Oncometabolite Tinkers with Genome Folding, Boosting Oncogene Expression.

Authors :: Ing-Simmons E
Merkenschlager M
Source :: Trends in molecular medicine [Trends Mol Med] 2016 Mar; Vol. 22 (3), pp. 185-187. Date of Electronic Publication: 2016 Feb 05.
Publication Year :: 2016
Abstract: A recent article makes a compelling case for a new mechanism by which heterozygous mutations in isocitrate dehydrogenases (IDH1/2)--implicated in cancer--undermine gene regulation. 2-Hydroxyglutarate (2HG) produced by mutant IDH alters the binding of the chromosomal organizer protein CTCF, disrupting the spatial and regulatory organization of the genome.<br /> (Copyright © 2016 Elsevier Ltd. All rights reserved.)