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Introduction: The main objective of this work was to investigate a possible link between lung density, small pulmonary vessels, and pulmonary hypertension (PH) in patients with progressive fibrosing interstitial lung disease (PF-ILD).Methods: The study focused on patients with PF-ILD, all of whom underwent right cardiac catheterization and chest computed tomography prior to lung transplantation. Computed tomography scans were analyzed quantitatively for density and pulmonary vascularity. The relationship between computed tomography features and PH was investigated.Results: Fifty-one patients with usual interstitial pneumonia (UIP) damage on lung explant were included. mPAP was positively correlated with lung mass (r=0.36, P=0.03) and lung volume (r=0.43, P=0.007). Patients with severe PH had more voxels lower than -856 Hounsfield Units (HU) (+16%, P=0.02), fewer voxels greater than -700 HU (-20%, P=0.03), and a higher lung volume (+1.57L, P=0.007) compared to patients without PH. No correlation was found between vascularization and HTP.Conclusions: Patients with PF-ILD and severe PH have lower lung density than patients with moderate or without PH.

International audience; Our research about life in medieval times was made using the pattern of dental mico-wear observed on a subject exposed during the release of the base of the Gallo-Roman tower of the St. Frambourg Royal Chapel at Senlis. Comparison of this model with that of various populations allows to discuss the nature of abrasive nature of food. This means of investigation illustrates the value of microscopic examination of tooth surfaces as a dietary indicator of good historical reliability.; Notre recherche à propos de la vie au Moyen-âge s’est faite à l’aide du motif de micro-usure dentaire relevé sur un sujet mis au jour lors du dégagement de la base de la tour gallo-romaine de la chapelle royale Saint-Frambourg à Senlis. La comparaison de ce motif avec celui de diverses populations permet de discuter l’influence du caractère abrasif de la nourriture. Ce moyen d’investigation illustre l’intérêt de l’examen au microscope des surfaces dentaires comme un indicateur de bonne fiabilité historique du choix alimentaire.

Our research about life in medieval times was made using the pattern of dental mico-wear observed on a subject exposed during the release of the base of the Gallo-Roman tower of the St. Frambourg Royal Chapel at Senlis. Comparison of this model with that of various populations allows to discuss the nature of abrasive nature of food. This means of investigation illustrates the value of microscopic examination of tooth surfaces as a dietary indicator of good historical reliability., Notre recherche à propos de la vie au Moyen-âge s’est faite à l’aide du motif de micro-usure dentaire relevé sur un sujet mis au jour lors du dégagement de la base de la tour gallo-romaine de la chapelle royale Saint-Frambourg à Senlis. La comparaison de ce motif avec celui de diverses populations permet de discuter l’influence du caractère abrasif de la nourriture. Ce moyen d’investigation illustre l’intérêt de l’examen au microscope des surfaces dentaires comme un indicateur de bonne fiabilité historique du choix alimentaire.

International audience