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First case of emergence of atovaquone resistance in Plasmodium falciparum during second-line atovaquone-proguanil treatment in South America

Authors :
Béatrice Volney
Eric Legrand
Philippe Esterre
Marc Quinternet
Christophe Rogier
Bernard Carme
Odile Puijalon
Magalie Demar
Marie-Thérèse Ekala
Christiane Bouchier
Thierry Fandeur
Institut Pasteur de la Guyane
Réseau International des Instituts Pasteur (RIIP)
Unité de Maladies infectieuses et tropicales-Hygiène hospitalière (EA 3593)
Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]
Immunologie moléculaire des parasites
Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)
Génomique (Plate-Forme) - Genomics Platform
Institut Pasteur [Paris]
Immunologie parasitaire (TOURS UMR IMMUNOLOGIE PARASIT)
Institut National de la Recherche Agronomique (INRA)-Faculte des Sciences Pharmaceutiques
Unité de Recherche en Biologie et Epidémiologie Parasitaires
Institut de Médecine Tropicale du Service de Santé des Armées-Centre National de la Recherche Scientifique (CNRS)
Epidémiologie des parasitoses et mycoses tropicales
Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG)
Centre Hospitalier Andrée Rosemon
Génomique (Plate-Forme)
Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
Institut Pasteur [Paris] (IP)
Source :
Antimicrobial Agents and Chemotherapy, Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2007, 51 (6), pp.2280-1. ⟨10.1128/AAC.01532-06⟩, Antimicrobial Agents and Chemotherapy, 2007, 51 (6), pp.2280-1. ⟨10.1128/AAC.01532-06⟩
Publication Year :
2007
Publisher :
HAL CCSD, 2007.

Abstract

The atovaquone-proguanil combination (Malarone) has been introduced in French Guiana for prophylaxis and second-line treatment for Plasmodium falciparum malaria in 2002. We report here a treatment failure in a patient who was given a second-line atovaquone-proguanil treatment. A nonimmune P.

Subjects

Subjects :
Drug Resistance
Drug resistance
Pharmacology
MESH: Parasitic Sensitivity Tests
Treatment failure
0302 clinical medicine
Second line
Parasitic Sensitivity Tests
Pharmacology (medical)
MESH: Animals
Malaria, Falciparum
Letter to the Editor
ComputingMilieux_MISCELLANEOUS
MESH: Plasmodium falciparum
0303 health sciences
biology
MESH: Malaria, Falciparum
MESH: Proguanil
3. Good health
Infectious Diseases
Proguanil
Combination
MESH: Drug Resistance
Drug Therapy, Combination
Atovaquone
medicine.drug
Falciparum
030231 tropical medicine
Plasmodium falciparum
MESH: Atovaquone
03 medical and health sciences
Antimalarials
Drug Therapy
parasitic diseases
medicine
Animals
Humans
[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology
MESH: Humans
030306 microbiology
MESH: South America
South America
medicine.disease
biology.organism_classification
Atovaquone/proguanil
Virology
MESH: Antimalarials
Malaria
MESH: Drug Therapy, Combination
human activities

Details

Language :
English
ISSN :
00664804 and 10986596
Database :
OpenAIRE
Journal :
Antimicrobial Agents and Chemotherapy, Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2007, 51 (6), pp.2280-1. ⟨10.1128/AAC.01532-06⟩, Antimicrobial Agents and Chemotherapy, 2007, 51 (6), pp.2280-1. ⟨10.1128/AAC.01532-06⟩
Accession number :
edsair.doi.dedup.....6093c300cbcd7634f22e76472a66e2ac
Full Text :
https://doi.org/10.1128/AAC.01532-06⟩
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