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Your search keyword '"Odile Puijalon"' showing total 3 results
3 results on '"Odile Puijalon"'

1. First case of emergence of atovaquone resistance in Plasmodium falciparum during second-line atovaquone-proguanil treatment in South America

Author

Béatrice Volney, Eric Legrand, Philippe Esterre, Marc Quinternet, Christophe Rogier, Bernard Carme, Odile Puijalon, Magalie Demar, Marie-Thérèse Ekala, Christiane Bouchier, Thierry Fandeur, Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP), Unité de Maladies infectieuses et tropicales-Hygiène hospitalière (EA 3593), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Immunologie moléculaire des parasites, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Génomique (Plate-Forme) - Genomics Platform, Institut Pasteur [Paris], Immunologie parasitaire (TOURS UMR IMMUNOLOGIE PARASIT), Institut National de la Recherche Agronomique (INRA)-Faculte des Sciences Pharmaceutiques, Unité de Recherche en Biologie et Epidémiologie Parasitaires, Institut de Médecine Tropicale du Service de Santé des Armées-Centre National de la Recherche Scientifique (CNRS), Epidémiologie des parasitoses et mycoses tropicales, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), Centre Hospitalier Andrée Rosemon, Génomique (Plate-Forme), Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), and Institut Pasteur [Paris] (IP)

Subjects
Drug Resistance, Drug resistance, Pharmacology, MESH: Parasitic Sensitivity Tests, Treatment failure, 0302 clinical medicine, Second line, Parasitic Sensitivity Tests, Pharmacology (medical), MESH: Animals, Malaria, Falciparum, Letter to the Editor, ComputingMilieux_MISCELLANEOUS, MESH: Plasmodium falciparum, 0303 health sciences, biology, MESH: Malaria, Falciparum, MESH: Proguanil, 3. Good health, Infectious Diseases, Proguanil, Combination, MESH: Drug Resistance, Drug Therapy, Combination, Atovaquone, medicine.drug, Falciparum, 030231 tropical medicine, Plasmodium falciparum, MESH: Atovaquone, 03 medical and health sciences, Antimalarials, Drug Therapy, parasitic diseases, medicine, Animals, Humans, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, MESH: Humans, 030306 microbiology, MESH: South America, South America, medicine.disease, biology.organism_classification, Atovaquone/proguanil, Virology, MESH: Antimalarials, Malaria, MESH: Drug Therapy, Combination, human activities
Abstract

The atovaquone-proguanil combination (Malarone) has been introduced in French Guiana for prophylaxis and second-line treatment for Plasmodium falciparum malaria in 2002. We report here a treatment failure in a patient who was given a second-line atovaquone-proguanil treatment. A nonimmune P.

Published
2007

2. Countrywide survey shows very high prevalence of Plasmodium falciparum multilocus resistance genotypes in Cambodia

Author

Nimol Khim, Socheat Doung, Odile Puijalon, Christiane Bouchier, Sandra Incardona, Ronan Jambou, Eric Legrand, Pharath Lim, Marie-Thérèse Ekala, Thierry Fandeur, Inconnu, Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP), Institut Pasteur [Paris] (IP), Immunologie moléculaire des parasites, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur de la Guyane, Institut Pasteur de Dakar, National Malaria Center, Ministère de la santé, Institut Pasteur [Paris], Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), and ProdInra, Migration

Subjects
[SDV]Life Sciences [q-bio], Genes, Protozoan, Protozoan Proteins, MESH: Tetrahydrofolate Dehydrogenase, Drug resistance, MESH: Parasitic Sensitivity Tests, MESH: Genotype, 0302 clinical medicine, Parasitic Sensitivity Tests, Genotype, Prevalence, MESH: Animals, Pharmacology (medical), MESH: Dihydropteroate Synthase, Malaria, Falciparum, MESH: Protozoan Proteins, MESH: Plasmodium falciparum, Genetics, 0303 health sciences, biology, Mefloquine, MESH: Malaria, Falciparum, Drug Resistance, Multiple, 3. Good health, [SDV] Life Sciences [q-bio], Infectious Diseases, MESH: Genes, Protozoan, MESH: ATP-Binding Cassette Transporters, Cambodia, medicine.drug, MESH: Thymidylate Synthase, MESH: Mutation, 030231 tropical medicine, Plasmodium falciparum, Context (language use), MESH: Drug Resistance, Multiple, 03 medical and health sciences, Antimalarials, parasitic diseases, medicine, Animals, Humans, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Experimental Therapeutics, MESH: Prevalence, Pharmacology, Dihydropteroate Synthase, MESH: Humans, 030306 microbiology, MESH: Cambodia, Haplotype, Thymidylate Synthase, medicine.disease, biology.organism_classification, MESH: Antimalarials, Tetrahydrofolate Dehydrogenase, Mutation, ATP-Binding Cassette Transporters, Dihydropteroate synthase, Malaria
Abstract

Cambodia is located in an area of resistance to multiple antimalarials and has been the first country to implement the systematic use of an artesunate-mefloquine combination as first-line treatment for Plasmodium falciparum malaria. Little is known, however, about the prevalence of resistance mutations within the natural parasite populations, impeding rational drug policy in this context. Using direct sequencing of PCR products, we have analyzed sequence polymorphism of the dihydrofolate reductase-thymidylate synthase, dihydropteroate synthetase, and multidrug resistance 1 genes in a large number of clinical P. falciparum isolates collected in various areas of Cambodia. This highlighted a 100% prevalence of haplotypes with multiple mutations in the target genes of antifolates after more than a decade without use of antifolates for malaria therapy. A high prevalence of mutations in Pfmdr1 , including mutations associated with decreased in vitro susceptibility to mefloquine and quinine, was also observed. In addition, novel, low-frequency mutations were detected in Pfmdr1 . Our findings show an alarming rate of multilocus resistance genotypes in Cambodia, requiring diligent surveillance and imposing limitations on possible future drug combinations.

Published
2005

3. Cross–reactive antigenic determinants present on different Plasmodium falciparum blood–stage antigens

Author

Rachanee Udomsangpetch, Artur Scherf, Klavs Berzins, Serge Bonnefoy, Luiz Pereira da Silva, Odile Puijalon, Micheline Guillotte, Benno Müjller–Hill, Gordon Langsley, Hans Werner Griesser, Denise Mattei, Mats Wahlgren, Peter Perlmann, Institut Pasteur [Paris] (IP), Stockholm University, Universität zu Köln = University of Cologne, and Institut Pasteur [Paris]

Subjects
Erythrocytes, MESH: Amino Acid Sequence, MESH: Base Sequence, medicine.disease_cause, Cross-reactivity, MESH: Antibodies, Monoclonal, MESH: Cross Reactions, Epitopes, 0302 clinical medicine, MESH: Animals, Cloning, Molecular, ComputingMilieux_MISCELLANEOUS, MESH: Plasmodium falciparum, chemistry.chemical_classification, 0303 health sciences, MESH: Erythrocytes, MESH: DNA, Antibodies, Monoclonal, 3. Good health, Amino acid, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Antibody, MESH: Epitopes, medicine.drug_class, Molecular Sequence Data, Plasmodium falciparum, 030231 tropical medicine, Immunology, MESH: Malaria, Antigens, Protozoan, Cross Reactions, Biology, Monoclonal antibody, 03 medical and health sciences, Antigen, parasitic diseases, medicine, Animals, Humans, MESH: Cloning, Molecular, Amino Acid Sequence, Northern blot, Gene, 030304 developmental biology, MESH: Humans, MESH: Molecular Sequence Data, Base Sequence, DNA, biology.organism_classification, Virology, Malaria, chemistry, biology.protein, Parasitology, MESH: Antigens, Protozoan
Abstract

International audience; A gene encoding a previously undescribed antigen of Plasmodium falciparum has been isolated from a genomic expression library by use of a pool of human immune sera. Northern blot analysis indicated that the gene is expressed at the late stages of the intra-erythrocytic cycle. This antigen, 332, contains a series of degenerated amino acid repeats. Human antibodies affinity-purified on the 332 recombinant antigen reacted with a family of parasite proteins that are products of different genes. We identified antigens 11.1 and Pf155-RESA as members of this family and confirmed, using a human monoclonal antibody, the presence of cross-reacting determinants. The sequences of these antigens also share some structural homologies. The significance of this family of blood-stage antigens is discussed.

Published
1989

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