landscape agronomy conceptual framework is intended to help understand what may be missing to achieve landscape agroecological transitions and to guide the design of research, education and training by raising awareness about the components and relationships of a system approach to agriculture., Projet n° ANR-22-CPJ1-0050-01 Chaire de Professeur Junior IRD en Géoagronomie
Published: 2022
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6. Landscape Agronomy: Lessons Learned and Challenges Ahead, from a European Perspective

Author: Claudine Thenail, Anna-Camilla Moonen, Sylvie Lardon, Elisa Marraccini, Davide Rizzo, Biodiversité agroécologie et aménagement du paysage (UMR BAGAP), Ecole supérieure d'Agricultures d'Angers (ESA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Rennes Angers, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Center of Plant Sciences, Scuola Universitaria Superiore Sant'Anna [Pisa] (SSSUP), Territoires (Territoires), AgroParisTech-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Dipartimento di Scienze Agrarie ed Ambientali - Universita Udine (DISA), Università degli Studi di Udine - University of Udine [Italie], Innovation, Territoire, Agriculture et Agro-industrie, Connaissance et Technologie (INTERACT), UniLaSalle, Laboratoire d'étude des Interactions Sol - Agrosystème - Hydrosystème (UMR LISAH), and Institut de Recherche pour le Développement (IRD)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier
Subjects: Policy-making, Integrated approach, Natural resource management, Farm management, Agriculture, Policy-making, Farm management, [SDV.SA.AGRO]Life Sciences [q-bio]/Agricultural sciences/Agronomy, Agriculture, Policymaking, Natural resource management, [SHS.GEO]Humanities and Social Sciences/Geography, Integrated approach
Abstract: International audience; Landscape Agronomy is expected to contribute to the observation, understanding and support of agriculture at the landscape level. The conceptual model of Landscape Agronomy was developed to integrate assessment and monitoring beyond the farm level and across multiple temporal and spatial scales. In this chapter, we evaluate the relevance of the Landscape Agronomy conceptual model by analysing three issues of integrated governance and public action. The three examples highlight the three parts of the conceptual model: (a) core agricultural landscape dynamics, illustrated by farmers’ collective projects of agroecological transition; (b) the three poles of the conceptual model—practices, resources and patterns—illustrated by Integrated Pest Management as an example of requirements for sustainable agroecosystem management; and (c) temporal and spatial interactions, illustrated by the concept of territorial circularity as a way to integrate landscape-based management into global issues related to nutrient cycles. Although it captures the key issues addressed by such perspectives, the Landscape Agronomy conceptual model still faces some challenges, such as explicit consideration of temporal dimensions and explicit inclusion of new (invisible) patterns emerging from newly available data and digitalisation.
Published: 2022
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7. Stomatal responses in grapevine become increasingly more tolerant to low water potentials throughout the growing season

Author: Astrid Forneck, Alberto Calderan, Hervé Cochard, Enrico Peterlunger, Gregory A. Gambetta, Uri Hochberg, Paolo Sivilotti, Jose Carlos Herrera, Universität für Bodenkultur Wien = University of Natural Resources and Life [Vienne, Autriche] (BOKU), Università degli Studi di Udine - University of Udine [Italie], Università degli studi di Trieste = University of Trieste, Ecophysiologie et Génomique Fonctionnelle de la Vigne (UMR EGFV), Université de Bordeaux (UB)-Institut des Sciences de la Vigne et du Vin (ISVV)-Ecole Nationale Supérieure des Sciences Agronomiques de Bordeaux-Aquitaine (Bordeaux Sciences Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire de Physique et Physiologie Intégratives de l’Arbre en environnement Fluctuant (PIAF), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Universität für Bodenkultur Wien [Vienne, Autriche] (BOKU), and University of Trieste
Subjects: 0106 biological sciences, Pressure-volume curves, Stomatal conductance, Osmosis, anisohydric, isohydric, Drought tolerance, Turgor pressure, Growing season, Plant Science, Biology, 01 natural sciences, 03 medical and health sciences, water stress, Osmotic Pressure, vine hydraulics, Genetics, Osmotic pressure, Vitis, Cultivar, Plant Physiological Phenomena, 030304 developmental biology, 2. Zero hunger, 0303 health sciences, fungi, Water, food and beverages, osmotic adjustment, Cell Biology, 15. Life on land, Adaptation, Physiological, Droughts, Plant Leaves, Horticulture, Vitis vinifera, drought acclimation, pressure-volume curves, stomatal conductance, 13. Climate action, Osmolyte, Plant Stomata, [SDE]Environmental Sciences, Seasons, 010606 plant biology & botany
Abstract: International audience; The leaf of a deciduous species completes its life cycle in a few months. During leaf maturation, osmolyte accumulation leads to a significant reduction of the turgor loss point (psi(TLP)), a known marker for stomatal closure. Here we exposed two grapevine cultivars to drought at three different times during the growing season to explore if the seasonal decrease in leaf psi(TLP) influences the stomatal response to drought. The results showed a significant seasonal shift in the response of stomatal conductance to stem water potential (g(s)similar to psi(stem)), demonstrating that grapevines become increasingly tolerant to low psi(stem) as the season progresses in coordination with the decrease in psi(TLP). We also used the SurEau hydraulic model to demonstrate a direct link between osmotic adjustment and the plasticity of g(s)similar to psi(stem). To understand the possible advantages of g(s)similar to psi(stem) plasticity, we incorporated a seasonally dynamic leaf osmotic potential into the model that simulated stomatal conductance under several water availabilities and climatic scenarios. The model demonstrated that a seasonally dynamic stomatal closure threshold results in trade-offs: it reduces the time to turgor loss under sustained long-term drought, but increases overall gas exchange particularly under seasonal shifts in temperature and stochastic water availability. A projected hotter future is expected to lower the increase in gas exchange that plants gain from the seasonal shift in g(s)similar to psi(stem). These findings show that accounting for dynamic stomatal regulation is critical for understanding drought tolerance.
Published: 2021
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8. Best Practice Recommendations for the Implementation of a Digital Pathology Workflow in the Anatomic Pathology Laboratory by the European Society of Digital and Integrative Pathology (ESDIP)

Author: Sabine Leh, David Ameisen, Norman Zerbe, António Polónia, Daniel Racoceanu, Tim-Rasmus Kiehl, Catarina Eloy, Rita Carvalho, Vincenzo L'Imperio, Vincenzo Della Mea, Filippo Fraggetta, Mircea Serbanescu, Università degli Studi di Milano-Bicocca [Milano] (UNIMIB), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Haukeland University Hospital, University of Bergen (UiB), University of Medicine and Pharmacy of Craiova, Faculty of Medicine, Craiova, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Department of Mathematics and Computer Science [Udine], Università degli Studi di Udine - University of Udine [Italie], Universidade do Porto, European Society of Digital and Integrative Pathology (ESDIP), University of Medicine and Pharmacy of Craiova, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Algorithms, models and methods for images and signals of the human brain (ARAMIS), Sorbonne Université (SU)-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU), Universidade do Porto = University of Porto, Fraggetta, F, L'Imperio, V, Ameisen, D, Carvalho, R, Leh, S, Kiehl, T, Serbanescu, M, Racoceanu, D, Mea, V, Polonia, A, Zerbe, N, Eloy, C, Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Medicine (General), Pathology, medicine.medical_specialty, Computer science, Process (engineering), Best practice, Clinical Biochemistry, Interoperability, Guidelines, laboratory information system, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, R5-920, 0302 clinical medicine, Software, medicine, Scope (project management), business.industry, Digital pathology, anatomic pathology workflow, Automation, MED/08 - ANATOMIA PATOLOGICA, whole slide imaging, Workflow, 030220 oncology & carcinogenesis, business, digital pathology, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; The interest in implementing digital pathology (DP) workflows to obtain whole slide image (WSI) files for diagnostic purposes has increased in the last few years. The increasing performance of technical components and the Food and Drug Administration (FDA) approval of systems for primary diagnosis led to increased interest in applying DP workflows. However, despite this revolutionary transition, real world data suggest that a fully digital approach to the histological workflow has been implemented in only a minority of pathology laboratories. The objective of this study is to facilitate the implementation of DP workflows in pathology laboratories, helping those involved in this process of transformation to identify: (a) the scope and the boundaries of the DP transformation; (b) how to introduce automation to reduce errors; (c) how to introduce appropriate quality control to guarantee the safety of the process and (d) the hardware and software needed to implement DP systems inside the pathology laboratory. The European Society of Digital and Integrative Pathology (ESDIP) provided consensus-based recommendations developed through discussion among members of the Scientific Committee. The recommendations are thus based on the expertise of the panel members and on the agreement obtained after virtual meetings. Prior to publication, the recommendations were reviewed by members of the ESDIP Board. The recommendations comprehensively cover every step of the implementation of the digital workflow in the anatomic pathology department, emphasizing the importance of interoperability, automation and tracking of the entire process before the introduction of a scanning facility. Compared to the available national and international guidelines, the present document represents a practical, handy reference for the correct implementation of the digital workflow in Europe.
Published: 2021
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9. Variance Reduction Applied to Machine Learning for Pricing Bermudan/American Options in High Dimension

Author: Goudenège, Ludovic, Molent, Andrea, Zanette, Antonino, Fédération de Mathématiques de CentraleSupélec (FR3487), CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Mathematical Risk Handling (MATHRISK), Université Paris-Est Marne-la-Vallée (UPEM)-École des Ponts ParisTech (ENPC)-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Università degli Studi di Udine - University of Udine [Italie], Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria), Oleg Kudryavtsev, Antonino Zanette, and Fédération de Mathématiques de l'Ecole Centrale Paris (FR3487)
Subjects: Control variate, [MATH.MATH-PR]Mathematics [math]/Probability [math.PR], machine learning, Computer Science::Computational Engineering, Finance, and Science, machine learning, Gaussian process regression, control variate, American options, Monte Carlo methods, Monte Carlo methods, American options, Finance, Gaussian process regression
Abstract: International audience; In this paper we propose an efficient method to compute the price of multi-asset American options, based on Machine Learning, Monte Carlo simulations and variance reduction technique. Specifically, the options we consider are written on a basket of assets, each of them following a Black-Scholes dynamics. In the wake of Ludkovski's approach [33], we implement here a backward dynamic programming algorithm which considers a finite number of uniformly distributed exercise dates. On these dates, the option value is computed as the maximum between the exercise value and the continuation value, which is obtained by means of Gaussian process regression technique and Monte Carlo simulations. Such a method performs well for low dimension baskets but it is not accurate for very high dimension baskets. In order to improve the dimension range, we employ the European option price as a control variate, which allows us to treat very large baskets and moreover to reduce the variance of price estimators. Numerical tests show that the proposed algorithm is fast and reliable, and it can handle also American options on very large baskets of assets, overcoming the problem of the curse of dimensionality.
Published: 2021

10. Principal Types as Lambda Nets

Author: Di Gianantonio, Pietro, Lenisa, Marina, Università degli Studi di Udine - University of Udine [Italie], and Di Gianantonio, Pietro
Subjects: Normalization, [INFO.INFO-LO] Computer Science [cs]/Logic in Computer Science [cs.LO], Theory of computation → Linear logic, Lambda nets, Theory of computation → Lambda calculus, Linear logic, Cut elimination, [INFO.INFO-LO]Computer Science [cs]/Logic in Computer Science [cs.LO], Theory of computation → Type structures, Principal types, Lambda calculus
Abstract: We show that there are connections between principal type schemata, cut-free λ-nets, and normal forms of the λ-calculus, and hence there are correspondences between the normalisation algorithms of the above structures, i.e. unification of principal types, cut-elimination of λ-nets, and normalisation of λ-terms. Once the above correspondences have been established, properties of the typing system, such as typability, subject reduction, and inhabitation, can be derived from properties of λ-nets, and vice-versa. We illustrate the above pattern on a specific type assignment system, we study principal types for this system, and we show that they correspond to λ-nets with a non-standard notion of cut-elimination. Properties of the type system are then derived from results on λ-nets., LIPIcs, Vol. 239, 27th International Conference on Types for Proofs and Programs (TYPES 2021), pages 5:1-5:23
Published: 2021

11. Augmentation index predicts mortality in patients with aortic stenosis: an echo-tracking study

Author: Olga Vriz, Ugolino Livi, Lucio Mos, Paolo Palatini, Julien Magne, Igor Vendramin, Hani Alsergani, Francesco Antonini-Canterin, King Saud University [Riyadh] (KSU), Alfaisal University, University of Udine Italy, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de cardiologie [CHU Limoges], CHU Limoges, and Clinical sciences
Subjects: medicine.medical_specialty, Aortic Valve Stenosis/diagnostic imaging, macromolecular substances, 030204 cardiovascular system & hematology, Severity of Illness Index, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Vascular Stiffness, Aortic valve replacement, Predictive Value of Tests, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, Mortality, 10. No inequality, Creatinine, Ejection fraction, business.industry, Proportional hazards model, Severe aortic stenosis, Aortic Valve Stenosis, ultrasonography, medicine.disease, Arterial stiffness, 3. Good health, Compliance (physiology), Stenosis, Echocardiography, chemistry, Aortic valve stenosis, Cardiology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Cardiology and Cardiovascular Medicine
Abstract: International audience; Aortic valve stenosis (AS) shares similarities with the atherosclerotic process but little is known about the effect of the mechanical properties of large arteries on outcome in patients with AS. The aims of this study were (1) to determine the relationship between indexes of carotid stiffness/compliance and the severity of AS and (2) to identify whether local arterial stiffness is independently associated with mortality. 133 patients with moderate to severe isolated AS and preserved LV ejection fraction (LVEF) were included. All underwent transthoracic echocardiography and local carotid stiffness evaluation by means of high-definition echo-tracking ultrasound with the calculation of stiffness/compliance parameters included augmentation index (AIx). None of the carotid stiffness parameters were significantly associated with AS severity parameters. During a mean follow-up of 51.6 ± 39.4 months, 70 patients received aortic valve replacement, 45 died and 18 were alive with no surgery. Who died were older (79.2 ± 6.9 vs. 73 ± 8.8 years, p < 0.0001), had higher carotid AIx (21.3 ± 14 vs. 16 ± 12%, p = 0.028). In multivariate Cox regression analysis AIx was independently associated with mortality (HR 1.048, 95% CI 1.01-1.07, p = 0.001), also after inclusion of age and creatinine. There was a significant association between the level of AIx and mortality in those patients who did not have surgery (p = 0.016). In severe AS and a normal LVEF, carotid AIx measured by echo-tracking system was independently associated with death. No relationship between AS severity and local carotid stiffness was found. These data emphasize the importance of arterial stiffness has a hallmark of long-term atherosclerotic burden and impaired prognosis.
Published: 2021
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12. From local spectral species to global spectral communities: A benchmark for ecosystem diversity estimate by remote sensing

Author: Kate S. He, Harini Nagendra, Michael Förster, Martin Wegmann, Thomas W. Gillespie, Vítĕzslav Moudrý, Birgit Kleinschmit, Duccio Rocchini, Carl Beierkuhnlein, Jean-Baptiste Féret, Marco Malavasi, Nicole Salvatori, Florian de Boissieu, Davnah Payne, Heidi C. Hauffe, Carol X. Garzon-Lopez, Alessandro Chiarucci, Petra Šímová, Jonathan Lenoir, Michele Torresani, University of Bologna/Università di Bologna, Università degli Studi di Udine - University of Udine [Italie], University of Bayreuth, Ecologie fonctionnelle et biogéochimie des sols et des agro-écosystèmes (UMR Eco&Sols), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Département Performances des systèmes de production et de transformation tropicaux (Cirad-PERSYST), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Technical University of Berlin / Technische Universität Berlin (TU), Universidad de los Andes [Bogota] (UNIANDES), University of California (UC), Fondazione Edmund Mach - Edmund Mach Foundation [Italie] (FEM), Ecologie et Dynamique des Systèmes Anthropisés - UMR CNRS 7058 (EDYSAN), Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS), Czech University of Life Sciences Prague (CZU), PES University [Bengaluru], University of Bern, Free University of Bozen-Bolzano, Territoires, Environnement, Télédétection et Information Spatiale (UMR TETIS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-AgroParisTech-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Horizon 2020 Framework ProgrammeCentre National d’Etudes Spatiales, ANR-17-CE32-0001,BioCop,Suivi de la biodiversité tropicale avec les satellites Sentinel-2 du programme Copernicus(2017), Rocchini D., Salvatori N., Beierkuhnlein C., Chiarucci A., de Boissieu F., Forster M., Garzon-Lopez C.X., Gillespie T.W., Hauffe H.C., He K.S., Kleinschmit B., Lenoir J., Malavasi M., Moudry V., Nagendra H., Payne D., Simova P., Torresani M., Wegmann M., Feret J.-B., Rocchini, D., Salvatori, N., Beierkuhnlein, C., Chiarucci, A., de Boissieu, F., Forster, M., Garzon-Lopez, C. X., Gillespie, T. W., Hauffe, H. C., He, K. S., Kleinschmit, B., Lenoir, J., Malavasi, M., Moudry, V., Nagendra, H., Payne, D., Simova, P., Torresani, M., Wegmann, M., Feret, J. -B., University of Bologna, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Technical University Berlin, and University of California
Subjects: 0106 biological sciences, Earth observation, Ecological informatic, Biodiversity, Earth Observations, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, 010603 evolutionary biology, 01 natural sciences, Modelling, Settore BIO/07 - ECOLOGIA, Satellite imagery, Ecosystem diversity, Imaging Spectroscopy, Ecology, Evolution, Behavior and Systematics, Remote sensing, Ecological informatics, Spectral signature, Ecology, 010604 marine biology & hydrobiology, Applied Mathematics, Ecological Modeling, 15. Life on land, Field (geography), Computer Science Applications, Computational Theory and Mathematics, 13. Climate action, Modeling and Simulation, [SDE]Environmental Sciences, Environmental science, Species richness, Rapideye, Global biodiversity
Abstract: In the light of unprecedented change in global biodiversity, real-time and accurate ecosystem and biodiversity assessments are becoming increasingly essential. Nevertheless, estimation of biodiversity using ecological field data can be difficult for several reasons. For instance, for very large areas, it is challenging to collect data that provide reliable information. Some of these restrictions in Earth observation can be avoided through the use ofremote sensingapproaches. Various studies have estimated biodiversity on the basis of the Spectral Variation Hypothesis (SVH). According to this hypothesis, spectral heterogeneity over the different pixel units of a spatial grid reflects a higher niche heterogeneity, allowing more organisms to coexist. Recently, the spectral species concept has been derived, following the consideration that spectral heterogeneity at a landscape scale corresponds to a combination of subspaces sharing a similarspectral signature. With the use of high resolution remote sensing data, on a local scale, these subspaces can be identified as separate spectral entities, the so called “spectral species”. Our approach extends this concept over wide spatial extents and to a higher level of biological organization. We applied this method toMODISimagery data across Europe. Obviously, in this case, a spectral species identified by MODIS is not associated to a singleplant speciesin the field but rather to a species assemblage, habitat, or ecosystem. Based on such spectral information, we propose a straightforward method to deriveα- (local relative abundance and richness of spectral species) andβ-diversity (turnover of spectral species) maps over wide geographical areas.
Published: 2021
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13. Highly sensitive detection of Campylobacter spp. In chicken meat using a silica nanoparticle enhanced dot blot DNA biosensor

Author: Carole Chaix, Marisa Manzano, Jasmina Vidic, Priya Vizzini, Thierry Meylheuc, Nalini Ramarao, Carole Farre, MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Interfaces & biosensors - Interfaces & biocapteurs, Institut des Sciences Analytiques (ISA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), The authors thank the Centre Technologique des Microstructures of the Lyon 1 University for providing access to its TEM facilities, and the MIMA2 platform Jouy en Josas for access to electron microscopy equipment (MIMA2, INRAE, 2018. Microscopy and Imaging Facility for Microbes, Animals and Foods, https://doi.org/10.15454/1.5572348210007727E12).JV thanks Maria-Vesna Nikolic (University of Belgrade, Serbia) for English editing. PV acknowledges a doctoral fellowship from the University of Udine, Italy. This research was supported in part by the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 872662 (IPANEMA), the European Union's Horizon 2020 research and by the University Paris-Saclay through the Poc in labs 2019 grant agreement No 00003469 (OSCAR)., European Project: 872662 ,IPANEMA, Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)
Subjects: Campylobacter, DNA dot Blot, Food safety, Multiplex bacterial detection, Si-nanoparticles, Meat, DNA polymerase, Biomedical Engineering, Biophysics, Dot blot, Food Contamination, Biosensing Techniques, 02 engineering and technology, 01 natural sciences, Horseradish peroxidase, Luminol, chemistry.chemical_compound, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Electrochemistry, Animals, [CHIM]Chemical Sciences, Multiplex, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Chromatography, biology, Chemistry, 010401 analytical chemistry, technology, industry, and agriculture, DNA, Hydrogen Peroxide, General Medicine, Silicon Dioxide, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Blot, Biotinylation, biology.protein, Nanoparticles, Campylobacter, DNA dot Blot, Si-nanoparticles, Food safety, Multiplex bacterial detection, 0210 nano-technology, Chickens, Biosensor, Biotechnology
Abstract: The authors thank the Centre Technologique des Microstructures of the Lyon 1 University for providing access to its TEM facilities, and the MIMA2 platform Jouy en Josas for access to electron microscopy equipment (MIMA2, INRAE, 2018. Microscopy and Imaging Facility for Microbes, Animals and Foods, https://doi.org/10.15454/1. 5572348210007727E12). JV thanks Maria-Vesna Nikolic (University of Belgrade, Serbia) for English editing.; International audience; Paper-based DNA biosensors are powerful tools in point-of-care diagnostics since they are affordable, portable, user-friendly, rapid and robust. However, their sensitivity is not always as high as required to enable DNA quantification. To improve the response of standard dot blots, we have applied a new enhancement strategy that increases the sensitivity of assays based on the use of biotinylated silica-nanoparticles (biotin-Si-NPs). After immobilization of a genomic Campylobacter DNA onto a paper membrane, and addition of a biotinylated-DNA detection probe, hybridization was evidenced using streptavidin-conjugated to horseradish peroxidase (HRP) in the presence of luminol and H2O2. Replacement of the single biotin by the biotin-Si-NPs boosted on average a 30 fold chemiluminescent read-out of the biosensor. Characterization of biotin-Si-NPs onto a paper with immobilized DNA was done using a scanning electron microscope. A limit of detection of 3 pg/μL of DNA, similar to the available qPCR kits, is achieved, but it is cheaper, easier and avoids inhibition of DNA polymerase by molecules from the food matrices. We demonstrated that the new dot blot coupled to biotin-Si-NPs successfully detected Campylobacter from naturally contaminated chicken meat, without needing a PCR step. Hence, such an enhanced dot blot paves the path to the development of a portable and multiplex paper based platform for point-of-care screening of chicken carcasses for Campylobacter.
Published: 2021
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14. Late Chalcolithic of Upper Mesopotamia and its interactions with Southern Uruk communities. Proceedings of the workshop held at the 11th ICAANE Conference, 5th April 2018, Munich

Author: Baldi, Johnny, Marco, Iamoni, Peyronel, Luca, Paola, Sconzo, ARCHEORIENT - Environnements et sociétés de l'Orient ancien (Archéorient), Université Lumière - Lyon 2 (UL2)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Udine - University of Udine [Italie], University of Milan, University of Tübingen, Baldi Johnny Samuele, Iamoni Marco, Peyronel Luca, and Sconzo Paola
Subjects: Late Chalcolithic, Mesopotamia, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, Uruk, [SHS.ANTHRO-SE]Humanities and Social Sciences/Social Anthropology and ethnology, ComputingMilieux_MISCELLANEOUS, Proto-urban
Abstract: International audience
Published: 2021

15. A prototype-based approach to object reclassification

Author: Ciaffaglione, Alberto, Gianantonio, Pietro, Honsell, Furio, Liquori, Luigi, Dipartimento di Matematica e Informatica - Universita Udine (DIMI), Università degli Studi di Udine - University of Udine [Italie], Logical Time for Formal Embedded System Design (KAIROS), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-COMmunications, Réseaux, systèmes Embarqués et Distribués (Laboratoire I3S - COMRED), Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), and Inria & Université Cote d'Azur, CNRS, I3S, Sophia Antipolis, France
Subjects: object reclassification, TheoryofComputation_MATHEMATICALLOGICANDFORMALLANGUAGES, TheoryofComputation_LOGICSANDMEANINGSOFPROGRAMS, static typing, Prototype-based calculi, [INFO.INFO-LO]Computer Science [cs]/Logic in Computer Science [cs.LO], [INFO.INFO-CL]Computer Science [cs]/Computation and Language [cs.CL]
Abstract: We investigate, in the context of functional prototype-based languages , a calculus of objects which might extend themselves upon receiving a message, a possibility referred to by Cardelli as a self-inflicted operation. We present a sound type system for this calculus which guarantees that evaluating a well-typed expression will never yield a message-not-found runtime error. The resulting calculus is an attempt towards the definition of a language combining the safety advantage of static type check with the flexibility normally found in dynamically typed languages.
Published: 2020

16. A prototype-based approach to object reclassification

Author: Ciaffaglione, Alberto, Gianantonio, Pietro, Honsell, Furio, Liquori, Luigi, Dipartimento di Matematica e Informatica - Universita Udine (DIMI), Università degli Studi di Udine - University of Udine [Italie], Logical Time for Formal Embedded System Design (KAIROS), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-COMmunications, Réseaux, systèmes Embarqués et Distribués (Laboratoire I3S - COMRED), Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), and Inria & Université Cote d'Azur, CNRS, I3S, Sophia Antipolis, France
Subjects: object reclassification, TheoryofComputation_MATHEMATICALLOGICANDFORMALLANGUAGES, TheoryofComputation_LOGICSANDMEANINGSOFPROGRAMS, static typing, Prototype-based calculi, [INFO.INFO-LO]Computer Science [cs]/Logic in Computer Science [cs.LO], [INFO.INFO-CL]Computer Science [cs]/Computation and Language [cs.CL]
Abstract: International audience; We investigate, in the context of functional prototype-based languages , a calculus of objects which might extend themselves upon receiving a message, a possibility referred to by Cardelli as a self-inflicted operation. We present a sound type system for this calculus which guarantees that evaluating a well-typed expression will never yield a message-not-found runtime error. The resulting calculus is an attempt towards the definition of a language combining the safety advantage of static type check with the flexibility normally found in dynamically typed languages.
Published: 2020

17. A prototype-based approach to object evolution

Author: Ciaffaglione, Alberto, Di Gianantonio, Pietro, Honsell, Furio, Liquori, Luigi, Dipartimento di Matematica e Informatica - Universita Udine (DIMI), Università degli Studi di Udine - University of Udine [Italie], Logical Time for Formal Embedded System Design (KAIROS), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-COMmunications, Réseaux, systèmes Embarqués et Distribués (Laboratoire I3S - COMRED), Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Inria & Université Cote d'Azur, CNRS, I3S, Sophia Antipolis, France, Université Nice Sophia Antipolis (... - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS)
Subjects: object reclassification, TheoryofComputation_MATHEMATICALLOGICANDFORMALLANGUAGES, TheoryofComputation_LOGICSANDMEANINGSOFPROGRAMS, static typing, Prototype-based calculi, [INFO.INFO-LO]Computer Science [cs]/Logic in Computer Science [cs.LO], [INFO.INFO-CL]Computer Science [cs]/Computation and Language [cs.CL]
Abstract: International audience; We investigate, in the context of functional prototype-based languages , a calculus of objects which might extend themselves upon receiving a message, a possibility referred to by Cardelli as a self-inflicted operation. We present a sound type system for this calculus which guarantees that evaluating a well-typed expression will never yield a message-not-found runtime error. The resulting calculus is an attempt towards the definition of a language combining the safety advantage of static type check with the flexibility normally found in dynamically typed languages.
Published: 2020

18. Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia

Author: Renzini, Alessandra, Marroncelli, Nicoletta, Cavioli, Giorgia, Di Francescantonio, Silvia, Forcina, Laura, Lambridis, Alessandro, Di Giorgio, Eros, Valente, Sergio, Mai, Antonello, Giampietri, Claudia, Magenta, Alessandra, de Santa, Francesca, Adamo, Sergio, Coletti, Dario, Moresi, Viviana, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Università degli Studi di Udine - University of Udine [Italie], Department of Drug Chemistry and Technologies = Dipartimento di Chimica et Tecnologie del Farmaco [Roma], Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Department of Anatomy, Histology, Forensic Medicine and Orthopedic [Roma] (DAHFMO), Department of Molecular Medicine, National Research Council (CNR), Adaptation Biologique et Vieillissement = Biological Adaptation and Ageing (B2A), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and COLETTI, DARIO
Subjects: 0301 basic medicine, lcsh:Diseases of the musculoskeletal system, Cachexia, Receptor for Advanced Glycation End Products, S100B, Muscle necroptosis, RAGE (receptor), Mice, 0302 clinical medicine, Neoplasms, Satellite cells, Orthopedics and Sports Medicine, HMGB1, cancer cachexia, cytokines, inflammation, muscle atrophy, myogenin, RAGE, biology, Myogenesis, HDACi, Cancer cachexia, lcsh:Human anatomy, Membrane repair mechanism, Muscle atrophy, 030220 oncology & carcinogenesis, Cytokines, Original Article, Tumor necrosis factor alpha, Myogenin, medicine.symptom, Duchenne muscular dystrophy, Inflammation, [SDV.CAN]Life Sciences [q-bio]/Cancer, lcsh:QM1-695, Proinflammatory cytokine, 03 medical and health sciences, [SDV.CAN] Life Sciences [q-bio]/Cancer, Physiology (medical), medicine, Animals, Humans, business.industry, HDAC4, Original Articles, medicine.disease, 030104 developmental biology, Cancer research, biology.protein, lcsh:RC925-935, business
Abstract: International audience; Background Cachexia, a multifactorial syndrome affecting more than 50% of patients with advanced cancer and responsible for ~20% of cancer-associated deaths, is still a poorly understood process without a standard cure available. Skeletal muscle atrophy caused by systemic inflammation is a major clinical feature of cachexia, leading to weight loss, dampening patients' quality of life, and reducing patients' response to anticancer therapy. RAGE (receptor for advanced glycation end-products) is a multiligand receptor of the immunoglobulin superfamily and a mediator of muscle regeneration, inflammation, and cancer. Methods By using murine models consisting in the injection of colon 26 murine adenocarcinoma (C26-ADK) or Lewis lung carcinoma (LLC) cells in BALB/c and C57BL/6 or Ager À/À (RAGE-null) mice, respectively, we investigated the involvement of RAGE signalling in the main features of cancer cachexia, including the inflammatory state. In vitro experiments were performed using myotubes derived from C2C12 myoblasts or primary myoblasts isolated from C57BL/6 wild type and Ager À/À mice treated with the RAGE ligand, S100B (S100 calcium-binding protein B), TNF (tumor necrosis factor)α±IFN (interferon) γ, and tumour cell-or masses-conditioned media to analyse hallmarks of muscle atrophy. Finally, muscles of wild type and Ager À/ À mice were injected with TNFα/IFNγ or S100B in a tumour-free environment. Results We demonstrate that RAGE is determinant to activate signalling pathways leading to muscle protein degradation in the presence of proinflammatory cytokines and/or tumour-derived cachexia-inducing factors. We identify the RAGE ligand, S100B, as a novel factor able to induce muscle atrophy per se via a p38 MAPK (p38 mitogen-activated protein kinase)/myogenin axis and STAT3 (signal transducer and activator of transcription 3)-dependent MyoD (myoblast determination protein 1) degradation. Lastly, we found that in cancer conditions, an increase in serum levels of tumour-derived S100B and HMGB1 (high mobility group box 1) occurs leading to chronic activation/overexpression of RAGE, which induces hallmarks of cancer cachexia (i.e. muscle wasting, systemic inflammation, and release of tumour-derived pro-cachectic factors). Absence of RAGE in mice translates into reduced serum levels of cachexia-inducing factors, delayed loss of muscle mass and strength, reduced tumour progression, and increased survival. Conclusions RAGE is a molecular determinant in inducing the hallmarks of cancer cachexia, and molecular targeting of RAGE might represent a therapeutic strategy to prevent or counteract the cachectic syndrome.
Published: 2020
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19. Asymmetric state feedback for linear plants with asymmetric input saturation

Author: Franco Blanchini, Simone Mariano, Luca Zaccarian, Simone Formentin, Centre de Recherche en Automatique de Nancy (CRAN), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Università degli Studi di Udine - University of Udine [Italie], Politecnico di Milano [Milan] (POLIMI), Dipartimento di Ingegneria Industriale [Trento], University of Trento [Trento], Équipe Méthodes et Algorithmes en Commande (LAAS-MAC), Laboratoire d'analyse et d'architecture des systèmes (LAAS), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées, Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT), and ANR-18-CE40-0010,HANDY,Systèmes Dynamiques Hybrides et en Réseau(2018)
Subjects: Physics, 0209 industrial biotechnology, Control and Optimization, Mathematical analysis, 02 engineering and technology, Constrained control, [SPI.AUTO]Engineering Sciences [physics]/Automatic, Lyapunov methods, stability of nonlinear systems, Nonlinear dynamical systems, Nonlinear system, 020901 industrial engineering & automation, Control and Systems Engineering, 0202 electrical engineering, electronic engineering, information engineering, Symmetric solution, 020201 artificial intelligence & image processing, Stability of nonlinear systems, Saturation (chemistry)
Abstract: International audience; We consider a linear plant with decentralized input saturation, whose limits are not necessarily symmetric. We propose a nonlinear static state feedback stabilizer that is asymmetric, in such a way that the non-symmetric nature of the saturation is fully exploited in the control design, for larger regions of attraction. We show by example that the proposed technique provides significantly larger regions of attractions as compared to the symmetric solution results, in a case where the positive and negative saturation limits are different.
Published: 2020
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20. Ethical issues concerning automated vehicles and their implications for transport

Author: Ebru Dogan, Federico Costantini, Rémy Le Boennec, VEhicule DEcarboné et COmmuniquant et sa Mobilité (VeDeCom), and Università degli Studi di Udine - University of Udine [Italie]
Subjects: Ethical theories, 0603 philosophy, ethics and religion, Societal level, Moral dilemma, AVs, [SHS.DROIT]Humanities and Social Sciences/Law, Artificial Intelligence, Policy decision, Moral agency, 0502 economics and business, Sociology, Transport policy, AVs, Artificial Intelligence, Ethics, Transport policy, Trolley problem, Ethics, 050210 logistics & transportation, ComputingMilieux_THECOMPUTINGPROFESSION, Ethical issues, 05 social sciences, [SHS.PHIL]Humanities and Social Sciences/Philosophy, 06 humanities and the arts, Trolley problem, Deontological ethics, Software deployment, Key (cryptography), Engineering ethics, Automated vehicle, 060301 applied ethics, Decision making
Abstract: International audience; The introduction of automated vehicles (AV) in the market progresses before the stakeholdersfully understand the capacity and the limitations of this complex technology.While this can be considered as a usual course of deployment of a new technology,future large-scale expansion of AV at the societal level makes public acceptance akey issue. One of the main aspects of public acceptance is the ethical concerns raisedby AV. In the current chapter, we will mainly review the research on the ethical issuesrelated to ethics-by-design of AV through its moral agency, application of different ethicaltheories to the decision making in critical situations, and whether ethics settingshould be mandatory or personal. Our review shows that while there are several ethicalframeworks proposed for AV, research on public acceptance mostly contrasts utilitarianand deontological ethics. Algorithmic implementation of the proposed frameworks,however, is yet to be done. In the second part, we will address several ethical issuesrelevant for the implementation of AV in transport system and policy decision making.
Published: 2020
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21. Gaussian process regression for pricing variable annuities with stochastic volatility and interest rate

Author: Andrea Molent, Antonino Zanette, Ludovic Goudenège, Fédération de Mathématiques de l'Ecole Centrale Paris (FR3487), CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Udine - University of Udine [Italie], Mathematical Risk Handling (MATHRISK), Université Paris-Est Marne-la-Vallée (UPEM)-École des Ponts ParisTech (ENPC)-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), and Fédération de Mathématiques de CentraleSupélec (FR3487)
Subjects: Mathematical optimization, Speedup, Computer science, Computation, 0211 other engineering and technologies, Gaussian Process Regression, Computational Finance (q-fin.CP), GMWB pricing · Heston–Hull–White model · Numerical method · Machine learning · Gaussian process regression, 02 engineering and technology, Numerical method, FOS: Economics and business, Machine Learning, Quantitative Finance - Computational Finance, Kriging, Bellman equation, 0502 economics and business, 050208 finance, 021103 operations research, Stochastic volatility, Numerical analysis, 05 social sciences, Function (mathematics), [MATH.MATH-PR]Mathematics [math]/Probability [math.PR], Variable (computer science), Heston Hull-White model, 8. Economic growth, GMWB pricing, General Economics, Econometrics and Finance, Finance
Abstract: In this paper, we investigate value and Greeks computation of a guaranteed minimum withdrawal benefit (GMWB) variable annuity, when both stochastic volatility and stochastic interest rate are considered together in the Heston–Hull–White model. In addition, as an insurance product, a guaranteed minimum death benefit is embedded in the contract. We consider a numerical method that solves the dynamic control problem due to the computing of the optimal withdrawal. Moreover, in order to speed up the computation, we employ Gaussian process regression (GPR), a machine learning technique that allows one to compute very fast approximations of a function from training data. In particular, starting from observed prices previously computed for some known combinations of model parameters, it is possible to approximate the whole value function on a defined domain. The regression algorithm consists of algorithm training and evaluation. The first step is the most time demanding, but it needs to be performed only once, while the latter is very fast and it requires to be performed only when predicting the target function. The developed method, as well as for the calculation of prices and Greeks, can also be employed to compute the no-arbitrage fee, which is a common practice in the variable annuities sector. Numerical experiments show that the accuracy of the values estimated by GPR is high with very low computational cost. Finally, we stress out that the analysis is carried out for a GMWB annuity, but it could be generalized to other insurance products.
Published: 2020
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22. Machine learning for pricing American options in high-dimensional Markovian and non-Markovian models

Author: Ludovic Goudenège, Andrea Molent, Antonino Zanette, Fédération de Mathématiques de CentraleSupélec (FR3487), CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Udine - University of Udine [Italie], Mathematical Risk Handling (MATHRISK), Université Paris-Est Marne-la-Vallée (UPEM)-École des Ponts ParisTech (ENPC)-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), This work was supported by a public grant as part of the Investissement d’avenir project, reference ANR-11-LABX-0056-LMH, LabEx LMH, and Fédération de Mathématiques de l'Ecole Centrale Paris (FR3487)
Subjects: Mathematical optimization, Computer science, Markov process, Computational Finance (q-fin.CP), High dimensional, Binomial Tree Method, FOS: Economics and business, Machine Learning, symbols.namesake, Quantitative Finance - Computational Finance, 0502 economics and business, 050207 economics, Multi-dimensional Black–Scholes model, Machine learning, American options, Rough Bergomi model, Binomial tree method, Exact integration, Exact Integration, 050208 finance, 05 social sciences, InformationSystems_DATABASEMANAGEMENT, [MATH.MATH-PR]Mathematics [math]/Probability [math.PR], Multi-dimensional Black-Scholes Model, Rough BergomiModel, American Options, symbols, Pricing of Securities (q-fin.PR), Quantitative Finance - Pricing of Securities, General Economics, Econometrics and Finance, Finance
Abstract: In this paper we propose two efficient techniques which allow one to compute the price of American basket options. In particular, we consider a basket of assets that follow a multi-dimensional Black-Scholes dynamics. The proposed techniques, called GPR Tree (GRP-Tree) and GPR Exact Integration (GPR-EI), are both based on Machine Learning, exploited together with binomial trees or with a closed formula for integration. Moreover, these two methods solve the backward dynamic programming problem considering a Bermudan approximation of the American option. On the exercise dates, the value of the option is first computed as the maximum between the exercise value and the continuation value and then approximated by means of Gaussian Process Regression. The two methods mainly differ in the approach used to compute the continuation value: a single step of binomial tree or integration according to the probability density of the process. Numerical results show that these two methods are accurate and reliable in handling American options on very large baskets of assets. Moreover we also consider the rough Bergomi model, which provides stochastic volatility with memory. Despite this model is only bidimensional, the whole history of the process impacts on the price, and handling all this information is not obvious at all. To this aim, we present how to adapt the GPR-Tree and GPR-EI methods and we focus on pricing American options in this non-Markovian framework., Comment: arXiv admin note: text overlap with arXiv:1903.11275
Published: 2020
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23. Acoustic Multi-Detection of Gliadin Using QCM Crystals Patterned with Controlled Sectors of TEM Grid and Annealed Nanoislands on Gold Electrode

Author: Giuliocesare Casari Bariani, Lan Zhou, Simone Poggesi, Rakesh Mittapalli, Marisa Manzano, Rodica Elena Ionescu, Lumière, nanomatériaux et nanotechnologies (L2n), Institut Charles Delaunay (ICD), Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Scienze AgroAlimentari, Ambientali e Animali - [Udine] (DI4A), and Università degli Studi di Udine - University of Udine [Italie]
Subjects: Materials science, General Chemical Engineering, Nanotechnology, 02 engineering and technology, 01 natural sciences, Article, Crystal, lcsh:Chemistry, multi-sensing platforms, Human health, General Materials Science, patterning nanoislands, 2. Zero hunger, chemistry.chemical_classification, annealed gold films, biology, Q-TEM and QCM-color crystals, 010401 analytical chemistry, nutritional and metabolic diseases, Quartz crystal microbalance, 021001 nanoscience & nanotechnology, Gluten, digestive system diseases, 0104 chemical sciences, 3. Good health, annealed quartz, chemistry, lcsh:QD1-999, Food products, Electrode, biology.protein, gliadin, [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, 0210 nano-technology, Gliadin, Annealed gold films, Annealed quartz, Multi-sensing platforms, Patterning nanoislands, Biosensor
Abstract: International audience; Celiac diseases are a group of gluten ingestion-correlated pathologies that are widespread and, in some cases, very dangerous for human health. The only effective treatment is the elimination of gluten from the diet throughout life. Nowadays, the food industries are very interested in cheap, easy-to-handle methods for detecting gluten in food, in order to provide their consumers with safe and high-quality food. Here, for the first time, the manufacture of controlled micropatterns of annealed gold nanoislands (AuNIs) on a single QCM crystal (QCM-color) and their biofunctionalization for the specific detection of traces of gliadin is reported. In addition, the modified quartz crystal with a TEM grid and 30 nm Au (Q-TEM grid crystal) is proposed as an acoustic sensitive biosensing platform for the rapid screening of the gliadin content in real food products.
Published: 2020
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24. Surface enhanced Raman spectroscopy phylogenetic tree for genosensing of Brettanomyces bruxellensis yeast on nanostructured ultrafine glass supports

Author: Giuliocesare Casari Bariani, Lan Zhou, Marisa Manzano, Rodica Elena Ionescu, Simone Poggesi, Pierre-Michel Adam, Rakesh Mittapalli, Lumière, nanomatériaux et nanotechnologies (L2n), Institut Charles Delaunay (ICD), Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Nanotechnologie et d'Instrumentation Optique (LNIO), Dipartimento di Scienze AgroAlimentari, Ambientali e Animali - [Udine] (DI4A), Università degli Studi di Udine - University of Udine [Italie], and ANR-17-EURE-0002,EIPHI,Ingénierie et Innovation par les sciences physiques, les savoir-faire technologiques et l'interdisciplinarité(2017)
Subjects: Genosensors, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Annealed nanostructures, Brettanomyces bruxellensis, Phylogenetic tree, SERS and LSPR on coverslips, [SDV]Life Sciences [q-bio], 02 engineering and technology, [SDV.TOX.TCA]Life Sciences [q-bio]/Toxicology/Toxicology and food chain, 01 natural sciences, [SPI.MAT]Engineering Sciences [physics]/Materials, symbols.namesake, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, [SDV.IDA]Life Sciences [q-bio]/Food engineering, Electrical and Electronic Engineering, Surface plasmon resonance, [SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics, [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials, ComputingMilieux_MISCELLANEOUS, Detection limit, Wine, Chromatography, biology, Chemistry, [SDE.IE]Environmental Sciences/Environmental Engineering, 010401 analytical chemistry, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [CHIM.MATE]Chemical Sciences/Material chemistry, Surface-enhanced Raman spectroscopy, 021001 nanoscience & nanotechnology, biology.organism_classification, Atomic and Molecular Physics, and Optics, Yeast, 0104 chemical sciences, Electronic, Optical and Magnetic Materials, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, [CHIM.POLY]Chemical Sciences/Polymers, [SDE]Environmental Sciences, symbols, [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, [SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology, 0210 nano-technology, Raman scattering
Abstract: International audience; Novel genosensors (Brett DNA) on nanostructured ultrafine coverslips are reported for the identification of Brettanomyces bruxellensis yeast that is well-known to create complex and difficult problems in aged red wine all over the world. Surface Enhanced Raman Scattering (SERS) and Localize Surface Plasmon Resonance (LSPR) are used as detection methods of target-ssDNA yeast. A specific detection is obtained in the presence of thiol-DNA probe. SERS technique made possible the detection of Brett-DNA with a limit of detection (LD) of 0.1 ng/μL((57.2 nM) and with a wide dynamic range (DR), while LSPR revealed a DL of 0,5 ng/μL real DNA extracted from Brettanomyces bruxellensis DKA in the laboratory and a limited DR (0.5 ng/μL to 5 ng/μL). In this work, fourteen yeasts that can be found in wine-growing environments were SERS tested to confirm the selectivity of the proposed Brett-DNA sensing schemes and used in the construction of the first SERS phylogenetic tree.
Published: 2020
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25. Plasma circulating tumor DNA in pancreatic adenocarcinoma for screening, diagnosis, prognosis, treatment and follow-up: A systematic review

Author: Pierre Laurent-Puig, Debora Basile, Aziz Zaanan, Raëf Abdallah, Jean-Baptiste Bachet, Daniel Pietrasz, Valérie Taly, Julien Taieb, Shulin Zhao, Léo Mas, TALY, Valerie, Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Università degli Studi di Udine - University of Udine [Italie], and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP)
Subjects: 0301 basic medicine, Oncology, medicine.medical_specialty, Poor prognosis, [SDV]Life Sciences [q-bio], Disease, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Diagnosis, medicine, Advanced disease, Biomarkers, Tumor, Humans, Radiology, Nuclear Medicine and imaging, Radical surgery, Circulating tumor DNA, business.industry, Treatment monitoring, General Medicine, medicine.disease, Prognosis, Minimal residual disease, 3. Good health, Clinical trial, Pancreatic Neoplasms, [SDV] Life Sciences [q-bio], 030104 developmental biology, 030220 oncology & carcinogenesis, Screening, Adenocarcinoma, business, Pancreatic adenocarcinoma, Carcinoma, Pancreatic Ductal, Follow-Up Studies
Abstract: International audience; While no biomarker is currently recommended for the management of pancreatic adenocarcinoma (PA), circulating tumor DNA (ctDNA) seems promising but little is known on how it may help to manage our patients in the near future. This systematic review of literature was designed to explore the current knowledge on ctDNA as a screening, diagnostic, prognostic, predictive and theranostic biomarker in the management of PA. We retrieved 62 full-text articles, 3 meta-analyses, 2 clinical trials, 1 abstract and 13 ongoing trials. Results were categorized into sections about screening, diagnosis, prognosis and follow-up of localized and advanced PA together with possible theranostics applications. Although its specificity is excellent, the current sensitivity of ctDNA remains a limitation especially in patients without metastatic disease. Therefore, this biomarker cannot be currently used as a screening or diagnostic tool. Increasing evidence suggests that ctDNA is a relevant candidate biomarker to assess minimal residual disease after radical surgery, but also a strong independent biomarker linked to a poor prognosis in advanced PA. Some recent data also indicates that ctDNA is an attractive biomarker for longitudinal follow-up and possibly early treatment adaptation. Its role in tumor profiling in advanced disease to decide targeted treatments remains to be explored. Altogether, ctDNA appears to be a reliable prognostic tool. Though promising results have been reported, further studies are still needed to define exactly how ctDNA can help physicians in the screening, diagnosis and treatment, as PA is expected to become a major cause of cancer-related deaths in the forthcoming decade.
Published: 2020
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26. Pluriattività rurale e lavoro agricolo in età contemporanea (secoli XIX-XX)

Author: Mignemi, Niccolò, Lorenzini, Claudio, mocarelli, luca, Laboratoire Interdisciplinaire des Energies de Demain (LIED (UMR_8236)), Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Università degli Studi di Udine - University of Udine [Italie], and Università degli Studi di Milano-Bicocca [Milano] (UNIMIB)
Subjects: [SHS.HIST]Humanities and Social Sciences/History, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2020

27. A draft genome of sweet cherry ( Prunus avium L.) reveals genome‐wide and local effects of domestication

Author: Michele Morgante, Ioannis Ganopoulos, Filippos A. Aravanopoulos, Gabriella Sonnante, Sara Pinosio, Michele Vidotto, Andrea Zuccolo, Fabio Marroni, Amy Iezzoni, Gabriele Magris, Giovanni G. Vendramin, Nicola Vitulo, Stéphanie Mariette, Marino Palasciano, Istituto di Genomica Applicata (IGA), Istituto di Genomica Applicata, Istituto di Bioscienze e BioRisorse [Palermo] (IBBR), Consiglio Nazionale delle Ricerche (CNR), Università degli Studi di Udine - University of Udine [Italie], Scuola Universitaria Superiore Sant'Anna [Pisa] (SSSUP), University of Verona (UNIVR), Biodiversité, Gènes & Communautés (BioGeCo), Institut National de la Recherche Agronomique (INRA)-Université de Bordeaux (UB), Aristotle University of Thessaloniki, Hellenic Agricultural Organization Demeter (HAO Demeter), Università degli Studi di Bari Aldo Moro, Institute of Applied Genomics [Udine] (IGA), Institute of Applied Genomics, Michigan State University [East Lansing], and Michigan State University System
Subjects: 0106 biological sciences, 0301 basic medicine, Candidate gene, Plant Science, DNA, Satellite, Biology, Prunus avium, Genes, Plant, 01 natural sciences, Genome, Chromosomes, Plant, Gene flow, 03 medical and health sciences, Prunus, domestication, Genetics, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Domestication, Gene, 2. Zero hunger, Genetic diversity, genome structure and evolution, Resistance (ecology), Chromosome Mapping, Genetic Variation, food and beverages, Cell Biology, genetic diversity, 15. Life on land, [SDE.ES]Environmental Sciences/Environmental and Society, Genetics, Population, 030104 developmental biology, Evolutionary biology, genome assembly, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Genome, Plant, 010606 plant biology & botany
Abstract: Sweet cherry (Prunus avium L.) trees are both economically important fruit crops but also important components of natural forest ecosystems in Europe, Asia and Africa. Wild and domesticated trees currently coexist in the same geographic areas with important questions arising on their historical relationships. Little is known about the effects of the domestication process on the evolution of the sweet cherry genome. We assembled and annotated the genome of the cultivated variety "Big Star*" and assessed the genetic diversity among 97 sweet cherry accessions representing three different stages in the domestication and breeding process (wild trees, landraces and modern varieties). The genetic diversity analysis revealed significant genome-wide losses of variation among the three stages and supports a clear distinction between wild and domesticated trees, with only limited gene flow being detected between wild trees and domesticated landraces. We identified 11 domestication sweeps and five breeding sweeps covering, respectively, 11.0 and 2.4 Mb of the P. avium genome. A considerable fraction of the domestication sweeps overlaps with those detected in the related species, Prunus persica (peach), indicating that artificial selection during domestication may have acted independently on the same regions and genes in the two species. We detected 104 candidate genes in sweep regions involved in different processes, such as the determination of fruit texture, the regulation of flowering and fruit ripening and the resistance to pathogens. The signatures of selection identified will enable future evolutionary studies and provide a valuable resource for genetic improvement and conservation programs in sweet cherry.
Published: 2020
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28. Premessa

Author: Severino, Caterina, Montanari, Laura, Droits international, comparé et européen / Centre de droit et de politique comparés Jean-Claude Escarras (DICE / CDPC), Droits International, Comparé et Européen (DICE), Aix Marseille Université (AMU)-Université de Pau et des Pays de l'Adour (UPPA)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Université de Pau et des Pays de l'Adour (UPPA)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Udine - University of Udine [Italie], Laura MONTANARI, and Caterina SEVERINO
Subjects: Droit d'asile, Italie, [SHS.DROIT]Humanities and Social Sciences/Law, Droit comparé, Droits et libertés fondamentaux, Droit des étrangers, Frane
Abstract: International audience
Published: 2020

29. Sistemi di welfare e protezione effettiva dei diritti degli stranieri. Una prospettiva multilivello

Author: Severino, Caterina, Montanari, Laura, Droits international, comparé et européen / Centre de droit et de politique comparés Jean-Claude Escarras (DICE / CDPC), Droits International, Comparé et Européen (DICE), Aix Marseille Université (AMU)-Université de Pau et des Pays de l'Adour (UPPA)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Université de Pau et des Pays de l'Adour (UPPA)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), and Università degli Studi di Udine - University of Udine [Italie]
Subjects: Diritti sociali, Francia, Gouvernance multi-niveaux, Italie, Espagne, Discriminazione, Effettività, Effectivité, Droit des étrangers, Droits humains, Vulnerabilità, Italia, Spagna, Governance multilivello, [SHS.DROIT]Humanities and Social Sciences/Law, Droit comparé, Diritti degli stranieri, Discrimination, Diritto comparato, Vulnérabilité, France, Royaume-Uni, Droits sociaux, Regno Unito, Diritti umani
Abstract: Actes du colloque "Cittadinanza, immigrazione e diritti : i sistemi di welfare alla prova delle nuove dinamiche migratorie : una prospettiva multilivello" : Udine, 17 mai 2019; International audience; Ce volume rassemble les actes du colloque "Citoyenneté, immigration et droits : les systèmes de protection sociale à l'épreuve des nouvelles dynamiques migratoires". Una prospettiva multi-niveaux L'ouvrage est le fruit d'une initiative conjointe du Département des Sciences Juridiques (DISG) de l'Université d'Udine et du Centre de Droit et Politique Comparés - J.C. Escarras (CDPC-JCE) de l'Université de Toulon, qui ont obtenu le Label de l'Université italo-française pour la publication de ce volume.; Il presente volume raccoglie gli atti del Convegno su “Cittadinanza, immigrazione e diritti: i sistemi di welfare alla prova delle nuove dinamiche migratorie. Una prospettiva multilivello” svoltosi a Udine il 17 maggio 2019 nell’ambito progetto di ricerca avente lo stesso titolo e finanziato dal Dipartimento di Scienze giuridiche dell’Università di Udine - Progetto di Ricerca di interesse dipartimentale (PRID 2017). L’iniziativa ha visto il coinvolgimento del Dipartimento di Scienze giuridiche (DISG) dell’Università di Udine e del Centro di Diritto e Politica Comparati – J.C. Escarras (CDPC-JCE) dell’Università di Tolone, che insieme hanno ottenuto il Label dell’Università Italo-Francese per la pubblicazione del presente volume.
Published: 2020

30. Existence and optimality of Cournot-Nash equilibria in a bilateral oligopoly with atoms and an atomless part

Author: Ludovic A. Julien, Sayantan Ghosal, Simone Tonin, Giulio Codognato, Francesca Busetto, Università degli Studi di Udine - University of Udine [Italie], EconomiX, Université Paris Nanterre (UPN)-Centre National de la Recherche Scientifique (CNRS), Adam Smith Business School, and University of Glasgow
Subjects: Pareto optimality, Statistics and Probability, Economics and Econometrics, 05 social sciences, 050301 education, Cournot competition, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, Oligopoly, Cournot–Nash equilibrium, Pareto optimal, symbols.namesake, Mathematics (miscellaneous), Corollary, Nash equilibrium, 0502 economics and business, symbols, Economics, Bilateral oligopoly, Statistics, Probability and Uncertainty, 0503 education, Mathematical economics, Social Sciences (miscellaneous), 050205 econometrics, Window model
Abstract: We consider a bilateral oligopoly version of the Shapley window model with large traders, represented as atoms, and small traders, represented by an atomless part. For this model, we provide a general existence proof of a Cournot-Nash equilibrium that allows one of the two commodities to be held only by atoms. Then, we show, using a corollary proved by Shitovitz (Econometrica 41:467-501, 1973), that a Cournot-Nash allocation is Pareto optimal if and only if it is a Walras allocation.
Published: 2020
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31. Francesco Robortello. Réception des Anciens et Construction de la Modernité, Rennes, PUR, collection « Hors série »

Author: Bouquet, Monique, Cappello, Sergio, Magnien, Michel, Lesage, Claire, Centre d'Etudes des Langues et Littératures Anciennes et Modernes (CELLAM), Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Università degli Studi di Udine - University of Udine [Italie], FIRL - Formes et Idées de la Renaissance aux Lumières - EA 174 (FIRL), and Université Sorbonne Nouvelle - Paris 3
Subjects: [SHS.LITT]Humanities and Social Sciences/Literature, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2020

32. Robortello, Réception de l’Antiquité et Construction de la Modernité

Author: Bouquet, Monique, Lesage, Claire, Magnien, Michel, Cappello, Sergio, Centre d'Etudes des Langues et Littératures Anciennes et Modernes (CELLAM), Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), FIRL - Formes et Idées de la Renaissance aux Lumières - EA 174 (FIRL), Université Sorbonne Nouvelle - Paris 3, and Università degli Studi di Udine - University of Udine [Italie]
Subjects: [SHS.LITT]Humanities and Social Sciences/Literature, ComputingMilieux_MISCELLANEOUS, [SHS]Humanities and Social Sciences
Abstract: International audience
Published: 2020

33. Sistema di accoglienza e protezione dei diritti fondamentali dei richiedenti asilo: una comparazione Italia-Francia

Author: Severino, Caterina, Montanari, Laura, Droits international, comparé et européen / Centre de droit et de politique comparés Jean-Claude Escarras (DICE / CDPC), Droits International, Comparé et Européen (DICE), Aix Marseille Université (AMU)-Université de Pau et des Pays de l'Adour (UPPA)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Université de Pau et des Pays de l'Adour (UPPA)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Udine - University of Udine [Italie], Laura MONTANARI, and Caterina SEVERINO
Subjects: Droit d'asile, Italie, [SHS.DROIT]Humanities and Social Sciences/Law, Droit comparé, Droits et libertés fondamentaux, Droit des étrangers, Frane
Abstract: International audience
Published: 2020

34. Genetic and genomic approaches for adaptation of grapevine to climate change

Author: Silvia Vezzulli, Eric Duchêne, Ludger Hausmann, Lorenza Dalla Costa, Nathalie Ollat, Pablo Carbonell-Bejerano, Anna Schwandner, Jérôme Grimplet, Pierre-François Bert, Mario Pecile, Luigi Bavaresco, Gabriele Di Gaspero, Mickael Malnoy, Michele Morgante, Serge Delrot, Ecophysiologie et Génomique Fonctionnelle de la Vigne (UMR EGFV), Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1-Université Victor Segalen - Bordeaux 2-Ecole Nationale Supérieure des Sciences Agronomiques de Bordeaux-Aquitaine (Bordeaux Sciences Agro), Centro de Investigacion y Tecnologia Agroalimentaria de Aragon (CITA), Max Planck Institute for Developmental Biology, Max-Planck-Gesellschaft, Julius Kühn-Institut (JKI), Santé de la vigne et qualité du vin (SVQV), Université de Strasbourg (UNISTRA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Università cattolica del Sacro Cuore [Roma] (Unicatt), Fondazione Edmund Mach - Edmund Mach Foundation [Italie] (FEM), Istituto di Genomica Applicata (IGA), Istituto di Genomica Applicata, Università degli Studi di Udine - University of Udine [Italie], Consiglio per la Ricerca in Agricoltura e l’analisi dell’economia agraria (CREA), Chittaranjan Kole, and KOLE, Chittaranjan
Subjects: 0106 biological sciences, Genotyping, Vitis vinifera L, Climate change, Biology, Terroir, 01 natural sciences, Vineyard, 03 medical and health sciences, Effects of global warming, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Regeneration (ecology), Vitis spp, Genetic resources, 030304 developmental biology, 2. Zero hunger, 0303 health sciences, Genetic diversity, business.industry, 15. Life on land, Data bases, Biotechnology, Settore AGR/07 - GENETICA AGRARIA, 13. Climate action, Phenotyping, Settore AGR/03 - ARBORICOLTURA GENERALE E COLTIVAZIONI ARBOREE, Rootstock, Adaptation, Viticulture, business, 010606 plant biology & botany
Abstract: International audience; The necessity to adapt to climate change is even stronger for grapevine than for other crops, because grape berry composition—a key determinant of fruit and wine quality, typicity and market value— highly depends on “terroir” (complete natural environment), on vintage (annual climate variability), and on their interactions. In the same time, there is a strong demand to reduce the use of pesticides. Thus, the equation that breeders and grape growers must solve has three entries that cannot be dissociated: adaptation to climate change, reduction of pesticides, and maintenance of wine typicity. Although vineyard management may cope to some extent to the short–medium-term effects of climate change, genetic improvement is necessary to provide long-term sustainable solutions to these problems. Most vineyards over the world are planted using vines that harbor two grafted plants’ genomes. Although this makes the range of interactions (scion-atmosphere, rootstock-soil, scion-rootstock) more complex, it also opens up wider possibilities for the genetic improvement of either or both the grafted genotypes. Positive aspects related to grapevine breeding are as follows: (a) a wide genetic diversity of rootstocks and scions that has not been thoroughly explored yet; (b) progress in sequencing technologies that allows high-throughput sequencing of entire genomes, faster mapping of targeted traits and easier determination of genetic relationships; (c) progress in new breeding technologies that potentially permit precise modifications on resident genes; (d) automation of phenotyping that allows faster and more complete monitoring of many traits on relatively large plant populations; (e) functional characterization of an increasing number of genes involved in the control of development, berry metabolism, disease resistance, and adaptation to environment. Difficulties involve: (a) the perennial nature and the large size of the plant that makes field testing long and demanding in manpower; (b) the low efficiency of transformation, regeneration and small size of breeding populations; (c) the complexity of the adaptive traits and the need to define more clearly future ideotypes; (d) the lack of shared and integrative platforms allowing a complete appraisal of the genotype-phenotype-environmental links; (e) legal, market and consumer acceptance of new genotypes. The present chapter provides an overview of suitable strategies and challenges linked to the adaptation of viticulture to a changing environment.
Published: 2020
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35. ON THE BETTI MAP ASSOCIATED TO ABELIAN LOGARITHMS

Author: ANDRE, YVES, Corvaja, Pietro, Zannier, Umberto, Institut de Mathématiques de Jussieu - Paris Rive Gauche (IMJ-PRG (UMR_7586)), Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Udine - University of Udine [Italie], Scuola Normale Superiore, and Scuola Normale Superore, Classe di Scienze
Subjects: [MATH.MATH-AC]Mathematics [math]/Commutative Algebra [math.AC], [MATH.MATH-AG]Mathematics [math]/Algebraic Geometry [math.AG], [MATH.MATH-NT]Mathematics [math]/Number Theory [math.NT]
Published: 2019

36. Un roman de Voltaire retrouvé? Voyage & avantures de Martin Nogué en Europe

Author: Rouvier, Emilien, Università degli Studi di Udine - University of Udine [Italie], and Università degli studi di Trieste
Subjects: [SHS.LITT]Humanities and Social Sciences/Literature
Abstract: Le présent article appelle l'attention des spécialistes de Voltaire sur un étonnant ouvrage anonyme publié à La Haye en 1728, Voyage & avantures de Martin Nogué en Europe, livre qui tient du récit de voyage (en Angleterre et en Hollande) et du roman picaresque. Une série de coïncidences entre les aventures du protagoniste et la vie de Voltaire, des anticipations stylistiques et thématiques des contes philosophiques, la curieuse destinée du volume qui, bien que représenté dans de nombreuses bibliothèques européennes, a jusqu'à très récemment échappé à l'attention des bibliographes, permettent de formuler, trois cent ans après, une attribution motivée à Voltaire.
Published: 2019

37. Surface Enhanced Raman Spectroscopy detection of Brettanomyces bruxellensis yeast on nanostructured ultrafine glass supports

Author: Ionescu, Rodica Elena, Poggesi, Simone, Zhou, Lan, Bariani, Giuliocesare Casari, Mittapalli, Rakesh, Adam, Pierre-Michel, Manzano, Marisa, Lumière, nanomatériaux et nanotechnologies (L2n), Institut Charles Delaunay (ICD), Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Scienze AgroAlimentari, Ambientali e Animali - [Udine] (DI4A), Università degli Studi di Udine - University of Udine [Italie], and ANR-17-EURE-0002,EIPHI,Ingénierie et Innovation par les sciences physiques, les savoir-faire technologiques et l'interdisciplinarité(2017)
Subjects: [CHIM.ANAL]Chemical Sciences/Analytical chemistry, [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, [CHIM.MATE]Chemical Sciences/Material chemistry
Abstract: International audience; Novel genosensors (Brett DNA) on nanostructured ultrafine coverslips are reported for the identification of Brettanomyces bruxellensis yeast that is well-known to create complex and difficult problems in aged red wine all over the word. Surface Enhanced Raman Scattering (SERS) and Localize Surface Plasmon Resonance (LSPR) are used as detection methods of target-ssDNA yeast. A specific detection is obtained in the presence of thiol-DNA probe. SERS technique made possible the detection of Brett-DNA with a limit of detection (LD) of 0,1 ng/μL((57,2 nM) and with a wide dynamic range (DR), while LSPR revealed a DL of 0,5 ng/μL real DNA extracted from Brettanomyces bruxellensis DKA in the laboratory and a limited DR (0.5 ng/ μL to 5 ng/ μL). In this work, 14 yeasts that can be found in wine-growing environments were SERS tested to confirm the selectivity of the proposed Brett-DNA sensing schemes and used in the construction of the first SERS phylogenetic tree.
Published: 2019
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38. Forest Biodiversity, Soil Functions and Human Behavior - A case study: the October 29 2018 catastrophe in North-East Italian Alps

Author: Zanella, Augusto, Ponge, Jean-François, Andreetta, Anna, Aubert, Michaël, Bernier, Nicolas, Bonifacio, Eleonora, Bonneval, Karine, Bolzonella, Cristian, Chertov, Oleg, De Nobili, Maria, Fusaro, Silvia, Hager, Herbert, Junod, Pascal, Kwiatkowska-Malina, Jolanta, Katzensteiner, Klaus, Safwan, Mohammad, Schnitzler, Annick, Sofo, Adriano, Tatti, Dylan, Department of Land, Environment, Agriculture and Forestry (TeSAF), Universita degli Studi di Padova, Mécanismes Adaptatifs et Evolution (MECADEV), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Étude et compréhension de la biodiversité (ECODIV), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Muséum national d'Histoire naturelle (MNHN), Università degli studi di Torino (UNITO), Ecole des Beaux-Arts d'Angoulême, Ecole Supérieure des Arts Décoratifs de Strasbourg, Ecole Supérieure des Arts Décoratifs de Strasbourg (ESAD), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.)-Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), University of Applied Sciences Bingen, Università degli Studi di Udine - University of Udine [Italie], Department of Forest and Soil Sciences, Universität für Bodenkultur Wien [Vienne, Autriche] (BOKU), Haute Ecole d'Ingénierie et de Gestion du Canton de Vaud [Yverdon-les-Bains] (HEIG-VD), Warsaw University of Technology [Warsaw], University of Debrecen, Université de Lorraine (UL), La scuola di Scienze Agrarie, forestali, alimentari e ambientali, University of Basilicata, and Bern University of Applied Sciences (BFH)
Subjects: soil organic carbon, climate change, [SDV.EE.ECO]Life Sciences [q-bio]/Ecology, environment/Ecosystems, wind damages, VAIA, humus, [SDV.SA.SDS]Life Sciences [q-bio]/Agricultural sciences/Soil study, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, ramial chipped wood
Abstract: The forests of 473 Italian Alpine municipalities were severely damaged by a strong wind at the end of October 2018. The affected forest area covers 42,500 ha. The president of one of the damaged regions asked for help from the TESAF Department of the University of Padua, Italy. Twenty-six international scientists (listed: 25; anonymous: 1) responded to the appeal and collectively wrote this article. At first the value of ramial chipped wood was discussed, then whether the forest should be left or not to its natural evolution, then whether there is a threat of bark beetles, then the time needed for the biodegradation of fallen trees was estimated from the on-site examination of humus forms, ending with political and social considerations. After eight months of discussion, with various reworkings and cuts, a controversial text was born, complete and practical at the same time.
Published: 2019

39. ECMM Candi Reg—A ready to use platform for outbreaks and epidemiological studies

Author: Alexandre Alanio, Axel Hamprecht, Mihai Mares, Paul E. Verweij, Maiken Cavling Arendrup, Suzana Hadina, Philipp Koehler, Jorg-Janne Vehreschild, Sevtap Arikan-Akdagli, Stéphane Bretagne, Katrien Lagrou, Oliver A. Cornely, Oliver Kurzai, Esther Segal, Cornelia Lass-Flörl, Neil A. R. Gow, Riina Rautemaa-Richardson, Tamás Papp, Jon Salmanton-García, Jean-Pierre Gangneux, Martin Hoenigl, Valentina Arsić Arsenijević, Petr Hamal, Elizabeth M. Johnson, Emmanuel Roilides, Felix C Koehler, Nikolay Klimko, Anna Maria Tortorano, Ana Alastruey-Izquierdo, Matteo Bassetti, Silke Schelenz, Raquel Sabino, Jacques F. Meis, Volkan Özenci, Lena Klingspor, Alida Fe Talento, University Hospital of Cologne [Cologne], Rigshospitalet [Copenhagen], Copenhagen University Hospital, Hacettepe University = Hacettepe Üniversitesi, Università degli Studi di Udine - University of Udine [Italie], Mycologie moléculaire - Molecular Mycology, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Karolinska University Hospital [Stockholm], Université Catholique de Louvain = Catholic University of Louvain (UCL), Leibniz Institute for Natural Product Research and Infection Biology (Hans Knoell Institute), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Pontchaillou [Rennes], Department of Microbiology [Szeged], University of Szeged [Szeged], Tel Aviv University [Tel Aviv], University of Cologne, European Confederation of Medical Mycology, Scynexis, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Tel Aviv University (TAU)
Subjects: 0301 basic medicine, Data platform, Male, medicine.medical_specialty, Databases, Factual, [SDV]Life Sciences [q-bio], 030106 microbiology, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Dermatology, Global Health, invasive fungal infection, Disease Outbreaks, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Epidemiology, medicine, Humans, Candidiasis, Invasive, Registries, Intensive care medicine, Candida, Infecções Sistémicas e Zoonoses, outbreak, business.industry, Mortality rate, Outbreak, Candidemia, General Medicine, invasive candidiasis, 3. Good health, epidemiology, Infectious Diseases, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], Candida auris, ECMM, Epidemiological Monitoring, Candida spp, Candida Registry, Ready to use, Female, business, Cohort study
Abstract: Background: Recent outbreaks of Candida auris further exemplify that invasive Candida infections are a substantial threat to patients and healthcare systems. Even short treatment delays are associated with higher mortality rates. Epidemiological shifts towards more resistant Candida spp. require careful surveillance. Objectives: Triggered by the emergence of C auris and by increasing antifungal resistance rates the European Confederation of Medical Mycology developed an international Candida Registry (FungiScope™ CandiReg) to allow contemporary multinational surveillance. Methods: CandiReg serves as platform for international cooperation to enhance research regarding invasive Candida infections. CandiReg uses the General Data Protection Regulation compliant data platform ClinicalSurveys.net that holds the electronic case report forms (eCRF). Data entry is supported via an interactive macro created by the software that can be accessed via any Internet browser. Results: CandiReg provides an eCRF for invasive Candida infections that can be used for a variety of studies from cohort studies on attributable mortality to evaluations of guideline adherence, offering to the investigators of the 28 ECMM member countries the opportunity to document their cases of invasive Candida infection. CandiReg allows the monitoring of epidemiology of invasive Candida infections, including monitoring of multinational outbreaks. Here, we describe the structure and management of the CandiReg platform. Conclusion: CandiReg supports the collection of clinical information and isolates to improve the knowledge on epidemiology and eventually to improve management of invasive Candida infections. CandiReg promotes international collaboration, improving the availability and quality of evidence on invasive Candida infection and contributes to improved patient management. CandiReg is an academic project and funded by ECMM via the ECMM Candida III study (PI: Hoenigl, Co‐PI Cornely; supported by Scynexis) and the University of Cologne. info:eu-repo/semantics/publishedVersion
Published: 2019
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40. Electrochemical and Optical Biosensors for the Detection of Campylobacter and Listeria: An Update Look

Author: Matteo Braidot, Jasmina Vidic, Priya Vizzini, Marisa Manzano, Dipartimento di Scienze AgroAlimentari, Ambientali e Animali - [Udine] (DI4A), Università degli Studi di Udine - University of Udine [Italie], MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), and Institut National de la Recherche Agronomique (INRA)-AgroParisTech
Subjects: [SDV.BIO]Life Sciences [q-bio]/Biotechnology, Computer science, lcsh:Mechanical engineering and machinery, Aptamer, [SDV]Life Sciences [q-bio], Nanotechnology, 02 engineering and technology, food pathogens, Listeria monocytogenes, Campylobacter, electrochemical biosensors, optical biosensors, medicine.disease_cause, 01 natural sciences, Early initiation, medicine, Food microbiology, lcsh:TJ1-1570, Electrical and Electronic Engineering, biology, business.industry, Mechanical Engineering, 010401 analytical chemistry, 021001 nanoscience & nanotechnology, biology.organism_classification, Food safety, 3. Good health, 0104 chemical sciences, Control and Systems Engineering, Listeria, [INFO.INFO-ET]Computer Science [cs]/Emerging Technologies [cs.ET], 0210 nano-technology, business, Biosensor
Abstract: International audience; Foodborne safety has aroused tremendous research interest in recent years because of a global public health problem. The rapid and precise detection of foodborne pathogens can reduce significantly infection diseases and save lives by the early initiation of an effective treatment. This review highlights current advances in the development of biosensors for detection of Campylobacter spp. and Listeria monocytogenes that are the most common causes of zoonosis. The consumption of pathogen contaminated food is responsible for humans hospitalization and death. The attention focused on the recognition elements such as antibodies (Ab), DNA probes and aptamers able to recognize cells, amplicons, and specific genes from different samples like bacteria, food, environment and clinical samples. Moreover, the review focused on two main signal-transducing mechanisms, i.e., electrochemical, measuring an amperometric, potentiometric and impedimetric signal; and optical, measuring a light signal by OLED (Organic Light Emitting Diode), SPR (Surface Plasmon Resonance), and Optical fiber. We expect that high-performance of devices being developed through basic research will find extensive applications in environmental monitoring, biomedical diagnostics, and food safety.
Published: 2019
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41. Sull'anatocismo nell'ammortamento progressivo: un'impostazione non convenzionale

Author: Pressacco, Flavio, Ziani, Laura, DIES - Dept. of Economics and Statistics (DIES), Università degli Studi di Udine - University of Udine [Italie], and Ziani, Laura
Subjects: JEL: G - Financial Economics/G.G2 - Financial Institutions and Services/G.G2.G21 - Banks • Depository Institutions • Micro Finance Institutions • Mortgages, [SHS.ECO] Humanities and Social Sciences/Economics and Finance, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, JEL: G - Financial Economics, JEL: G - Financial Economics/G.G1 - General Financial Markets/G.G1.G12 - Asset Pricing • Trading Volume • Bond Interest Rates
Abstract: In this paper we analyze, from a logical-mathematical point of view, the problem of the existence of interests on interests (so-called anatocism) in traditional amortization plans for a debt.The elementary methods of repayment of a debt (Bullet Bond and Zero Coupon Bond) are analyzed. It is noted that in them there is respectively absence (BB) or presence (ZCB) of interest on interest. We introduce the decomposition of a debt as a sequence of debts repayable with the two elementary methods. Equivalent decompositions are defined, in one or the other modality, those that give rise to a consolidated amortization that coincides with the traditional amortization plan. An apparent paradox emerges: there would be the presence of interest on interest in the equivalent decomposition ZCB and absence in the equivalent decomposition BB. The paradox can be solved by considering the mathematical consequences of the cadence of the collectability of interest., Keywords: ammortamento progressivo, anatocismo, bullet bond, zero coupon bond. In questo lavoro si analizza, da un punto di vista logico-matematico, il problema dell'esistenza di interessi su interessi (cosiddetto anatocismo) in piani di ammortamento tradizionale di un debito.Dopo aver analizzato le modalità elementari di rimborso di un debito (Bullet Bond e Zero Coupon Bond) e constatato che in esse vi è assenza (BB) o presenza (ZCB) di interessi su interessi, si valutano le conseguenze della scomposizione di un debito in una sequenza di debiti rimborsabili con le due modalità elementari e si definiscono rigorosamente scomposizioni equivalenti, nell'una o nell'altra modalità, quelle che danno vita ad un ammortamento consolidato che coincide con un piano di ammortamento tradizionale. Ne emerge un paradosso apparente: vi sarebbe presenza di interessi nella scomposizione equivalente ZCB e assenza nella scomposizione equivalente BB. Il paradosso si può risolvere considerando le conseguenze matematiche della cadenza dell'esigibilità degli interessi.
Published: 2019

42. Robust SERS Platforms Based on Annealed Gold Nanostructures Formed on Ultrafine Glass Substrates for Various (Bio)Applications

Author: Marisa Manzano, Giuliocesare Casari Bariani, Rodica Elena Ionescu, Pierre-Michel Adam, Simone Poggesi, Rakesh Mittapalli, Lan Zhou, Lumière, nanomatériaux et nanotechnologies (L2n), Institut Charles Delaunay (ICD), Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Scienze AgroAlimentari, Ambientali e Animali - [Udine] (DI4A), and Università degli Studi di Udine - University of Udine [Italie]
Subjects: Indoles, Nanostructure, Materials science, Surface Properties, lcsh:Biotechnology, SERS on ultrafine solid supports, glass coverslips, BPE, annealed gold nanostructures, Clinical Biochemistry, Metal Nanoparticles, Biosensing Techniques, 02 engineering and technology, Spectrum Analysis, Raman, 010402 general chemistry, 01 natural sciences, Article, Spectral line, lcsh:TP248.13-248.65, Molecule, Hot plate, Particle Size, Thin layers, Aqueous solution, Temperature, General Medicine, Surface-enhanced Raman spectroscopy, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Chemical engineering, Colloidal gold, thiol-DNA probe, Glass, Gold, DNA Probes, 0210 nano-technology, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing
Abstract: In this study, stable gold nanoparticles (AuNPs) are fabricated for the first time on commercial ultrafine glass coverslips coated with gold thin layers (2 nm, 4 nm, 6 nm, and 8 nm) at 25 &deg, C and annealed at high temperatures (350 &deg, C, 450 &deg, C, and 550 &deg, C) on a hot plate for different periods of time. Such gold nanostructured coverslips were systematically tested via surface enhanced Raman spectroscopy (SERS) to identify their spectral performances in the presence of different concentrations of a model molecule, namely 1,2-bis-(4-pyridyl)-ethene (BPE). By using these SERS platforms, it is possible to detect BPE traces (10&minus, 12 M) in aqueous solutions in 120 s. The stability of SERS spectra over five weeks of thiol-DNA probe (2 &micro, L) deposited on gold nano-structured coverslip is also reported.
Published: 2019
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43. Set-Based Analysis for Biological Modeling

Author: Thao Dang, Tommaso Dreossi, Eric Fanchon, Alexandre Rocca, Carla Piazza, Oded Maler, Berkeley University of California (UC BERKELEY), Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Udine - University of Udine [Italie], Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), VERIMAG (VERIMAG - IMAG), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Biologie Computationnelle et Mathématique (TIMC-IMAG-BCM), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), and ZOPPIS, Catherine
Subjects: 0303 health sciences, 0209 industrial biotechnology, Biological data, Dynamical systems theory, Computer science, [SDV]Life Sciences [q-bio], Systems biology, Constraint (computer-aided design), 02 engineering and technology, Parameter space, Rotation formalisms in three dimensions, [SDV] Life Sciences [q-bio], 03 medical and health sciences, Nonlinear system, 020901 industrial engineering & automation, Statistical physics, Differential (infinitesimal), [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], ComputingMilieux_MISCELLANEOUS, 030304 developmental biology
Abstract: International audience; The understanding of biological systems and processes requires the development of dynamical models characterized by nonlinear laws and often intricate regulation architectures. Differential and difference equations are common formalisms to characterize such systems. Hybrid dynamical systems come in handy when the modeled system combines continuous and discrete evolutions or different evolution modes such as where slow evolution phases are interrupted by fast ones. Biological data with kinetic content are often scarce, thus it can be appropriate to reason in terms of sets of (parametrized) models and sets of trajectories. In doing so, uncertainties and lack of knowledge are explicitly taken into account and more reliable predictions can be made. A crucial problem in Systems Biology is thus to identify regions of parameter space for which model behavior is consistent with experimental observations. In this chapter, we investigate the use of set-based analysis techniques, designed to compute on sets of behaviors, for the validation of biological models under uncertainties and perturbations. In addition, these techniques can be used for the synthesis of model parameter sets, so that the execution of the considered biological model under the influence of the synthesized parameters is guaranteed to satisfy a given constraint or property. The proposed approach is illustrated by several case studies, namely a model of iron homeostasis in mammalian cells and some epidemic models.
Published: 2019
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44. Pricing and hedging GMWB in the Heston and in the Black–Scholes with stochastic interest rate models

Author: Andrea Molent, Ludovic Goudenège, Antonino Zanette, Fédération de Mathématiques de l'Ecole Centrale Paris (FR3487), Ecole Centrale Paris-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Udine - University of Udine [Italie], Mathematical Risk Handling (MATHRISK), Université Paris-Est Marne-la-Vallée (UPEM)-École des Ponts ParisTech (ENPC)-Inria de Paris, and Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)
Subjects: Stochastic modelling, Variable Annuities, stochastic volatility, stochastic interest rate, optimal withdrawal, media_common.quotation_subject, Monte Carlo method, Variable annuities, Computational Finance (q-fin.CP), 010103 numerical & computational mathematics, Black–Scholes model, 01 natural sciences, Management Information Systems, FOS: Economics and business, Quantitative Finance - Computational Finance, Computer Science::Computational Engineering, Finance, and Science, Stochastic volatility, 0101 mathematics, Optimal withdrawal, media_common, Mathematics, Stochastic interest rate, Interest rate, Heston model, 010101 applied mathematics, [MATH.MATH-PR]Mathematics [math]/Probability [math.PR], GMWB pricing, Pricing of Securities (q-fin.PR), Volatility (finance), Greeks, Quantitative Finance - Pricing of Securities, Mathematical economics, Information Systems
Abstract: Valuing Guaranteed Minimum Withdrawal Benefit (GMWB) has attracted significant attention from both the academic field and real world financial markets. As remarked by Yang and Dai, the Black and Scholes framework seems to be inappropriate for such a long maturity products. Also Chen Vetzal and Forsyth in showed that the price of these products is very sensitive to interest rate and volatility parameters. We propose here to use a stochastic volatility model (Heston model) and a Black Scholes model with stochastic interest rate (Hull White model). For this purpose we present four numerical methods for pricing GMWB variables annuities: a hybrid tree-finite difference method and a Hybrid Monte Carlo method, an ADI finite difference scheme, and a Standard Monte Carlo method. These methods are used to determine the no-arbitrage fee for the most popular versions of the GMWB contract, and to calculate the Greeks used in hedging. Both constant withdrawal, optimal surrender and optimal withdrawal strategies are considered. Numerical results are presented which demonstrate the sensitivity of the no-arbitrage fee to economic, contractual and longevity assumptions., Comment: arXiv admin note: substantial text overlap with arXiv:1509.02686
Published: 2019
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45. Phytoplasma transmission: insect rearing and infection protocols

Author: L. Pagliari, J Chuche, D Thiéry, Domenico Bosco, Department of Agricultural, Food, Environmental and Animal Sciences, Università degli Studi di Udine - University of Udine [Italie], Institut Français de la Vigne et du Vin (IFV), Universita di Torino, Santé et agroécologie du vignoble (UMR SAVE), and Institut National de la Recherche Agronomique (INRA)-Université de Bordeaux (UB)-Institut des Sciences de la Vigne et du Vin (ISVV)-Ecole Nationale Supérieure des Sciences Agronomiques de Bordeaux-Aquitaine (Bordeaux Sciences Agro)
Subjects: 0106 biological sciences, 0301 basic medicine, Phytoplasma, media_common.quotation_subject, Euscelidius variegatus, [SDV]Life Sciences [q-bio], 030106 microbiology, Arabidopsis, Insect, 01 natural sciences, Hemiptera, 03 medical and health sciences, Arabidopsis thaliana, Animals, Herbivory, media_common, Plant Diseases, Macrosteles quadripunctulatus, biology, Obligate, Transmission (medicine), fungi, Scaphoideus titanus, food and beverages, Euscelidius variegatus,Macrosteles quadripunctulatus,Hyalesthes obsoletus,Scaphoideus titanus, infection protocol, biology.organism_classification, Virology, Insect Vectors, Hyalesthes obsoletus, Infection protocol, [SDE]Environmental Sciences, 010606 plant biology & botany
Abstract: Chapitre 3; International audience; Phytoplasmas are obligate pathogens and thus they can be studied only in association with their plants or insect hosts. In this chapter, we present protocols for rearing some phytoplasma insect vectors, to obtain infected insects and plants under controlled environmental conditions. We focus on Euscelidius variegatus and Macrosteles quadripunctulatus that can infect Arabidopsis thaliana, and Hyalesthes obsoletus and Scaphoideus titanus, that can infect grapevine.
Published: 2019
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46. Update in Antibiotic Therapy in Intensive Care Unit Report from the 2019 Nimes International Symposium

Author: Michael Neely, Didier Payen, Adrien Bouglé, Jason A. Roberts, Matteo Bassetti, Boris Jung, Matthieu Legrand, Jordi Rello, Marc Leone, Claire Roger, Fredrik Sjövall, Jean-Philippe Lavigne, José Artur Paiva, Service Anesthésie et Réanimation [Hôpital Nord - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], Aix Marseille Université (AMU), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), University of Queensland [Brisbane], Università degli Studi di Udine - University of Udine [Italie], University of Genoa (UNIGE), CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Virulence bactérienne et maladies infectieuses (VBMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), University of California [San Francisco] (UCSF), University of California, Marqueurs cardiovasculaires en situation de stress (MASCOT (UMR_S_942 / U942)), Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris 13 (UP13)-Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Children’s Hospital Los Angeles [Los Angeles], Keck School of Medicine [Los Angeles], University of Southern California (USC), Universidade do Porto, Université Paris Diderot - Paris 7 (UPD7), Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III [Madrid] (ISC), Vall d'Hebron University Hospital [Barcelona], Caractéristiques féminines des dysfonctions des interfaces cardio-vasculaires (EA 2992), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Skane University Hospital [Malmo], Lund University [Lund], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), MORNET, Dominique, Università degli studi di Genova = University of Genoa (UniGe), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), University of California [San Francisco] (UC San Francisco), University of California (UC), Université Paris 13 (UP13)-Université Paris-Sud - Paris 11 (UP11)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS), Universidade do Porto = University of Porto, and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: medicine.medical_specialty, Combination therapy, medicine.drug_class, Antibiotics, Critical Care and Intensive Care Medicine, antibiotics, law.invention, sepsis, 03 medical and health sciences, 0302 clinical medicine, stewardship, 030202 anesthesiology, law, Antibiotic therapy, medicine, Dosing, Intensive care medicine, De-escalation, Sepsis, Stewardship, Critically ill, business.industry, 030208 emergency & critical care medicine, General Medicine, Intensive care unit, dosing, 3. Good health, de-escalation, Anesthesiology and Pain Medicine, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business
Abstract: International audience; The 2019 Nîmes International Symposium in Antibiotic Therapy Optimisation aimed at determining the best approaches of a number of the antibiotic management strategies for critically ill patients. Experts reviewed the latest literature relating to requirements for an optimal antibiotic stewardship program, risks of sub-therapeutic dosing of antibiotics in critically ill patients, persisting issues about efficiency of combination therapy and the value of de-escalation, new perspectives of pharmacokinetics, drug toxicities including collateral damages-associated with antibiotics, the place of nebulisation of antibiotics, management of patients receiving extracorporeal therapies and the place of new antibiotics. In this paper, each of these issues is discussed with key messages presented after a brief review of evidence.
Published: 2019
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47. L'interrogative insaisissable

Author: Vecchiato, Sara and Università degli Studi di Udine - University of Udine [Italie]
Subjects: French, Italian, Interrogative indirecte, Lexicon-Grammar, Italien, Lessico-grammatica, Interrogativa indiretta, Francese, Italiano, [SHS.LANGUE]Humanities and Social Sciences/Linguistics, Lexique-grammaire, Indirect question, Français
Abstract: International audience; Les phrases interrogatives en français ne cessent de susciter l'intérêt des syntacticiens en raison de leurs caractéristiques de protéiformité, de polyvalence et de « polychromie », car elles présentent une variété de formes qui se sont stabilisées à différentes époques. Le volume propose une sélection d'articles sur la répartition des subordonnées dites interrogatives indirectes. La spécificité de ces structures est que pour les former, comme en italien et dans diverses langues indo-européennes, le français utilise des morphèmes communs à d'autres types de phrases : la conjonction "si", qui introduit notoirement l'hypothétique et le circonstanciel, et la série "qu-", utilisée dans les pronoms et adjectifs relatifs et indéfinis.Une confirmation récente de l'importance de ce type de subordonnées vient d'études qui ont proposé de repenser la série "qu-" à partir de la difficulté de décrire les morphèmes interrogatifs. Ce volume se distingue par une approche comparative français/italien et par un cadre méthodologique qui prend fortement en compte la dimension lexicale de la phrase : à ce titre, plusieurs contributions traitent de l'exception à la règle, désignant par ce terme non seulement les règles établies par les grammaires normatives, mais aussi les généralisations proposées par les linguistes. C'est le cas des « interrogatives impossibles » attestées avec des verbes qui ne sont généralement pas considérés comme des introducteurs d'interrogatives indirectes. La publication s'adresse aux spécialistes des langues française et italienne, aux syntacticiens et, plus généralement, aux linguistes intéressés par l'interface entre lexique et grammaire.; Nella sintassi francese, le frasi interrogative non cessano di suscitare l'interesse degli studiosi a causa delle loro caratteristiche di proteiformità, polivalenza e ‘policronia', in quanto presentano una varietà di forme che si sono stabilizzate in epoche diverse. Il volume offre una selezione di articoli sulla distribuzione delle subordinate note come interrogative indirette. La specificità di queste strutture è data dal fatto che per formarle, analogamente a quanto accade in italiano e in diverse lingue indoeuropee, il francese ricorre a morfemi comuni ad altri tipi di frase: la congiunzione si, che notoriamente introduce le ipotetiche e circostanziali, e la serie qu-, impiegata nei pronomi e aggettivi relativi e indefiniti.Conferme recenti dell'importanza di questo tipo di subordinata vengono da alcuni studi, che hanno proposto di ripensare la serie qu- partendo appunto dalla difficoltà di descrivere i morfemi interrogativi. Questo volume si distingue per un approccio comparativo francese/italiano e per un quadro metodologico che tiene fortemente in considerazione la dimensione lessicale della frase: per questo motivo, diversi contributi trattano dell'eccezione alla regola, intendendo con questo termine non solo le regole stabilite dalle grammatiche normative, ma anche le generalizzazioni proposte dai linguisti. È il caso delle ‘interrogative impossibili' attestate con verbi che generalmente non sono considerati introduttori di interrogative indirette. La pubblicazione si rivolge agli specialisti di lingua francese e italiana, ai sintatticisti e più in generale ai linguisti interessati all'interfaccia fra lessico e grammatica.
Published: 2019

48. Dalla fonte al database: per una storia economica e sociale delle popolazioni del passato

Author: Gasperoni, Michael, Fornasin, Alessio, Centre de Recherche Roland Mousnier Histoire et Civilisation (CRM), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris-Sorbonne (UP4)-Centre National de la Recherche Scientifique (CNRS), Department of Statistics, Università degli Studi di Udine - University of Udine [Italie], Centro Sammarinese di Studi Storici, Sori, Ercole, Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sorbonne (UP4)-École pratique des hautes études (EPHE), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)
Subjects: [SHS.STAT]Humanities and Social Sciences/Methods and statistics, [SHS.DEMO]Humanities and Social Sciences/Demography, [SHS.HIST]Humanities and Social Sciences/History, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

49. A protoype-based approach to object reclassification

Author: Ciaffaglione, Alberto, Gianantonio, Pietro, Honsell, Furio, Liquori, Luigi, Dipartimento di Matematica e Informatica - Universita Udine (DIMI), Università degli Studi di Udine - University of Udine [Italie], Logical Time for Formal Embedded System Design (KAIROS), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-COMmunications, Réseaux, systèmes Embarqués et Distribués (Laboratoire I3S - COMRED), Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), and Inria & Université Cote d'Azur, CNRS, I3S, Sophia Antipolis, France
Subjects: object reclassification, TheoryofComputation_MATHEMATICALLOGICANDFORMALLANGUAGES, TheoryofComputation_LOGICSANDMEANINGSOFPROGRAMS, static typing, Prototype-based calculi, [INFO.INFO-LO]Computer Science [cs]/Logic in Computer Science [cs.LO], [INFO.INFO-CL]Computer Science [cs]/Computation and Language [cs.CL]
Abstract: We investigate, in the context of functional prototype-based languages , a calculus of objects which might extend themselves upon receiving a message, a possibility referred to by Cardelli as a self-inflicted operation. We present a sound type system for this calculus which guarantees that evaluating a well-typed expression will never yield a message-not-found runtime error. The resulting calculus is an attempt towards the definition of a language combining the safety advantage of static type check with the flexibility normally found in dynamically typed languages.
Published: 2019

50. The ∆-framework

Author: Honsell, F., Liquori, L., Stolze, C., Scagnetto, I., Dipartimento di Matematica e Informatica - Universita Udine (DIMI), Università degli Studi di Udine - University of Udine [Italie], Logical Time for Formal Embedded System Design (KAIROS), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-COMmunications, Réseaux, systèmes Embarqués et Distribués (Laboratoire I3S - COMRED), Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), and European Project: COST Action CA15123 ,COST - European Cooperation in Science and Technology,EUTYPES(2016)
Subjects: Logic of programs, Type theory, λ-calculus, TheoryofComputation_MATHEMATICALLOGICANDFORMALLANGUAGES, TheoryofComputation_LOGICSANDMEANINGSOFPROGRAMS, Computer Science::Logic in Computer Science, [INFO.INFO-LO]Computer Science [cs]/Logic in Computer Science [cs.LO], [INFO.INFO-CL]Computer Science [cs]/Computation and Language [cs.CL]
Abstract: International audience; We introduce a dependent-type theory ∆-framework, LF-∆ , based on the Edinburgh Logical Framework LF, extended with the strong proof-functional connectives intersection, union, and relevant implication. Proof-functional connectives take into account the shape of logical proofs, thus allowing the user to reflect polymorphic features of proofs in formulae. This is in contrast to classical and intuitionistic connectives where the meaning of a compound formula is dependent only on the truth value or the provability of its subformulae. Both Logical Frameworks and Proof Functional Logics consider proofs as first class citizens albeit differently. The former mention proofs explicitly, while the latter mention proofs implicitly. Their combination therefore opens up new possibilites of formal reasoning on proof-theoretic semantics. We study the metatheory of LF-∆ and provide various examples of applications. Moreover, we discuss a prototype implementation of a type checker and a refiner allowing the user to accelerate and possibly automate, the proof development process. This proof-functional type theory can be plugged in existing common proof assistants.
Published: 2018
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