1. Mechanistic similarities in recognition of histone tails and DNA by epigenetic readers.
- Author
-
Vann KR, Klein BJ, and Kutateladze TG
- Subjects
- Chromatin, DNA genetics, Epigenesis, Genetic, Protein Processing, Post-Translational, Histones metabolism, Nucleosomes
- Abstract
The past two decades have witnessed rapid advances in the identification and characterization of epigenetic readers, capable of recognizing or reading post-translational modifications in histones. More recently, a new set of readers with the ability to interact with the nucleosome through concomitant binding to histones and DNA has emerged. In this review, we discuss mechanistic insights underlying bivalent histone and DNA recognition by newly characterized readers and highlight the importance of binding to DNA for their association with chromatin., Competing Interests: Conflict of interest statement Nothing declared., (Copyright © 2021 Elsevier Ltd. All rights reserved.)
- Published
- 2021
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