Back to Search
Start Over
Integration of DNA methylation & health scores identifies subtypes in myalgic encephalomyelitis/chronic fatigue syndrome.
- Source :
-
Epigenomics [Epigenomics] 2018 May; Vol. 10 (5), pp. 539-557. Date of Electronic Publication: 2018 Apr 25. - Publication Year :
- 2018
-
Abstract
- Aim: To identify subtypes in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) based on DNA methylation profiles and health scores.<br />Methods: DNA methylome profiles in immune cells were integrated with symptomatology from 70 women with ME/CFS using similarity network fusion to identify subtypes.<br />Results: We discovered four ME/CFS subtypes associated with DNA methylation modifications in 1939 CpG sites, three RAND-36 categories and five DePaul Symptom Questionnaire measures. Methylation patterns of immune response genes and differences in physical functioning and postexertional malaise differentiated the subtypes.<br />Conclusion: ME/CFS subtypes are associated with specific DNA methylation differences and health symptomatology and provide additional evidence of the potential relevance of metabolic and immune differences in ME/CFS with respect to specific symptoms.
Details
- Language :
- English
- ISSN :
- 1750-192X
- Volume :
- 10
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Epigenomics
- Publication Type :
- Academic Journal
- Accession number :
- 29692205
- Full Text :
- https://doi.org/10.2217/epi-2017-0150