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Your search keyword '"Emmanuella Di Scala"' showing total 4 results
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4 results on '"Emmanuella Di Scala"'

1. Conformational state of human cardiac 5-HT4(g) receptors influences the functional effects of polyclonal anti-5-HT4 receptor antibodies

Author

Emmanuella Di Scala, Véronique Bozon, Pierre Cosnay, J Argibay, Olivier Herault, S Rose, Communications, Médiations, Organisations, Savoirs ( CIMEOS ), Université de Bourgogne ( UB ), CNRS UMR 6542, Faculté des Sciences, Université de Tours, France., Hôpital Bretonneau, and Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)

Subjects
Protein Conformation, conformational state, Immune receptor, Biology, Biochemistry, Antibodies, 03 medical and health sciences, Cricetulus, Antibody Specificity, Cricetinae, antibody, Animals, Humans, Protease-activated receptor, 5-HT4 receptor, Receptor, 5-HT receptor, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, G protein-coupled receptor, Pharmacology, 0303 health sciences, G protein-coupled receptor kinase, [ SDV ] Life Sciences [q-bio], Myocardium, 030302 biochemistry & molecular biology, CHO cells, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, musculoskeletal system, Molecular biology, inverse-agonist, serotonin, Metabotropic receptor, 5-HT1 receptor, Receptors, Serotonin, 5-HT4
Abstract

International audience; The functional effects of the anti-G21V antibody directed against the second extracellular loop of human heart S-HT4 receptors can differ when the receptors are expressed in different cell lines. Here, we extend these studies to show variation in the responses of 5-HT4(g) receptors to the antibody within the same expression system. In a previous report no effect of the anti-G21V antibodies had been shown upon 5-HT4(g) receptors expressed in CHO cells. Here the same antibodies alone or when added before 5-HT had a functional "inverse-agonist like" effect upon 5-HT4(g) receptors expressed in a separate line of CHO cells. Although these CHO cells showed a lower efficacy of cAMP production evoked by 5-HT than the previous report they express a similar hS-HT4(g) receptor density. Inhibition of either phosphodiesterases or Gi proteins had no effect upon the action of the antibody. Conformational states of the 5-HT4 receptor and/or equilibrium between different states of receptors may then determine the functional effect of antibodies against this receptor. (c) 2006 Elsevier Inc. All rights reserved.

Published
2007

2. High Efficiency Activation of L-Type Ca 2+ Current by 5-HT in Human Atrial Myocytes

Author

Véronique Bozon, Pierre Cosnay, Ian Findlay, Emmanuella Di Scala, Michel Aupart, S Rose, J Argibay, CNRS UMR 6542, Faculté des Sciences, Université de Tours, France., CHU Trousseau [Tours], and Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)

Subjects
Male, Time Factors, Clinical Biochemistry, Stimulation, 030204 cardiovascular system & hematology, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Ca current, Cyclic AMP, Myocyte, atrial fibrillation, Cells, Cultured, Aged, 80 and over, 0303 health sciences, Forskolin, Voltage-dependent calcium channel, Middle Aged, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, serotonin, Electrophysiology, Female, medicine.symptom, Adult, medicine.medical_specialty, Calcium Channels, L-Type, human atrial myocytes, Adrenergic beta-Antagonists, Context (language use), 03 medical and health sciences, Internal medicine, cAMP, medicine, Humans, Heart Atria, 5-HT receptor, Aged, 030304 developmental biology, Pharmacology, Muscle Cells, Dose-Response Relationship, Drug, Myocardium, Colforsin, Isoproterenol, Cell Biology, Mechanism of action, chemistry, Calcium, Serotonin
Abstract

International audience; In human atrial myocytes, serotonin rather than sympathetic, stimulation is more frequently associated with atrial fibrillation. So does the arrhythmogenic effect of serotonin result from the mechanism of action of the receptor or the context of its action upon cardiac myocytes? The capacity of agonists to produce cAMP followed the sequence 5-HT < Iso < Forskolin to increase ICaL with 5-HT = Iso = Forskolin. The simultaneous application of threshold concentrations of 5-HT and Iso maximally increased ICaL. We will show that the effect of 5-HT upon human atrial myocytes is an imbalance between low production of cAMP and maximal activation of ICaL.

Published
2004

3. Se dirige-t-on vers un changement de paradigme dans la recherche biomédicale ? »

Author

Di Scala, Emmanuella, Di Scala, Emmanuella, Communications, Médiations, Organisations, Savoirs ( CIMEOS ), Université de Bourgogne ( UB ), Emmanuella Di Scala, Communications, Médiations, Organisations, Savoirs (CIMEOS), and Université de Bourgogne (UB)

Subjects
recherche biomédicale, paradigme, [ SHS ] Humanities and Social Sciences, crise scientifique, [SHS] Humanities and Social Sciences, ComputingMilieux_MISCELLANEOUS, [SHS]Humanities and Social Sciences
Abstract

National audience

Published
2016

4. Réflexion autour des Représentations en question

Author

Di Scala , Emmanuella, Communications, Médiations, Organisations, Savoirs (CIMEOS), Université de Bourgogne (UB), Emmanuella Di Scala, Communications, Médiations, Organisations, Savoirs ( CIMEOS ), Université de Bourgogne ( UB ), and Di Scala, Emmanuella

Subjects
[ SHS ] Humanities and Social Sciences, représentations, sciences, [SHS] Humanities and Social Sciences, société, ComputingMilieux_MISCELLANEOUS, [SHS]Humanities and Social Sciences
Abstract

National audience

Published
2015

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