1. Bats host major mammalian paramyxoviruses
- Author
-
Jan Felix Drexler, Victor Max Corman, Marcel Alexander Müller, Gael Darren Maganga, Peter Vallo, Tabea Binger, Florian Gloza-Rausch, Veronika M. Cottontail, Andrea Rasche, Stoian Yordanov, Antje Seebens, Mirjam Knörnschild, Samuel Oppong, Yaw Adu Sarkodie, Célestin Pongombo, Alexander N. Lukashev, Jonas Schmidt-Chanasit, Andreas Stöcker, Aroldo José Borges Carneiro, Stephanie Erbar, Andrea Maisner, Florian Fronhoffs, Reinhard Buettner, Elisabeth K. V. Kalko, Thomas Kruppa, Carlos Roberto Franke, René Kallies, Emmanuel R.N. Yandoko, Georg Herrler, Chantal Reusken, Alexandre Hassanin, Detlev H. Krüger, Sonja Matthee, Rainer G. Ulrich, Eric M. Leroy, Christian Drosten, Institute of Virology, University of Bonn Medical Centre, Centre International de Recherches Médicales de Franceville (CIRMF), Institute of Vertebrate Biology, Czech Academy of Sciences [Prague] (CAS), Noctalis, Centre for Bat Protection and Information, Institute of Virology [Hannover], Hannover Medical School [Hannover] (MHH), Forestry Board Directorate of Strandja Natural Park, Strandja Natural Park, Kwame Nkrumah University of Science and Technology [GHANA] (KNUST), University of Lubumbashi, Chumakov Institute of Poliomyelitis and Viral Encephalitides, Department of Virology, Bernhard Nocht Institute for Tropical Medicine - Bernhard-Nocht-Institut für Tropenmedizin [Hamburg, Germany] (BNITM), Infectious Diseases Research Laboratory, Universidade Federal da Bahia (UFBA)-University Hospital Professor Edgard Santos, School of Veterinary Medicine, Universidade Federal da Bahia (UFBA), Institut für Virologie, Philipps University, Institute of Pathology, University of Cologne Medical Centre, Smithsonian Tropical Research Institute, Institute of Experimental Ecology, Universität Ulm - Ulm University [Ulm, Allemagne], Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Institut Pasteur de Bangui, Réseau International des Instituts Pasteur (RIIP), Netherlands Center for Infectious Disease Control, Muséum national d'Histoire naturelle (MNHN), Institute of Medical Virology (Helmut Ruska Haus), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Department of Conservation Ecology and Entomology, Stellenbosch University, Institute of Novel and Emerging Infectious Diseases (INNT), Friedrich-Loeffler-Institut (FLI), Institut de Recherche pour le Développement (IRD [France-Sud]), This study was funded by the European Union FP7 projects EMPERIE (Grant agreement number 223498) and EVA (Grant agreement number 228292), the German Federal Ministry of Education and Research (BMBF, project code 01KIO701), the German Research Foundation (DFG, Grant agreement number DR 772/3-1) to CD, the German Federal Ministry of Education and Research (BMBF) through the National Research Platform for Zoonoses (project code 01KI1018), the Umweltbundesamt (FKZ 370941401) and the Robert Koch-Institut (FKZ 1362/1-924) to RGU, through the Government of Gabon, Total-Fina-Elf Gabon and the Ministère des Affaires Etrangères, France., European Project: 223498,EC:FP7:HEALTH,FP7-HEALTH-2007-B,EMPERIE(2009), Kwame Nkrumah University of Science and Technology (KNUST), and Université de Lubumbashi (UNILU)
- Subjects
animal structures ,Paramyxoviridae ,viruses ,Molecular Sequence Data ,General Physics and Astronomy ,Mumps virus ,medicine.disease_cause ,Article ,General Biochemistry, Genetics and Molecular Biology ,Mice ,03 medical and health sciences ,Pneumovirinae ,Dogs ,Chiroptera ,Veterinary virology ,medicine ,Animals ,Humans ,Phylogeny ,Disease Reservoirs ,030304 developmental biology ,Mammals ,0303 health sciences ,Paramyxoviridae Infections ,Multidisciplinary ,Ebola virus ,biology ,030306 microbiology ,Canine distemper ,General Chemistry ,biology.organism_classification ,medicine.disease ,Virology ,Sendai virus ,3. Good health ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,Henipavirus - Abstract
The large virus family Paramyxoviridae includes some of the most significant human and livestock viruses, such as measles-, distemper-, mumps-, parainfluenza-, Newcastle disease-, respiratory syncytial virus and metapneumoviruses. Here we identify an estimated 66 new paramyxoviruses in a worldwide sample of 119 bat and rodent species (9,278 individuals). Major discoveries include evidence of an origin of Hendra- and Nipah virus in Africa, identification of a bat virus conspecific with the human mumps virus, detection of close relatives of respiratory syncytial virus, mouse pneumonia- and canine distemper virus in bats, as well as direct evidence of Sendai virus in rodents. Phylogenetic reconstruction of host associations suggests a predominance of host switches from bats to other mammals and birds. Hypothesis tests in a maximum likelihood framework permit the phylogenetic placement of bats as tentative hosts at ancestral nodes to both the major Paramyxoviridae subfamilies (Paramyxovirinae and Pneumovirinae). Future attempts to predict the emergence of novel paramyxoviruses in humans and livestock will have to rely fundamentally on these data., The large virus family, Paramyxoviridae, includes several human and livestock viruses. This study, testing 119 bat and rodent species distributed globally, identifies novel putative paramyxovirus species, providing data with potential uses in predictions of the emergence of novel paramyxoviruses in humans and livestock.
- Published
- 2012