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Mechanistic similarities in recognition of histone tails and DNA by epigenetic readers.
- Source :
-
Current opinion in structural biology [Curr Opin Struct Biol] 2021 Dec; Vol. 71, pp. 1-6. Date of Electronic Publication: 2021 May 13. - Publication Year :
- 2021
-
Abstract
- The past two decades have witnessed rapid advances in the identification and characterization of epigenetic readers, capable of recognizing or reading post-translational modifications in histones. More recently, a new set of readers with the ability to interact with the nucleosome through concomitant binding to histones and DNA has emerged. In this review, we discuss mechanistic insights underlying bivalent histone and DNA recognition by newly characterized readers and highlight the importance of binding to DNA for their association with chromatin.<br />Competing Interests: Conflict of interest statement Nothing declared.<br /> (Copyright © 2021 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-033X
- Volume :
- 71
- Database :
- MEDLINE
- Journal :
- Current opinion in structural biology
- Publication Type :
- Academic Journal
- Accession number :
- 33993059
- Full Text :
- https://doi.org/10.1016/j.sbi.2021.04.003