1. Gene Drives: Dynamics and Regulatory Matters—A Report from the Workshop 'Evaluation of Spatial and Temporal Control of Gene Drives,' April 4–5, 2019, Vienna
- Author
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Florence Débarre, Philipp W. Messer, Nicholas H. Barton, Marc F. Schetelig, Bernd Giese, Nikolai Windbichler, Johannes L. Frieß, Harald Meimberg, Christophe Boëte, University of Natural Resources and Applied Life Sciences (BOKU), Institute of Science and Technology Austria [Klosterneuburg, Austria] (IST), Department of Systems & Computational Biology [New York], Albert Einstein College of Medicine, Institut d'écologie et des sciences de l'environnement de Paris (IEES (UMR_7618 / UMR_D_242 / UMR_A_1392 / UM_113) ), Institut National de la Recherche Agronomique (INRA)-Sorbonne Université (SU)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Justus-Liebig-Universität Gießen (JLU), Department of Life Sciences, Imperial College London, Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), University of Natural Resources and Life Sciences (BOKU), Institute of Science and Technology [Austria] (IST Austria), Albert Einstein College of Medicine [New York], Institut d'écologie et des sciences de l'environnement de Paris (iEES Paris), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR226, German Federal Agency for Nature Conservation (BfN) [3518 84 0500], Universität für Bodenkultur Wien = University of Natural Resources and Life [Vienne, Autriche] (BOKU), Institute of Science and Technology [Klosterneuburg, Austria] (IST Austria), Justus-Liebig-Universität Gießen = Justus Liebig University (JLU), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Institute of Science and Technology [Austria] - IST Austria (IST Austria), and Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE)
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[SDV]Life Sciences [q-bio] ,Population ,Control (management) ,Biology ,Risk Assessment ,Population control ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,0302 clinical medicine ,population dynamics ,Humans ,education ,Gene ,Risk management ,ComputingMilieux_MISCELLANEOUS ,030304 developmental biology ,0303 health sciences ,education.field_of_study ,Organisms, Genetically Modified ,business.industry ,Gene Drive Technology ,Prospective risk ,modeling ,Gene drive ,Risk analysis (engineering) ,Paradigm shift ,gene drive ,business ,030217 neurology & neurosurgery ,population control - Abstract
International audience; Gene Drives are regarded as future tools with a high potential for population control. Due to their inherent ability to overcome the rules of Mendelian inheritance, gene drives (GD) may spread genes rapidly through populations of sexually reproducing organisms. A release of organisms carrying a GD would constitute a paradigm shift in the handling of genetically modified organisms because gene drive organisms (GDO) are designed to drive their transgenes into wild populations and thereby increase the number of GDOs. The rapid development in this field and its focus on wild populations demand a prospective risk assessment with a focus on exposure related aspects. Presently, it is unclear how adequate risk management could be guaranteed to limit the spread of GDs in time and space, in order to avoid potential adverse effects in socio-ecological systems. The recent workshop on the “Evaluation of Spatial and Temporal Control of Gene Drives” hosted by the Institute of Safety/Security and Risk Sciences (ISR) in Vienna aimed at gaining some insight into the potential population dynamic behavior of GDs and appropriate measures of control. Scientists from France, Germany, England, and the USA discussed both topics in this meeting on April 4–5, 2019. This article summarizes results of the workshop.
- Published
- 2019