1. Digestive Inflammation: Role of Proteolytic Dysregulation
- Author
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Soufien Rhimi, Houda Boudaya, Vincent Mariaule, Souha Soussou, Juan Hernandez, Moez Rhimi, Emmanuelle Maguin, Aicha Kriaa, Adam Lesner, MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), This work received funding from the Microbiology and the Food Chain division (MICA) of the INRAE Institute through the metaprogramme MEM-Meta-omics and microbial ecosystems, and Titan-ANR number ANR-18-CE18-0019-03 and SerpinGuTarget ANR-CE16-0018-01 project, the CMCU-PHC Utique (No. 19G0819)-Campus France (41786NC) and the Twinning European project MICAfrica 952583., ANR-16-CE16-0018,EPITRACES,Traces épigénétiques neuronales des récompenses(2016), European Project: 9525833(1995), Microbiota Interaction with Human and Animal (MIHA), Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, and University of Gdańsk (UG)
- Subjects
0301 basic medicine ,Proteases ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,Inflammation ,Review ,Serpin ,Matrix metalloproteinase ,Gut flora ,digestive inflammation ,gut microbiota ,holobiont ,protease ,serpin ,Catalysis ,lcsh:Chemistry ,Inorganic Chemistry ,Pathogenesis ,Serine ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Animals ,Humans ,[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology ,Physical and Theoretical Chemistry ,lcsh:QH301-705.5 ,Molecular Biology ,Spectroscopy ,Protease ,biology ,Organic Chemistry ,General Medicine ,Inflammatory Bowel Diseases ,biology.organism_classification ,Matrix Metalloproteinases ,3. Good health ,Computer Science Applications ,Cell biology ,030104 developmental biology ,[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology ,lcsh:Biology (General) ,lcsh:QD1-999 ,Proteolysis ,030211 gastroenterology & hepatology ,Serine Proteases ,medicine.symptom - Abstract
International audience; Dysregulation of the proteolytic balance is often associated with diseases. Serine proteases and matrix metalloproteases are involved in a multitude of biological processes and notably in the inflammatory response. Within the framework of digestive inflammation, several studies have stressed the role of serine proteases and matrix metalloproteases (MMPs) as key actors in its pathogenesis and pointed to the unbalance between these proteases and their respective inhibitors. Substantial efforts have been made in developing new inhibitors, some of which have reached clinical trial phases, notwithstanding that unwanted side effects remain a major issue. However, studies on the proteolytic imbalance and inhibitors conception are directed toward host serine/MMPs proteases revealing a hitherto overlooked factor, the potential contribution of their bacterial counterpart. In this review, we highlight the role of proteolytic imbalance in human digestive inflammation focusing on serine proteases and MMPs and their respective inhibitors considering both host and bacterial origin.
- Published
- 2021
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