1. Integration of DNA methylation & health scores identifies subtypes in myalgic encephalomyelitis/chronic fatigue syndrome.
- Author
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de Vega WC, Erdman L, Vernon SD, Goldenberg A, and McGowan PO
- Subjects
- Epigenesis, Genetic, Fatigue Syndrome, Chronic genetics, Female, Humans, Middle Aged, Surveys and Questionnaires, DNA Methylation, Fatigue Syndrome, Chronic classification, Severity of Illness Index
- Abstract
Aim: To identify subtypes in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) based on DNA methylation profiles and health scores., Methods: DNA methylome profiles in immune cells were integrated with symptomatology from 70 women with ME/CFS using similarity network fusion to identify subtypes., Results: We discovered four ME/CFS subtypes associated with DNA methylation modifications in 1939 CpG sites, three RAND-36 categories and five DePaul Symptom Questionnaire measures. Methylation patterns of immune response genes and differences in physical functioning and postexertional malaise differentiated the subtypes., Conclusion: ME/CFS subtypes are associated with specific DNA methylation differences and health symptomatology and provide additional evidence of the potential relevance of metabolic and immune differences in ME/CFS with respect to specific symptoms.
- Published
- 2018
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