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This article discusses a prospective study conducted in France that aimed to evaluate the feasibility of placing fiducial markers under Endoscopy Ultra-Sound (EUS) guidance for the treatment of esophageal or rectal cancers. The study included 33 patients with rectal or esophageal tumors who required radiation therapy. The results showed a high success rate of fiducial marker placement, with no technical failures reported. The procedure was safe, with no adverse events, and the markers remained visible on imaging throughout the course of radiation therapy. Overall, the study highlights the effectiveness and safety of using fiducial markers under EUS guidance for the treatment of these types of cancers. [Extracted from the article]

This article, published in the journal Endoscopy, presents the findings of a multicenter tandem randomized controlled trial that aimed to evaluate the impact of linked color imaging (LCI) on the proximal adenoma miss rate (pAMR) during routine colonoscopy. The study compared standard colonoscopy with white light imaging (WLI) to colonoscopy with LCI. The primary outcome, pAMR, was not significantly higher in the WLI-first group compared to the LCI-first group. The study concludes that LCI does not provide significant benefits in terms of pAMR during routine colonoscopy. [Extracted from the article]

This article discusses the risk of lymph node metastasis and recurrence after endoscopic resection of T1 colorectal adenocarcinoma with submucosal invasion greater than 1000µm and no other histological pejorative factors. The study, conducted in 24 European centers, included 219 patients who underwent endoscopic resection between December 2009 and December 2022. The results showed that lesions with submucosal invasion greater than or equal to 2000µm were significantly associated with lymph node metastases and recurrence. The authors suggest that the 1000µm threshold may be too restrictive and that the 2000µm threshold is more relevant for predicting the risk of lymph node metastases. [Extracted from the article]

This article discusses the use of next-generation sequencing (NGS) as a tool for diagnosing genomic abnormalities in pancreatic cyst fluid. The study aimed to evaluate the feasibility and performance of NGS on pancreatic cyst fluid in a real-life setting. The researchers validated the DNA extraction technique and tested a panel of 91 genes by comparing the genomic abnormalities in the cyst fluid with those in histological samples. They then performed DNA extraction and NGS on pancreatic cyst fluids collected through endoscopic ultrasound (EUS). The results showed that NGS was concordant for 90% of the patients, and genomic abnormalities were detected in 20 out of 54 patients. The study concludes that NGS of pancreatic cystic fluid sampled by EUS is possible and effective, although genetic abnormalities were not detected in some patients. [Extracted from the article]

This article, published in the journal Endoscopy, discusses the evaluation of artificial intelligence (AI) for the diagnosis of pancreatic cancer using linear endoscopic ultrasound (EUS). The study aimed to address the limitations of EUS, such as variable echogenicity and difficulty visualizing infiltrative forms of pancreatic cancer. The researchers used a database of linear EUS images and a Transfer Learning algorithm to diagnose pancreatic cancer with a diagnostic performance of approximately 75%. The study included 609 patients, and the AI demonstrated a sensitivity of 80%, specificity of 90%, and accuracy of 86% for diagnosing pancreatic cancer in linear EUS. The findings suggest that AI may be effective in diagnosing pancreatic tumors using this technique. [Extracted from the article]