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1. Oncometabolite Tinkers with Genome Folding, Boosting Oncogene Expression.

Author

Ing-Simmons E and Merkenschlager M

Subjects
Humans, Gene Expression Regulation, Neoplastic, Glioma enzymology, Glioma genetics, Insulator Elements genetics, Isocitrate Dehydrogenase genetics, Mutation genetics, Oncogenes genetics
Abstract

A recent article makes a compelling case for a new mechanism by which heterozygous mutations in isocitrate dehydrogenases (IDH1/2)--implicated in cancer--undermine gene regulation. 2-Hydroxyglutarate (2HG) produced by mutant IDH alters the binding of the chromosomal organizer protein CTCF, disrupting the spatial and regulatory organization of the genome., (Copyright © 2016 Elsevier Ltd. All rights reserved.)

Published
2016
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