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1. Introduction

Author: Le Roux, Muriel, Thébaud-Sorger, Marie-Aline, Le Roux, Muriel, and Muriel Le Roux
Subjects: [SHS.HISPHILSO] Humanities and Social Sciences/History, Philosophy and Sociology of Sciences, longue durée, [SHS.HIST] Humanities and Social Sciences/History, [SHS] Humanities and Social Sciences, histoire des sciences, communication scientifique
Published: 2023

2. Inactivation of Toxoplasma gondii in dry sausage and processed pork, and quantification of the pathogen in pig tissues prior to production

Author: Dámek, Filip, Fremaux, Bastien, Aubert, Dominique, Thoumire, Sandra, Delsart, Maxime, Martin, Jean-Luc, Vuillermet, Sandra, Opsteegh, Marieke, Jokelainen, Pikka, Le Roux, Delphine, Boireau, Pascal, Villena, Isabelle, Blaga, Radu, Biologie moléculaire et immunologie parasitaires et fongiques (BIPAR), École nationale vétérinaire - Alfort (ENVA)-Laboratoire de santé animale, sites de Maisons-Alfort et de Normandie, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut du Porc (IFIP), Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle (ESCAPE), Université de Reims Champagne-Ardenne (URCA)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Centre Hospitalier Universitaire de Reims (CHU Reims), Centre National de Référence (CNR) Toxoplasmose/Toxoplasma Biological Resource Center (BRC) (CNR Toxoplasmose-Toxoplasma BRC), CHU Limoges, Epidémiologie des maladies animales infectieuses (EpiMAI USC), École nationale vétérinaire - Alfort (ENVA)-Epidémiologie (EPI), Laboratoire de santé animale, sites de Maisons-Alfort et de Normandie, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Laboratoire de santé animale, sites de Maisons-Alfort et de Normandie, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Statens Serum Institut [Copenhagen], Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), This work was supported by funding from the France-Agri-Mer: contract number 0917003490 and the European Union's Horizon 2020 Research and Innovation programme under grant agreement No 773830: One Health European Joint Programme (projects ToxSauQMRA and TOXOSOURCES)., and European Project: 773830, H2020-SFS-2017-1 ,One Health EJP(2018)
Subjects: [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, meat, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, nitrate, Epidemiology, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, viability, distribution, salt, Parasitology, nitrite
Abstract: Toxoplasma gondiiis an important zoonotic foodborne parasite. Meat of infected animals appears to be a major source of infection in Europe. Pork is the most consumed meat in France, with dry sausages well represented. The risk of transmission via consumption of processed pork products is largely unknown, mainly since processing will affect viability but may not entirely inactivate allT. gondiiparasites. We investigated the presence and concentration ofT. gondiiDNA in the shoulder, breast, ham, and heart of pigs orally inoculated with 1000 oocysts (n= 3) or tissue cysts (n = 3) and naturally infected pigs (n= 2), by means of magnetic capture qPCR (MC-qPCR). Muscle tissues of experimentally infected pigs were further used to evaluate the impact of manufacturing processes of dry sausages, including different concentrations of nitrates (0, 60, 120, 200 ppm), nitrites (0, 60, 120 ppm), and NaCl (0, 20, 26 g/kg), ripening (2 days at 16-24 °C) and drying (up to 30 days at 13 °C), by a combination of mouse bioassay, qPCR and MC-qPCR. DNA ofT. gondiiwas detected in all eight pigs, including in 41.7% (10/24) of muscle samples (shoulder, breast and ham) and 87.5% (7/8) of hearts by MC-qPCR. The number of parasites per gram of tissue was estimated to be the lowest in the hams (arithmetic mean (M) = 1, standard deviation (SD) = 2) and the highest in the hearts (M = 147, SD = 233). However, theT. gondiiburden estimates varied on the individual animal level, the tissue tested and the parasitic stage used for the experimental infection (oocysts or tissue cysts). Of dry sausages and processed pork, 94.4% (51/54) were positive forT. gondiiby MC-qPCR or qPCR, with the meanT. gondiiburden estimate equivalent to 31 parasites per gram (SD = 93). Only the untreated processed pork sample collected on the day of production was positive by mouse bioassay. The results suggest an uneven distribution ofT. gondiiin the tissues examined, and possibly an absence or a concentration below the detection limit in some of them. Moreover, the processing of dry sausages and processed pork with NaCl, nitrates, and nitrites has an impact on the viability ofT. gondiifrom the first day of production. Results are valuable input for future risk assessments aiming to estimate the relative contribution of different sources ofT. gondiihuman infections.
Published: 2023

3. Frequency and Predictors for Chronic Thromboembolic Pulmonary Hypertension after a first Unprovoked Pulmonary Embolism: results from PADIS studies

Author: Alexandre Fauché, Emilie Presles, Olivier Sanchez, Xavier Jaïs, Raphael Le Mao, Philippe Robin, Gilles Pernod, Laurent Bertoletti, Patrick Jego, Florence Parent, Catherine A. Lemarié, Florent Leven, Pierre‐Yves Le Roux, Pierre‐Yves Salaun, Michel Nonent, Philippe Girard, Karine Lacut, Laurent Savale, Solen Mélac, Marie Guégan, Patrick Mismetti, Silvy Laporte, Christophe Leroyer, David Montani, Francis Couturaud, Cécile Tromeur, Guy Meyer, Elisabeth Duhamel, Karine Provost, Dominique Mottier, Aurélia Le Hir, Stéphane Lenoir, Christian Lamer, Jean François Bergmann, Denis Wahl, Ludovic Drouet, Patrick Chevarier, Nicolas Monte, Florence Morvan, Véronique Kouassi, Nabahats Ibrir, Gaid El Asri, Pierre Yves Salaun, Pierre Yves Le Roux, Luc Bressollette, Philippe Quéhé, Simon Gestin, Jérôme Bahuon, Lucille Deloire, Benjamin Planquette, Yannick Jobic, Yves Etienne, Romain Didier, Loic Leroux, Hubert Galinat, Cédric Le Maréchal, Lénaïck Gourhant, Fanny Mingant, Emmanuelle Lemoigne, Luc De Saint Martin, Aurélien Delluc, Grégoire Le Gal, Nicolas Paleiron, Raphaël Le Mao, Christophe Pison, Philippe Guéret, Hervé Décousus, Sandrine Accassat, CIC Brest, Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital de la Cavale Blanche, Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), INSERM U1059, SAINBIOSE - Santé, Ingénierie, Biologie, Saint-Etienne (SAINBIOSE-ENSMSE), Centre Ingénierie et Santé (CIS-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Saint-Etienne, F-Crin Innovte [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Innovations thérapeutiques en hémostase (IThEM - U1140), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Hôpital Bicêtre, Pôle des Cardiopathies Congénitales du Nouveau-Né à L'adulte - Centre Constitutif Cardiopathies Congénitales Complexes M3C, Groupe Hospitalier Paris Saint-Joseph, Hôpital Marie-Lannelongue, Inserm U999, Université Paris-Saclay, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), CHU Grenoble, Université Grenoble Alpes (UGA), CIC Saint Etienne, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Nord (Saint Etienne), Université de Rennes (UR), CHU Pontchaillou [Rennes], Institut Mutualiste de Montsouris (IMM), PADIS-PE Investigators: Francis Couturaud, Patrick Mismetti, Christophe Leroyer, Guy Meyer, Olivier Sanchez, Patrick Jego, Gilles Pernod, Elisabeth Duhamel, Karine Provost, Florence Parent, Laurent Bertoletti, Cécile Tromeur, Dominique Mottier, Marie Guégan, Solen Mélac, Aurélia Le Hir, Philippe Girard, Stéphane Lenoir, Christian Lamer, Jean François Bergmann, Denis Wahl, Ludovic Drouet, Emilie Presles, Silvy Laporte, Patrick Chevarier, Nicolas Monte, Florence Morvan, Véronique Kouassi, Nabahats Ibrir, Gaid El Asri, Pierre Yves Salaun, Philippe Robin, Pierre Yves Le Roux, Luc Bressollette, Philippe Quéhé, Simon Gestin, Michel Nonent, Jérôme Bahuon, Lucille Deloire, Benjamin Planquette, Yannick Jobic, Yves Etienne, Romain Didier, Florent Leven, Loic Leroux, Hubert Galinat, Cédric Le Maréchal, Lénaïck Gourhant, Fanny Mingant, Karine Lacut, Emmanuelle Lemoigne, Luc De Saint Martin, Aurélien Delluc, Grégoire Le Gal, Nicolas Paleiron, Raphaël Le Mao, Christophe Pison, Philippe Guéret, Hervé Décousus, Sandrine Accassat, Jonchère, Laurent, Santé Ingénierie Biologie Saint-Etienne (SAINBIOSE), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Innovations thérapeutiques en hémostase = Innovative Therapies in Haemostasis (IThEM - U1140), Centre d'Investigation Clinique - Epidémiologie Clinique Saint-Etienne (CIC-EC), and Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: [SDV] Life Sciences [q-bio], Pulmonary Hypertension, Risk Factors, Hypertension, Pulmonary, Incidence, [SDV]Life Sciences [q-bio], Chronic Disease, Clinical Studies, Humans, Anticoagulants, Hematology, Pulmonary Embolism, Aged
Abstract: International audience; Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening pulmonary embolism's (PE) complication whose incidence and predictors are not precisely determined.Objective: To determine the frequency and predictors for CTEPH after a first unprovoked PE.Patients/methods: In a randomized trial comparing an additional 18-month warfarin versus placebo in patients after a first unprovoked PE initially treated with vitamin K antagonist for 6 months, we applied recommended CTEPH screening strategies through 8-year follow-up to determine cumulative incidence of CTEPH. CTEPH predictors were estimated using Cox models. Pulmonary vascular obstruction (PVO) and systolic pulmonary arterial pressure (sPAP) at PE diagnosis and 6 months were studied by receiver operating curves analysis. All CTEPH cases and whether they were incident or prevalent were adjudicated.Results: During a median follow-up of 8.7 years, 9 CTEPH cases were diagnosed among 371 patients, with a cumulative incidence of 2.8% (95% confidence interval [CI], 0.95-4.64), and of 1.31% (95%CI, 0.01-2.60) after exclusion of 5 cases adjudicated as prevalent. At PE diagnosis, PVO>45% and sPAP>56mmHg were associated with CTEPH with a hazard ratio (HR) of 33.00 (95%CI 1.64-667.00, p=0.02) and 12.50 (95%CI 2.10-74.80, p65 years, lupus anticoagulant antibodies and non-O blood groups were also predictive of CTEPH. PVO>14% and sPAP>34mmHg at 6-month were associated with CTEPH (HRs 63.90 [95%CI, 3.11-1310.00, p
Published: 2022

4. Table ronde : Sobriété et responsabilités

Author: Le Roux, Julien, Oberlé, Philippe, Wisner, Vincent, Chauvin, Hortense, and Le Roux, Julien
Subjects: [SDE] Environmental Sciences
Published: 2023

5. Les guerres de Religion (3e éd)

Author: Le Roux, Nicolas and Le Roux, Nicolas
Subjects: [SHS.HIST] Humanities and Social Sciences/History, [SHS] Humanities and Social Sciences
Published: 2023

6. Long-Term Drift in Several Properties of Newer Pharmaceuticals: Are They Increasingly Recalcitrant to Removal in Wastewater Treatment?

Author: Straub, Jürg Oliver, Le Roux, Julien, Tedoldi, Damien, and Le Roux, Julien
Subjects: pharmaceuticals, wastewater, treatment, statistics, biodegradability, adsorption, [SDE] Environmental Sciences
Abstract: This study investigates whether newer pharmaceutical organic active substances (OASs) are more recalcitrant tobiodegradation than older ones, and examines possible consequences in terms of removal in wastewater treatment plants (WWTPs). 1850 unique small-molecule OASs were considered; for 1641 of them a year of introduction was found, ranging from 1840 to present. Experimental data on (i) n-octanol/water partition coefficients (logKow), (ii) ready biodegradability – as defined by the OECD Test Guidelines 301 (1992) – and (iii) removal in WWTPs, were collected from the literature as well as chemical databases; then the dataset was expanded using the common, free, quantitative structure-property software EPISuite (US EPA, 2017). After checking the goodness of fit of EPISuite predictions against the available experimental data, time series statistics were applied to the dataset.Molecular mass and logKow values displayed a positive shift over time with newly introduced OASs (Figure 1), hardly compatible with the hypothesis of same parent distributions. Readily biodegradable compounds were found to represent a relatively small proportion of all OASs, and this proportion tended to decrease over time. However, despite newer OASs being less biodegradable, the EPISuite-predicted removal in WWTPs showed an increase over time for the upper half of the values, reflecting an expected increase in adsorption to sludge. Likely reasons for this result will be discussed, together with the value of modelling tools like EPISuite for basic, initial environmental fate estimation for OASs.
Published: 2023

7. Can quarantine plant-parasitic nematodes within wastes be managed by useful tools in a circular economy approach?

Author: Hoël Hotte, Marie-Sophie Neveux, Fabrice Ollivier, Nicolas Mariette, Laurent Folcher, Anne-Claire Le Roux, Unité de Nématologie (LSV Rennes), Laboratoire de la santé des végétaux (LSV), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Institut de Génétique, Environnement et Protection des Plantes (IGEPP), Université de Rennes (UR)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Rennes Angers, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), and This work was supported by the CASDAR program of the French Ministry of Agriculture ‘NEMATOOLS’, coordinated by FN3PT (A-C. Le Roux) in partnership with ANSES and INRAE.
Subjects: Waste stabilization ponds, Environmental Engineering, Nematoda, Swine, MESH: Waste Management, MESH: Recycling, Incineration, Management, Monitoring, Policy and Law, MESH: Nematoda, Heat treatment, Waste Management, MESH: Incineration, Animals, Humans, Chlorination, Globodera, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Recycling, MESH: Animals, MESH: Chlorine, Waste Management and Disposal, MESH: Swine, MESH: Humans, Composting, Methanation, General Medicine, MESH: Refuse Disposal, Refuse Disposal, MESH: Cattle, Quarantine, Cattle, Chlorine, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, MESH: Quarantine
Abstract: International audience; Seen as an integral part of sustainable development, circular economy represents a model of production and consumption notably based on the limitation of both resource wastage and environmental impact. Laboratories and commercial companies working on plant pathogens, in particular quarantine species, must effectively disinfect their waste to avoid disseminating these organisms. The methods used for waste disinfection can however incur high energy costs or pose environmental and human health hazards. Here, we tested the effectiveness of five disinfection methods - chlorination, heat treatment, composting, mesophilic methanation and waste stabilization ponds - on plant-parasitic nematodes belonging to the genera Globodera and Meloidogyne. For the widely used chlorination and heat treatment methods, we showed that they can be very effective in inactivating nematodes at relatively low chlorine doses and temperatures (60 °C-3 min and 50 °C-30 min), respectively. For the three other disinfection methods tested, initially designed for waste recycling, we obtained different levels of efficiency. Composting and mesophilic methanation (based on cattle or pig slurry) both led to the complete elimination of nematodes, even for short treatment durations. However, waste stabilization ponds showed contrasting results, ranging from virtually no effect to high levels of inactivation of nematodes. Our study demonstrates that it is possible to use more environmentally friendly disinfection methods to control plant-parasitic nematodes. In particular, this finding paves the way towards the treatment of infected plant materials using composting or methanation, providing that disinfection is still reached under other (real-life) treatment conditions, especially with other kinds of waste. Both composting and methanation recycle and thus valorize infected waste; they are viable alternatives to landfilling or incineration, thereby demonstrating the usefulness of a circular economy approach.
Published: 2022

8. AraDiv: a dataset of functional traits and leaf hyperspectral reflectance of Arabidopsis thaliana

Author: Maria Stefania Przybylska, Cyrille Violle, Denis Vile, J. F. Scheepens, Benoit Lacombe, Xavier Le Roux, Lisa Perrier, Lou Sales-Mabily, Mariette Laumond, Mariona Vinyeta, Pierre Moulin, Gregory Beurier, Lauriane Rouan, Denis Cornet, François Vasseur, Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Université Paul-Valéry - Montpellier 3 (UPVM)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM), Écophysiologie des Plantes sous Stress environnementaux (LEPSE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, Goethe-University Frankfurt am Main, Institut des Sciences des Plantes de Montpellier (IPSIM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Laboratoire d'Ecologie Microbienne - UMR 5557 (LEM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Ecole Nationale Vétérinaire de Lyon (ENVL)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Amélioration génétique et adaptation des plantes méditerranéennes et tropicales (UMR AGAP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Agence National de la Recherche (ANR, European Research Council (ERC) Starting Grant Project 'Ecophysiological and biophysical constraints on domestication in crop plants' (Grant ERC-StG-2014- 639706-CONSTRAINTS, European Research Council (ERC) Starting Grant Project 'PHENOVIGOUR' (Grant ERC-StG-2020-949843), ANR-17-CE02-0018,AraBreed,Exploration des réponses évolutives des plantes à des changements environnementaux à la lumière des théories écologiques : un test expérimental chez l'espèce modèle Arabidopsis thaliana(2017), and European Project: 639706,H2020,ERC-2014-STG,CONSTRAINTS(2015)
Subjects: Statistics and Probability, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Library and Information Sciences, Statistics, Probability and Uncertainty, Computer Science Applications, Education, Information Systems
Abstract: Data from functional trait databases have been increasingly used to address questions related to plant diversity and trait-environment relationships. However, such databases provide intraspecific data that combine individual records obtained from distinct populations at different sites and, hence, environmental conditions. This prevents distinguishing sources of variation (e.g., genetic-based variation vs. phenotypic plasticity), a necessary condition to test for adaptive processes and other determinants of plant phenotypic diversity. Consequently, individual traits measured under common growing conditions and encompassing within-species variation across the occupied geographic range have the potential to leverage trait databases with valuable data for functional and evolutionary ecology. Here, we recorded 16 functional traits and leaf hyperspectral reflectance (NIRS) data for 721 widely distributed Arabidopsis thaliana natural accessions grown in a common garden experiment. These data records, together with meteorological variables obtained during the experiment, were assembled to create the AraDiv dataset. AraDiv is a comprehensive dataset of A. thaliana’s intraspecific variability that can be explored to address questions at the interface of genetics and ecology.
Published: 2023

9. Is a dissipation half-life of 5 years for chlordecone in soils of the French West Indies relevant?

Author: Pierre-Loïc Saaidi, Olivier Grünberger, Anatja Samouëlian, Yves Le Roux, Antoine Richard, Damien A. Devault, Cyril Feidt, Pierre Benoit, Olivier Evrard, Gwenaël Imfeld, Christophe Mouvet, Marc Voltz, Génomique métabolique (UMR 8030), Genoscope - Centre national de séquençage [Evry] (GENOSCOPE), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'étude des Interactions Sol - Agrosystème - Hydrosystème (UMR LISAH), Institut de Recherche pour le Développement (IRD)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Unité de Recherches Animal et Fonctionnalités des Produits Animaux (URAFPA), Université de Lorraine (UL)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Agrosystèmes tropicaux (ASTRO), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Universitaire de Formation et de Recherche de Mayotte (CUFR), Ecologie fonctionnelle et écotoxicologie des agroécosystèmes (ECOSYS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Géochimie Des Impacts (GEDI), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES), and Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)
Subjects: Dissipation, Chlordecone, Health, Toxicology and Mutagenesis, Environmental fate, Persistent organic pollutants, Modeling, Soils, General Medicine, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Toxicology, [CHIM.OTHE]Chemical Sciences/Other, Pollution
Abstract: International audience; Recently, Comte et al. (2022) re-examined the natural degradation of chlordecone (CLD) in the soils of the French West Indies (FWI) by introducing an additional ‘dissipation parameter’ into the WISORCH model developed by Cabidoche et al. (2009). Recent data sets of CLD concentrations in FWI soils obtained by Comte et al. enabled them optimizing the model parameters, resulting in significantly shorter estimates of pollution persistence than in the original model. Their conclusions jeopardize the paradigm of a very limited degradation of CLD in FWI soils, which may lead to an entire revision of the management of CLD contamination. However, we believe that their study is questionable on several important aspects. This includes potential biases in the data sets and in the modeling approach. It results in an inconsistency between the estimated dissipation half-life time (DT50) of five years that the authors determined for CLD and the fate of CLD in soil from the application period 1972–1993 until nowadays. Most importantly, a rapid dissipation of CLD in the field as proposed by Comte et al. is not sufficiently supported by data and estimates. Hence, the paradigm of long-term persistence of CLD in FWI soils is still to be considered.
Published: 2023

10. Grazing and ecosystem service delivery in global drylands

Author: Maestre, Fernando T., Le Bagousse-Pinguet, Yoann, Delgado-Baquerizo, Manuel, Eldridge, David J., Saiz, Hugo, Berdugo, Miguel, Gozalo, Beatriz, Ochoa, Victoria, Guirado, Emilio, García-Gómez, Miguel, Valencia, Enrique, Gaitán, Juan J., Asensio, Sergio, Mendoza, Betty J., Plaza, César, Díaz-Martínez, Paloma, Rey, Ana, Hu, Hang-Wei, He, Ji-Zheng, Wang, Jun-Tao, Lehmann, Anika, Rillig, Matthias C., Cesarz, Simone, Eisenhauer, Nico, Martínez-Valderrama, Jaime, Moreno-Jiménez, Eduardo, Sala, Osvaldo, Abedi, Mehdi, Ahmadian, Negar, Alados, Concepción L., Aramayo, Valeria, Amghar, Fateh, Arredondo, Tulio, Ahumada, Rodrigo J., Bahalkeh, Khadijeh, Ben Salem, Farah, Blaum, Niels, Boldgiv, Bazartseren, Bowker, Matthew A., Bran, Donaldo, Bu, Chongfeng, Canessa, Rafaella, Castillo-Monroy, Andrea P., Castro, Helena, Castro, Ignacio, Castro-Quezada, Patricio, Chibani, Roukaya, Conceição, Abel A., Currier, Courtney M., Darrouzet-Nardi, Anthony, Deák, Balázs, Donoso, David A., Dougill, Andrew J., Durán, Jorge, Erdenetsetseg, Batdelger, Espinosa, Carlos I., Fajardo, Alex, Farzam, Mohammad, Ferrante, Daniela, Frank, Anke S. K., Fraser, Lauchlan H., Gherardi, Laureano A., Greenville, Aaron C., Guerra, Carlos A., Gusmán-Montalvan, Elizabeth, Hernández-Hernández, Rosa M., Hölzel, Norbert, Huber-Sannwald, Elisabeth, Hughes, Frederic M., Jadán-Maza, Oswaldo, Jeltsch, Florian, Jentsch, Anke, Kaseke, Kudzai F., Köbel, Melanie, Koopman, Jessica E., Leder, Cintia V., Linstädter, Anja, le Roux, Peter C., Li, Xinkai, Liancourt, Pierre, Liu, Jushan, Louw, Michelle A., Maggs-Kölling, Gillian, Makhalanyane, Thulani P., Issa, Oumarou Malam, Manzaneda, Antonio J., Marais, Eugene, Mora, Juan P., Moreno, Gerardo, Munson, Seth M., Nunes, Alice, Oliva, Gabriel, Oñatibia, Gastón R., Peter, Guadalupe, Pivari, Marco O. D., Pueyo, Yolanda, Quiroga, R. Emiliano, Rahmanian, Soroor, Reed, Sasha C., Rey, Pedro J., Richard, Benoit, Rodríguez, Alexandra, Rolo, Víctor, Rubalcaba, Juan G., Ruppert, Jan C., Salah, Ayman, Schuchardt, Max A., Spann, Sedona, Stavi, Ilan, Stephens, Colton R. A., Swemmer, Anthony M., Teixido, Alberto L., Thomas, Andrew D., Throop, Heather L., Tielbörger, Katja, Travers, Samantha, Val, James, Valkó, Orsolya, van den Brink, Liesbeth, Ayuso, Sergio Velasco, Velbert, Frederike, Wamiti, Wanyoike, Wang, Deli, Wang, Lixin, Wardle, Glenda M., Yahdjian, Laura, Zaady, Eli, Zhang, Yuanming, Zhou, Xiaobing, Singh, Brajesh K., Gross, Nicolas, Universidad de Alicante, Instituto de Recursos Naturales y Agrobiología de Sevilla (IRNAS), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), University of New South Wales [Sydney] (UNSW), University of Zaragoza - Universidad de Zaragoza [Zaragoza], Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Université d'Alicante, Espagne (UA), Universidad Politécnica de Madrid (UPM), Chinese Academy of Agricultural Sciences (CAAS), Université Clermont Auvergne (UCA), Unité Mixte de Recherche sur l'Ecosystème Prairial - UMR (UREP), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), European Research Council, Generalitat Valenciana, Alexander von Humboldt Foundation, German Centre for Integrative Biodiversity Research, German Research Foundation, European Commission, Asia Foundation, Fundação para a Ciência e a Tecnologia (Portugal), Ministerio de Ciencia e Innovación (España), Comunidad de Madrid, Northern Arizona University, Consejo Nacional de Ciencia y Tecnología (México), Ministério da Ciência, Tecnologia e Inovação (Brasil), National Science Foundation (US), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil), National Research Foundation (South Africa), Federal Ministry of Education and Research (Germany), Natural Sciences and Engineering Research Council of Canada, Australian Research Council, Agencia Estatal de Investigación (España), Junta de Andalucía, National Natural Science Foundation of China, Universidad Nacional de Río Negro, Junta de Extremadura, Ferdowsi University of Mashhad, Environmental Investment Fund of Namibia, Taylor Family Foundation, Maestre, Fernando T., Delgado-Baquerizo, Manuel, Eldridge, David J., Sáiz, Hugo, Berdugo, Miguel, Gozalo, Beatriz, Ochoa, Victoria, Guirado, Emilio, García-Gómez, Miguel, Valencia, Enrique, Gaitán, Juan J., Deák, Balázs, Donoso, David, Dougill, Andrew, Erdenetsetseg, Batdegleg, Espinosa, Carlos Iván, Fajardo, Alex, Farzam, Mohammad, Ferrante, Daniela, Frank, Anke S. K., fraser, Lauchlan, Jeltsch, Florian, Gherardi, Laureano, Greenville, Aaron, Guerra, Carlos A., Gusmán Montalván, Elizabeth, Hernández Hernández, Rosa M., Huber-Sannwald, E., Hughes, Frederic M., Jadán-Maza, O., Jentsch, Anke, Kaseke, Kudzai Farai, Köbel, Melanie, Koopman, Jesica E., Leder, Cintia, Linstädter, Anja, Le Roux, Peter C., Liancourt, Pierre, Liu, Jushan, Munson, Seth M., Low, Michelle A., Maggs Kölling, Gillian, Makhalanyane, Thulani P.7, Malam Issa, Oumarou7, Manzaneda, Antonio J., Marais, Eugene, Mora, Juan P., Moreno, Gerardo, Nunes, Alice, Oliva, Gabriel, Oñatibia, Gastón, Peter, Guadalupe, Pivari, Marco O. D., Pueyo, Yolanda, Quiroga, R Emiliano, Reed, Sasha C., Rey, P.J., Teixido, Alberto L., Richard, Benoit, Rodríguez, Alexandra, Rolo, Víctor, Rubalcaba, Juan G., Salah, Ayman, Stavi, Ilan, Stephens, Colton R. A., Swemmer, Anthony, Thomas, Andrew, Throop, Heather L., Travers, Samantha, Val, James, Valkó, Orsolya, van den Brink, Liesbeth, Velasco Ayuso, Sergio, Velbert, Frederike, Wamiti, Wanyoike, Asencio, Sergio, Wang, Deli, Wang, Lixin, Wardle, Glenda M., Yahdjian, Laura, Zaady, Eli, Yuanming, Zhang, Singh, Brajesh K., Gross, Nicolas, Mendoza, Betty J., Plaza de Carlos, César, Rey, Ana, Hu, Hang-Wei, He, Ji-Zheng, Wang, Jun-Tao, Lehmann, Anika, Rillig, Matthias C., Cesarz, Simone, Eisenhauer, Nico, Martínez-Valderrama, Jaime, Moreno-Jiménez, Eduardo, Salas, O., Abedi, Mehdi, Ahmadian , Negar, Alados, Concepción L., Aramayo, Valeria, Amghar, Fateh, Arredondo, Tulio, Ahumada, Rodrigo J., Bahalkeh, Khadijeh, Salem, Farah Ben, Blaum, Niels, Boldgiv, Bazartseren, Browker, Matthew A., Bran, Donaldo, Bu, Chongfeng, Canessa, Rafaella, Castro, Helena, Castro, Ignacio, Castro-Quezada, Patricio, Conceição, Abel A., Currier, Courtney M., Darrouzet-Nardi, Anthony, Universidad de Alicante. Departamento de Ecología, Universidad de Alicante. Instituto Multidisciplinar para el Estudio del Medio 'Ramón Margalef', Laboratorio de Ecología de Zonas Áridas y Cambio Global (DRYLAB), Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), Universidad Rey Juan Carlos [Madrid] (URJC), Centre d'Études Biologiques de Chizé - UMR 7372 (CEBC), La Rochelle Université (ULR)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Repositório da Universidade de Lisboa
Subjects: Livestock, Multidisciplinary, Climate Change, Drylands, Systems, Wild, Biodiversity, 580 Plants (Botany), Soil, Grazing, [SDE]Environmental Sciences, Ecosystem services, Herbivory, Rangeland
Abstract: 7 páginas.- 4 figuras.- 32 referencias.- Supplementary materials: science.org/doi/10.1126/science.abq4062 Materials and Methods Figs. S1 to S19 Tables S1 to S28 References (33–269) MDAR Reproducibility Checklist Movie S1.- Grazing represents the most extensive use of land worldwide. Yet its impacts on ecosystem services remain uncertain because pervasive interactions between grazing pressure, climate, soil properties, and biodiversity may occur but have never been addressed simultaneously. Using a standardized survey at 98 sites across six continents, we show that interactions between grazing pressure, climate, soil, and biodiversity are critical to explain the delivery of fundamental ecosystem services across drylands worldwide. Increasing grazing pressure reduced ecosystem service delivery in warmer and speciespoor drylands, whereas positive effects of grazing were observed in colder and species-rich areas. Considering interactions between grazing and local abiotic and biotic factors is key for understanding the fate of dryland ecosystems under climate change and increasing human pressure. Copyright © 2022 the authors, Grazing represents the most extensive use of land worldwide. Yet its impacts on ecosystem services remain uncertain because pervasive interactions between grazing pressure, climate, soil properties, and biodiversity may occur but have never been addressed simultaneously. Using a standardized survey at 98 sites across six continents, we show that interactions between grazing pressure, climate, soil, and biodiversity are critical to explain the delivery of fundamental ecosystem services across drylands worldwide. Increasing grazing pressure reduced ecosystem service delivery in warmer and species-poor drylands, whereas positive effects of grazing were observed in colder and species-rich areas. Considering interactions between grazing and local abiotic and biotic factors is key for understanding the fate of dryland ecosystems under climate change and increasing human pressure. Copyright © 2022 the authors, Funding: This research was funded by the European Research Council [ERC grant agreement 647038 (BIODESERT)] and Generalitat Valenciana (CIDEGENT/2018/ 041). F.T.M. acknowledges support from a Rei Jaume I Award, the Alexander von Humboldt Foundation, and the Synthesis Center (sDiv) of the German Centre for Integrative Biodiversity Research Halle–Jena–Leipzig (iDiv). C.A.G., S.C., and N.E. acknowledge support from iDiv and the Deutsche Forschungsgemeinschaft (DFG– FZT 118, 202548816; Flexpool proposal 34600850). Y.L.B.-P. was supported by a Marie Sklodowska-Curie Actions Individual Fellowship (MSCA-IF) within the European Program Horizon 2020 (DRYFUN Project 656035). N.G. was supported by CAP 20-25 (16-IDEX-0001) and the AgreenSkills+ fellowship program, which has received funding from the EU’s Seventh Framework Programme under grant agreement N° FP7-609398 (AgreenSkills+ contract). B.B. and B.E. were supported by the Taylor Family–Asia Foundation Endowed Chair in Ecology and Conservation Biology. J.D., A.Ro., and H.C. acknowledge support from the Fundação para a Ciência e a Tecnologia (IF/00950/ 2014 and 2020.03670.CEECIND, SFRH/BDP/108913/2015, and in the scope of the framework contract foreseen in the numbers 4-6 of the article 23, of the Decree-Law 57/2016, August 29, changed by Law 57/2017, July 19, respectively), as well as from the MCTES, FSE, UE, and the CFE (UIDB/04004/2020) research unit financed by Fundação para a Ciência e a Tecnologia/MCTES through national funds (PIDDAC). C.P. acknowledges support from the Spanish Ministry of Science and Innovation (ref. AGL201675762-R, AEI/FEDER, UE, and PID2020-116578RB-I00, MCIN/AEI/10.13039/501100011033) and the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement no. 101000224. E.V. was funded by the 2017 program for attracting and retaining talent of Comunidad de Madrid (no. 2017‐T2/ AMB‐5406). M.A.B. acknowledges support from the School of Forestry and College of the Environment, Forestry and Natural Sciences of Northern Arizona University. E.H.-S. acknowledges support from the Consejo Nacional de Ciencia y Tecnología (SEP-CB-2015-01-251388, PN 2017-5036 and PRONAII 319059). F.M.H. acknowledges support from the National Council for Scientific and Technological Development (CNPq - PCI/INMA) of the Brazilian Ministry of Science, Technology and Innovation (MCTI, processes number 302381/2020-1). H.L.T. acknowledges support from the US National Science Foundation (NSF) (DEB 0953864). A.N. and M.K. acknowledge support from the Fundação para a Ciência e a Tecnologia (SFRH/BD/130274/2017, CEECIND/02453/2018/CP1534/CT0001, PTDC/ASP-SIL/7743/2020 and UIDB/00329/2020). A.A.C. acknowledges support from the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001. J.E.K. and T.P.M. acknowledge the National Research Foundation of South Africa (grant no. 114412). F.J. and N.B. acknowledge support from the German Federal Ministry of Education and Research (BMBF) in the framework of the SPACES projects OPTIMASS (FKZ: 01LL1302A) and ORYCS (FKZ:01LL1804A). A.Li. and A.S.K.F. acknowledge support from the German Federal Ministry of Education and Research (BMBF) in the framework of the SPACES projects Limpopo Living Landscapes (FKZ: 01LL1304D) and SALLnet (FKZ: 01LL1802C). L.W. acknowledges support from the US NSF (EAR 1554894). L.H.F. acknowledges support from the Natural Sciences and Engineering Research Council of Canada Industrial Research Chair Program in Ecosystem Reclamation. S.C.R. acknowledges support from the US Geological Survey Ecosystems Mission Area and the US Bureau of Land Management. G.M.W. acknowledges support from the Australian Research Council. L.v.d.B. and K.T. acknowledge support from the German Research Foundation (DFG) priority research program SPP-1803 “EarthShape: Earth Surface Shaping by Biota” (TI 338/14-1). M.D.-B. acknowledges support from the Spanish Ministry of Science and Innovation for the I+D+i project PID2020-115813RA-I00 funded by MCIN/AEI/10.13039/501100011033. M.D.-B. is also supported by a project of the Fondo Europeo de Desarrollo Regional (FEDER) and the Consejería de Transformación Económica, Industria, Conocimiento y Universidades of the Junta de Andalucía (FEDER Andalucía 2014-2020 Objetivo temático “01 - Refuerzo de la investigación, el desarrollo tecnológico y la innovación”) associated with the research project P20_00879 (ANDABIOMA). P.J.R. and A.J.M. acknowledge support from Fondo Europeo de Desarrollo Regional through the FEDER Andalucía operative program, FEDER-UJA 1261180 project. A.F. thanks ANID PIA/BASAL FB210006 and Millennium Science Initiative Program NCN2021-050. A.J. acknowledges support from the Bavarian Research Alliance Germany (BayIntAn_UBT_2017_61). C.B. acknowledges the National Natural Science Foundation of China (grant no. 41971131). Biodiversity and ecosystem function research in the B.K.S. laboratory is funded by the Australian Research Council (DP210102081). Any use of trade, product, or firm names in this paper is for descriptive purposes only and does not imply endorsement by the US government. H.S. is supported by a María Zambrano fellowship funded by the Ministry of Universities and European Union-Next Generation plan. G.P. and C.V.L. acknowledge support from Universidad Nacional de Río Negro (PI 40-C-873 and 654). V.R. acknowledges support from the Regional Government of Extremadura (Spain) through a “Talento” fellowship (TA18022). M.F. acknowledges support from the Department of Range and Watershed Management, Ferdowsi University of Mashhad, Mashhad, Iran. Participation of recent graduates in collecting field data at four sites in Namibia was supported by a capacity building grant to Gobabeb–Namib Research Institute by the Environmental Investment Fund in Namibia.
Published: 2022

11. Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma

Author: Rana Salam, Alexa Saliou, Franck Bielle, Mathilde Bertrand, Christophe Antoniewski, Catherine Carpentier, Agusti Alentorn, Laurent Capelle, Marc Sanson, Emmanuelle Huillard, Léa Bellenger, Justine Guégan, Isabelle Le Roux, Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de Neuropathologie [CHU Pitié Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Service Production et Analyse de données en Sciences de la vie et en Santé (PASS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Institut Français de Bioinformatique (IFB-CORE), Institut National de Recherche en Informatique et en Automatique (Inria)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Service de Neurologie [CHU Pitié-Salpêtrière], IFR70-CHU Pitié-Salpêtrière [AP-HP], LE ROUX, Isabelle, CHU Charles Foix [AP-HP], CNRS, INSERM, ICM, Ligue Contre le Cancer, comité île de France, Fondation ARC pour la recherche sur la Cancer, SIRIC-CURAMUS, and Ligue Nationale Contre le Cancer
Subjects: [SDV] Life Sciences [q-bio], Multidisciplinary, Brain Tumor, [SDV]Life Sciences [q-bio], General Physics and Astronomy, Microenvironnement Tumoral, scRNAseq, General Chemistry, Senescence, Mice model, General Biochemistry, Genetics and Molecular Biology
Abstract: Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, yet it remains refractory to systemic therapy. Elimination of senescent cells has emerged as a promising new treatment approach against cancer. Here, we investigated the contribution of senescent cells to GBM progression. Senescent cells are identified in patient and mouse GBMs. Partial removal of p16Ink4a-expressing malignant senescent cells, which make up less than 7 % of the tumor, modifies the tumor ecosystem and improves the survival of GBM-bearing female mice. By combining single cell and bulk RNA sequencing, immunohistochemistry and genetic knockdowns, we identify the NRF2 transcription factor as a determinant of the senescent phenotype. Remarkably, our mouse senescent transcriptional signature and underlying mechanisms of senescence are conserved in patient GBMs, in whom higher senescence scores correlate with shorter survival times. These findings suggest that senolytic drug therapy may be a beneficial adjuvant therapy for patients with GBM.
Published: 2022

12. Préface (La Construction de l’État monarchique en France de 1370 à 1715)

Author: Le Roux, Nicolas, Le Roux, Nicolas, and NICOLAS LE ROUX
Subjects: Histoire moderne -- 17e siècle, Histoire du 16e siècle, [SHS.HIST] Humanities and Social Sciences/History, Etat France
Abstract: De quoi l’État monarchique est-il fait ? D’institutions, assurément, ainsi que de multiples acteurs, individuels comme collectifs, identifiables comme invisibles, qui incarnent et dépassent ces institutions, participent – par leur action ou leur statut – au gouvernement du royaume et influent sur la conception, l’exercice et la représentation du pouvoir royal. Cet État monarchique ne constitue néanmoins nullement l’aboutissement mais le cœur même d’un processus, aussi peu linéaire que multiforme qui, prenant ses origines au Moyen Âge, devient, à l’époque moderne, une réalité tangible. L’historiographie a qualifié cette dernière d’État moderne, de monarchie administrative, de monarchie absolue ou encore de monarchie de papier et, à partir de sources inédites, les contributions de ce volume viennent la questionner, l’analyser et la reconstruire. Loin de constituer un objet figé, l’État monarchique prend ainsi forme dans des dynamiques permanentes de structuration, de spécialisation ou encore de négociation, qui lui permettent de se détacher progressivement de la seule figure du roi et de mieux maîtriser la diversité de son territoire comme de sa population.
Published: 2022

13. Une princesse intolérante ? Catherine de Médicis aux états généraux de Blois (1576-1577)

Author: Le Roux, Nicolas, Le Roux, Nicolas, Caroline Callard, Tatiana Debbagi Baranova, and Nicolas Le Roux
Subjects: Etats généraux, [SHS.HIST] Humanities and Social Sciences/History, Guerres de Religion 1562-1629, [SHS] Humanities and Social Sciences, Catherine de Medicis, Henri III
Published: 2022

14. Avant-propos. Faire œuvre d’historien : l’énigme Denis Crouzet

Author: Le Roux, Nicolas, Callard, Caroline, Debbagi Baranova, Tatiana, Le Roux, Nicolas, Caroline Callard, Tatiana Debbagi Baranova, and Nicolas Le Roux
Subjects: Historiographie -- France -- 16e siècle, Denis Crouzet, [SHS.HIST] Humanities and Social Sciences/History, Guerres de Religion 1562-1629, [SHS] Humanities and Social Sciences, Histoire du XVIe siècle
Published: 2022

15. Relevance of Howell‐Jolly body counts for measuring spleen function in sickle cell disease

Author: Charlotte Pourdieu, Sara El Hoss, Enora Le Roux, Justine Pages, Bérengère Koehl, Florence Missud, Laurent Holvoet, Ghislaine Ithier, Malika Benkerrou, Zinedine Haouari, Lydie Da Costa, Wassim El Nemer, Sandrine Laurance, Yves Colin Aronovicz, Caroline Le Van Kim, Odile Fenneteau, Elodie Lainey, Valentine Brousse, AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université (SU), King‘s College London, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), and Etablissement Français du Sang Provence-Alpes Côte-d'Azur et Corse (EFS)
Subjects: [SDV]Life Sciences [q-bio], Hematology
Published: 2023

16. The Arabidopsis transcription factor NLP2 regulates early nitrate responses and integrates nitrate assimilation with energy and carbon skeleton supply

Author: Mickaël Durand, Virginie Brehaut, Gilles Clement, Zsolt Kelemen, Julien Macé, Regina Feil, Garry Duville, Alexandra Launay-Avon, Christine Paysant-Le Roux, John E Lunn, François Roudier, Anne Krapp, Reproduction et développement des plantes (RDP), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), ANR-14-CE19-0008,IMANA,Identification de régulations moléculaires majeures impliquées dans l'adaptation des plantes à la disponibilité en azote(2014), and European Project
Subjects: [SDV]Life Sciences [q-bio], Cell Biology, Plant Science
Abstract: Nitrate signaling improves plant growth under limited nitrate availability and, hence, optimal resource use for crop production. Ongoing work has identified several transcriptional regulators of nitrate signaling, including the Arabidopsis thaliana transcription factor NIN-LIKE PROTEIN 7 (NLP7), but additional regulators likely remain to be identified. Here, we characterized Arabidopsis NLP2 as a master upstream transcriptional regulator of early nitrate responses that interacts with NLP7 in vivo and shares key molecular features such as nitrate-dependent nuclear localization, a DNA binding motif, and some target genes with NLP7. Additional genetic, genomic and metabolic approaches revealed a specific role for NLP2 in the nitrate-dependent regulation of carbon and energy-related processes that likely influence plant growth under distinct nitrogen environments. Our findings highlight the complementarity and specificity of NLP2 and NLP7 in orchestrating a multi-tiered nitrate regulatory network that links nitrate assimilation with carbon and energy metabolism for efficient nitrogen use and biomass production.One-sentence summaryNLP2 and NLP7 orchestrate plant responses to nitrate supply and control nitrate- dependent regulation of carbon and energy metabolism.
Published: 2023

17. Synchronie entre l'offre et la demande dans le cycle des nutriments: apprendre des écosystèmes naturels pour construire des agrosystèmes durables

Author: Fontaine, Sébastien, Abbadie, Luc, Aubert, Michaël, Barot, Sébastien, Bloor, Juliette, Derrien, Delphine, Duchene, Olivier, Gross, Nicolas, Henneron, Ludovic, Le Roux, Xavier, Loeuille, Nicolas, Michel, Jennifer, Recous, Sylvie, Wipf, Daniel, Alvarez, Gaël, Unité Mixte de Recherche sur l'Ecosystème Prairial - UMR (UREP), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut d'écologie et des sciences de l'environnement de Paris (iEES Paris ), Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Département écologie et biodiversité des milieux forestiers, prairiaux et aquatiques (ECODIV), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de recherche Biogéochimie des Ecosystèmes Forestiers (BEF), Agroécologie et Environnement (AGE), Isara, Universidad Rey Juan Carlos [Madrid] (URJC), Centre d'Études Biologiques de Chizé - UMR 7372 (CEBC), La Rochelle Université (ULR)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Etude et Compréhension de la biodiversité (ECODIV), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Laboratoire d'Ecologie Microbienne - UMR 5557 (LEM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Ecole Nationale Vétérinaire de Lyon (ENVL)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Liège, Fractionnement des AgroRessources et Environnement (FARE), Université de Reims Champagne-Ardenne (URCA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Agroécologie [Dijon], Université de Bourgogne (UB)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Dijon, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), and Fontaine, Sébastien
Subjects: [SDV.SA.AGRO] Life Sciences [q-bio]/Agricultural sciences/Agronomy, agroecology, [SDV.SA.AGRO]Life Sciences [q-bio]/Agricultural sciences/Agronomy, nutrient cycling, carbon cycling, ecosystem nutrient economy, [SDV.SA.SDS]Life Sciences [q-bio]/Agricultural sciences/Soil study, mimicking, soil carbon sequestration, [SDV.EE.ECO]Life Sciences [q-bio]/Ecology, environment/Ecosystems, litter, nitrogen fixation, soil organic matter, soil nutrient dissolution, [SDV.EE.ECO] Life Sciences [q-bio]/Ecology, environment/Ecosystems, organic nutrient reserve, [SDV.SA.SDS] Life Sciences [q-bio]/Agricultural sciences/Soil study, rhizosphere, plant-soil interactions, feedbacks
Abstract: Redesigning agrosystems with more ecological regulations can help feed a growing population, preserve soils for future productivity and reduce environmental impacts. However, guidelines for redesigning agrosystems from natural systems are limited. Reviewing the last knowledge of ecosystem functioning, we outlined four ecological systems synchronizing the supply of soluble nutrients by soil biota to fluctuating plant nutrient demand. This synchrony limits deficiencies and excesses of soluble nutrient, which usually penalize both production and regulating services of agrosystems such as nutrient retention and soil carbon storage. We detail how ecological systems promoting synchrony can be installed in agrosystems to improve their sustainability and reduce the use of mineral fertilizers.
Published: 2023

18. Comment on: amanitin intoxication

Author: Morgane Cellier, Jérémy Lecot, Chloe Bruneau, Marie Deguigne, Marc Fadel, Gaël Le Roux, Alexis Descatha, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hofstra University [Hempstead], and TEC-TOP for AD and MC (Pays de la Loire Region, Angers Loire Metropole, University of Angers, CHU Angers)
Subjects: [SDV]Life Sciences [q-bio], General Medicine, Toxicology
Abstract: International audience
Published: 2023

19. Organic Micropollutants Removal through Performic Acid-UV Photolysis: kinetics and wastewater matrix influence

Author: Nabintu Kajoka, Christelle, Brosillon, S., Gasperi, Johnny, Oliveira, Marcos, Rocher, Vincent, Chebbo, Ghassan, Le Roux, Julien, and Gasperi, Johnny
Subjects: [SDE] Environmental Sciences, [CHIM] Chemical Sciences
Published: 2023

20. Grapevine yield gap: identification of environmental limitations by soil and climate zoning in the region of Languedoc-Roussillon (South of France)

Author: Fernandez-Mena, Hugo, Guilpart, Nicolas, Lagacherie, Philippe, Le Roux, Renan, Plaige, Mayeul, Dumont, Maxime, Gautier, Marine, Graveline, Nina, Touzard, Jean-Marc, Hannin, Hervé, Gary, Christian, Agrosystèmes Biodiversifiés (UMR ABSys), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre International de Hautes Etudes Agronomiques Méditerranéennes - Institut Agronomique Méditerranéen de Montpellier (CIHEAM-IAMM), Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Environnement Méditerranéen et Modélisation des Agro-Hydrosystèmes (EMMAH), Avignon Université (AU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Agronomie, AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire d'étude des Interactions Sol - Agrosystème - Hydrosystème (UMR LISAH), Institut de Recherche pour le Développement (IRD)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Agroclim (AGROCLIM), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Technologies et Méthodes pour les Agricultures de demain (UMR ITAP), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Innovation et Développement dans l'Agriculture et l'Alimentation (UMR Innovation), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Montpellier Interdisciplinary center on Sustainable Agri-food systems (Social and nutritional sciences) (UMR MoISA), and Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Centre International de Hautes Etudes Agronomiques Méditerranéennes - Institut Agronomique Méditerranéen de Montpellier (CIHEAM-IAMM)
Subjects: climate change, classification, terroir, cartography, [SDV.SA.AEP]Life Sciences [q-bio]/Agricultural sciences/Agriculture, economy and politics, viticulture, mapping, big-data
Abstract: International audience; Often unable to fulfill theoretical production potentials and to obtain the maximum yields set by wine quality labels, many vineyards and cellars need to solve the issue of so-called grapevine yield gaps in order to assure their durability. These yield gaps particularly occur in Mediterranean wine regions, where extreme events have intensified because of climate change. Yield gaps at the regional level have been widely studied in arable crops using big datasets, but much less so in perennial crops, such as grapevine. Understanding the environmental factors involved in yield gaps, such as those linked to climate and soil, is the first step in grapevine yield gap analysis. At a regional scale, there are numerous studies on 'terroir' linked to wine typicity and quality; however, none have classified spatial zones based on environmental factors identified as being involved in grapevine yield. In the present study, we aggregated into one big dataset information obtained from producers at the municipality level in the wine region Languedoc-Roussillon (South of France) between 2010 and 2018. We used a backward stepwise model selection process using linear mixed-effect models to discriminate and select the statistically significant indicators capable of estimating grapevine yield at the municipality level. We then determined spatial zones by using the selected indicators to create clusters of municipalities with similar soil and climate characteristics. Finally, we analysed the indicators of each zone related to the grapevine yield gap, as well as the variations among the grapevine varieties in the zones. Our selection process evidenced 6 factors that could explain annual grapevine yield annually (R 2 = 0.112) and average yield for the whole period (R 2 = 0.546): Soil Available Water Capacity (SAWC), soil pH, Huglin Index, the Climate Dryness Index, the number of Very Hot Days and Days of Frost. The clustering results show seven different zones with two marked yield gap levels, although all the zones had municipalities with no or high yield gaps. On each zone, grapevine yield was found to be driven by a combination of climate and soil factors, rather than by a single environmental factor. The white wine varieties showed larger yield gaps than the red and rosé wine varieties. Environmental factors at this scale largely explained yield variability across the municipalities, but they were not performant in terms of annual yield prediction. Further research is required on the interactions between environmental variables and plant material and farming practices, as well as on vineyard strategies, which also play an important role in grapevine yield gaps at vineyard and regional scale.
Published: 2023

21. Effect of process parameters of Plain Water Jet on the cleaning quality, surface and material integrity of Inconel 718 milled by Abrasive Water Jet

Author: L. Cano-Salinas, X. Sourd, K. Moussaoui, S. Le Roux, M. Salem, A. Hor, R. Zitoune, Institut Clément Ader (ICA), Institut Supérieur de l'Aéronautique et de l'Espace (ISAE-SUPAERO)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi), and Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)
Subjects: [SPI]Engineering Sciences [physics], Water jet machining, Mechanics of Materials, Inconel 718, Erosion, Mechanical Engineering, Residual stress, Surfaces and Interfaces, Texture, Grit embedment, Surfaces, Coatings and Films
Abstract: International audience; Abrasive Water Jet (AWJ) is considered as a promising milling method for difficult-to-machine aeronautical materials as Inconel alloy 718 (IN718). However, grit embedment during AWJ is known as a detrimental effect on certain applications as aircraft repair, where surface condition may play an important role on additive material technologies. To overcome this problem, Plain Water Jet (PWJ) has been used in the present study as cleaning process and demonstrated to be an effective method to remove grit particles from the surface with marginal alterations of surface state. In this paper, firstly the influence of AWJ process parameters on abrasive embedment and surface texture on IN718 specimens milled by AWJ were addressed. Then these surfaces were subjected to PWJ cleaning process and were extensively characterized in terms of grit embedment, surface texture and roughness, erosion depth, microhardness and residual stresses. Before cleaning, the milled surfaces presented a grit embedment level varying between 7 % and 14 %. One setting condition was selected for performing PWJ cleaning which reduced the grit level up to a quarter of the initial total surface area (less than 4 % in all cleaned surfaces) without relatively modifying neither the surface texture nor the erosion depth. Comparable microhardness gradients were observed before and after PWJ cleaning which corresponded to ∼ 30 % higher than the bulk values at surface and then decreased beneath the surface up to 200 µm before to reach bulk value (∼ 245 HV). Compressive residual stress state at surface initially induced by AWJ milling in some surfaces remained unchanged after PWJ process but in other ones was slightly relieved (∼ 50 MPa). Residual stresses after PWJ process resulted from − 630 MPa to – 315 MPa depending on the milling process parameters.
Published: 2023

22. Deep learning for archaeological wood charcoal classification : first results and perspectives

Author: Corneli, Marco, Coli, Vanna Lisa, Le Roux, Quentin, Puech, Elysandre, Théry-Parisot, Isabelle, Culture et Environnements, Préhistoire, Antiquité, Moyen-Age (CEPAM), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Analyse fonctionnelle pour la conception et l'analyse de systèmes (FACTAS), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Université Côte d'Azur (UCA), and University of the Witwatersrand [Johannesburg] (WITS)
Subjects: [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, [MATH]Mathematics [math], [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI], [SHS]Humanities and Social Sciences
Abstract: International audience
Published: 2022

23. Ensuring the safety of laying hen rearing on organochlorine-contaminated soils: evaluation of amendment strategies using biochar and activated carbon

Author: Feidt, Cyril, Le Roux, Yves, Fournier, Agnès, El Wanny, Nadine, Woignier, Thierry, Delannoy, Matthieu, Unité de Recherches Animal et Fonctionnalités des Produits Animaux (URAFPA), Université de Lorraine (UL)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Faculty of Public Health [Lebanese University] (FSP III), Lebanese University [Beirut] (LU), Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), ADEME, CPSN - comité de pilotage scientifique national chlordécone, PIEGEACHLOR, ANR-16-CE21-0008,INSSICCA,Stratégies innovantes pour sécuriser les systèmes d'élevage dans les zones contaminées par la chlordécone. Une approche modèle développée dans les Antilles et applicable dans les zones contaminées à l'échelle mondiale(2016), DELANNOY, Matthieu, and Stratégies innovantes pour sécuriser les systèmes d'élevage dans les zones contaminées par la chlordécone. Une approche modèle développée dans les Antilles et applicable dans les zones contaminées à l'échelle mondiale - - INSSICCA2016 - ANR-16-CE21-0008 - AAPG2016 - VALID
Subjects: [SDV.SA.AGRO] Life Sciences [q-bio]/Agricultural sciences/Agronomy, [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, [SDE.IE]Environmental Sciences/Environmental Engineering, laying hens, [SDV.BA.MVSA] Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, [SDV.SA.AGRO]Life Sciences [q-bio]/Agricultural sciences/Agronomy, sequestration, [SDV.SA.ZOO]Life Sciences [q-bio]/Agricultural sciences/Zootechny, [SDV.TOX.TCA]Life Sciences [q-bio]/Toxicology/Toxicology and food chain, [SDV.SA.SDS]Life Sciences [q-bio]/Agricultural sciences/Soil study, Poule Pondeuse, Biochar, [SDV.TOX.TCA] Life Sciences [q-bio]/Toxicology/Toxicology and food chain, [SDV.SA.SPA]Life Sciences [q-bio]/Agricultural sciences/Animal production studies, organochlorines, [SDE.IE] Environmental Sciences/Environmental Engineering, [SDV.SA.SPA] Life Sciences [q-bio]/Agricultural sciences/Animal production studies, Séquestration, [SDV.SA.SDS] Life Sciences [q-bio]/Agricultural sciences/Soil study, [SDV.SA.ZOO] Life Sciences [q-bio]/Agricultural sciences/Zootechny, Chlordécone, Organochlorés
Abstract: Organochlorine pollutants are particularly well known for their persistence and the soil appears to be the perennial reservoir of these historical contaminations. If chlordecone (CLD) is an obvious example in the French West Indies, PCBs, PCDD/Fs are the counterpart in mainland France. Particularly bioavailable, these pollutants undermine open-air breeding systems by degrading the chemical safety of the food produced. To reduce the exposure of animals, the amendment of contaminated soils with porous matrices, such as biochars (BC) and activated carbons (AC), may prove to be an effective strategy. However, there is currently little literature linking the impact of pollutant and biochar characteristics on the efficiency of this sequestration strategy.In this study, the respective effectiveness of 3 biochars and 3 activated carbons was evaluated by amending 2% (by mass) of OECD-contaminated soils with either (i) CLD or (ii) a mixture of PCBs and PCDD/Fs. The profiles and concentrations applied to these soils were chosen to correspond to typical cases found in the French West Indies (for CLD) or on a polluted site in France (PCB and PCDD/F mixture). After maturation for 3 months, these soils were introduced into the feed distributed to laying hens (up to 10%) for 21 days. The eggs collected on the last three days of exposure were then analysed (n = 3) for CLD, PCB and PCDD/F. The porosity of the carbonaceous materials and the physicochemical characteristics of the molecules were then related to the results obtained.No significant reduction in transfer was observed when the 3 biochars or the granular CA were used. However, a significant reduction was observed when the two powdered activated carbons were used. This was even more pronounced for PCDD/F and PCB-DL, which showed a reduction of 79-82% (TEQ basis) in the eggs. For CLD and PCB-NDL, only a slight reduction in concentrations was obtained with these activated carbons: 26-33% and 20-72% respectively. By relating these results to the characteristics of the porous materials and those of the molecules, this difference can be explained mainly by the distribution of porosity of the materials. Thus a positive correlation between the relative surface area of the pores between 0-3nm and 4.4 and 20nm and the reduction of the concentrations was observed. More moderately, the results are also explained by the characteristics of the molecules, the log Kow, the conformation of the molecules illustrating the observed hierarchy of sequestration efficiency: heavy PCDD/F > light PCDD/F > PCB 77 > PCB-NDL = CLDIn summary, (i) biochars were not found to be effective in reducing the transfer of halogenated pollutants to animals, (ii) CA powder amendments reduced the bioavailability of POPs in the soil, and (iii) the effectiveness of such a strategy therefore depends on both the characteristics of the matrix and the pollutants, Les polluant organochlorés sont particulièrement reconnus pour leur persistance et le sol apparaît comme le réservoir pérenne de ces contaminations historiques. Si la chlordécone (CLD) en est un exemple évident aux Antilles françaises, les PCB, PCDD/F en sont le pendant pour la Métropole. Particulièrement biodisponibles, ces polluants mettent à mal les systèmes d’élevage en plein air en dégradant la sureté chimique des denrées produites. Pour diminuer l’exposition des animaux, l'amendement des sols contaminés par des matrices poreuses, comme les biochars (BC) et les charbons actifs (CA), peut s’avérer être une stratégie efficace. Actuellement, peu de littérature permet toutefois de lier l’impact des caractéristiques des polluants et des biochars sur l’efficience de cette stratégie de séquestration.Dans cette étude, l'efficacité respective de 3 biochars et 3 charbons actifs a été évaluée en amendant à hauteur de 2% (en masse) des sols OCDEcontaminés par soit (i) de la CLD, soit (ii) un mélange de PCB et PCDD/F. Les profils et les concentrations appliqués sur ces sols ont été choisis pour qu’ils correspondent à des cas typiques retrouvés aux Antilles françaises (pour le CLD) ou sur un site pollué métropolitain (mélange PCB et PCDD/F). Après une maturation de 3 mois ces sols ont été introduits dans l’alimentation distribuée aux poules pondeuses (à hauteur de 10%) durant 21 jours. Les œufs collectés les trois derniers jours d’exposition ont ensuite été analysés (n = 3) pour déterminer les teneurs en CLD, PCB et PCDD/F. La porosité des matériaux carbonés et les caractéristiques physico-chimiques des molécules ont ensuite été mises en relation avec les résultats obtenus.Aucune réduction significative du transfert n'a été observée lorsque les 3 biochars ou le CA sous forme de granulés ont été utilisés. Une réduction significative a été toutefois mise en évidence quand les deux charbons actifs sous forme de poudre ont été utilisés. Cela a été d’autant plus marqué pour les PCDD/F et PCB-DL qui présentaient une réduction de 79-82% (base TEQ) dans les œufs. Pour la CLD et les PCB-NDL, seule une légère réduction des concentrations a été obtenue avec ces charbons actifs : 26-33% et 20-72%respectivement. En mettant en relation ces résultats avec les caractéristiques des matériaux poreux et celles des molécules, cette différence peut s’expliquer principalement par la distribution de porosité des matériaux. Ainsi une corrélation positive entre la surface relative des pores entre 0-3nm et 4,4 et 20nm et la réduction des concentrations a été observées. Plus modérément les résultats s’expliquent aussi par les caractéristiques des molécules, le log de Kow, la conformation des molécule illustrant la hiérarchie d’efficacité de séquestration observée : PCDD/F lourds > PCDD/F légers > PCB 77 > PCB-NDL = CLDEn synthèse, (i) les biochars ne se sont pas avérés efficaces pour réduire le transfert de polluants halogénés vers les animaux, (ii) les amendements en poudre de CA ont permis de réduire la biodisponibilité des POP présents dans le sol, et (iii) l'efficacité d'une telle stratégie dépend donc à la fois des caractéristiques de la matrice et des polluants.
Published: 2022

24. Socio-Economic Variations Determine the Clinical Presentation, Aetiology and Outcome of Infective Endocarditis: a Prospective Cohort Study from the ESC-EORP EURO-ENDO (European Infective Endocarditis) Registry

Author: Sengupta, Shantanu P, Prendergast, Bernard, Laroche, Cécile, Furnaz, Shumaila, Ronderos, Ricardo, Almaghraby, Abdallah, Asch, Federico M, Blechova, Kamila, Zaky, Hosam, Strahilevitz, Jacob, Dworakowski, Rafal, Miyasaka, Yoko, Sebag, Igal, Izumi, Chisato, Axler, Olivier, Jamiel, Abdulrahman, Philip, Mary, Campos Vieira, Marcelo Luiz, Lancellotti, Patrizio, Habib, Gilbert, P Gale, C, Beleslin, B, Budaj, A, Chioncel, O, Dagres, N, Danchin, N, Emberson, J, Erlinge, D, Glikson, M, Gray, A, Kayikcioglu, M, P Maggioni, A, K Nagy, V, Nedoshivin, A, A-S, Petronio, Roos-Hesselink, J, Wallentin, L, Zeymer, U, Habib, G, Lancellotti, P, Cosyns, B, Donal, E, Erba, P, Iung, B, A Popescu, B, Prendergast, B, Tornos, P, Andarala, M, Berle, C, Brunel-Lebecq, A, Fiorucci, E, Laroche, C, Missiamenou, V, Taylor, C, N Ali Tatar-Chentir, N, Al-Mallah, M, M Astrom Aneq, Athanassopoulos, G, P Badano, L, Benyoussef, S, E Calderon Aranda, M Cardim, N, K-L, Chan, Cruz, I, Edvardsen, T, Goliasch, G, Hagendorff, A, Hristova, K, Kamp, O, D-H, Kang, Kong, W, Matskeplishvili, S, Meshaal, M, Mirocevic, M, N Neskovic, A, Pazdernik, M, Plonska-Gosciniak, E, Raissouni, M, Ronderos, R, E Sade, L, Sadeghpour, A, Sambola, A, Sengupta, S, Separovic-Hanzevacki, J, Takeuchi, M, Tucay, E, C Tude Rodrigues, A, Varga, A, Vaskelyte, J, Yamagata, K, Yiangou, K, Zaky, H, Granada, I, Mahia, M, Ressi, S, Nacinovich, F, Iribarren, A, P Fernandez Oses, Avegliano, G, Filipini, E, Obregon, R, Bangher, M, Dho, J, Cartasegna, L, L Plastino, M, Novas, V, Shigel, C, Reyes, G, M De Santos, Gastaldello, N, M Granillo Fernandez, Potito, M, Streitenberger, G, Velazco, P, H Casabé, J, Cortes, C, Guevara, E, Salmo, F, Seijo, M, Weidinger, F, Heger, M, Brooks, R, Stöllberger, C, C-Y, Ho, Perschy, L, Puskas, L, Binder, C, Rosenhek, R, Schneider, M, M-P, Winter, Hoffer, E, Melissopoulou, M, Lecoq, E, Legrand, D, Jacquet, S, Massoz, M, Pierard, L, Marchetta, S, Dulgheru, R, D Emal, C, Oury, C, Droogmans, S, Kerkhove, D, Plein, D, Soens, L, Weytjens, C, Motoc, A, Roosens, B, Lemoine, I, Rodrigus, I, Paelinck, B, Amsel, B, Unger, P, Konopnicki, D, Beauloye, C, Pasquet, A, L Vanoverschelde, J, Pierard, S, Vancraeynest, D, Sinnaeve, F, L Andrade, J, Staszko, K, R Dos Santos Monteiro, H Miglioranza, M, L Shuha, D, Alcantara, M, Cravo, V, Fazzio, L, Felix, A, Iso, M, Musa, C, P Siciliano, A, F Villaca Filho, Rodrigues, A, Vilela, F, Braga, J, Silva, R, Rodrigues, D, Silva, L, Morhy, S, Fischer, C, Vieira, M, Afonso, T, Abreu, J, N Falcao, S, A Moises, V, Gouvea, A, J Mancuso, F, C Souza, A, Y Silva, C, João, G, S Abboud, C, R Bellio de Mattos Barretto, Ramos, A, Arnoni, R, E Assef, J, J Della Togna, D, D Le Bihan, Miglioli, L, P Romero Oliveira, A, R Tadeu Magro Kroll, Cortez, D, L Gelape, C, M D, C Peirira Nunes, C De Abreu Ferrari, T, Hay, K, V, Le, Page, M, Poulin, F, Sauve, C, Serri, K, Mercure, C, Beaudoin, J, Pibarot, P, A Sebag, I, G Rudski, L, Ricafort, G, Barsic, B, Krajinovic, V, Vargovic, M, 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Tahir, J, Zarger, P, Baslib, F, Woldman, S, Menezes, L, Primus, C, Uppal, R, Bvekerwa, I, Chandrasekaran, B, Kopanska, A, Chambers, J, Hancock, J, Klein, J, Rajani, R, P Ursi, M, Cannata, S, Dworakowski, R, Fife, A, Breeze, J, Browne-Morgan, M, Gunning, M, Streather, S, M Asch, F, Zemedkun, M, Alyavi, B, Uzokov, J, Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Département de Cardiologie [Hôpital de la Timone - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), CHU Pontchaillou [Rennes], ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), 2011–21, Abbott Vascular, 2009–18, Amgen, 2016–19, Edwards, 2014–16, Gedeon Richter, 2009–12, Menarini Group, 2011–14, MSD, 2014–20, Novartis Pharma, 2014–16, ResMed Foundation, 2009–11, Sanofi, 2009–21, Servier, 2019–22, Vifor Pharma, 2014–21, AstraZeneca, 2009–18, Bayer AG, 2009–19, Boehringer Ingelheim, 2009–12, Boston Scientific, Bristol Myers Squibb, 2011–19, Pfizer Alliance, 2011–20, Daiichi Sankyo Company, 2014–17, Eli Lilly and Company, Sengupta, S, Prendergast, B, Laroche, C, Furnaz, S, Ronderos, R, Almaghraby, A, Asch, F, Blechova, K, Zaky, H, Strahilevitz, J, Dworakowski, R, Miyasaka, Y, Sebag, I, Izumi, C, Axler, O, Jamiel, A, Philip, M, Vieira, M, Lancellotti, P, Habib, G, Gale, C, Beleslin, B, Budaj, A, Chioncel, O, Dagres, N, Danchin, N, Emberson, J, Erlinge, D, Glikson, M, Gray, A, Kayikcioglu, M, Maggioni, A, Nagy, V, Nedoshivin, A, Petronio, A, Roos-Hesselink, J, Wallentin, L, Zeymer, U, Cosyns, B, Donal, E, Erba, P, Iung, B, Popescu, B, Tornos, P, Andarala, M, Berle, C, Brunel-Lebecq, A, Fiorucci, E, Missiamenou, V, 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Mercure, C, Beaudoin, J, Pibarot, P, Rudski, L, Ricafort, G, Barsic, B, Krajinovic, V, Vargovic, M, Lovric, D, Reskovic-Luksic, V, Vincelj, J, Jaksic Jurinjak, S, Yiannikourides, V, Ioannides, M, Pofaides, C, Masoura, V, Pudich, J, Linhart, A, Siranec, M, Marek, J, Kamenik, M, Pelouch, R, Coufal, Z, Mikulica, M, Griva, M, Jancova, E, Mikulcova, M, Taborsky, M, Precek, J, Jecmenova, M, Latal, J, Widimsky, J, Butta, T, Machacek, S, Vancata, R, Spinar, J, Holicka, M, Pow Chon Long, F, Anzules, N, Bajana Carpio, A, Largacha, G, Penaherrera, E, Moreira, D, Mahfouz, E, Elsafty, E, Soliman, A, Zayed, Y, Aboulenein, J, Abdel-Hay, M, Abdelnaby, M, Ahmed, M, Hammad, B, Saleh, Y, Zahran, H, El-Gebaly, O, Saad, A, Ali, M, Zeid, A, El Sharkawy, R, Al Kholy, A, Doss, R, Osama, D, Rizk, H, Elmogy, A, Mishriky, M, Assayag, P, El Hatimi, S, Hubert, S, Casalta, J, Gouriet, F, Arregle, F, Cammilleri, S, Tessonnier, L, Riberi, A, Botelho-Nevers, E, Gagneux-Brunon, A, Pierrard, R, Tulane, C, Campisi, S, Fuzellier, J, Detoc, M, Mehalla, T, Boutoille, D, Lecompte, A, Lefebvre, M, Pattier, S, Al Habash, O, Asseray-Madani, N, Biron, C, Brochard, J, Caillon, J, Cueff, C, Le Tourneau, T, Lecomte, R, Magali Michel, M, Orain, J, Delarue, S, Le Bras, M, Faucher, J, Aboyans, V, Bee-Harry, A, Durox, H, Lacoste, M, Magne, J, Mohty, D, David, A, Pradel, V, Sierra, V, Neykova, A, Bettayeb, B, Elkentaoui, S, Tzvetkov, B, Landry, G, Strady, C, Ainine, K, Baumard, S, Brasselet, C, Tassigny, C, Valente-Pires, V, Lefranc, M, Hoen, B, Lefevre, B, Curlier, E, Callier, C, Fourcade, N, Jobic, Y, Ansard, S, Le Berre, R, Le Ven, F, Pouliquen, M, Prat, G, Le Roux, P, Bouchart, F, Savoure, A, Alarcon, C, Chapuzet, C, Gueit, I, Tribouilloy, C, Bohbot, Y, Peugnet, F, Gun, M, Duval, X, Lescure, X, Ilic-Habensus, E, Sadoul, N, Selton-Suty, C, Alla, F, Goehringer, F, Huttin, O, Chevalier, E, Garcia, R, Le Marcis, V, Tattevin, P, Flecher, E, Revest, M, Chirouze, C, Bouiller, K, Hustache-Mathieu, L, Klopfenstein, T, Moreau, J, Fournier, D, Brunel, A, Lim, P, Oliver, L, Ternacle, J, Moussafeur, A, Chavanet, P, Piroth, L, Salmon-Rousseau, A, Buisson, M, Mahy, S, Martins, C, Go-Hier, S, Baumann, F, Lebras, S, Piper, C, Guckel, D, Borgermann, J, Horstkotte, D, Winkelmann, E, Brockmeier, B, Grey, D, Nick-Enig, G, Schueler, R, Ozturk, C, Stohr, E, Hamm, C, Walther, T, Brandt, R, Fruhauf, A, Hartung, C, Hellner, C, Wild, C, Becker, M, Hamada, S, Kaestner, W, Stangl, K, Knebel, F, Baldenhofer, G, Brecht, A, Dreger, H, Isner, C, Pfafflin, F, Stegemann, M, Zahn, R, Fraiture, B, Kilkowski, C, Karcher, A, Klinger, S, Tolksdorf, H, Tousoulis, D, Aggeli, C, Sideris, S, Venieri, E, Sarri, G, Tsiapras, D, Armenis, I, Koutsiari, A, Floros, G, Grassos, C, Dragasis, S, Rallidis, L, Varlamos, C, Michalis, L, Naka, K, Bechlioulis, A, Kotsia, A, Lakkas, L, Pappas, K, Papadopoulos, C, Kiokas, S, Lioni, A, Misailidou, S, Bar-Betseas, J, Bonou, M, Kapelios, C, Tomprou, I, Zerva, K, Manolis, A, Hamodraka, E, Athanasiou, D, Haralambidis, G, Samaras, H, Poulimenos, L, Nagy, A, Bartykowszki, A, Gara, E, Mungulmare, K, Kasliwal, R, Bansal, M, Ranjan, S, Bhan, A, Kyavar, M, Maleki, M, Noohi Bezanjani, F, Alizadehasl, A, Boudagh, S, Ghavidel, A, Morad-Nejad, P, Pasha, H, Ghadrdoost, B, Gilon, D, Wanounou, M, Israel, S, D'Agostino, C, Colonna, P, De Michele, L, Fumarola, F, Stante, M, Mar-Chionni, N, Scheggi, V, Alterini, B, Del Pace, S, Stefano, P, Sparano, C, Ruozi, N, Tenaglia, R, Muraru, D, Limbruno, U, Cresti, A, Baratta, P, Solari, M, Giannattasio, C, Moreo, A, De Chiara, B, Lopez Montero, B, Musca, F, Orcese, C, Panzeri, F, Spano, F, Russo, C, Alferi, O, De Bonis, M, Chiappetta, S, Del Forno, B, Ripa, M, Scarpellini, P, Tassan Din, C, Castiglioni, B, Pasci-Uta, R, Carletti, S, Ferrara, D, Guffanti, M, Iaci, G, Lapenna, E, Nisi, T, Oltolini, C, Busnardo, E, Pajoro, U, Agricola, E, Meneghin, R, Schiavi, D, Piscione, F, Citro, R, Benvenga, R, Greco, L, Soriente, L, Radano, I, Prota, C, Bellino, M, Di Vece, D, Santini, F, Salsano, A, Olivieri, G, Turrini, F, Messora, R, Tondi, S, Olaru, A, Agnoletto, V, Grassi, L, Leonardi, C, Sansoni, S, Del Ponte, S, Actis Dato, G, De Martino, A, Ohte, N, Kikuchi, S, Wakami, K, Aonuma, K, Seo, Y, Ishizu, T, Machino-Ohtsuka, T, Yamamoto, M, Iida, N, Nakajima, H, Nakagawa, Y, Amano, M, Miyake, M, Takahashi, K, Shiojima, I, Maeba, H, Suwa, Y, Taniguchi, N, Tsujimoto, S, Kitai, T, Ota, M, Yuda, S, Sasaki, S, Hagiwara, N, Yamazaki, K, Ashihara, K, Arai, K, Saitou, C, Saitou, S, Suzuki, G, Shibata, Y, Watanabe, N, Nishino, S, Ashikaga, K, Kuriyama, N, Mahara, K, Okubo, T, Fujimaki, H, Shi-Tan, H, Yamamoto, H, Abe, K, Terada, M, Takanashi, S, Sata, M, Yamada, H, Kusunose, K, Saijo, Y, Seno, H, Yuichiro, O, Onishi, T, Sera, F, Nakatani, S, Mizuno, H, Sengoku, K, Park, S, Eun Kyoung, K, Ga Yeon, L, Hwang, J, Jin-Oh, C, Sang-Chol, L, Sung-A, C, Jang, S, Heo, R, Lee, S, Song, J, Jung, E, Plisiene, J, Dambrauskaite, A, Gruodyte, G, Jonkaitiene, R, Mizariene, V, Atkocaityte, J, Zvirblyte, R, Sow, R, Codreanu, A, Staub, T, Michaux, C, De la Vega, E, Jacobs-Orazi, L, Mallia Azzopardi, C, Xuereb, R, Pis-Copo, T, Farrugia, J, Fenech, M, Pllaha, E, Vella, C, Borg, D, Casha, R, Grib, L, Raevschi, E, Gre-Jdieru, A, Kravcenco, D, Prisacari, E, Samohvalov, E, Samohvalov, S, Sceglova, N, Panfle, E, Cardaniuc, L, Corcea, V, Feodorovici, A, Gaina, V, Girbu, L, Jimbei, P, Balan, G, Cardaniuc, I, Benesco, I, Marian, V, Sumarga, N, Bozovic, B, Bulatovic, N, Lakovic, P, Music, L, Budde, R, Waha-Dat, A, Gamela, T, Meijers, T, Van Melle, J, Deursen, V, Crijns, H, Bekkers, S, Cheriex, E, Gilbers, M, Kietselaer, B, Knackstedt, C, Lorusso, R, Schalla, S, Streukens, S, Chamuleau, S, Cramer, M, Teske, A, Van der Spoel, T, Wind, A, Lokhorst, J, Liesbek, O, Van Heusden, H, Tanis, W, Van der Bilt, I, Vriend, J, De Lange-Van Bruggen, H, Karijodikoro, E, Riezebos, R, van Dongen, E, Schoep, J, Stolk, V, Offstad, J, Beitnes, J, Helle-Valle, T, Skulstad, H, Skardal, R, Qamar, N, Ahmed, B, Butt, M, Khanzada, M, Saghir, T, Wahid, A, Hryniewiecki, T, Szymanski, P, Marzec, K, Misztal-Ogonowska, M, Kosmala, W, Przewlocka-Kosmala, M, Rojek, A, Woznicka, K, Zachwyc, J, Lisowska, A, Kamin-Ska, M, Kasprzak, J, Kowalczyk, E, Strzecka, D, Wejner-Mik, P, Trabulo, M, Freitas, P, Ranchordas, S, Rodrigues, G, Pinto, P, Queiros, C, Azevedo, J, Marques, L, Seabra, D, Branco, L, Cruz, M, Galrinho, A, Moreira, R, Rio, P, Timoteo, A, Selas, M, Carmelo, V, Duque Neves, B, Pereira, H, Guerra, A, Marques, A, Pintassilgo, I, Tomescu, M, Trofenciuc, N, Andor, M, Bordejevic, A, Branea, H, Caruntu, F, Velcean, L, Mavrea, A, Onel, M, Parvanescu, T, Pop, D, Pop-Moldovan, A, Puticiu, M, Cirin, L, Citu, I, Cotoraci, C, Darabantiu, D, Farcas, R, Marincu, I, Ionac, A, Cozma, D, Mornos, C, Goanta, F, Popescu, I, Beyer, R, Mada, R, Rancea, R, Tomoaia, R, Rosianu, H, Stanescu, C, Kobalava, Z, Karaulova, J, Ko-Tova, E, Milto, A, Pisaryuk, A, Povalyaev, N, Sorokina, M, Alrahimi, J, Elshiekh, A, Ahmed, A, Attia, N, Putnikovic, B, Dimic, A, Ivanovic, B, Matic, S, Trifunovic, D, Petrovic, J, Kosevic, D, Stojanovic, I, Petrovic, I, Dabic, P, Milojevic, P, Srdanovic, I, Susak, S, Velicki, L, Vulin, A, Kovacevic, M, Redzek, A, Stefanovic, M, Yeo, T, Poh, K, Vi-Lacosta, I, Ferrera, C, Olmos, C, Abd El-Nasser, M, Calvo Iglesias, F, Bianco-Gonzalez, E, Bravo Amaro, M, Lopez-Rodriguez, E, Lugo Adan, J, Germinas, A, Pazos-Lopez, P, Pereira Loureiro, M, Perez, M, Raposeiras-Roubin, S, Rasheed Yas, S, Suarez-Varela, M, Vasallo Vidal, F, Garcia-Dorado, D, Fernandez-Hidalgo, N, Gonzalez-Alujas, T, Lozano, J, Maisterra, O, Pizzi, N, Rios, R, Bayes-Genis, A, Pedro Botet, L, Vallejo, N, Llibre, C, Mateu, L, Nunez, R, Quesada, D, Berastegui, E, Bosch Portell, D, Aboal Vinas, J, Albert Bertran, X, Brugada Tar-Radellas, R, Loma-Osorio Ricon, P, Tiron de Llano, C, Arnau, M, Bel, A, Blanes, M, Osa, A, Anguita, M, Carrasco, F, Castillo, J, Zamorano, J, Moya Mur, J, Alvaro, M, Fernandez-Golfin, C, Monteagudo, J, Navas Elorza, E, Farinas Alvarez, M, Aguero Balbin, J, Zarauza, J, Gutierrez-Diez, J, Arminanzas, C, Arnaiz de las Revillas, F, Arnaiz Garcia, A, Cobo Belaustegui, M, Fernandez Sampedro, M, Gutierrez Cuadra, M, Garcia Cuello, L, Gonzalez Rico, C, Rodriguez-Alvarez, R, Goikoetxea, J, Montejo, M, Miro, J, Almela, M, Ambrosioni, J, Moreno, A, Quintana, E, Sandoval, E, Tellez, A, Tolosana, J, Vidal, B, Falces, C, Fuster, D, Garcia-De-la-Maria, C, Hernandez-Meneses, M, Llopis, J, Marco, F, Ruiz-Zamora, I, Bardaji Ruiz, A, Sanz Girgas, E, Garcia-Pardo, G, Guillen Marzo, M, Rodriguez Oviedo, A, Villares Jimenez, A, Abid, L, Ham-Mami, R, Kammoun, S, Mourali, M, Mghaieth Zghal, F, Ben Hlima, M, Boudiche, S, Ouali, S, Zakhama, L, Antit, S, Slama, I, Gulel, O, Sahin, M, Karacaglar, E, Kucukoglu, S, Cetinarslan, O, Sinan, U, Canpolat, U, Mutlu, B, Atas, H, Dervishova, R, Ileri, C, Alhashmi, J, Tahir, J, Zarger, P, Baslib, F, Woldman, S, Menezes, L, Primus, C, Uppal, R, Bvekerwa, I, Chandrasekaran, B, Kopanska, A, Chambers, J, Hancock, J, Klein, J, Rajani, R, Ursi, M, Cannata, S, Fife, A, Breeze, J, Browne-Morgan, M, Gunning, M, Streather, S, Zemedkun, M, Alyavi, B, and Uzokov, J
Subjects: Socioeconomic, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Endocarditis, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Health Policy, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Socio-economic, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Endocarditi, Cardiology and Cardiovascular Medicine, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
Abstract: Aims Infective endocarditis (IE) is a life-threatening disease associated with high mortality and morbidity worldwide. We sought to determine how socioeconomic factors might influence its epidemiology, clinical presentation, investigation and management, and outcome, in a large international multicentre registry. Methods and results The EurObservational Programme (EORP) of the European Society of Cardiology EURO-ENDO (European Infective Endocarditis) registry comprises a prospective cohort of 3113 adult patients admitted for IE in 156 hospitals in 40 countries between January 2016 and March 2018. Patients were separated in three groups, according to World Bank economic stratification [group 1: high income (75.6%); group 2: upper-middle income (15.4%); group 3: lower-middle income (9.1%)]. Group 3 patients were younger [median age (interquartile range, IQR): group 1, 66 (53–75) years; group 2, 57 (41–68) years; group 3, 33 (26–43) years; P < 0.001] with a higher frequency of smokers, intravenous drug use, and human immunodeficiency virus infection (all P < 0.001) and presented later [median (IQR) days since symptom onset: group 1, 12 (3–35); group 2, 19 (6–54); group 3, 31 (12–62); P < 0.001] with a higher likelihood of developing congestive heart failure (13.6%, 11.1%, and 22.6%, respectively; P < 0.001) and persistent fever (9.8%, 14.2%, and 27.9%, respectively; P < 0.001). Among 2157 (69.3%) patients with theoretical indication for cardiac surgery, surgery was performed less frequently in group 3 patients (75.5%, 76.8%, and 51.3%, respectively; P < 0.001), who also demonstrated the highest mortality (15.0%, 23.0%, and 23.7%, respectively; P < 0.001). Conclusion Socioeconomic factors influence the clinical profile of patients presenting with IE across the world. Despite younger age, patients from the poorest countries presented with more frequent complications and higher mortality associated with delayed diagnosis and lower use of surgery.
Published: 2022

25. A peat core Hg stable isotope reconstruction of Holocene atmospheric Hg deposition at Amsterdam Island (37.8oS)

Author: Chuxian Li, Maxime Enrico, Oliver Magand, Beatriz F. Araujo, Gaël Le Roux, Stefan Osterwalder, Aurélien Dommergue, Yann Bertrand, Jérôme Brioude, François De Vleeschouwer, Jeroen E. Sonke, Laboratoire Ecologie Fonctionnelle et Environnement (LEFE), Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT), Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux (IPREM), Université de Pau et des Pays de l'Adour (UPPA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut des Géosciences de l’Environnement (IGE), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Laboratoire de l'Atmosphère et des Cyclones (LACy), Institut national des sciences de l'Univers (INSU - CNRS)-Université de La Réunion (UR)-Centre National de la Recherche Scientifique (CNRS)-Météo-France, Instituto Franco-Argentino sobre Estudios de Clima y sus Impactos [Buenos Aires] (IFAECI), Centro de Investigaciones del Mar y la Atmósfera (CIMA), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET)-Facultad de Ciencias Exactas y Naturales [Buenos Aires] (FCEyN), Universidad de Buenos Aires [Buenos Aires] (UBA)-Universidad de Buenos Aires [Buenos Aires] (UBA)-Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET)-Facultad de Ciencias Exactas y Naturales [Buenos Aires] (FCEyN), and Universidad de Buenos Aires [Buenos Aires] (UBA)-Universidad de Buenos Aires [Buenos Aires] (UBA)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, Hg stable isotopes Southern Hemisphere Peat Rain Hg deposition, Hg stable isotopes, Climate Research, [CHIM.POLY]Chemical Sciences/Polymers, Geochemistry and Petrology, Southern Hemisphere, Peat, Rain, Hg deposition, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry
Abstract: Mercury (Hg) stable isotopes have been broadly used to investigate the sources, transformation and deposition of atmospheric Hg during the industrial era thanks to the multiple isotope signatures deriving from mass-dependent (represented by δ) and mass-independent fractionation (represented by Δ) in the environment. Less is known about the impact of past climate change on atmospheric Hg deposition and cycling, and whether Hg isotopes covary with past climate. Here, we investigate Hg concentration and Hg isotope signatures in a 6600-year-old ombrotrophic peat record from Amsterdam Island (AMS, 37.8oS), and in modern rainfall and gaseous elemental Hg (Hg0) samples. Results show that Holocene atmospheric Hg deposition and plant Hg uptake covary with dust deposition, and are both lower under a high humidity regime associated with enhanced Southern Westerly Winds (SWW). Modern AMS gaseous Hg0 and rainfall HgII isotope signatures are similar to those in the Northern Hemisphere (NH). Holocene peat Δ199Hg and Δ200Hg are significantly correlated (R2 = 0.67, P < 0.001, n = 58), consistently oscillating between the modern Hg0 and rainfall HgII end-members. Peat Δ200Hg and Δ199Hg provide evidence of plant uptake of Hg0 as the dominant pathway of Hg deposition to AMS peatland, with some exceptions during humid periods. In contrast to NH archives generally documenting a modern increase in Δ199Hg, recent peat layers (post-1900CE) from AMS show the lowest Δ199Hg in the peat profile (-0.42 ± 0.27 ‰, 1σ, n = 8). This potentially reflects changes in the isotopic composition of the SH atmospheric Hg pool in response to industrial emissions, including associated changes in atmospheric Hg chemistry, and/or changes in peat soil Hg mobility. We further find that the oscillations of Hg isotopes are consistent with established Holocene climate variability from dust proxies. We suggest peat Hg isotope records might be a valid rainfall indicator., Geochimica et Cosmochimica Acta, 341, ISSN:0016-7037, ISSN:1872-9533
Published: 2022

26. An artificial intelligence approach to classify archaeological wood charcoals : introduction of a case study with southernAfrican Prehistoric charcoals

Author: Puech, Elysandre, Coli, Vanna Lisa, Corneli, Marco, Le Roux, Quentin, Théry-Parisot, Isabelle, Culture et Environnements, Préhistoire, Antiquité, Moyen-Age (CEPAM), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), University of the Witwatersrand [Johannesburg] (WITS), Analyse fonctionnelle pour la conception et l'analyse de systèmes (FACTAS), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), and Université Côte d'Azur (UCA)
Subjects: [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, [MATH]Mathematics [math], [SHS]Humanities and Social Sciences, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI]
Abstract: International audience
Published: 2022

27. Désinfection des eaux usées traitées par l’acide performique et sa réactivité avec les composés organiques

Author: Nabintu Kajoka, Christelle, Nihemaiti, Maolida, Huynh, Nina, Gasperi, Johnny, Brosillon, S., Oliveira, Marcos, Rocher, Vincent, Chebbo, Ghassan, Le Roux, Julien, École des Ponts ParisTech (ENPC), Université Paris-Est Créteil Val-de-Marne - Faculté des sciences et technologie (UPEC FST), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Laboratoire Eau Environnement et Systèmes Urbains (LEESU), École des Ponts ParisTech (ENPC)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Eau et Environnement (GERS-LEE ), Université Gustave Eiffel, Institut Européen des membranes (IEM), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Université de Montpellier (UM), SIAAP - Direction du Développement et de la Prospective, SIAAP, and NABINTU KAJOKA, Christelle
Subjects: [SDE] Environmental Sciences, [CHIM] Chemical Sciences, [SDE]Environmental Sciences, [CHIM]Chemical Sciences
Abstract: International audience
Published: 2022

28. Suivi de l’évolution des infrastructures urbaines et des pratiques de consommation et de l’état de santé de la population : Observation de la qualité des eaux usées franciliennes

Author: Lopez Viveros, Mélissa, Rocher, Vincent, Azimi, Sami, Moilleron, Régis, Le-Roux, Julien, Vulliet, Emmanuelle, SIAAP - Direction du Développement et de la Prospective, SIAAP, SIAAP DIRECTION INNOVATION ET ENVIRONNEMENT COLOMBES FRA, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), laboratoire Eau Environnement et Systèmes Urbains (LEESU), AgroParisTech-École des Ponts ParisTech (ENPC)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Laboratoire Eau Environnement et Systèmes Urbains (LEESU), École des Ponts ParisTech (ENPC)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institut des Sciences Analytiques (ISA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Vulliet, Emmanuelle
Subjects: [SDE.ES] Environmental Sciences/Environmental and Society, [SDE.ES]Environmental Sciences/Environmental and Society
Abstract: International audience
Published: 2022

29. Soil and climate zoning determining grapevine resource yield-gaps in Languedoc-Roussillon vineyards

Author: Fernandez-Mena, Hugo, Guilpart, Nicolas, Lagacherie, Philippe, Le Roux, Renan, Plaige, Mayeul, Dumont, Maxime, Gautier, Marine, Touzard, Jean-Marc, Graveline, Nina, Hannin, Hervé, Gary, Christian, Agrosystèmes Biodiversifiés (UMR ABSys), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre International de Hautes Etudes Agronomiques Méditerranéennes - Institut Agronomique Méditerranéen de Montpellier (CIHEAM-IAMM), Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Environnement Méditerranéen et Modélisation des Agro-Hydrosystèmes (EMMAH), Avignon Université (AU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), UFR Diagnostic et conception des itinéraires techniques et des systèmes de culture (DISC), AgroParisTech, Laboratoire d'étude des Interactions Sol - Agrosystème - Hydrosystème (UMR LISAH), Institut de Recherche pour le Développement (IRD)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Agroclim (AGROCLIM), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Innovation et Développement dans l'Agriculture et l'Alimentation (UMR Innovation), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Montpellier Interdisciplinary center on Sustainable Agri-food systems (Social and nutritional sciences) (UMR MoISA), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Centre International de Hautes Etudes Agronomiques Méditerranéennes - Institut Agronomique Méditerranéen de Montpellier (CIHEAM-IAMM), IHEV Institut des hautes études de la vigne et du vin, Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), MUSE - Montpellier Université d'Excellence, Université de Montpellier (UM), Institut national de recherche pour l'agriculture, l'alimentation et l'environnement, and L'Institut Agro Montpellier
Subjects: vineyard regional mapping, yield declinin, [SPI]Engineering Sciences [physics], [SDE]Environmental Sciences, grapevine yield-gaps, climate and soil indicators, [SHS]Humanities and Social Sciences
Abstract: International audience; Grapevine yield has been historically overlooked, assuming a strong trade-off between grape yield and wine quality. At present, menaced by climate change, many vineyards in Southern France are far from the quality label threshold, becoming grapevine yield-gaps a major subject of concern. Although yieldgaps are well studied in arable crops, we know very little about grapevine yield-gaps. In the present study, we analysed the environmental component of grapevine yield-gaps linked to climate and soil resources in the Languedoc Roussillon. We used SAFRAN data and IGP Pays d’Oc wine yields from 2010 to 2018. We selected climate and soil indicators proving to have a significant effect on average wine yield-gaps at the municipality scale. The most significant factors of grapevine yield were the Soil Available Water Capacity; followed by the Huglin Index and the Climatic Dryness Index. The Days of Frost; the Soil pH; and the Very Hot Days were also significant. Then, we clustered geographical zones presenting similar indicators, facilitating the identification of resources yield-gaps. We discussed the number of zones with the experts of IGP Pays d'Oc label, obtaining 7 zones with similar limitations for grapevine yield. Finally, we analysed the main resources causing yield-gaps and the grapevine varieties planted on each zone. Mapping grapevine resource yield-gaps are the first stage for understanding grapevine yield-gaps at the regional scale.
Published: 2022

30. Experiences of parents and caregivers in pediatric intensive care units: A qualitative study

Author: G. Durand, B. Branger, V. Durier, J.-M. Liet, G. Dabouis, G. Picherot, E. Cartron, S. Blache, E. Joram, F. Millasseau, E. Gratton, V. Guilbaud, J. Nizard, O. Bricaud, B. Gaillard-Le Roux, Centre Atlantique de Philosophie (CAPHI), Université de Rennes (UR)-Université de Brest (UBO)-Institut Brestois des Sciences de l'Homme et de la Société (IBSHS), Université de Brest (UBO)-Nantes Université - UFR Lettres et Langages (Nantes Univ - UFR LL), Nantes Université - pôle Humanités, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Humanités, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Centre hospitalier universitaire de Nantes (CHU Nantes), Ethologie animale et humaine (EthoS), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en éducation de Nantes (CREN), Le Mans Université (UM)-Nantes Université - UFR Lettres et Langages (Nantes Univ - UFR LL), Université d'Angers (UA), Excitabilité nerveuse et thérapeutique (ENT), Hôpital Henri Mondor-EA 4391, Service de Physiologie Explorations Fonctionnelles-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Nantes Université (Nantes Univ), Ethics of invasive care in Pediatric Intensive Care Unit: taking into account the child's expression' is coordinated by G. Durand and Dr. J-M. Liet and funded by the Region des Pays de la Loire within the framework of \'Paris Scientifiques\' (2017-2021)., Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Brest (UBO)-Institut Brestois des Sciences de l'Homme et de la Société (IBSHS), Normandie Université (NU)-Normandie Université (NU)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Parents, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, Health Personnel, Care, Intensive Care Units, Pediatric, Pediatrics, [SCCO]Cognitive science, Clinical ethics, Caregivers, Pediatrics, Perinatology and Child Health, Humans, Intensive care unit, Child, Qualitative Research
Abstract: International audience; BACKGROUND: In pediatric intensive care units (PICUs), parents and healthcare professionals attend to children who verbally and non-verbally express their pain and suffering, fears, anxieties, desires, and wishes in complex intensive care situations. What can we learn from these experiences to improve the way we can take care of and support children? OBJECTIVES: The main objective of this clinical ethics study was to focus on the experience stories of parents during their child’s hospitalization in a PICU, to analyze their discourse, and to propose an ethical perspective. METHOD: The current research collects the experience reports of parents during their child’s hospitalization in a PICU and those of the caregivers who treated them. A total of 17 semi-directive interviews were conducted in the PICU of the Nantes University Hospital from November 2017 to June 2019. Each interview lasted around 1 h. The main results of our study are analyzed and informed by the four ethical principles of T. Beauchamp and J. Childress: autonomy, beneficence, non-maleficence, and justice. RESULTS: The interviews highlighted the difficulties encountered by parents during the hospitalization of their children, such as the distance between their home and the hospital, the technicality of PICU environment, and the difficulty in finding their place as parents. For medical and paramedical teams, their main concerns are undoubtedly to improve the coherence and continuity of their stand toward parents, to promote parental autonomy, and to remain fully aware of the profound existential changes that the child’s illness brings about for parents: It is the caregivers’ duty to take this into account and to respect the parents’ rhythm as much as possible. CONCLUSIONS: The main disagreements between healthcare teams and parents, where they exist, are communication problems that are easily controlled, for the most part, by caregivers.
Published: 2022

31. Utilisation des assistants de preuves pourl’enseignement en L1

Author: Kerjean, Marie, Le Roux, Frédéric, Massot, Patrick, Mayero, Micaela, Mesnil, Zoé, Modeste, Simon, Narboux, Julien, Rousselin, Pierre, Laboratoire d'Informatique de Paris-Nord (LIPN), Centre National de la Recherche Scientifique (CNRS)-Université Sorbonne Paris Nord, Institut de Mathématiques de Jussieu - Paris Rive Gauche (IMJ-PRG (UMR_7586)), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Faculté des Sciences d’Orsay, Université Paris-Saclay, 91405 Orsay Cedex, France., Laboratoire de Didactique André Revuz (LDAR (URP_4434)), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Université de Lille-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Université Paris Cité (UPCité)-CY Cergy Paris Université (CY), Institut Montpelliérain Alexander Grothendieck (IMAG), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Analyse, Géométrie et Applications (LAGA), Université Paris 8 Vincennes-Saint-Denis (UP8)-Centre National de la Recherche Scientifique (CNRS)-Université Sorbonne Paris Nord, Université Sorbonne Paris Nord, and Narboux, Julien
Subjects: [MATH.MATH-GM]Mathematics [math]/General Mathematics [math.GM], [INFO.EIAH] Computer Science [cs]/Technology for Human Learning, proof, proving, assistant de preuve, enseignement de la démonstration, [MATH.MATH-GM] Mathematics [math]/General Mathematics [math.GM], [INFO.EIAH]Computer Science [cs]/Technology for Human Learning, Proof assistant, teaching
Abstract: National audience; Utilisation des assistants de preuves pour l'enseignement en L1 Utilisation des assistants de preuves pour l'enseignement en L1 Retours d'expériences Nous rendons compte de cinq expériences récentes de l'enseignement de la démonstration utilisant les assistants de preuve Coq, D∃∀DUCTION, Edukera et Lean.
Published: 2022

32. Organ donation by Maastricht-III pediatric patients: Recommendations of the Groupe Francophone de Réanimation et Urgences Pédiatriques (GFRUP) and Association des Anesthésistes Réanimateurs Pédiatriques d'Expression Française (ADARPEF). Part II: Specific organizational and technical considerations

Author: S, Dauger, S, Blanot, A, Deho, J, Beaux, F, Bonnin, F, Bordet, R, Cremer, S, Dupont, A, Klusiewicz, A, Lafargue, M, Lemains, F, Michel, R, Quéré, L de Saint, Blanquat, M, Samyn, M-L, Saulnier, L, Temper, Z, Merchaoui, B Gaillard-Le, Roux, Groupe-Francophone-de-Réanimation-Et-Urgences-Pédiatriques-Gfrup, Association-des-Anesthésistes-Réanimateurs-Pédiatriques-d'Expression-Française-Adarpef, Société française d'anesthésie et de réanimation (SFAR), SFAR, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), and Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS)
Subjects: Donation after circulatory death, MESH: Heart Arrest, Tissue and Organ Procurement, MESH: Humans, Treatment discontinuation, [SDV]Life Sciences [q-bio], Normothermic regional perfusion, MESH: Airway Extubation, MESH: Tissue and Organ Procurement, Agonal phase, Heart Arrest, Death, Perfusion, Sedation, MESH: Child, Airway Extubation, Functional warm ischemia, Humans, Circulatory arrest, MESH: Death, Child, MESH: Perfusion
Abstract: International audience; A panel of pediatric experts met to develop recommendations on the technical requirements specific to pediatric controlled donation after planned withdrawal of life-sustaining therapies (Maastricht category III). The panel recommends following the withdrawal of life-sustaining therapies protocol usually applied in each unit, which may or may not include immediate extubation. The organ retrieval process should be halted if death does not occur within 3 h of life-support discontinuation. Circulatory arrest is defined as loss of pulsatile arterial pressure and should be followed by a 5-min no-touch observation period. Death is declared based on a list of clinical criteria assessed by two senior physicians. The no-flow time should be no longer than 30, 45, and 90 min for the liver, kidneys, and lungs, respectively. At present, the panel does not recommend pediatric heart donation after death by circulatory arrest. The mean arterial pressure cutoff that defines the start of the functional warm ischemia (FWI) phase is 45 mmHg in patients older than 5 years and/or weighing more than 20 kg. The panel recommends normothermic regional perfusion in these patients. The FWI phase should not exceed 30 and 45 min for retrieving the pancreas and liver, respectively. There is no time limit to the FWI phase for the lungs and kidneys. The panel recommends routine sharing of experience with Maastricht-III donation among all healthcare institutions involved in order to ensure optimal outcome assessment and continuous discussion on the potential difficulties, notably those related to the management of normothermic regional perfusion in small children.
Published: 2022

33. Chronologie des phases glaciaires et de la formation des lacs de montagnes dans les secteurs de l’OHM Pyrénées (Projet OHM 'Néolacs')

Author: Chapron, Emmanuel, Jomelli, Vincent, Lacou, Alexandre, Le Roux, G., van Beek, Pieter, Géographie de l'environnement (GEODE), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire Ecologie Fonctionnelle et Environnement (LEFE), Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT), Laboratoire d'études en Géophysique et océanographie spatiales (LEGOS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), CNRS UMR 5602 GEODE, and ANR-11-LABX-0010,DRIIHM / IRDHEI,Dispositif de recherche interdisciplinaire sur les Interactions Hommes-Milieux(2011)
Subjects: Changement climatique, OHM Pyrenees, datations 10Be, [SDE]Environmental Sciences, datations 14C, Lacs, impacts anthropiques, datations 137Cs, LABEX DRIIHM, Glaciers, Pyrénées françaises
Abstract: National audience; La synthèse des données géomorphologiques, stratigraphiques et géochronologiques collectées ces dernières années notamment dans le cadre du projet OHM Pyrénées "Néolacs" (2020-2021), et des données scientifiques disponibles dans les secteurs de l'OHM Pyrénées (vallée du Haut Vicdessos en Ariège et Parc National des Pyrénées dans les Pyrénées Centrales) permet aujourd'hui de mieux contraindre la chronologie des dernières phases glaciaires et de la formation des lacs de montagnes dans ces deux secteurs des Pyrénées françaises. Cette présentation résume (i) les ages 10Be disponibles sur les blocs erratiques associés à des cordons morainiques ou sur des roches moutonnées; (ii) les ages 14C disponibles dans les remplissages lacustres de montagne localisés à proximité de formations glaciaires et parfois encore des derniers glaciers pyrénéens (notamment dans le cirque de Troumouze, et dans le bassin versant des Oulettes de Gaube) et (iii) les ages radionucléides (137Cs) obtenus dans les sédiments lacustres récents de quelques lacs. Les travaux en cours et programmés dans le cadre du projet "Néo Pyrénées" permettront d'harmoniser la base de données paléoenvironnementales à disposition dans les deux secteurs de l'OHM Pyrénées pour préciser la chronologie du retrait et de la fonte des glaciers würmiens, de la mise en place d'une néoglaciation dans les Pyrénées ainsi que leur influence sur la formation et la dynamique sédimentaire des environnements lacustres d'altitude.
Published: 2022

34. Synthetic silico-metallic mineral particles SSMMP: a new option for CO2 capture and CO2/N2 separation from post-combustion technology

Author: Daniela Rodrigues, Franciele Bernard, Christophe Le Roux, Evandro Duarte, Pierre Micoud, Alain Castillo, François Martin, Sandra Einloft, Géosciences Environnement Toulouse (GET), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), and Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)
Subjects: Geochemistry and Petrology, [CHIM]Chemical Sciences, Geology
Abstract: International audience
Published: 2022

35. Unraveling late Quaternary atmospheric circulation in the Southern Hemisphere through the provenance of Pampean loess

Author: Gabriela Torre, Diego Gaiero, Renata Coppo, Nicolás J. Cosentino, Steven L. Goldstein, François De Vleeschouwer, Gael Le Roux, Louise Bolge, Yael Kiro, André Oliveira Sawakuchi, Instituto Franco-Argentino sobre Estudios de Clima y sus Impactos [Buenos Aires] (IFAECI), Centro de Investigaciones del Mar y la Atmósfera (CIMA), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET)-Facultad de Ciencias Exactas y Naturales [Buenos Aires] (FCEyN), Universidad de Buenos Aires [Buenos Aires] (UBA)-Universidad de Buenos Aires [Buenos Aires] (UBA)-Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET)-Facultad de Ciencias Exactas y Naturales [Buenos Aires] (FCEyN), Universidad de Buenos Aires [Buenos Aires] (UBA)-Universidad de Buenos Aires [Buenos Aires] (UBA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Ecologie Fonctionnelle et Environnement (LEFE), Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), and Université de Toulouse (UT)
Subjects: ISÓTOPOS, General Earth and Planetary Sciences, [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment
Abstract: International audience
Published: 2022

36. « Les Du Bellay après les Du Bellay : femmes, hommes, mémoires »

Author: Le Roux, Nicolas and Le Roux, Nicolas
Subjects: [SHS.HIST] Humanities and Social Sciences/History, [SHS] Humanities and Social Sciences
Published: 2022

37. 1559-1629. Les guerres de Religion

Author: Le Roux, Nicolas and Le Roux, Nicolas
Subjects: [SHS.HIST] Humanities and Social Sciences/History, Guerres de Religion 1562-1629, [SHS] Humanities and Social Sciences
Abstract: 1559-1629 est une séquence dramatique pour le royaume de France, profondément divisé par la question religieuse. Les protestants constituent environ 10 % de la population française au début des années 1560. Les monarques sont de jeunes hommes incapables de gouverner par eux-mêmes ou des princes déconsidérés aux yeux de leurs sujets. En dépit des efforts de Catherine de Médicis et du chancelier Michel de L’Hospital, qui accordent aux protestants la liberté de culte, le royaume sombre dans le chaos : exactions et batailles se succèdent et les violences culminent en 1572 avec la Saint-Barthélemy. On assiste même à deux régicides (Henri III en 1589 et Henri IV en 1610).Temps de crise sans précédent, les guerres de Religion constituent le creuset de la monarchie absolue d’Ancien Régime. Henri IV parvient à reconstituer l’unité du royaume autour de l’idéal d’obéissance à la figure royale et son fils Louis XIII bénéficie de ses succès pour achever de créer une monarchie puissante capable de s’imposer sur la scène européenne.
Published: 2022

38. Phage-host coevolution in natural populations

Author: Damien Piel, Maxime Bruto, Yannick Labreuche, François Blanquart, David Goudenège, Rubén Barcia-Cruz, Sabine Chenivesse, Sophie Le Panse, Adèle James, Javier Dubert, Bruno Petton, Erica Lieberman, K. Mathias Wegner, Fatima A. Hussain, Kathryn M. Kauffman, Martin F. Polz, David Bikard, Sylvain Gandon, Eduardo P. C. Rocha, Frédérique Le Roux, Unité de Physiologie Fonctionnelle des Organismes Marins, Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Laboratoire de Biologie Intégrative des Modèles Marins (LBI2M), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Station biologique de Roscoff (SBR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Universidade de Santiago de Compostela [Spain] (USC ), Fédération de recherche de Roscoff (FR2424), Station biologique de Roscoff (SBR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Department of Civil and Environmental Engineering [Cambridge] (CEE), Massachusetts Institute of Technology (MIT), Eligo Bioscience, Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung (AWI), Universität Wien, Biologie de Synthèse - Synthetic biology, Université Paris Cité (UPCité)-Microbiologie Intégrative et Moléculaire (UMR6047), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Université Paul-Valéry - Montpellier 3 (UPVM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM), Génomique évolutive des Microbes / Microbial Evolutionary Genomics, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), We thank M. A. Petit, M. Blokesch, M. Sullivan and A. Bernheim for valuable suggestions, M. Touchon and A. Bernheim for assistance with vibrio genome annotation, Z. Chaplain for the illustrations and help during the time series sampling, the staff of the station Ifremer Argenton and Bouin, the ABIMS (Roscoff) and LABGeM (Evry) platforms for technical assistance, Z. Allouche, Biomics Platform, C2RT, Institut Pasteur, Paris, France, supported by France Génomique (ANR-10-INBS-09-09) and IBISA, and G. Riddihough from Life Science Editors for help with the manuscript. This work was supported by funding from the Agence Nationale de la Recherche (ANR-16-CE32-0008-01, REVENGE, ANR-20-CE35-0014, RESISTE), the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 884988, Advanced ERC Dynamic) to F.L.R. and Ifremer to D.P. The work was further supported by a grant from the Simons Foundation (LIFE ID 572792) to M.F.P. Part of the Vibrio crassostreae genome sequencing was conducted by the US Department of Energy Joint Genome Institute, a DOE Office of Science User Facility, and is supported by the Office of Science of the US Department of Energy under Contract No. DE-AC02-05CH11231. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript., ANR-10-INBS-0009,France-Génomique,Organisation et montée en puissance d'une Infrastructure Nationale de Génomique(2010), ANR-16-CE32-0008,REVENGE,L'huître comme niche de l'évolution et l'émergence de vibrios pathogènes(2016), ANR-20-CE35-0014,RESISTE,Comprendre l'évolution de la résistance aux antimicrobiens chez les vibrios environnementaux(2020), European Project: 884988,ERC-2019-ADG,DYNAMIC(2021), Le Roux, Frédérique, Organisation et montée en puissance d'une Infrastructure Nationale de Génomique - - France-Génomique2010 - ANR-10-INBS-0009 - INBS - VALID, L'huître comme niche de l'évolution et l'émergence de vibrios pathogènes - - REVENGE2016 - ANR-16-CE32-0008 - AAPG2016 - VALID, Comprendre l'évolution de la résistance aux antimicrobiens chez les vibrios environnementaux - - RESISTE2020 - ANR-20-CE35-0014 - AAPG2020 - VALID, A mechanistic approach to understand microbiome-viriome dynamics in nature - DYNAMIC - - ERC-2019-ADG2021-01-01 - 2025-12-31 - 884988 - VALID, Université Paul-Valéry - Montpellier 3 (UPVM)-École Pratique des Hautes Études (EPHE), Physiologie Fonctionnelle des Organismes Marins (PFOM), Laboratoire de Biologie Intégrative (LBI), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire des Sciences de l'Environnement Marin (LEMAR) (LEMAR), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Brest (UBO)-Institut Universitaire Européen de la Mer (IUEM), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Alfred Wegener Institute for Polar and Marine Research (AWI), University of Vienna [Vienna], Institut Pasteur [Paris] (IP), and Génétique des génomes - Genetics of Genomes (UMR 3525)
Subjects: Water microbiology, Microbiology (medical), MESH: Host Specificity, [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], Immunology, Cell Biology, [SDV.EE.IEO] Life Sciences [q-bio]/Ecology, environment/Symbiosis, Applied Microbiology and Biotechnology, Microbiology, Host Specificity, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Genetics, [SDV.BID.EVO] Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], Bacteriophages, MESH: Bacteriophages, [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology, Viral genetics, Coevolution, [SDV.EE.IEO]Life Sciences [q-bio]/Ecology, environment/Symbiosis
Abstract: International audience; Coevolution between bacteriophages (phages) and their bacterial hosts occurs through changes in resistance and counter-resistance mechanisms. To assess phage-host evolution in wild populations, we isolated 195 Vibrio crassostreae strains and 243 vibriophages during a 5-month time series from an oyster farm and combined these isolates with existing V. crassostreae and phage isolates. Cross-infection studies of 81,926 host-phage pairs delineated a modular network where phages are best at infecting cooccurring hosts, indicating local adaptation. Successful propagation of phage is restricted by the ability to adsorb to closely related bacteria and further constrained by strain-specific defence systems. These defences are highly diverse and predominantly located on mobile genetic elements, and multiple defences are active within a single genome. We further show that epigenetic and genomic modifications enable phage to adapt to bacterial defences and alter host range. Our findings reveal that the evolution of Please note that this is an author-produced PDF of an article accepted for publication following peer review. The definitive publisher-authenticated version is available on the publisher Web site. bacterial defences and phage counter-defences is underpinned by frequent genetic exchanges with, and between, mobile genetic elements.
Published: 2022

39. Un tragique XVIe siècle

Author: Callard, Caroline, Debbagi Baranova, Tatiana, Le Roux, Nicolas, and Le Roux, Nicolas
Subjects: [SHS.HIST] Humanities and Social Sciences/History
Abstract: Ce volume est un hommage au grand historien Denis Crouzet, professeur à l’université Lyon III (1989-1994), puis à Sorbonne Université (1994-2021), qui a pris sa retraite en 2021.Il a été composé par les très nombreux amis et élèves de Denis Crouzet. Celui-ci est sans contestation possible l’historien moderniste qui a le plus marqué les années 1990-2020 et qui a eu le plus grand nombre de disciples. Sa thèse monumentale, Les guerriers de Dieu. La violence au temps des troubles de religion, publiée chez Champ Vallon en 1990, a entièrement renouvelé la compréhension de la Réforme et des guerres de Religion.Ce livre porte sur l’histoire du XVIe siècle européen et propose un panorama sans équivalent des principaux thèmes sur lesquels Denis Crouzet a travaillé : la violence, les pouvoirs, les croyances, les conflits interconfessionnels. Il se penche particulièrement sur quelques personnages à propos desquels Denis Crouzet a proposé des études extrêmement originales (Charles Quint, Catherine de Médicis).Il propose aussi des analyses, jusque-là jamais réalisées, de quelques points centraux de la pensée de Denis Crouzet – la question de la psychanalyse en histoire, la réflexion sur le statut des acteurs –, mais aussi de la réception de son œuvre, en particulier dans le monde anglo-saxon.Tout comme l’œuvre de Denis Crouzet, complexe mais fascinante, ce livre marquera une étape importante dans l’historiographie des Temps dits modernes, dont on sait aujourd’hui qu’ils ont été traversés par des angoisses et des tensions d’une violence inouïe.
Published: 2022

40. Genome-Wide Transcriptomic Analysis of the Effects of Infection with the Hemibiotrophic Fungus Colletotrichum lindemuthianum on Common Bean

Author: Juan C. Alvarez-Diaz, Richard Laugé, Etienne Delannoy, Stéphanie Huguet, Christine Paysant-Le Roux, Ariane Gratias, Valérie Geffroy, Institut des Sciences des Plantes de Paris-Saclay (IPS2 (UMR_9213 / UMR_1403)), Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), BIOlogie et GEstion des Risques en agriculture (BIOGER), Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), ANR-17-CE20-0025,HIPATH,Induction des réponses pathogenesis-related par le fort CO2 chez les plantes: signalisation, voies métaboliques, et impact agronomique(2017), and ANR-17-EURE-0007,SPS-GSR,Ecole Universitaire de Recherche de Sciences des Plantes de Paris-Saclay(2017)
Subjects: NL, Ecology, Phaseolus vulgaris, Colletotrichum lindemuthianum, RNA-seq, transcriptome, Co-resistance genes, resistance response, PR10, Bet vI, NLR, [SDV]Life Sciences [q-bio], Plant Science, [SDE]Environmental Sciences, RPR10, Ecology, Evolution, Behavior and Systematics
Abstract: International audience; Bean anthracnose caused by the hemibiotrophic fungus Colletotrichum lindemuthianum is one of the most important diseases of common bean (Phaseolus vulgaris) in the world. In the present study, the whole transcriptome of common bean infected with C. lindemuthianum during compatible and incompatible interactions was characterized at 48 and 72 hpi, corresponding to the biotrophy phase of the infection cycle. Our results highlight the prominent role of pathogenesis-related (PR) genes from the PR10/Bet vI family as well as a complex interplay of different plant hormone pathways including Ethylene, Salicylic acid (SA) and Jasmonic acid pathways. Gene Ontology enrichment analysis reveals that infected common bean seedlings responded by down-regulation of photosynthesis, ubiquitination-mediated proteolysis and cell wall modifications. In infected common bean, SA biosynthesis seems to be based on the PAL pathway instead of the ICS pathway, contrarily to what is described in Arabidopsis. Interestingly, ~30 NLR were up-regulated in both contexts. Overall, our results suggest that the difference between the compatible and incompatible reaction is more a question of timing and strength, than a massive difference in differentially expressed genes between these two contexts. Finally, we used RT-qPCR to validate the expression patterns of several genes, and the results showed an excellent agreement with deep sequencing.
Published: 2022

41. Effect of exercise on energy expenditure and body composition in astronauts onboard the International Space Station

Author: Pierre, Bourdier, Alexandre, Zahariev, Dale, Schoeller, Isabelle, Chery, Le Roux, Elisa, Cécile, Thevenot, Alain, Maillet, Maël, Garnotel, Guillemette, Gauquelin-Koch, Audrey, Bergouignan, Stéphane, Blanc, Simon, Chantal, Département Ecologie, Physiologie et Ethologie (DEPE-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), University of Wisconsin-Madison, Institut de Médecine et de Physiologie Spatiales (MEDES), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université de Bordeaux (UB)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Université Jean Monnet - Saint-Étienne (UJM)-Université de Tours (UT)-Université de Clermont-Ferrand-Centre National d'Études Spatiales [Toulouse] (CNES), CADMOS-CNES, Centre National d’Études Spatiales [Paris] (CNES), University of Colorado [Denver], Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hospices Civils de Lyon (HCL), and Gaillard, Brigitte
Subjects: [SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Abstract: International audience; Objective: Body mass (BM) loss and body composition (BC) changes threaten astronauts' health and mission success. However, the energetics contribution of the exercise countermeasure to these changes has never been investigated during long-term missions. We studied energy balance and BC in astronauts during 6-month missions onboard the International Space Station. Methods: Before and after at least 3 months in space, BM, BC, total and activity energy expenditure (TEE and AEE) were measured using the doubly labeled water method in 11 astronauts (2011-2017). Physical activity (PA) was assessed by the SensewearPro® activity-device. Results: Three-month spaceflight decreased BM (-1.20kg (SE 0.5); P=0.04), mainly due to non-significant fat-free mass loss (FFM;-0.94kg (0.59)). The decrease in walking time (-63.2min/day (11.5); P
Published: 2022

42. Spatio-temporal dynamics of driftwood in the alluvial plain of the Allier Valley (France)

Author: Hortobágyi, Borbála, Petit, Stéphane, Melun, Gabriel, Le Roux, Guillaume, Thauvin, Frédéric, Piégay, Hervé, Environnement, Ville, Société (EVS), École normale supérieure de Lyon (ENS de Lyon)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Lumière - Lyon 2 (UL2)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-École Nationale des Travaux Publics de l'État (ENTPE)-École nationale supérieure d'architecture de Lyon (ENSAL)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SHS]Humanities and Social Sciences
Published: 2022

43. High-Resolution Mass Spectrometry Screening of Wastewater Effluent for Micropollutants and Their Transformation Products during Disinfection with Performic Acid

Author: Maolida Nihemaiti, Nina Huynh, Romain Mailler, Perrine Mèche-Ananit, Vincent Rocher, Rachid Barhdadi, Régis Moilleron, Julien Le Roux, Laboratoire Eau Environnement et Systèmes Urbains (LEESU), École des Ponts ParisTech (ENPC)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), SUEZ ENVIRONNEMENT (FRANCE), SIAAP - Direction du Développement et de la Prospective, and SIAAP
Subjects: wastewater disinfection, Chemistry (miscellaneous), trace organic chemicals, transformation products, lidocaine, [SDE]Environmental Sciences, Environmental Chemistry, Chemical Engineering (miscellaneous), [CHIM]Chemical Sciences, peracids, Water Science and Technology, N-oxide
Abstract: International audience; Performic acid (PFA) is an emerging disinfectant applied for full-scale disinfection of wastewater effluent. While many studies have focused on assessing the microbial water quality during PFA disinfection, studies on the ability of PFA to oxidize organic micropollutants are still scarce. In this study, nontarget screening of wastewater secondary effluent during PFA treatment was performed using liquid chromatography−high-resolution mass spectrometry. A low dose (2 mg/L) of PFA was able to affect the organic matter composition within a short exposure time (10 min). Multivariate analysis as well as suspect screening indicated that PFA oxidation largely reduced the intensities of micropollutants with a tertiary amine moiety and led to the formation of their mono-oxygenated derivatives, N-oxides, a class of transformation products that are known as biologically stable but whose impact on aquatic organisms still needs to be assessed. Mechanistic studies were conducted on selected micropollutants (i.e., lidocaine, amisulpride, tramadol, and clarithromycin). The minimum apparent second-order rate constant of PFA with lidocaine was determined as 7.54 M −1 s −1 at pH 8.0. Lidocaine was mainly converted (∼95%) into its N-oxide via direct oxygen transfer from PFA. Overall results revealed a strong electrophilic reactivity of PFA toward electron-rich moieties (e.g., amines) of micropollutants.
Published: 2022

44. Added value of high-resolution electrical source imaging of ictal activity in children with structural focal epilepsy

Author: Marie Le Roux, Gaëlle Milon-Harnois, Matthieu Delion, Matthieu Labriffe, Josselin Démas, Isabelle Merlet, Patrick Van Bogaert, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Laboratoire Angevin de Recherche en Ingénierie des Systèmes (LARIS), Université d'Angers (UA), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Jonchère, Laurent
Subjects: [SDV.IB] Life Sciences [q-bio]/Bioengineering, Neurology, Physiology (medical), [SDV.IB]Life Sciences [q-bio]/Bioengineering, Neurology (clinical), Sensory Systems
Abstract: International audience
Published: 2022

45. Reactivity of performic acid with organic micropollutants and model compounds

Author: Nabintu Kajoka, Christelle, Gasperi, Johnny, Brosillon, Stephan, Oliveira, Marcos, Rocher, Vincent, Chebbo, Ghassan, Le Roux, Julien, Laboratoire Eau Environnement et Systèmes Urbains (LEESU), École des Ponts ParisTech (ENPC)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), and NABINTU KAJOKA, Christelle
Subjects: [CHIM.ANAL] Chemical Sciences/Analytical chemistry, [SDE.IE]Environmental Sciences/Environmental Engineering, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, [SDE.IE] Environmental Sciences/Environmental Engineering, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2022

46. Linking wood flux video monitoring and semi-controlled experiment of downstream wood diffusion to better understand wood transport

Author: Hortobágyi, Borbála, Petit, Stéphane, Melun, Gabriel, Le Roux, Guillaume, Thauvin, Frédéric, Piégay, Hervé, Environnement, Ville, Société (EVS), École normale supérieure de Lyon (ENS de Lyon)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Lumière - Lyon 2 (UL2)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-École Nationale des Travaux Publics de l'État (ENTPE)-École nationale supérieure d'architecture de Lyon (ENSAL)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SHS]Humanities and Social Sciences
Published: 2022

47. The causes of the selection of biological nitrification inhibition (BNI) in relation to ecosystem functioning and a research agenda to explore them

Author: Jean-Christophe Lata, Xavier Le Roux, Kouamé Fulgence Koffi, Lambiénou Yé, Tharaniya Srikanthasamy, Sarah Konaré, Sébastien Barot, Institut d'écologie et des sciences de l'environnement de Paris (iEES Paris ), Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire d'Ecologie Microbienne - UMR 5557 (LEM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Ecole Nationale Vétérinaire de Lyon (ENVL)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Nangui Abrogoua (UNA), Université de Dédougou (UDDG), Université Polytechnique Nazi Boni Bobo-Dioulasso (UNB), European Joint Programme on Soil (EJP Soil), and ANR-19-CE02-0009,GAIN-GRASS,Évaluation globale de l'inhibition de la nitrification par les Poacées tropicales(2019)
Subjects: [SDV.EE]Life Sciences [q-bio]/Ecology, environment, Biology nitrification inhibition, Ecology, Evolution, [SDV]Life Sciences [q-bio], [CHIM]Chemical Sciences, Soil Science, Research agenda, Biological nitrification inhibition, Agronomy and Crop Science, Microbiology, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, ComputingMilieux_MISCELLANEOUS
Abstract: International audience; Biological nitrification inhibition (BNI) has already led to several studies mainly focused on underlying molecular mechanisms and applications to agriculture. We argue that it is also important to study BNI more systematically from the ecological and evolutionary points of view to understand its implications for plants and soil nitrifiers as well as its consequences for ecosystems. Therefore, we propose here a dedicated research agenda identifying the most critical research questions: (1) How is BNI distributed across plant phylogeny and why has it been selected? (2) What are the costs-to-benefits balance of producing BNI compounds and the relative impacts on BNI evolution? (3) Can we understand the evolutionary pressures leading to BNI and identify the environmental conditions favorable to BNI plants? (4) How has BNI coevolved with plant preference for ammonium vs. nitrate? (5) Diverse BNI compounds and various inhibition mechanisms have been described, but implications of this diversity are not understood. Does it allow inhibition of various groups of nitrifiers? (6) Does this diversity of BNI compounds increase the efficiency, spatial extension, and duration of BNI effect? (7) What are the impacts of BNI compounds on other soil functions? (8) Can field experiments, coupled to scanning of the diversity of BNI capabilities within plant communities, evaluate whether BNI influences plant-plant competition and plant coexistence? (9) Can field quantification of various nitrogen (N) fluxes assess whether BNI lead to more efficient N cycling with lower losses and hence increased primary production? (10) Can the impact of BNI on N budgets and climate (through its impact on N2O emissions and its indirect impact on carbon budget) be evaluated at the regional scale? We discuss why implementing this research program is crucial both for the sake of knowledge and to develop applications of BNI for agriculture.
Published: 2022

48. Genome-Wide Association Study for Resistance to Rhynchosporium in a Diverse Collection of Spring Barley Germplasm

Author: Jean-Noël Thauvin, Joanne Russell, Dominique Vequaud, Mark Looseley, Micha Bayer, Pierre-Marie Le Roux, Pierre Pin, Robbie Waugh, Anna Avrova, The James Hutton Institute, Division of Plant Sciences, College of Life Sciences, Scottish Crop Research Institute, Invergowrie, University of Dundee, Génétique Diversité et Ecophysiologie des Céréales (GDEC), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Secobra Recherches, Partenaires INRAE, Agriculture and Horticulture Development Board (AHDB), and Scottish Government: Rural and Environment Science and Analytical Services (RESAS)
Subjects: landraces, QTL, [SDV]Life Sciences [q-bio], [SDV.SA.AGRO]Life Sciences [q-bio]/Agricultural sciences/Agronomy, food and beverages, barley, SNP, resistance, [SDV.BV.AP]Life Sciences [q-bio]/Vegetal Biology/Plant breeding, rhynchosporium, genetic markers, GWAS, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Agronomy and Crop Science
Abstract: International audience; Rhynchosporium is one of the main biotic stresses on barley production worldwide. A set of 312 spring barley accessions was tested in four different locations over 3 years, to identify novel genetic resistances to rhynchosporium and to explore the allelic diversity for resistance genes present in this global germplasm collection. High-density genotypes from exome capture and RNA-seq were used to conduct high-resolution association mapping. Seven quantitative trait loci (QTL) were detected, including one in the Rrs2 region, amongst five containing known resistances. Relatively short physical intervals harbouring these resistances were proposed, providing a platform for the identification of underlying genes and tightly linked genetic markers for use in marker assisted selection. Genes encoding kinases were present in four of the QTL, in addition to Rrs1 and Rrs18, two loci known to contribute to rhynchosporium resistance. The frequencies and distributions of these novel and known QTL were superimposed on the regional origin of the landrace genotypes comprising the genome-wide association studies (GWAS) panel, highlighting the value of genetic resources as a source of diverse genetically controlled resistance to rhynchosporium. The detected QTL along with their linked genetic markers, could be exploited either directly for breeding purposes or for candidate gene identification in future studies.
Published: 2022

49. Paleoseismological investigations of the La Rouvière fault, unexpected source of the 11-11-2019, Mw 4.9 Le Teil surface rupturing earthquake (Cévennes fault system, France)

Author: Ritz, Jean-François, Baize, Stéphane, Hannouz, Estelle, Riesner, Magali, Cathelin, Nicolas, Thomasset, Camille, Ferry, Matthieu, Bollinger, Laurent, Larroque, Christophe, Audin, Laurence, Manchuel, Kévin, Rizza, Magali, Jomard, Herve, Sue, Christian, Arroucau, Pierre, Le Roux-Mallouf, Romain, Géosciences Montpellier, Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA)-Université de Montpellier (UM), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Institut des Sciences de la Terre (ISTerre), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de recherche pour le développement [IRD] : UR219-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Gustave Eiffel-Université Grenoble Alpes (UGA), CEA, Bruyeres le Chatel, France, affiliation inconnue, EDF-DIPNN-DI-TEGG, Aix-en-Provence, Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Projet FREMTEIL (CNRS-INSU, Programme TELLUS)
Subjects: Paléosismologie, Le Teil Earthquake, Séisme de Le Teil, RESIF, Paleosismology, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, France
Abstract: International audience; The 11-11-2019 Le Teil earthquake (Mw4.9), located in the Rhône river valley occurred along the La Rouvière fault (LRF) within the NE termination of the Cévennes faults system (CFS). This very shallow moderate magnitude and reverse-faulting event inverted an Oligocene normal fault which was not assessed to be potentially active, causing surface rupture and strong ground shaking. Its morphology shows no evidence of cumulative reverse faulting during the Quaternary. These observations lead to the question whether the fault was reactivated for the first time since the Oligocene during the Teil earthquake, or if it had broken the surface before, during the Quaternary period, but could not be detected in the morphology.
Published: 2022

50. Indications de vitrification ovocytaire dans les pathologies gynécologiques bénignes : conseils de bonne pratique du CNGOF après étude de consensus par méthode Delphi

Author: B. Courbiere, E. Le Roux, E. Mathieu d’Argent, A. Torre, C. Patrat, C. Poncelet, J. Montagut, A.-S. Gremeau, H. Creux, M. Peigne, I. Chanavaz-Lacheray, L. Dirian, X. Fritel, J.-L. Pouly, A. Fauconnier, Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), Department of Gynecology-Obstetric and Reproductive Medicine, AP-HM, Hôpital La Conception, 13005 Marseille, France, Unité d’Epidémiologie Clinique, Hôpital Universitaire Robert Debré, AP-HP Nord-Université de Paris, Inserm, CIC 1426, 75019 Paris, France, Inserm, ECEVE UMR 1123, université de Paris, Paris, France, Groupe de recherche clinique Centre Expert en Endométriose (GRC 6 - C3E), Sorbonne Université (SU), Department of gynecology-obstetric and reproductive medicine, CHU Rouen, 37, boulevard Gambetta, 76000 Rouen, France, Inserm U1016, service de biologie de la reproduction – CECOS, AP–HP centre – université de Paris, site Cochin, 24, rue du Faubourg-Saint-Jacques, 75014 Paris, France, Department of gynecology – obstetrics/UFR SMBH Leonard de Vinci, centre hospitalier de René Dubos/université Sorbonne Paris Nord – université Paris 13, Cergy-Pontoise, France, Institut Francophone de Recherche et d’Etudes Appliquées à la Reproduction, Ifreares Toulouse, 31000 Toulouse, France, Department of gynecologic surgery and IVF, university hospital Clermont-Ferrand, Clermont-Ferrand, France, Clinique Saint Roch, Department of Gynecology-Obstetric and Reproductive Medicine, 34000 Montpellier, France, Department of reproductive medicine and fertility preservation, hôpital Jean-Verdier, université Sorbonne Paris Nord-Paris 13, AP–HP, Bondy, France, Clinique Tivoli Ducos, centre d’endométriose, Bordeaux, France, EndoFrance, Association française de lutte contre l’endométriose, Paris, France, Inserm CIC-P 1402, department of gynecology-obstetric and reproductive medicine, CHU Poitiers, Poitiers, France, Department of gynecology-obstetric, centre hospitalier Moulins Yzeure, Moulins, France, and Department of gynecology and obstetrics/research unit 7285 risk and safety in clinical medicine for women and perinatal health, CHI Poissy-Saint-Germain-en Laye/Paris-Saclay university, Poissy, France
Subjects: [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, Reproductive Medicine, [SDV]Life Sciences [q-bio], Obstetrics and Gynecology
Abstract: International audience; ObjectivesTo provide clinical practice guidelines about fertility preservation (FP) for women with benign gynecologic disease (BGD) developed by a modified Delphi consensus process for oocyte vitrification in women with benign gynecologic disease.MethodsA steering committee composed of 14 healthcare professionals and a patient representative with lived experience of endometriosis identified 42 potential practices related to FP for BGD. Then 114 key stakeholders including various healthcare professionals (n = 108) and patient representatives (n = 6) were asked to participate in a modified Delphi process via two online survey rounds from February to September 2020 and a final meeting. Due to the COVID-19 pandemic, this final meeting to reach consensus was held as a videoconference in November 2020.ResultsSurvey response of stakeholders was 75 % (86/114) for round 1 and 87 % (75/86) for round 2. Consensus was reached for the recommendations for 28 items, that have been distributed into five general categories: (i) Information to provide to women of reproductive age with a BGD, (ii) Technical aspects of FP for BGD, (iii) Indications for FP in endometriosis, (iv) Indications for FP for non-endometriosis BGD, (v) Indications for FP after a fortuitous diagnosis of an idiopathic diminished ovarian reserve.ConclusionThese guidelines provide some practice advice to help health professionals better inform women about the possibilities of cryopreserving their oocytes prior to the management of a BGD that may affect their ovarian reserve and fertility.; ObjectifsÉlaborer des conseils de bonnes pratiques sous l’égide du CNGOF pour préserver la fertilité des femmes devant être prise en charge pour une pathologie gynécologique bénigne risquant d’altérer la fertilité.MéthodesUn comité de pilotage composé de 14 médecins et d’une représentante d’association de patientes a identifié dans un premier temps 42 propositions de conseils de bonne pratique, qui ont ensuite été soumis à l’expertise de 108 médecins experts Francophones provenant de différentes spécialités et de 6 représentantes d’association de patientes. Les 2 tours de Delphi ont été réalisés en ligne entre février et septembre 2020 avec une réunion finale de concertation en visioconférence en novembre 2020.RésultatsLe taux de participation a été de 75 % (86/114) au 1er tour et 87 % (75/86) au 2e tour. Au total, 28 conseils de bonnes pratiques ont été retenus par le panel d’experts après consensus Delphi et ont été réparties en 5 thématiques : (i) Information à donner aux femmes en âge de procréer devant être traitées pour une pathologie gynécologique bénigne, (ii) aspects techniques de la préservation de la fertilité pour les pathologies gynécologique bénignes, (iii) indications de préservation de la fertilité dans le cadre de l’endométriose, (iv) indications de préservation de la fertilité dans les pathologies gynécologiques bénignes hors endométriose, (v) indications de préservation de la fertilité en cas de découverte fortuite d’une diminution idiopathique de la réserve ovarienne.ConclusionCette étude Delphi a permis de dégager des conseils de bonne pratique afin d’aider les professionnels de santé à mieux informer les femmes sur les possibilités de préserver leurs ovocytes avant prise en charge d’une pathologie gynécologique risquant d’altérer leur fertilité.
Published: 2022

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